Details of the Drug Inactive Ingredient (DIG)

General Information of DIG (ID: E09IPB)
DIG Name	Polyethylene glycol 3350
DIG Function	Coating agent; Diluent; Ointment base; Plasticizing agent; Solvent; Suppository base; lubricant

Full List of Active Pharmaceutical Ingredients (APIs) Co-administrated with This DIG
ICD Disease Classification 01		Infectious/parasitic disease	Click to Show/Hide
Minocycline	API Info	Streptococcus bacterial infection [ICD-11: 1C41]		[1]
Metronidazole	API Info	Amebiasis [ICD-11: 1A36]		[2]
Ribavirin	API Info	Viral hepatitis [ICD-11: 1E51]		[3]
Griseofulvin	API Info	Dermatophytosis [ICD-11: 1F28]		[4]
Raltegravir	API Info	Human immunodeficiency virus infection [ICD-11: 1C60]		[5]
Chloroquine	API Info	Malaria [ICD-11: 1F40]		[6]
Entecavir	API Info	Viral hepatitis [ICD-11: 1E51]		[7]
Ritonavir	API Info	Human immunodeficiency virus infection [ICD-11: 1C60]		[8]
Darunavir	API Info	Human immunodeficiency virus infection [ICD-11: 1C60]		[9]
Zidovudine	API Info	Human immunodeficiency virus infection [ICD-11: 1C60]		[10]
Hydroxychloroquine	API Info	Malaria [ICD-11: 1F40]		[11]
Elvitegravir	API Info	Human immunodeficiency virus infection [ICD-11: 1C60]		[12]
Cobicistat	API Info	Human immunodeficiency virus infection [ICD-11: 1C60]		[13]
Telaprevir	API Info	Viral hepatitis [ICD-11: 1E51]		[14]
Posaconazole	API Info	Candidiasis [ICD-11: 1F23]		[15]
Tenofovir alafenamide	API Info	Viral hepatitis [ICD-11: 1E51]		[16]
Voriconazole	API Info	Candidiasis [ICD-11: 1F23]		[17]
ICD Disease Classification 02		Benign/in-situ/malignant neoplasm	Click to Show/Hide
Letrozole	API Info	Breast cancer [ICD-11: 2C60]		[18]
Abiraterone	API Info	Prostate cancer [ICD-11: 2C82]		[19]
Osimertinib	API Info	Lung cancer [ICD-11: 2C25]		[20]
Bosutinib	API Info	Chronic myelogenous leukaemia [ICD-11: 2A20]		[21]
Cobimetinib	API Info	Melanoma [ICD-11: 2C30]		[22]
Mitotane	API Info	Adrenocortical carcinoma [ICD-11: 2D11]		[23]
Regorafenib	API Info	Colon cancer [ICD-11: 2B90]		[24]
Vemurafenib	API Info	Melanoma [ICD-11: 2C30]		[25]
ICD Disease Classification 03		Blood/blood-forming organ disease	Click to Show/Hide
Deferiprone	API Info	Thalassaemia [ICD-11: 3A50]		[26]
ICD Disease Classification 04		Immune system disease	Click to Show/Hide
Cetirizine	API Info	Allergy [ICD-11: 4A80]		[27]
ICD Disease Classification 05		Endocrine/nutritional/metabolic disease	Click to Show/Hide
Fenofibrate	API Info	Hypertriglyceridaemia [ICD-11: 5C80]		[28]
Simvastatin	API Info	Dyslipidaemia [ICD-11: 5C81]		[29]
Glipizide	API Info	Diabetes mellitus [ICD-11: 5A10]		[30]
Rosuvastatin	API Info	Hypertriglyceridaemia [ICD-11: 5C80]		[31]
Metformin	API Info	Diabetes mellitus [ICD-11: 5A10]		[32]
Benzphetamine	API Info	Obesity [ICD-11: 5B81]		[33]
Fluvastatin	API Info	Hypertriglyceridaemia [ICD-11: 5C80]		[34]
Gemfibrozil	API Info	Hypertriglyceridaemia [ICD-11: 5C80]		[35]
Rosiglitazone	API Info	Diabetes mellitus [ICD-11: 5A10]		[36]
Canagliflozin	API Info	Diabetes mellitus [ICD-11: 5A10]		[37]
Ertugliflozin	API Info	Diabetes mellitus [ICD-11: 5A10]		[38]
ICD Disease Classification 06		Mental/behavioural/neurodevelopmental disorder	Click to Show/Hide
Risperidone	API Info	Schizophrenia [ICD-11: 6A20]		[39]
Bupropion	API Info	Nicotine dependence [ICD-11: 6C4A]		[40]
Fluoxetine	API Info	Major depressive disorder [ICD-11: 6A70]		[41]
Duloxetine	API Info	Major depressive disorder [ICD-11: 6A70]		[42]
Venlafaxine	API Info	Major depressive disorder [ICD-11: 6A70]		[43]
Sertraline	API Info	Major depressive disorder [ICD-11: 6A70]		[44]
Hydroxyzine	API Info	Anxiety disorder [ICD-11: 6B00]		[45]
Methylphenidate	API Info	Attention deficit hyperactivity disorder [ICD-11: 6A05]		[46]
Trazodone	API Info	Major depressive disorder [ICD-11: 6A70]		[47]
Tranylcypromine	API Info	Major depressive disorder [ICD-11: 6A70]		[48]
Protriptyline	API Info	Major depressive disorder [ICD-11: 6A70]		[49]
Phenelzine	API Info	Major depressive disorder [ICD-11: 6A70]		[50]
ICD Disease Classification 07		Sleep-wake disorder	Click to Show/Hide
Eszopiclone	API Info	Insomnia [ICD-11: 7A00]		[51]
ICD Disease Classification 08		Nervous system disease	Click to Show/Hide
Morphine	API Info	Anaesthesia [ICD-11: 8E22]		[52]
Gabapentin	API Info	Focal seizure [ICD-11: 8A68]		[53]
Valproic acid	API Info	Epilepsy [ICD-11: 8A60]		[54]
Levetiracetam	API Info	Focal seizure [ICD-11: 8A68]		[55]
Tramadol	API Info	Anaesthesia [ICD-11: 8E22]		[56]
Topiramate	API Info	Focal seizure [ICD-11: 8A68]		[57]
Hydromorphone	API Info	Anaesthesia [ICD-11: 8E22]		[58]
Hydrocodone	API Info	Anaesthesia [ICD-11: 8E22]		[59]
Donepezil	API Info	Alzheimer disease [ICD-11: 8A20]		[60]
Sumatriptan	API Info	Migraine [ICD-11: 8A80]		[61]
Naratriptan	API Info	Migraine [ICD-11: 8A80]		[62]
Pimavanserin	API Info	Parkinsonism [ICD-11: 8A00]		[63]
Brivaracetam	API Info	Focal seizure [ICD-11: 8A68]		[64]
ICD Disease Classification 10		Ear/mastoid process disease	Click to Show/Hide
Amoxicillin	API Info	Acute otitis media [ICD-11: AB00]		[65]
ICD Disease Classification 11		Circulatory system disease	Click to Show/Hide
Metoprolol	API Info	Essential hypertension [ICD-11: BA00]		[66]
Losartan	API Info	Essential hypertension [ICD-11: BA00]		[67]
Nifedipine	API Info	Angina pectoris [ICD-11: BA40]		[68]
Clopidogrel	API Info	Deep vein thrombosis [ICD-11: BD71]		[69]
Valsartan	API Info	Essential hypertension [ICD-11: BA00]		[70]
Spironolactone	API Info	Congestive heart failure [ICD-11: BD10]		[71]
Labetalol	API Info	Essential hypertension [ICD-11: BA00]		[72]
Nitroglycerin	API Info	Acute coronary syndrome [ICD-11: BA4Z]		[73]
Rivaroxaban	API Info	Deep vein thrombosis [ICD-11: BD71]		[74]
Ambrisentan	API Info	Pulmonary hypertension [ICD-11: BB01]		[75]
Ranolazine	API Info	Angina pectoris [ICD-11: BA40]		[76]
ICD Disease Classification 12		Respiratory system disease	Click to Show/Hide
Montelukast	API Info	Asthma [ICD-11: CA23]		[77]
Clarithromycin	API Info	Pneumocystis pneumonia [ICD-11: CA40]		[78]
Ivacaftor	API Info	Cystic fibrosis [ICD-11: CA25]		[79]
Pirfenidone	API Info	Idiopathic pulmonary fibrosis [ICD-11: CB03]		[80]
ICD Disease Classification 13		Digestive system disease	Click to Show/Hide
Doxycycline	API Info	Periodontal disease [ICD-11: DA0C]		[81]
Omeprazole	API Info	Gastro-oesophageal reflux disease [ICD-11: DA22]		[82]
Mycophenolate mofetil	API Info	Crohn disease [ICD-11: DD70]		[83]
Ursodeoxycholic acid	API Info	Hepatic fibrosis/cirrhosis [ICD-11: DB93]		[84]
Famotidine	API Info	Peptic ulcer [ICD-11: DA61]		[85]
Alvimopan	API Info	Gastrointestinal disease [ICD-11: DE2Z]		[86]
Obeticholic acid	API Info	Cholangitis [ICD-11: DC13]		[87]
ICD Disease Classification 14		Skin disease	Click to Show/Hide
Pseudoephedrine	API Info	Erythema multiforme [ICD-11: EB12]		[88]
ICD Disease Classification 15		Musculoskeletal/connective-tissue disease	Click to Show/Hide
Naproxen	API Info	Rheumatoid arthritis [ICD-11: FA20]		[89]
Risedronic acid	API Info	Paget's disease [ICD-11: FB85]		[90]
Leflunomide	API Info	Rheumatoid arthritis [ICD-11: FA20]		[91]
Tofacitinib	API Info	Rheumatoid arthritis [ICD-11: FA20]		[92]
ICD Disease Classification 16		Genitourinary system disease	Click to Show/Hide
Ibuprofen	API Info	Dysmenorrhea [ICD-11: GA34]		[93]
Oxybutynin	API Info	Overactive bladder [ICD-11: GC50]		[94]
Sevelamer	API Info	Chronic kidney disease [ICD-11: GB61]		[95]
Trospium	API Info	Overactive bladder [ICD-11: GC50]		[96]
ICD Disease Classification 17		Sexual health-related condition	Click to Show/Hide
Sildenafil	API Info	Erectile dysfunction [ICD-11: HA01]		[97]

Full List of Biological Targets of DIG (DBTs) Regulated by This DIG
Oxidoreductase (ORase)
DBT Name: Albendazole monooxygenase (CYP3A4)		Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Biological Activity	Protein expression upregulation (tested by experiment)		[98]
Tested Species	Homo sapiens (Human)
UniProt ID	CP3A4_HUMAN
Primary active transporter (PAT)
DBT Name: Multidrug resistance protein 1 (ABCB1)		Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Biological Activity	Protein expression downregulation (tested by experiment)		[98]
Tested Species	Homo sapiens (Human)
UniProt ID	MDR1_HUMAN

References
1	FDA label for approved minocycline from the official website of the U.S. Food and Drug Administration.
2	FDA label for approved metronidazole from the official website of the U.S. Food and Drug Administration.
3	FDA label for approved ribavirin from the official website of the U.S. Food and Drug Administration.
4	FDA label for approved griseofulvin from the official website of the U.S. Food and Drug Administration.
5	2007 FDA drug approvals: a year of flux. Nat Rev Drug Discov. 2008 Feb;7(2):107-9.
6	FDA label for approved chloroquine from the official website of the U.S. Food and Drug Administration.
7	FDA label for approved entecavir from the official website of the U.S. Food and Drug Administration.
8	FDA label for approved ritonavir from the official website of the U.S. Food and Drug Administration.
9	FDA label for approved darunavir from the official website of the U.S. Food and Drug Administration.
10	FDA label for approved zidovudine from the official website of the U.S. Food and Drug Administration.
11	FDA label for approved hydroxychloroquine from the official website of the U.S. Food and Drug Administration.
12	FDA label for approved elvitegravir from the official website of the U.S. Food and Drug Administration.
13	FDA label for approved cobicistat from the official website of the U.S. Food and Drug Administration.
14	FDA label for approved telaprevir from the official website of the U.S. Food and Drug Administration.
15	FDA label for approved posaconazole from the official website of the U.S. Food and Drug Administration.
16	FDA label for approved tenofovir alafenamide from the official website of the U.S. Food and Drug Administration.
17	FDA label for approved voriconazole from the official website of the U.S. Food and Drug Administration.
18	FDA label for approved letrozole from the official website of the U.S. Food and Drug Administration.
19	FDA label for approved abiraterone from the official website of the U.S. Food and Drug Administration.
20	FDA label for approved osimertinib from the official website of the U.S. Food and Drug Administration.
21	FDA label for approved bosutinib from the official website of the U.S. Food and Drug Administration.
22	FDA label for approved cobimetinib from the official website of the U.S. Food and Drug Administration.
23	FDA label for approved mitotane from the official website of the U.S. Food and Drug Administration.
24	FDA label for approved regorafenib from the official website of the U.S. Food and Drug Administration.
25	FDA label for approved vemurafenib from the official website of the U.S. Food and Drug Administration.
26	FDA label for approved deferiprone from the official website of the U.S. Food and Drug Administration.
27	FDA label for approved cetirizine from the official website of the U.S. Food and Drug Administration.
28	FDA label for approved fenofibrate from the official website of the U.S. Food and Drug Administration.
29	FDA label for approved simvastatin from the official website of the U.S. Food and Drug Administration.
30	FDA label for approved glipizide from the official website of the U.S. Food and Drug Administration.
31	FDA label for approved rosuvastatin from the official website of the U.S. Food and Drug Administration.
32	FDA label for approved metformin from the official website of the U.S. Food and Drug Administration.
33	FDA label for approved benzphetamine from the official website of the U.S. Food and Drug Administration.
34	FDA label for approved fluvastatin from the official website of the U.S. Food and Drug Administration.
35	FDA label for approved gemfibrozil from the official website of the U.S. Food and Drug Administration.
36	FDA label for approved rosiglitazone from the official website of the U.S. Food and Drug Administration.
37	FDA label for approved canagliflozin from the official website of the U.S. Food and Drug Administration.
38	FDA label for approved ertugliflozin from the official website of the U.S. Food and Drug Administration.
39	FDA label for approved risperidone from the official website of the U.S. Food and Drug Administration.
40	FDA label for approved bupropion from the official website of the U.S. Food and Drug Administration.
41	FDA label for approved fluoxetine from the official website of the U.S. Food and Drug Administration.
42	FDA label for approved duloxetine from the official website of the U.S. Food and Drug Administration.
43	FDA label for approved venlafaxine from the official website of the U.S. Food and Drug Administration.
44	FDA label for approved sertraline from the official website of the U.S. Food and Drug Administration.
45	FDA label for approved hydroxyzine from the official website of the U.S. Food and Drug Administration.
46	FDA label for approved methylphenidate from the official website of the U.S. Food and Drug Administration.
47	FDA label for approved trazodone from the official website of the U.S. Food and Drug Administration.
48	FDA label for approved tranylcypromine from the official website of the U.S. Food and Drug Administration.
49	FDA label for approved protriptyline from the official website of the U.S. Food and Drug Administration.
50	FDA label for approved phenelzine from the official website of the U.S. Food and Drug Administration.
51	FDA label for approved eszopiclone from the official website of the U.S. Food and Drug Administration.
52	FDA label for approved morphine from the official website of the U.S. Food and Drug Administration.
53	FDA label for approved gabapentin from the official website of the U.S. Food and Drug Administration.
54	FDA label for approved valproic acid from the official website of the U.S. Food and Drug Administration.
55	FDA label for approved levetiracetam from the official website of the U.S. Food and Drug Administration.
56	FDA label for approved tramadol from the official website of the U.S. Food and Drug Administration.
57	FDA label for approved topiramate from the official website of the U.S. Food and Drug Administration.
58	FDA label for approved hydromorphone from the official website of the U.S. Food and Drug Administration.
59	FDA label for approved hydrocodone from the official website of the U.S. Food and Drug Administration.
60	FDA label for approved donepezil from the official website of the U.S. Food and Drug Administration.
61	FDA label for approved sumatriptan from the official website of the U.S. Food and Drug Administration.
62	FDA label for approved naratriptan from the official website of the U.S. Food and Drug Administration.
63	FDA label for approved pimavanserin from the official website of the U.S. Food and Drug Administration.
64	FDA label for approved brivaracetam from the official website of the U.S. Food and Drug Administration.
65	FDA label for approved amoxicillin from the official website of the U.S. Food and Drug Administration.
66	FDA label for approved metoprolol from the official website of the U.S. Food and Drug Administration.
67	FDA label for approved losartan from the official website of the U.S. Food and Drug Administration.
68	FDA label for approved nifedipine from the official website of the U.S. Food and Drug Administration.
69	FDA label for approved clopidogrel from the official website of the U.S. Food and Drug Administration.
70	FDA label for approved valsartan from the official website of the U.S. Food and Drug Administration.
71	FDA label for approved spironolactone from the official website of the U.S. Food and Drug Administration.
72	FDA label for approved labetalol from the official website of the U.S. Food and Drug Administration.
73	FDA label for approved nitroglycerin from the official website of the U.S. Food and Drug Administration.
74	FDA label for approved rivaroxaban from the official website of the U.S. Food and Drug Administration.
75	FDA label for approved ambrisentan from the official website of the U.S. Food and Drug Administration.
76	FDA label for approved ranolazine from the official website of the U.S. Food and Drug Administration.
77	FDA label for approved montelukast from the official website of the U.S. Food and Drug Administration.
78	FDA label for approved clarithromycin from the official website of the U.S. Food and Drug Administration.
79	FDA label for approved ivacaftor from the official website of the U.S. Food and Drug Administration.
80	FDA label for approved pirfenidone from the official website of the U.S. Food and Drug Administration.
81	FDA label for approved doxycycline from the official website of the U.S. Food and Drug Administration.
82	FDA label for approved omeprazole from the official website of the U.S. Food and Drug Administration.
83	FDA label for approved mycophenolate mofetil from the official website of the U.S. Food and Drug Administration.
84	FDA label for approved ursodeoxycholic acid from the official website of the U.S. Food and Drug Administration.
85	FDA label for approved famotidine from the official website of the U.S. Food and Drug Administration.
86	FDA label for approved alvimopan from the official website of the U.S. Food and Drug Administration.
87	FDA label for approved obeticholic acid from the official website of the U.S. Food and Drug Administration.
88	A study of sustained action pseudoephedrine in allergic rhinitis. Ann Allergy. 1982 Feb;48(2):87-92.
89	FDA label for approved naproxen from the official website of the U.S. Food and Drug Administration.
90	FDA label for approved risedronic acid from the official website of the U.S. Food and Drug Administration.
91	FDA label for approved leflunomide from the official website of the U.S. Food and Drug Administration.
92	FDA label for approved tofacitinib from the official website of the U.S. Food and Drug Administration.
93	FDA label for approved ibuprofen from the official website of the U.S. Food and Drug Administration.
94	FDA label for approved oxybutynin from the official website of the U.S. Food and Drug Administration.
95	FDA label for approved sevelamer from the official website of the U.S. Food and Drug Administration.
96	FDA label for approved trospium from the official website of the U.S. Food and Drug Administration.
97	FDA label for approved sildenafil from the official website of the U.S. Food and Drug Administration.
98	Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12.

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