Details of the Active Pharmaceutical Ingredient (API)
General Information of API (ID: D00634) | |||||
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Name |
Sofosbuvir
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Synonyms |
Click to Show/Hide the Synonyms of This API
SOFOSBUVIR; PSI-7977; SOVALDI; 1190307-88-0; GS-7977; PSI 7977; UNII-WJ6CA3ZU8B; WJ6CA3ZU8B; CHEBI:85083; Sofosbuvir [USAN:INN]; C22H29FN3O9P; Hepcinat; Hepcvir; SoviHep; HSDB 8226; Sovaldi (TN); GS7977; Sofosbuvir (PSI-7977, GS-7977); Sofosbuvir (JAN/USAN); Sofosbuvir(PSI-7977); 2-((5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-ylmethoxy)phenoxyphosphorylamino)propionic acid isopropyl ester; GTPL7368; SCHEMBL2010114; SofosbuvirPSI7977GS-7977; CHEMBL1259059; AMMD00019; EX-A389; isopropyl ((S)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)-L-alaninate; isopropyl (2S)-2-[[[(2R,3R,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-4-fluoro-3-hydroxy-4-methyl-tetrahydrofuran-2-yl]methoxy-phenoxy-phosphoryl]amino]propanoate; AKOS024464753; ZINC100074252; AM84279; CCG-269909; CS-0554; DB08934; GI 7977; GI-7977; HY-15005; SW219116-1; D10366; Q2502747; (S)-2-{[(1R,4R,5R)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-(R)-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-ylmethoxy]phenoxyphosphorylamino}propionic acid (S)-isopropyl ester; (S)-Isopropyl 2-(((S)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-h; (S)-isopropyl 2-(((S)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate; isopropyl (2S)-2-{[(S)-{[(2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl]methoxy}(phenoxy)phosphoryl]amino}propanoate; S)-Isopropyl 2-((S)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4- dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)- (phenoxy)phosphorylamino)propanoate
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Clinical Status |
Approved
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Disease Indication | Viral hepatitis | ICD-11: 1E51 | [1] | ||
PubChem CID | |||||
Formula |
C22H29FN3O9P
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Canonical SMILES |
C[C@@H](C(=O)OC(C)C)N[P@](=O)(OC[C@@H]1[C@H]([C@@]([C@@H](O1)N2C=CC(=O)NC2=O)(C)F)O)OC3=CC=CC=C3
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InChI |
1S/C22H29FN3O9P/c1-13(2)33-19(29)14(3)25-36(31,35-15-8-6-5-7-9-15)32-12-16-18(28)22(4,23)20(34-16)26-11-10-17(27)24-21(26)30/h5-11,13-14,16,18,20,28H,12H2,1-4H3,(H,25,31)(H,24,27,30)/t14-,16+,18+,20+,22+,36-/m0/s1
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InChIKey |
TTZHDVOVKQGIBA-IQWMDFIBSA-N
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Click to Show/Hide the Molecular Data (Structure/Property) of This API | |||||
Structure |
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=45375808"></iframe>
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3D MOL | 2D MOL | ||||
Physicochemical Properties | Molecular Weight | 529.5 | Topological Polar Surface Area | 153 | |
XlogP | 1 | Complexity | 913 | ||
Heavy Atom Count | 36 | Rotatable Bond Count | 11 | ||
Hydrogen Bond Donor Count | 3 | Hydrogen Bond Acceptor Count | 11 | ||
Full List of Drug Formulations (DFMs) Containing This API | ||||||
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Sofosbuvir 400 mg tablet | Click to Show/Hide the Full List of Formulation(s): 1 Formulation(s) | |||||
Drug Formulation 1 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Mannitol; Ferric oxide yellow; Talc; Titanium dioxide; Water; Croscarmellose sodium; Silicon dioxide; Microcrystalline cellulose; Polyethylene glycol, unspecified; Polyvinyl alcohol, unspecified
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Dosage Form | Oral Tablet | |||||
Company | Gilead Sciences | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
Mannitol | DIG Info | Glycine receptor alpha-1 (EC50 = 12589.25 nM) | [2] | |||
Magnesium stearate | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [3] | |||
Carmellose sodium | DIG Info | Albendazole monooxygenase (Protein expression upregulation) | [3] | |||
Silicon dioxide | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [3] | |||
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