Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D00233)
Name
Ephedrine
Synonyms    Click to Show/Hide the Synonyms of This API
Ephedrine; l-Ephedrine; (-)-Ephedrine; 299-42-3; Ephedrin; Ephedrol; Mandrin; Sanedrine; Fedrin; L(-)-Ephedrine; 1-Sedrin; (1R,2S)-2-(methylamino)-1-phenylpropan-1-ol; Ephedrital; Ephedrosan; Ephedrotal; Ephedsol; Ephendronal; Ephoxamin; Kratedyn; Lexofedrin; Manadrin; Vencipon; Efedrin; Zephrol; I-Sedrin; racephedrine; UNII-GN83C131XS; l-alpha-(1-Methylaminoethyl)benzyl alcohol; NCI-C55652; Norephedrine, N-methyl-; GN83C131XS; 299-42-3 (free base); Biophedrin; Ephedremal; Eciphin; Ephedral; CHEBI:15407; (1R,2S)-2-(methylamino)-1-phenyl-1-propanol; l-Erythro-2-(methylamino)-1-phenylpropan-1-ol; (1R,2S)-1-phenyl-1-hydroxy-2-methylaminopropane; (1R,2S)-2-(methylamino)-1-phenyl-propan-1-ol; 1-Phenyl-2-methylaminopropanol; l-2-Methylamino-1-phenylpropanol; Ephedrine, L-(-)-; Sal-Phedrine; Ephedrine l-form; Ephedrine [USAN:BAN]; 1-Hydroxy-2-methylamino-1-phenylpropane; (-)-Ephedrine hemisulfate; (L)-EPHEDRINE; (-)-(1R,2S)-Ephedrine; Ephedrine (TN); Ephedrine (USP); HSDB 3072; 1-2-Methylamino-1-phenylpropanol; 2-Methylamino-1-phenyl-1-propanol; NSC 8971; EINECS 206-080-5; NSC 170951; 1-Phenyl-1-hydroxy-2-methylaminopropane; alpha-Hydroxy-beta-methylaminopropylbenzene; NSC-8971; 1-alpha-(1-Methylaminoethyl)benzyl alcohol; AI3-02761; alpha-(1-(Methylamino)ethyl)benzenemethanol; Benzenemethanol, .alpha.-[(1S)-1-(methylamino)ethyl]-, (.alpha.R)-; NSC170951; alpha-Hydroxy-beta-methyl amine propylbenzene; (-)-alpha-(1-Methylaminoethyl)benzyl alcohol; NSC-170951; 1(-)ephedrine; PubChem5778; Benzenemethanol, alpha-(1-(methylamino)ethyl)-, (R-(R*,S*))-; DEA Code 8113; (1R,2S)-2-methylamino-1-phenylpropan-1-ol; EC 206-080-5; SCHEMBL4785; Lopac0_000501; GTPL556; (1r, 2s)-(-)-ephedrine; (1R,2S)-(-)-Ephedrin; CHEMBL211456; Benzenemethanol, alpha-(1-(methylamino)ethyl)-, (-)-; DTXSID0022985; ZINC74836; Benzenemethanol, alpha-((1S)-1-(methylamino)ethyl)-, (alphaR)-; HY-B1195; PDSP2_001327; PDSP2_001330; (1R,2S)-(-)-Ephedrine, 98%; AKOS016011257; Emerphed (ephedrine sulfate injection); CCG-204592; CS-4802; DB01364; MCULE-1217859840; NCGC00162174-01; NCGC00162174-02; SBI-0051362.P003; (1R,2S)-2-Methylamino-1-phenyl-1-propanol; C01575; D00124; (1R*,2S*)-2-methylamino-1-phenyl-1-propanol; AB00375843_06; 299E423; A820118; Q219626; SR-01000075166; (1R,2S)-(-)-2-Methylamino-1-phenyl-1-propanol; J-500280; SR-01000075166-1; (1R,2S)-(-)-2-(N-methylamino)-1-phenylpropan-1-ol; (1R,2S)-(-)-alpha-(1-Methylaminoethyl)benzenemethanol; UNII-03VRY66076 component KWGRBVOPPLSCSI-WPRPVWTQSA-N
Clinical Status
Approved
Disease Indication Contraception ICD-11: JA65 [1]
PubChem CID
9294
Formula
C10H15NO
Canonical SMILES
C[C@@H]([C@@H](C1=CC=CC=C1)O)NC
InChI
1S/C10H15NO/c1-8(11-2)10(12)9-6-4-3-5-7-9/h3-8,10-12H,1-2H3/t8-,10-/m0/s1
InChIKey
KWGRBVOPPLSCSI-WPRPVWTQSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
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3D MOL 2D MOL
Physicochemical Properties Molecular Weight 165.23 Topological Polar Surface Area 32.299
XlogP 0.9 Complexity 121
Heavy Atom Count 12 Rotatable Bond Count 3
Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 2
Full List of Drug Formulations (DFMs) Containing This API
          Ephedrine 25 mg capsule Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Fd&c red no. 3; Colloidal silicon dioxide; Gelatin; Starch, corn
                   Dosage Form Oral Capsule
                   Company West-Ward Pharmaceticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C red no. 3 DIG Info Phosphodiesterase 3A (IC50 = 0.092 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
References
1 FDA label for approved ephedrine from the official website of the U.S. Food and Drug Administration.
2 The activities of drug inactive ingredients on biological targets. Science. 2020 Jul 24;369(6502):403-413.
3 Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12.

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