Drug Information

Drug General Information
Drug ID
D0NY9Q
Former ID
DIB006422
Drug Name
MK2 inhibitors
Synonyms
MK2 inhibitors (autoimmune disease); MAPKAPK2 inhibitors (autoimmune disease), Novartis; MK2 inhibitors (autoimmune disease), Novartis; Mitogen-activated protein kinase activated protein kinase 2 inhibitors (autoimmune disease), Novartis
Indication Autoimmune diabetes [ICD10:E08-E13] Investigative [552072]
Company
Novartis AG
Structure
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2D MOL

3D MOL
Canonical SMILES
c1nc(cc2c3c(CCc12)c1c([nH]3)CC2(CC2)NC1=O)c1cnc(cc1)F
Target and Pathway
Target(s) MAPKAP kinase 2 Target Info Inhibitor [543553]
KEGG Pathway MAPK signaling pathway
VEGF signaling pathway
Neurotrophin signaling pathway
Viral carcinogenesis
NetPath Pathway IL2 Signaling Pathway
PANTHER Pathway Angiogenesis
Interleukin signaling pathway
PDGF signaling pathway
VEGF signaling pathway
Ras Pathway
p38 MAPK pathway
Pathway Interaction Database IL2-mediated signaling events
p38 signaling mediated by MAPKAP kinases
Signaling mediated by p38-alpha and p38-beta
Signaling events mediated by VEGFR1 and VEGFR2
Trk receptor signaling mediated by the MAPK pathway
Reactome p38MAPK events
Oxidative Stress Induced Senescence
Regulation of HSF1-mediated heat shock response
VEGFA-VEGFR2 Pathway
activated TAK1 mediates p38 MAPK activation
WikiPathways Serotonin Receptor 4/6/7 and NR3C Signaling
Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
Serotonin HTR1 Group and FOS Pathway
p38 MAPK Signaling Pathway
MAPK Signaling Pathway
FAS pathway and Stress induction of HSP regulation
MAP kinase activation in TLR cascade
Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
Arachidonic acid metabolism
Structural Pathway of Interleukin 1 (IL-1)
Regulation of Microtubule Cytoskeleton
IL-1 signaling pathway
NGF signalling via TRKA from the plasma membrane
MAPK targets/ Nuclear events mediated by MAP kinases
References
Ref 552072In vivo and in vitro SAR of tetracyclic MAPKAP-K2 (MK2) inhibitors. Part II. Bioorg Med Chem Lett. 2010 Aug 1;20(15):4719-23
Ref 543553(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2094).

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