Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D00152)
Name
Cortisone acetate
Synonyms    Click to Show/Hide the Synonyms of This API
CORTISONE ACETATE; Cortisone 21-acetate; Cortone acetate; Incortin; Biocort acetate; Artriona; Cortadren; Scheroson; Cortisyl; Adreson; Irisone acetate; Cortelan; Cortistab; Ricortex; Cortogen acetate; Compound E acetate; Pregn-4-ene-3,11,20-trione, 21-(acetyloxy)-17-hydroxy-; Cortisone monoacetate; NSC 49420; Cortisone, 21-acetate; Cortilen; UNII-883WKN7W8X; 11-Dehydro-17-hydroxycorticosterone-21-acetate; 11-Dehydro-17-hydroxycorticosterone acetate; 17,21-Dihydroxypregn-4-ene-3,11,20-trione 21-acetate; 883WKN7W8X; CHEBI:3897; Pregn-4-ene-3,11,20-trione, 17,21-dihydroxy-, 21-acetate; Cortisone (acetate); MFCD00003609; NSC-49420; NCGC00021191-07; DSSTox_CID_2858; DSSTox_RID_76761; DSSTox_GSID_22858; 17-Hydroxy-3,11,20-trioxopregn-4-en-21-yl acetate; 21-Acetoxy-4-pregnen-17alpha-ol-3,11,20-trione; Cortisone 21-acetate, 98+%; 17,21-Dihydroxypregn-4-ene-3,11,20-trione-21-acetate; 17alpha,21-dihydroxypregn-4-ene-3,11,20-trione acetate; CAS-50-04-4; SMR000059124; CCRIS 3661; Cortisone acetate (Cortone); EINECS 200-006-5; cortisoneacetate; Cortisone acetate [USP:JAN]; Acetate cortisone; Cortisyl artriona; component of Neosone; Neosone (Salt/Mix); 21-(Acetyloxy)-17-hydroxypregn-4-ene-3,11,20-trione; Cortisone-21-acetate; 21-Acetoxy-17,alpha-hydroxy-3,11,20-triketopregnene-4; 21-Acetoxy-17,alpha-hydroxypregn-4-ene-3,11,20-trione; Cortone acetate (TN); 4-Pregnene-17,alpha,21-diol-3,11,20-trione 21-acetate; SCHEMBL4501; CHEMBL1650; Lopac0_000271; MLS000069478; MLS002207136; MLS002548859; ARONIS24358; Cortisone acetate (JP17/USP); DTXSID0022858; Cortisone 21-acetate, >=99%; HMS2235D24; HMS3259N19; HMS3260H04; BCP08487; NSC49420; ZINC3875334; Tox21_113482; Tox21_500271; BDBM50455157; HY-17461A; LMST02030120; SBB080776; AKOS005267225; Tox21_113482_1; AC-6827; CCG-204366; CS-1742; DB01380; LP00271; MCULE-8390750975; NC00677; SDCCGSBI-0050259.P002; NCGC00021191-03; NCGC00021191-06; NCGC00021191-08; NCGC00021191-09; NCGC00021191-16; NCGC00260956-01; AS-13692; ST075179; EU-0100271; C08173; D00973; J10115; AB00384283-08; AB00384283_09; 003C609; W-105993; BRD-K86161929-001-13-3; Pregn-4-ene-3,20-trione, 21-(acetyloxy)-17-hydroxy-; 17-Hydroxy-3,11,20-trioxopregn-4-en-21-yl acetate #; 21-Acetoxy-17.alpha.-hydroxy-3,11,20-triketopregnene-4; 21-Acetoxy-17.alpha.-hydroxypregn-4-ene-3,11,20-trione; 4-Pregnen-17.alpha.,21-diol-3,11,20-trione 21-acetate; 4-Pregnene-17alpha,21-diol-3,11,20-trione 21-acetate; Pregn-4-ene-3,20-trione, 17,21-dihydroxy-, 21-acetate; 17alpha,21-Dihydroxy-4-pregnene-3,11,20-trione 21-acetate; 4-Pregnene-17.alpha.,21-diol-3,11,20-trione 21-acetate; Cortisone acetate, European Pharmacopoeia (EP) Reference Standard; Cortisone acetate, United States Pharmacopeia (USP) Reference Standard
Clinical Status
Approved
Disease Indication Prostate cancer ICD-11: 2C82 [1]
PubChem CID
5745
Formula
C23H30O6
Canonical SMILES
CC(=O)OCC(=O)[C@]1(CC[C@@H]2[C@@]1(CC(=O)[C@H]3[C@H]2CCC4=CC(=O)CC[C@]34C)C)O
InChI
1S/C23H30O6/c1-13(24)29-12-19(27)23(28)9-7-17-16-5-4-14-10-15(25)6-8-21(14,2)20(16)18(26)11-22(17,23)3/h10,16-17,20,28H,4-9,11-12H2,1-3H3/t16-,17-,20+,21-,22-,23-/m0/s1
InChIKey
ITRJWOMZKQRYTA-RFZYENFJSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=5745"></iframe>
3D MOL 2D MOL
Physicochemical Properties Molecular Weight 402.5 Topological Polar Surface Area 97.7
XlogP 2.1 Complexity 827
Heavy Atom Count 29 Rotatable Bond Count 4
Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 6
Full List of Drug Formulations (DFMs) Containing This API
          Cortisone acetate 25 mg tablet Click to Show/Hide the Full List of Formulation(s):          2 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Sodium lauryl sulfate; Magnesium stearate; Silicon dioxide; Cellulose, microcrystalline; Sodium starch glycolate type a potato
                   Dosage Form Oral Tablet
                   Company Hikma Pharmaceutical; West-Ward Pharmaceticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Sodium lauryl sulfate; Magnesium stearate; Cellulose, microcrystalline; Colloidal silicon dioxide; Sodium starch glycolate type a potato
                   Dosage Form Oral Tablet
                   Company West-Ward Pharmaceticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
References
1 FDA label for approved cortisone acetate from the official website of the U.S. Food and Drug Administration.
2 Bacterial metabolism rescues the inhibition of intestinal drug absorption by food and drug additives. Proc Natl Acad Sci U S A. 2020 Jul 7;117(27):16009-16018.
3 Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12.

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