Details of the Drug Inactive Ingredient (DIG)

General Information of DIG (ID: E0RE5T)
DIG Name
Sorbitan monolaurate
Synonyms    Click to Show/Hide the Synonyms of This DIG
Sorbitan monolaurate; Span 20; Arlacel 20; Sorbitan laurate; UNII-6W9PS8B71J; 6W9PS8B71J; 1338-39-2; (R)-2-((2R,3R,4S)-3,4-dihydroxytetrahydrofuran-2-yl)-2-hydroxyethyl dodecanoate; 5959-89-7; [(2R)-2-[(2R,3R,4S)-3,4-dihydroxyoxolan-2-yl]-2-hydroxyethyl] dodecanoate; Sorbitan laurate [INN]; Sorbitan, monododecanoate; Sorbitani lauras; Glycomul L; Glycomul LC; Alkamuls SML; Armotan ML; Dehymuls SML; Lonzest SML; Texnol SPT; 1,4-anhydro-6-O-dodecanoyl-D-glucitol; Laurate de sorbitan; Arlacel-20; Montane 20; Alkamuls S 20; Laurato de sorbitano; Radiasurf 7125; Sorgen 90; Kemotan S 20; Sorbitan, monolaurate; Emasol L 10; Nonion LP 20R; Nonion LR 20R; Sorbon S 20; Emasol 110; Rheodol SP-L 10; Disponil SML 100; Value SP 20; Atmer 100; Emsorb 2515; Ionet S 20; Emasol L 10(F); Nissan Nonion LP 20R; L 250 (ester); Anhydrosorbitol monolaurate; Lauric acid sorbitan ester; Rheodol Super SP-L 10; Emasol Super L 10(F); SCHEMBL3833; CCRIS 709; Sorbitan lauric acid monoester; Sorbitani lauras [INN-Latin]; CHEMBL3706389; DTXSID9027609; Sorbitan monolaurate [USAN:NF]; NRF 201; Sorbitan, esters, monododecanoate; SP-L 10; Laurate de sorbitan [INN-French]; ZINC8214457; EINECS 215-663-3; Laurato de sorbitano [INN-Spanish]; 1,4-Anhydro-D-glucitol, 6-dodecanoate; L 250; S0059; EC 215-663-3; Sorbitan monolaurate. (Compound usually contains also associated fatty acids.)
DIG Function
Dispersing agent; Emulsifying agent; Solubilizing agent; Surfactant; Suspending agent; Vaccine adjuvant
PubChem CID
11046239
Formula
C18H34O6
Canonical SMILES
CCCCCCCCCCCC(=O)OC[C@H]([C@@H]1[C@@H]([C@H](CO1)O)O)O
InChI
1S/C18H34O6/c1-2-3-4-5-6-7-8-9-10-11-16(21)23-13-15(20)18-17(22)14(19)12-24-18/h14-15,17-20,22H,2-13H2,1H3/t14-,15+,17+,18+/m0/s1
InChIKey
LWZFANDGMFTDAV-BURFUSLBSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This DIG
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=11046239"></iframe>
3D MOL 2D MOL
Physicochemical Properties Molecular Weight 346.5 Topological Polar Surface Area 96.2
XlogP 3.7 Complexity 336
Heavy Atom Count 24 Rotatable Bond Count 14
Hydrogen Bond Donor Count 3 Hydrogen Bond Acceptor Count 6
Full List of Active Pharmaceutical Ingredients (APIs) Co-administrated with This DIG
       ICD Disease Classification 01 Infectious/parasitic disease Click to Show/Hide
Dicloxacillin
 API Info
Streptococcus bacterial infection [ICD-11: 1C41]
 [1]
Ritonavir
 API Info
Human immunodeficiency virus infection [ICD-11: 1C60]
 [2]
       ICD Disease Classification 06 Mental/behavioural/neurodevelopmental disorder Click to Show/Hide
Aripiprazole
 API Info
Schizophrenia [ICD-11: 6A20]
 [3]
       ICD Disease Classification 08 Nervous system disease Click to Show/Hide
Carbamazepine
 API Info
Epilepsy [ICD-11: 8A60]
 [4]
Topiramate
 API Info
Focal seizure [ICD-11: 8A68]
 [5]
       ICD Disease Classification 11 Circulatory system disease Click to Show/Hide
Aspirin
 API Info
Myocardial infarction [ICD-11: BA41]
 [6]
Caffeine
 API Info
Orthostatic hypotension [ICD-11: BA21]
 [7]
Disopyramide
 API Info
Ventricular tachyarrhythmia [ICD-11: BC71]
 [8]
Full List of Biological Targets of DIG (DBTs) Regulated by This DIG
      Primary active transporter (PAT)
            DBT Name: Multidrug resistance protein 1 (ABCB1) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Biological Activity Inhibition ratio > 70 % (tested by experiment) [9]
                    Tested Species Homo sapiens (Human)
                    UniProt ID MDR1_HUMAN ; MDR3_HUMAN ; ABCB5_HUMAN
            DBT Name: Urate exporter (BCRP) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Biological Activity Inhibition ratio > 30 % (tested by experiment) [9]
                    Tested Species Homo sapiens (Human)
                    UniProt ID ABCG2_HUMAN
References
1 FDA label for approved dicloxacillin from the official website of the U.S. Food and Drug Administration.
2 FDA label for approved ritonavir from the official website of the U.S. Food and Drug Administration.
3 FDA label for approved aripiprazole from the official website of the U.S. Food and Drug Administration.
4 FDA label for approved carbamazepine from the official website of the U.S. Food and Drug Administration.
5 FDA label for approved topiramate from the official website of the U.S. Food and Drug Administration.
6 FDA label for approved aspirin from the official website of the U.S. Food and Drug Administration.
7 FDA label for approved caffeine from the official website of the U.S. Food and Drug Administration.
8 FDA label for approved disopyramide from the official website of the U.S. Food and Drug Administration.
9 Effect of excipients on breast cancer resistance protein substrate uptake activity. J Control Release. 2007 Dec 4;124(1-2):1-5.

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