Details of the Active Pharmaceutical Ingredient (API)
General Information of API (ID: D00536) | |||||
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Name |
Pirfenidone
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Synonyms |
Click to Show/Hide the Synonyms of This API
PIRFENIDONE; 53179-13-8; 5-methyl-1-phenylpyridin-2(1H)-one; Esbriet; AMR-69; Deskar; 5-Methyl-1-phenyl-2-(1H)-pyridone; Pirfenidonum; Pirfenidona; Pirespa; 2(1H)-Pyridinone, 5-methyl-1-phenyl-; AMR 69; 5-methyl-1-phenyl-2(1H)-pyridinone; 5-Methyl-1-phenyl-1H-pyridin-2-one; 5-methyl-1-phenyl-2-pyridinone; 5-Methyl-1-phenyl-2(1H)-pyridone; 5-methyl-1-phenylpyridin-2-one; UNII-D7NLD2JX7U; MFCD00866047; D7NLD2JX7U; CHEBI:32016; NCGC00015806-03; DSSTox_CID_25183; DSSTox_RID_80731; DSSTox_GSID_45183; Pirfenidone [USAN:INN]; Pirfenidonum [INN-Latin]; Pirfenidona [INN-Spanish]; CAS-53179-13-8; SR-01000076061; BRN 1526549; Prfendone; Pirfenidone (JAN/USAN/INN); 5-methyl-1-phenyl-pyridin-2-one; Esbriet (TN); Pirfenidone(AMR69); KS-5041; 2(1H)-Pyridone, 5-methyl-1-phenyl-; Tocris-1093; Lopac-P-2116; ACMC-209t1g; P 2116; SCHEMBL4708; Lopac0_000907; 5-21-07-00197 (Beilstein Handbook Reference); MLS000860042; 5-Methyl-1-phenyl-2-pyridone; GTPL7532; ZINC1958; CHEMBL1256391; DTXSID4045183; 1-phenyl-5-methyl-2-pyridinone; HSDB 8340; Pirfenidone, >=97% (HPLC); Bio1_000397; Bio1_000886; Bio1_001375; HMS2234G24; HMS3262F16; HMS3267I06; HMS3372A08; HMS3412G13; HMS3651P08; HMS3676G13; AOB31717; BCP04473; EBD52457; HY-B0673; Tox21 110225; Tox21_110225; Tox21_500907; 5-methyl-1-phenyl-2(1H)pyridinone; ANW-41906; BDBM50005201; CP0088; NSC748456; AKOS006273697; Tox21_110225_1; AB07515; AC-6797; AM84939; CCG-204989; DB04951; LP00907; NSC-748456; SDCCGSBI-0050882.P002; 5-methyl-1-phenyl-2-(1H)-pyridinone;; NCGC00015806-01; NCGC00015806-02; NCGC00015806-04; NCGC00015806-05; NCGC00015806-06; NCGC00015806-17; NCGC00024992-01; NCGC00024992-02; NCGC00024992-03; NCGC00261592-01; 5-METHYL-N-PHENYL-2-1H-PYRIDONE; AK-72929; BR-72929; SMR000326900; SY034783; AB0006721; EU-0100907; FT-0602686; FT-0672092; SW220156-1; D01583; J90039; M-2515; 179P138; A829431; J-523979; Q2060696; SR-01000076061-1; SR-01000076061-3; BRD-K96862998-001-03-1; BRD-K96862998-001-09-8; Pirfenidone, European Pharmacopoeia (EP) Reference Standard
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Clinical Status |
Approved
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Disease Indication | Idiopathic pulmonary fibrosis | ICD-11: CB03 | [1] | ||
PubChem CID | |||||
Formula |
C12H11NO
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Canonical SMILES |
CC1=CN(C(=O)C=C1)C2=CC=CC=C2
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InChI |
1S/C12H11NO/c1-10-7-8-12(14)13(9-10)11-5-3-2-4-6-11/h2-9H,1H3
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InChIKey |
ISWRGOKTTBVCFA-UHFFFAOYSA-N
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Click to Show/Hide the Molecular Data (Structure/Property) of This API | |||||
Structure |
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=40632"></iframe>
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3D MOL | 2D MOL | ||||
Physicochemical Properties | Molecular Weight | 185.22 | Topological Polar Surface Area | 20.3 | |
XlogP | 1.9 | Complexity | 285 | ||
Heavy Atom Count | 14 | Rotatable Bond Count | 1 | ||
Hydrogen Bond Donor Count | 0 | Hydrogen Bond Acceptor Count | 1 | ||
Full List of Drug Formulations (DFMs) Containing This API | ||||||
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Pirfenidone 801 mg tablet | Click to Show/Hide the Full List of Formulation(s): 1 Formulation(s) | |||||
Drug Formulation 1 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Ferric oxide red; Ferrosoferric oxide; Talc; Titanium dioxide; Croscarmellose sodium; Polyethylene glycol 3350; Povidone k30; Silicon dioxide; Microcrystalline cellulose; Polyvinyl alcohol, unspecified
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Dosage Form | Oral Tablet | |||||
Company | Genentech | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
Magnesium stearate | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [2] | |||
Carmellose sodium | DIG Info | Albendazole monooxygenase (Protein expression upregulation) | [2] | |||
Polyethylene glycol 3350 | DIG Info | Albendazole monooxygenase (Protein expression upregulation) | [2] | |||
Silicon dioxide | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [2] | |||
Pirfenidone 267 mg tablet | Click to Show/Hide the Full List of Formulation(s): 1 Formulation(s) | |||||
Drug Formulation 1 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Ferric oxide yellow; Talc; Titanium dioxide; Croscarmellose sodium; Polyethylene glycol 3350; Povidone k30; Silicon dioxide; Microcrystalline cellulose; Polyvinyl alcohol, unspecified
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Dosage Form | Oral Tablet | |||||
Company | Genentech | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
Magnesium stearate | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [2] | |||
Carmellose sodium | DIG Info | Albendazole monooxygenase (Protein expression upregulation) | [2] | |||
Polyethylene glycol 3350 | DIG Info | Albendazole monooxygenase (Protein expression upregulation) | [2] | |||
Silicon dioxide | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [2] | |||
Pirfenidone 267 mg capsule | Click to Show/Hide the Full List of Formulation(s): 1 Formulation(s) | |||||
Drug Formulation 1 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Ammonia; Ferric oxide red; Ferric oxide yellow; Ferrosoferric oxide; Titanium dioxide; Croscarmellose sodium; Gelatin, unspecified; Microcrystalline cellulose; Povidone, unspecified; Shellac
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Dosage Form | Oral Capsule | |||||
Company | Genentech | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
Magnesium stearate | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [2] | |||
Carmellose sodium | DIG Info | Albendazole monooxygenase (Protein expression upregulation) | [2] | |||
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