Details of the Active Pharmaceutical Ingredient (API)
General Information of API (ID: D00415) | |||||
---|---|---|---|---|---|
Name |
Methsuximide
|
||||
Synonyms |
Click to Show/Hide the Synonyms of This API
METHSUXIMIDE; Mesuximide; 77-41-8; Celontin; Methsuximid; Petinutin; 1,3-dimethyl-3-phenylpyrrolidine-2,5-dione; Metsuccimide; Mesuximidum; alpha-Methylphensuximide; N,2-Dimethyl-2-phenylsuccinimide; 1,3-Dimethyl-3-phenylsuccinimide; Metosuccimmide [DCIT]; Mesuximidum [INN-Latin]; Mesuximida [INN-Spanish]; 2,5-Pyrrolidinedione, 1,3-dimethyl-3-phenyl-; 1,3-Dimethyl-3-phenyl-2,5-dioxopyrrolidine; 1,3-Dimethyl-3-phenyl-2,5-pyrrolidinedione; 1,3-Dimethyl-3-phenyl-pyrrolidin-2,5-dione; PM 396; Succinimide, N,2-dimethyl-2-phenyl-; N-Methyl-alpha-methyl-alpha-phenylsuccinimide; alpha-Methyl-alpha-phenyl N-methyl succinimide; (RS)-1,3-Dimethyl-3-phenyl-2,5-pyrrolidindion; Mesuximide (INN); Methsuximide (USP); Methsuximide [USP]; mesuximid; Mesuximide [INN]; MFCD00072132; NCGC00189077-01; Metosuccimmide; Mesuximida; Celontin (TN); HSDB 3124; EINECS 201-026-7; BRN 0168315; (+-)-N,2-Dimethyl-2-phenylsuccinimide; .alpha.-Methylphensuximide; DSSTox_CID_3293; CHEMBL697; 2,5-Pyrrolidinedione,1,3-dimethyl-3-phenyl-; DSSTox_RID_76960; DSSTox_GSID_23293; SCHEMBL34852; 5-21-11-00209 (Beilstein Handbook Reference); CHEBI:6846; GTPL7228; 2,5-Pyrrolidinedione,1,3-dimethyl-3-phenyl-, (+-)-; DTXSID5023293; HMS3264P21; Pharmakon1600-01505443; Tox21_113613; NSC760075; AKOS015962173; CCG-213444; DB05246; NSC-760075; CAS-77-41-8; AC-15963; SY251111; FT-0671397; FT-0671398; 1,3-Dimethyl-3-phenyl-2,5-pyrrolidinedione #; 2,5-Pyrrolidinedione, 1,3-dimethyl-3-phenyl; D00404; AB01563316_01; N-Methyl-.alpha.,.alpha.-methylphenylsuccinimide; 077M418; N-Methyl-.alpha.-methyl-.alpha.-phenylsuccinimide; Q906414; SR-01000942246; .alpha.-Methyl-.alpha.-phenyl N-methyl succinimide; SR-01000942246-1
|
||||
Clinical Status |
Approved
|
||||
Disease Indication | Epilepsy | ICD-11: 8A60 | [1] | ||
PubChem CID | |||||
Formula |
C12H13NO2
|
||||
Canonical SMILES |
CC1(CC(=O)N(C1=O)C)C2=CC=CC=C2
|
||||
InChI |
1S/C12H13NO2/c1-12(9-6-4-3-5-7-9)8-10(14)13(2)11(12)15/h3-7H,8H2,1-2H3
|
||||
InChIKey |
AJXPJJZHWIXJCJ-UHFFFAOYSA-N
|
||||
Click to Show/Hide the Molecular Data (Structure/Property) of This API | |||||
Structure |
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=6476"></iframe>
|
||||
3D MOL | 2D MOL | ||||
Physicochemical Properties | Molecular Weight | 203.24 | Topological Polar Surface Area | 37.4 | |
XlogP | 1.2 | Complexity | 294 | ||
Heavy Atom Count | 15 | Rotatable Bond Count | 1 | ||
Hydrogen Bond Donor Count | 0 | Hydrogen Bond Acceptor Count | 2 | ||
Full List of Drug Formulations (DFMs) Containing This API | ||||||
---|---|---|---|---|---|---|
Methsuximide 300 mg capsule | Click to Show/Hide the Full List of Formulation(s): 1 Formulation(s) | |||||
Drug Formulation 1 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM
Sodium lauryl sulfate; D&c yellow no. 10; Fd&c yellow no. 6; Silicon dioxide; Gelatin; Starch, corn
|
|||||
Dosage Form | Oral Capsule | |||||
Company | Parke-Davis Div of Pfizer Inc | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
Sunset yellow FCF | DIG Info | Solute carrier SLCO2B1 (Ki = 68.4 uM) | [2] | |||
Sodium lauryl sulfate | DIG Info | Solute carrier SLCO2B1 (Ki = 1.98 uM) | [2] | |||
Quinoline yellow WS | DIG Info | Estrogen receptor alpha (IC50 = 18 uM) | [3] | |||
Silicon dioxide | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [4] | |||
If you find any error in data or bug in web service, please kindly report it to Dr. Zhang and Dr. Mou.