General Information of DIG (ID: E07VCZ)
DIG Name	Carmine
DIG Function	Colorant

Full List of Active Pharmaceutical Ingredients (APIs) Co-administrated with This DIG
ICD Disease Classification 15			Musculoskeletal/connective-tissue disease		Click to Show/Hide
Cyclosporin A		API Info	Rheumatoid arthritis [ICD-11: FA20]			[1]

Full List of Biological Targets of DIG (DBTs) Regulated by This DIG
Potential-driven transporter (PDT)
DBT Name: Solute carrier SLCO2B1 (OATPB)			Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Biological Activity	Inhibition ratio = 29.4 % (tested by experiment)				[2]
Tested Species	Homo sapiens (Human)
UniProt ID	SO2B1_HUMAN

References
1	FDA label for approved cyclosporin A from the official website of the U.S. Food and Drug Administration.
2	Bacterial metabolism rescues the inhibition of intestinal drug absorption by food and drug additives. Proc Natl Acad Sci U S A. 2020 Jul 7;117(27):16009-16018.

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