Details of the Drug Inactive Ingredient (DIG)
| General Information of DIG (ID: E07IJK) | |||||
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| DIG Name |
Pluronic F123
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| DIG Function |
Emulsifying agent; Solubilizing agent; Surfactant
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| Full List of Biological Targets of DIG (DBTs) Regulated by This DIG | ||||||
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| Primary active transporter (PAT) | ||||||
| DBT Name: Multidrug resistance protein 1 (ABCB1) | Click to Show/Hide | |||||
| Detailed Information |
DBT Info
 click to show the detail info of this DBT
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| Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
| Biological Activity | Inhibition ratio = 85 % (tested by experiment) | [1] | ||||
| Tested Species | Homo sapiens (Human) | |||||
| UniProt ID | MDR1_HUMAN ; MDR3_HUMAN ; ABCB5_HUMAN | |||||
| References | |||||
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| 1 | Effect of pluronic P123 and F127 block copolymer on P-glycoprotein transport and CYP3A metabolism. Arch Pharm Res. 2011 Oct;34(10):1719-28. | ||||
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