General Information of DIG (ID: E0MK8U)
DIG Name	D&C orange no. 4
DIG Function	Colorant

Full List of Biological Targets of DIG (DBTs) Regulated by This DIG
Potential-driven transporter (PDT)
DBT Name: Solute carrier SLCO2B1 (OATPB)			Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment (1) for Assessing the Biological Activity of the Studied DIG on This DBT
Biological Activity	Inhibition ratio = 86.6 % (tested by experiment)				[1]
Tested Species	Homo sapiens (Human)
UniProt ID	SO2B1_HUMAN
Experiment (2) for Assessing the Biological Activity of the Studied DIG on This DBT
Biological Activity	Ki = 2.11 uM (tested by experiment)				[1]
Tested Species	Homo sapiens (Human)
UniProt ID	SO2B1_HUMAN
Experiment (3) for Assessing the Biological Activity of the Studied DIG on This DBT
Biological Activity	Ki = 1.9 uM (tested by experiment)				[2]
Tested Species	Homo sapiens (Human)
UniProt ID	SO2B1_HUMAN

References
1	Bacterial metabolism rescues the inhibition of intestinal drug absorption by food and drug additives. Proc Natl Acad Sci U S A. 2020 Jul 7;117(27):16009-16018.
2	The activities of drug inactive ingredients on biological targets. Science. 2020 Jul 24;369(6502):403-413.

If you find any error in data or bug in web service, please kindly report it to Dr. Zhang and Dr. Mou.