Details of the Drug Inactive Ingredient (DIG)

General Information of DIG (ID: E0CW9H)
DIG Name
Myristic acid
Synonyms    Click to Show/Hide the Synonyms of This DIG
Tetradecanoic acid; MYRISTIC ACID; 544-63-8; n-Tetradecanoic acid; Crodacid; n-Tetradecoic acid; 1-Tridecanecarboxylic acid; n-Tetradecan-1-oic acid; Hydrofol acid 1495; Univol U 316S; Emery 655; Myristinsaeure; Myristate; tetradecoic acid; Hystrene 9014; Neo-fat 14; C14 fatty acid; Myristic acid, pure; n-Myristic acid; Myristic acid (natural); Tetradecanoate; acide tetradecanoique; NSC 5028; FEMA No. 2764; CCRIS 4724; CH3-[CH2]12-COOH; HSDB 5686; C14:0; UNII-0I3V7S25AW; Philacid 1400; CHEBI:28875; AI3-15381; Prifac 2942; MFCD00002744; 1-tetradecanecarboxylic acid; 0I3V7S25AW; CHEMBL111077; NSC5028; Myristic acid, 99%; DSSTox_CID_1666; n-tetradecan-1-oate; DSSTox_RID_76274; DSSTox_GSID_21666; CAS-544-63-8; Myristic acid [NF]; EINECS 208-875-2; BRN 0508624; myristoate; myristoic acid; Lead dimyristate; n-Tetradecanoate; 3usx; Myristic acid pure; Myristic Acid Flake; Hystrene 9514; Kortacid 1499; Edenor C 14; Myristic Acid 655; 1-Tridecanecarboxylate; Prifrac 2942; MAGNESIUMARSENATE; Myristic acid, 95%; Myristic acid, natural; tridecanecarboxylic acid; Myristic acid (8CI); Myristic Acid, Reagent; 3v2n; 3w9k; Myristic acid, puriss.; ACMC-1AKMJ; 32112-52-0; Tetradecanoic acid (9CI); bmse000737; Epitope ID:176772; SCHEMBL6374; 4-02-00-01126 (Beilstein Handbook Reference); MLS002152942; WLN: QV13; Tetradecanoic (Myristic) acid; Myristic acid-[9,10-3H]; CCCCCCCCCCCCCC([O])=O; GTPL2806; DTXSID6021666; s161; HMS3039E15; HMS3648O20; Myristic acid, analytical standard; HY-N2041; MYRISTIC-1,2-13C2 ACID; NSC-5028; TETRADECANOIC-6,6-D2 ACID; ZINC1530417; EINECS 250-924-5; Myristic acid, >=98.0% (GC); Tox21_201852; Tox21_302781; ANW-32091; BDBM50147581; LMFA01010014; s5617; SBB060024; STL185697; Myristic acid, >=95%, FCC, FG; Myristic acid, Sigma Grade, >=99%; AKOS009156714; CCG-266785; DB08231; DS-3833; MCULE-9671122893; NE10225; NCGC00091068-01; NCGC00091068-02; NCGC00091068-03; NCGC00256547-01; NCGC00259401-01; AK114664; SMR001224536; ST023797; CS-0018531; FT-0602832; FT-0770860; M0476; EN300-78099; Myristic acid-13,13,14,14,14-[d5]; C06424; Myristic acid, Vetec(TM) reagent grade, 98%; Q422658; SR-01000854525; SR-01000854525-3; W-109088; F8889-5016; EDAE4876-C383-4AD4-A419-10C0550931DB; UNII-13FB83DEYU component TUNFSRHWOTWDNC-UHFFFAOYSA-N; UNII-5U9XZ261ER component TUNFSRHWOTWDNC-UHFFFAOYSA-N; UNII-96GS7P39SN component TUNFSRHWOTWDNC-UHFFFAOYSA-N; UNII-Q8Y7S3B85M component TUNFSRHWOTWDNC-UHFFFAOYSA-N; UNII-79P21R4317 component TUNFSRHWOTWDNC-UHFFFAOYSA-N; Myristic acid, United States Pharmacopeia (USP) Reference Standard; Tetradecanoic acid; 1-Tridecanecarboxylic acid; n-Tetradecanoic acid; Myristic acid, Pharmaceutical Secondary Standard; Certified Reference Material; 124511-74-6; 30719-21-2; 327077-03-2; 72878-02-5
DIG Function
Emulsifying agent; Penetration agent; lubricant
PubChem CID
11005
Formula
C14H28O2
Canonical SMILES
CCCCCCCCCCCCCC(=O)O
InChI
1S/C14H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14(15)16/h2-13H2,1H3,(H,15,16)
InChIKey
TUNFSRHWOTWDNC-UHFFFAOYSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This DIG
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=11005"></iframe>
3D MOL 2D MOL
Physicochemical Properties Molecular Weight 228.37 Topological Polar Surface Area 37.3
XlogP 5.3 Complexity 155
Heavy Atom Count 16 Rotatable Bond Count 12
Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 2
Full List of Active Pharmaceutical Ingredients (APIs) Co-administrated with This DIG
       ICD Disease Classification 08 Nervous system disease Click to Show/Hide
Oxycodone
 API Info
Anaesthesia [ICD-11: 8E22]
 [1]
Full List of Biological Targets of DIG (DBTs) Regulated by This DIG
      G-protein coupled receptor (GPCR)
            DBT Name: GPCR84 receptor (GPR84) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Biological Activity Ki = 2640 nM (tested by experiment) [2]
                    Tested Species Homo sapiens (Human)
                    UniProt ID GPR84_HUMAN
      Oxidoreductase (ORase)
            DBT Name: Prostaglandin G/H synthase 1 (COX-1) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Biological Activity IC50 > 500000 nM (tested by experiment) [3]
                    Tested Species Bos taurus (Bovine)
                    UniProt ID PGH1_BOVIN
            DBT Name: Prostaglandin G/H synthase 2 (COX-2) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Biological Activity IC50 > 500000 nM (tested by experiment) [3]
                    Tested Species Ovis aries (Sheep)
                    UniProt ID PGH2_SHEEP
      Hydrolase (HDase)
            DBT Name: Dynamin-1 (DNM1) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Biological Activity IC50 > 100000 nM (tested by experiment) [4]
                    Tested Species Homo sapiens (Human)
                    UniProt ID DYN1_HUMAN
            DBT Name: Toll-like receptor 2 (TLR2) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Biological Activity IC50 = 5000 nM (tested by experiment) [5]
                    Tested Species Homo sapiens (Human)
                    UniProt ID TLR2_HUMAN
      Nuclear receptor (NR)
            DBT Name: PPAR-alpha (PPARA) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Biological Activity IC50 = 5400 nM (tested by experiment) [6]
                    Tested Species Homo sapiens (Human)
                    UniProt ID PPARA_HUMAN
            DBT Name: PPAR-delta (PPARD) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Biological Activity IC50 = 24000 nM (tested by experiment) [6]
                    Tested Species Homo sapiens (Human)
                    UniProt ID PPARD_HUMAN
            DBT Name: PPAR-gamma (PPARG) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Biological Activity IC50 = 21000 nM (tested by experiment) [6]
                    Tested Species Homo sapiens (Human)
                    UniProt ID PPARG_HUMAN
References
1 Efficacy of oxycodone in neuropathic pain: a randomized trial in postherpetic neuralgia. Neurology. 1998 Jun;50(6):1837-41.
2 An Agonist Radioligand for the Proinflammatory Lipid-Activated G Protein-Coupled Receptor GPR84 Providing Structural Insights. J Med Chem. 2020 Mar 12; 63(5):2391-2410.
3 Cox-2 inhibitory effects of naturally occurring and modified fatty acids. J Nat Prod. 2001 Jun; 64(6):745-9.
4 Long chain amines and long chain ammonium salts as novel inhibitors of dynamin GTPase activity. Bioorg Med Chem Lett. 2004 Jun 21; 14(12):3275-8.
5 Lipolanthionine peptides act as inhibitors of TLR2-mediated IL-8 secretion. Synthesis and structure-activity relationships. J Med Chem. 2006 Mar 9; 49(5):1754-65.
6 Molecular properties of fatty acids related to PPAR binding and metabolic diseases. Med Chem Res (2013) 22:3126-3133.

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