Details of the Drug Inactive Ingredient (DIG)

General Information of DIG (ID: E0Q6DQ)
DIG Name
Mannitol
Synonyms    Click to Show/Hide the Synonyms of This DIG
D-mannitol; mannitol; 69-65-8; Mannite; Osmitrol; Manna sugar; Osmofundin; Cordycepic acid; 87-78-5; Mannit; Osmosal; Mannazucker; Mannidex; Mannigen; Mannistol; Resectisol; Diosmol; Invenex; Isotol; Marine Crystal; Maniton-S; D-(-)-Mannitol; Mannogem 2080; Mannitol, D-; Mannitol (VAN); Bronchitol; (2R,3R,4R,5R)-Hexane-1,2,3,4,5,6-hexaol; (2R,3R,4R,5R)-hexane-1,2,3,4,5,6-hexol; Aridol; SDM No. 35; Hexahydroxyhexane; NCI-C50362; UNII-3OWL53L36A; MFCD00064287; Mannitol (USP); Mannitol [USP]; BRN 1721898; DL-Mannitol; CHEBI:16899; D-Mannitol, ACS reagent; 3OWL53L36A; mannitol-d; Mannitol 5%; Mannitol [USAN]; 1,2,3,4,5,6-Hexanehexol; Mannitol 10%; Mannitol 15%; Mannitol 20%; C6H14O6; NCGC00164246-01; E421; D-Mannitol, 98+%; Mannidex 16700; E-421; DSSTox_CID_3235; Osmitrol 5% In Water; DSSTox_RID_76936; Osmitrol 10% In Water; Osmitrol 15% In Water; Osmitrol 20% In Water; DSSTox_GSID_23235; MTL; MANNITOL 25%; Resectisol In Plastic Container; Mannitol 5% In Plastic Container; Mannitol 10% In Plastic Container; Mannitol 15% In Plastic Container; Mannitol 20% In Plastic Container; CAS-69-65-8; Osmitrol (TN); SMR000857324; CCRIS 369; HSDB 714; SR-01000838849; D-Mannitol, EP, USP grade; NSC 9256; EINECS 200-711-8; EINECS 201-770-2; OSMITROL 5% IN WATER IN PLASTIC CONTAINER; NSC 407017; OSMITROL 10% IN WATER IN PLASTIC CONTAINER; OSMITROL 15% IN WATER IN PLASTIC CONTAINER; OSMITROL 20% IN WATER IN PLASTIC CONTAINER; Cordycepate; Manitol; D-mitobronitol; MANNITOL 10% W/ DEXTROSE 5% IN DISTILLED WATER; Mushroom sugar; AI3-19511; Maniton s; Mannit p; D-Mannit; NSC-407017; Bronchitol (TN); (D)-mannitol; Mannitol,(S); D-Mannitol (Osmitrol); D-Mannitol (JP17); MANNITOL 15% W/ DEXTROSE 5% IN SODIUM CHLORIDE 0.45%; MANNITOL 5% W/ DEXTROSE 5% IN SODIUM CHLORIDE 0.12%; D-Mannitol, >=98%; M0044; SCHEMBL919; bmse000099; CHEMBL689; Epitope ID:114705; Isomalt impurity, mannitol-; 4-01-00-02841 (Beilstein Handbook Reference); ED1D1E61-FEFB-430A-AFDC-D1F4A957FC3D; MLS001335977; MLS001335978; D-Mannitol, AR, >=99%; D-Mannitol, LR, >=99%; INS NO.421; DTXSID1023235; DTXSID30858955; INS-421; HMS2230N11; AMY33410; HY-N0378; ZINC2041302; Tox21_112092; Tox21_201487; Tox21_300483; POTASSIUMNONAFLUORO-T-BUTOXIDE; AKOS006280947; D-Mannitol, plant cell culture tested; Tox21_112092_1; BCP9000575; CCG-266445; D-Mannit 1000 microg/mL in Methanol; D-Mannitol, BioXtra, >=98% (GC); DB00742; D-Mannitol, NIST(R) SRM(R) 920; NCGC00164246-03; NCGC00164246-04; NCGC00164246-05; NCGC00254277-01; NCGC00259038-01; AC-12776; AC-14054; AS-30501; D-Mannitol, tested according to Ph.Eur.; K167; D-Mannitol, p.a., 96.0-101.5%; D-Mannitol, SAJ first grade, >=99.0%; AB0008020; B2090; D-Mannitol, SAJ special grade, >=99.0%; E 421; S2381; SW220287-1; 1630-EP2269989A1; 1630-EP2269994A1; 1630-EP2269996A1; 1630-EP2269999A1; 1630-EP2270000A1; 1630-EP2270002A1; 1630-EP2270005A1; 1630-EP2270007A1; 1630-EP2270008A1; 1630-EP2270011A1; 1630-EP2270012A1; 1630-EP2270013A1; 1630-EP2270014A1; 1630-EP2272517A1; 1630-EP2272537A2; 1630-EP2272817A1; 1630-EP2272826A1; 1630-EP2272848A1; 1630-EP2275412A1; 1630-EP2275413A1; 1630-EP2275420A1; 1630-EP2275421A1; 1630-EP2277507A1; 1630-EP2277565A2; 1630-EP2277566A2; 1630-EP2277567A1; 1630-EP2277568A2; 1630-EP2277569A2; 1630-EP2277570A2; 1630-EP2277861A1; 1630-EP2277867A2; 1630-EP2277877A1; 1630-EP2277879A1; 1630-EP2280003A2; 1630-EP2280008A2; 1630-EP2280010A2; 1630-EP2281559A1; 1630-EP2281818A1; 1630-EP2281823A2; 1630-EP2283811A1; 1630-EP2284149A1; 1630-EP2284159A1; 1630-EP2284166A1; 1630-EP2286795A1; 1630-EP2287147A2; 1630-EP2287156A1; 1630-EP2287160A1; 1630-EP2287165A2; 1630-EP2287166A2; 1630-EP2289509A2; 1630-EP2289518A1; 1630-EP2289893A1; 1630-EP2289894A2; 1630-EP2292222A1; 1630-EP2292227A2; 1630-EP2292231A1; 1630-EP2292234A1; 1630-EP2292280A1; 1630-EP2292593A2; 1630-EP2292597A1; 1630-EP2292611A1; 1630-EP2292612A2; 1630-EP2292613A1; 1630-EP2292616A1; 1630-EP2292617A1; 1630-EP2292620A2; 1630-EP2292622A1; 1630-EP2292624A1; 1630-EP2292630A1; 1630-EP2295053A1; 1630-EP2295055A2; 1630-EP2295402A2; 1630-EP2295408A1; 1630-EP2295416A2; 1630-EP2295424A1; 1630-EP2295426A1; 1630-EP2295427A1; 1630-EP2295430A2; 1630-EP2295431A2; 1630-EP2295432A1; 1630-EP2295433A2; 1630-EP2295437A1; 1630-EP2295439A1; 1630-EP2298734A2; 1630-EP2298743A1; 1630-EP2298744A2; 1630-EP2298747A1; 1630-EP2298748A2; 1630-EP2298752A1; 1630-EP2298758A1; 1630-EP2298759A1; 1630-EP2298764A1; 1630-EP2298765A1; 1630-EP2298770A1; 1630-EP2298773A1; 1630-EP2298775A1; 1630-EP2298779A1; 1630-EP2298783A1; 1630-EP2301533A1; 1630-EP2301540A1; 1630-EP2301922A1; 1630-EP2301923A1; 1630-EP2301931A1; 1630-EP2301937A1; 1630-EP2301938A1; 1630-EP2305243A1; 1630-EP2305248A1; 1630-EP2305250A1; 1630-EP2305254A1; 1630-EP2305636A1; 1630-EP2305641A1; 1630-EP2305653A1; 1630-EP2305663A1; 1630-EP2305664A1; 1630-EP2305665A1; 1630-EP2305668A1; 1630-EP2305675A1; 1630-EP2305680A2; 1630-EP2305681A1; 1630-EP2305695A2; 1630-EP2305696A2; 1630-EP2305697A2; 1630-EP2305698A2; 1630-EP2308492A1; 1630-EP2308510A1; 1630-EP2308562A2; 1630-EP2308812A2; 1630-EP2308828A2; 1630-EP2308833A2; 1630-EP2308852A1; 1630-EP2308861A1; 1630-EP2308869A1; 1630-EP2308872A1; 1630-EP2308873A1; 1630-EP2308875A1; 1630-EP2308877A1; 1630-EP2311453A1; 1630-EP2311464A1; 1630-EP2311494A1; 1630-EP2311806A2; 1630-EP2311807A1; 1630-EP2311809A1; 1630-EP2311821A1; 1630-EP2311825A1; 1630-EP2311829A1; 1630-EP2311831A1; 1630-EP2311836A1; 1630-EP2311837A1; 1630-EP2311838A1; 1630-EP2311840A1; 1630-EP2311842A2; 1630-EP2314295A1; 1630-EP2314575A1; 1630-EP2314584A1; 1630-EP2314586A1; 1630-EP2314590A1; 1630-EP2314591A1; 1630-EP2314593A1; 1630-EP2316470A2; 1630-EP2316829A1; 1630-EP2316831A1; 1630-EP2316832A1; 1630-EP2316833A1; 1630-EP2316834A1; 1630-EP2316836A1; 1630-EP2371811A2; 1630-EP2374454A1; 1630-EP2374790A1; 1630-EP2374792A1; 1630-EP2377849A2; C00392; D00062; X-3269; 27808-EP2269993A1; 27808-EP2270505A1; 27808-EP2277874A1; 27808-EP2277880A1; 27808-EP2281823A2; 27808-EP2284160A1; 27808-EP2287155A1; 27808-EP2292610A1; 27808-EP2292612A2; 27808-EP2295406A1; 27808-EP2295414A1; 27808-EP2295432A1; 27808-EP2298731A1; 27808-EP2298767A1; 27808-EP2298772A1; 27808-EP2301938A1; 27808-EP2305219A1; 27808-EP2308839A1; 27808-EP2311822A1; 27808-EP2314587A1; AB00443917_06; 065M361; Q407646; Q-101039; SR-01000838849-3; SR-01000838849-4; D-Mannitol, ACS reagent, for microbiology, >=99.0%; D-Mannitol, meets EP, FCC, USP testing specifications; Mannitol, European Pharmacopoeia (EP) Reference Standard; D-Mannitol, BioUltra, >=99.0% (sum of enantiomers, HPLC); Mannitol, United States Pharmacopeia (USP) Reference Standard; D-Mannitol, >=99.9999% (metals basis), for boron determination; Mannitol, Pharmaceutical Secondary Standard; Certified Reference Material
DIG Function
Diluent; Flavoring agent; Lyophilization aid; Plasticizing agent; Tonicity agent
PubChem CID
6251
Formula
C6H14O6
Canonical SMILES
C([C@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O)O
InChI
1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4-,5-,6-/m1/s1
InChIKey
FBPFZTCFMRRESA-KVTDHHQDSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This DIG
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=6251"></iframe>
3D MOL 2D MOL
Physicochemical Properties Molecular Weight 182.17 Topological Polar Surface Area 121
XlogP -3.1 Complexity 105
Heavy Atom Count 12 Rotatable Bond Count 5
Hydrogen Bond Donor Count 6 Hydrogen Bond Acceptor Count 6
Full List of Active Pharmaceutical Ingredients (APIs) Co-administrated with This DIG
       ICD Disease Classification 01 Infectious/parasitic disease Click to Show/Hide
Amantadine
 API Info
Influenza virus infection [ICD-11: 1E30]
 [1]
Ribavirin
 API Info
Viral hepatitis [ICD-11: 1E51]
 [2]
Cefaclor
 API Info
Clostridium difficile infection [ICD-11: 1A04]
 [3]
Ciprofloxacin
 API Info
Endocarditis [ICD-11: 1B12]
 [4]
Linezolid
 API Info
Streptococcus bacterial infection [ICD-11: 1C41]
 [5]
Raltegravir
 API Info
Human immunodeficiency virus infection [ICD-11: 1C60]
 [6]
Cefixime
 API Info
Streptococcus bacterial infection [ICD-11: 1C41]
 [7]
Entecavir
 API Info
Viral hepatitis [ICD-11: 1E51]
 [8]
Albendazole
 API Info
Cysticercosis [ICD-11: 1F70]
 [9]
Dolutegravir
 API Info
Human immunodeficiency virus infection [ICD-11: 1C60]
 [10]
Tenofovir disoproxil
 API Info
Human immunodeficiency virus infection [ICD-11: 1C60]
 [11]
Sofosbuvir
 API Info
Viral hepatitis [ICD-11: 1E51]
 [12]
Tedizolid phosphate
 API Info
Streptococcus bacterial infection [ICD-11: 1C41]
 [13]
       ICD Disease Classification 02 Benign/in-situ/malignant neoplasm Click to Show/Hide
Temozolomide
 API Info
Brain cancer [ICD-11: 2A00]
 [14]
Prednisolone
 API Info
Multiple myeloma [ICD-11: 2A83]
 [15]
Everolimus
 API Info
Renal cell carcinoma [ICD-11: 2C90]
 [16]
Imatinib
 API Info
Leiomyosarcoma [ICD-11: 2B58]
 [17]
Letrozole
 API Info
Breast cancer [ICD-11: 2C60]
 [18]
Exemestane
 API Info
Breast cancer [ICD-11: 2C60]
 [19]
Trametinib
 API Info
Melanoma [ICD-11: 2C30]
 [20]
Lomustine
 API Info
Brain cancer [ICD-11: 2A00]
 [21]
Pomalidomide
 API Info
Breast cancer [ICD-11: 2C60]
 [22]
Sunitinib
 API Info
Leiomyosarcoma [ICD-11: 2B58]
 [23]
Topotecan
 API Info
Ovarian cancer [ICD-11: 2C73]
 [24]
Olaparib
 API Info
Ovarian cancer [ICD-11: 2C73]
 [25]
Panobinostat
 API Info
Multiple myeloma [ICD-11: 2A83]
 [26]
Bexarotene
 API Info
Anaplastic large cell lymphoma [ICD-11: 2A90]
 [27]
Osimertinib
 API Info
Lung cancer [ICD-11: 2C25]
 [28]
Tamoxifen
 API Info
Breast cancer [ICD-11: 2C60]
 [29]
Neratinib
 API Info
Breast cancer [ICD-11: 2C60]
 [30]
Procarbazine
 API Info
Hodgkin lymphoma [ICD-11: 2B30]
 [31]
       ICD Disease Classification 03 Blood/blood-forming organ disease Click to Show/Hide
Eltrombopag
 API Info
Thrombocytopenia [ICD-11: 3B64]
 [32]
       ICD Disease Classification 04 Immune system disease Click to Show/Hide
Cetirizine
 API Info
Allergy [ICD-11: 4A80]
 [33]
       ICD Disease Classification 05 Endocrine/nutritional/metabolic disease Click to Show/Hide
Levothroid
 API Info
Hypothyroidism [ICD-11: 5A00]
 [34]
Fenofibrate
 API Info
Hypertriglyceridaemia [ICD-11: 5C80]
 [35]
Atorvastatin
 API Info
Hyperlipidaemia [ICD-11: 5C8Z]
 [36]
Phentermine
 API Info
Obesity [ICD-11: 5B81]
 [37]
Pravastatin
 API Info
Dyslipidaemia [ICD-11: 5C81]
 [38]
Rosuvastatin
 API Info
Hypertriglyceridaemia [ICD-11: 5C80]
 [39]
Nateglinide
 API Info
Diabetes mellitus [ICD-11: 5A10]
 [40]
Liothyronine
 API Info
Hypothyroidism [ICD-11: 5A00]
 [41]
Diethylpropion
 API Info
Obesity [ICD-11: 5B81]
 [42]
Alogliptin
 API Info
Diabetes mellitus [ICD-11: 5A10]
 [43]
Pioglitazone
 API Info
Diabetes mellitus [ICD-11: 5A10]
 [44]
Lorcaserin
 API Info
Obesity [ICD-11: 5B81]
 [45]
       ICD Disease Classification 06 Mental/behavioural/neurodevelopmental disorder Click to Show/Hide
Risperidone
 API Info
Schizophrenia [ICD-11: 6A20]
 [46]
Bupropion
 API Info
Nicotine dependence [ICD-11: 6C4A]
 [47]
Alprazolam
 API Info
Anxiety disorder [ICD-11: 6B00]
 [48]
Lamotrigine
 API Info
Bipolar disorder [ICD-11: 6A60]
 [49]
Fluoxetine
 API Info
Major depressive disorder [ICD-11: 6A70]
 [50]
Duloxetine
 API Info
Major depressive disorder [ICD-11: 6A70]
 [51]
Venlafaxine
 API Info
Major depressive disorder [ICD-11: 6A70]
 [52]
Olanzapine
 API Info
Schizophrenia [ICD-11: 6A20]
 [53]
Aripiprazole
 API Info
Schizophrenia [ICD-11: 6A20]
 [54]
Methylphenidate
 API Info
Attention deficit hyperactivity disorder [ICD-11: 6A05]
 [55]
Mirtazapine
 API Info
Major depressive disorder [ICD-11: 6A70]
 [56]
Desipramine
 API Info
Attention deficit hyperactivity disorder [ICD-11: 6A05]
 [57]
Fluvoxamine
 API Info
Obsessive-compulsive disorder [ICD-11: 6B20]
 [58]
Clozapine
 API Info
Schizophrenia [ICD-11: 6A20]
 [59]
Buprenorphine
 API Info
Opiate dependence [ICD-11: 6C43]
 [60]
Escitalopram
 API Info
Major depressive disorder [ICD-11: 6A70]
 [61]
Lisdexamfetamine
 API Info
Attention deficit hyperactivity disorder [ICD-11: 6A05]
 [62]
Citalopram
 API Info
Major depressive disorder [ICD-11: 6A70]
 [63]
Amphetamine
 API Info
Attention deficit hyperactivity disorder [ICD-11: 6A05]
 [64]
Vortioxetine
 API Info
Major depressive disorder [ICD-11: 6A70]
 [65]
Phenelzine
 API Info
Major depressive disorder [ICD-11: 6A70]
 [66]
Asenapine
 API Info
Schizophrenia [ICD-11: 6A20]
 [67]
Lurasidone
 API Info
Schizophrenia [ICD-11: 6A20]
 [68]
       ICD Disease Classification 07 Sleep-wake disorder Click to Show/Hide
Zolpidem
 API Info
Insomnia [ICD-11: 7A00]
 [69]
Modafinil
 API Info
Narcolepsy [ICD-11: 7A20]
 [70]
       ICD Disease Classification 08 Nervous system disease Click to Show/Hide
Acetaminophen
 API Info
Anaesthesia [ICD-11: 8E22]
 [71]
Morphine
 API Info
Anaesthesia [ICD-11: 8E22]
 [72]
Gabapentin
 API Info
Focal seizure [ICD-11: 8A68]
 [73]
Oxycodone
 API Info
Anaesthesia [ICD-11: 8E22]
 [74]
Valproic acid
 API Info
Epilepsy [ICD-11: 8A60]
 [75]
Pramipexole
 API Info
Parkinsonism [ICD-11: 8A00]
 [76]
Ropinirole
 API Info
Parkinsonism [ICD-11: 8A00]
 [77]
Levetiracetam
 API Info
Focal seizure [ICD-11: 8A68]
 [78]
Tramadol
 API Info
Anaesthesia [ICD-11: 8E22]
 [79]
Carbamazepine
 API Info
Epilepsy [ICD-11: 8A60]
 [80]
Clonazepam
 API Info
Epilepsy [ICD-11: 8A60]
 [81]
Topiramate
 API Info
Focal seizure [ICD-11: 8A68]
 [82]
Phenytoin
 API Info
Epilepsy [ICD-11: 8A60]
 [83]
Galantamine
 API Info
Alzheimer disease [ICD-11: 8A20]
 [84]
Hydromorphone
 API Info
Anaesthesia [ICD-11: 8E22]
 [85]
Rizatriptan
 API Info
Migraine [ICD-11: 8A80]
 [86]
Donepezil
 API Info
Alzheimer disease [ICD-11: 8A20]
 [87]
Zolmitriptan
 API Info
Migraine [ICD-11: 8A80]
 [88]
Fentanyl
 API Info
Anaesthesia [ICD-11: 8E22]
 [89]
Almotriptan
 API Info
Migraine [ICD-11: 8A80]
 [90]
Entacapone
 API Info
Parkinsonism [ICD-11: 8A00]
 [91]
Sumatriptan
 API Info
Migraine [ICD-11: 8A80]
 [92]
Rasagiline
 API Info
Parkinsonism [ICD-11: 8A00]
 [93]
Selegiline
 API Info
Parkinsonism [ICD-11: 8A00]
 [94]
Ticagrelor
 API Info
Cerebral stroke [ICD-11: 8B11]
 [95]
Deutetrabenazine
 API Info
Huntington disease [ICD-11: 8A01]
 [96]
Droxidopa
 API Info
Neurogenic orthostatic hypotension [ICD-11: 8D87]
 [97]
Valbenazine
 API Info
Dyskinesia [ICD-11: 8A02]
 [98]
Benzocaine
 API Info
Anaesthesia [ICD-11: 8E22]
 [99]
Dihydroergotamine
 API Info
Migraine [ICD-11: 8A80]
 [100]
Fingolimod
 API Info
Multiple sclerosis [ICD-11: 8A40]
 [101]
Guanidine
 API Info
Lambert-eaton syndrome [ICD-11: 8C62]
 [102]
       ICD Disease Classification 09 Visual system disease Click to Show/Hide
Dextromethorphan
 API Info
Allergic conjunctivitis [ICD-11: 9A60]
 [103]
       ICD Disease Classification 10 Ear/mastoid process disease Click to Show/Hide
Diphenhydramine
 API Info
Meniere disease [ICD-11: AB31]
 [104]
Amoxicillin
 API Info
Acute otitis media [ICD-11: AB00]
 [105]
       ICD Disease Classification 11 Circulatory system disease Click to Show/Hide
Diltiazem
 API Info
Essential hypertension [ICD-11: BA00]
 [106]
Lisinopril
 API Info
Essential hypertension [ICD-11: BA00]
 [107]
Aspirin
 API Info
Myocardial infarction [ICD-11: BA41]
 [108]
Hydralazine
 API Info
Essential hypertension [ICD-11: BA00]
 [109]
Losartan
 API Info
Essential hypertension [ICD-11: BA00]
 [110]
Amlodipine
 API Info
Angina pectoris [ICD-11: BA40]
 [111]
Clopidogrel
 API Info
Deep vein thrombosis [ICD-11: BD71]
 [112]
Valsartan
 API Info
Essential hypertension [ICD-11: BA00]
 [113]
Telmisartan
 API Info
Essential hypertension [ICD-11: BA00]
 [114]
Carvedilol
 API Info
Congestive heart failure [ICD-11: BD10]
 [115]
Irbesartan
 API Info
Essential hypertension [ICD-11: BA00]
 [116]
Prasugrel
 API Info
Myocardial infarction [ICD-11: BA41]
 [117]
Betaxolol
 API Info
Essential hypertension [ICD-11: BA00]
 [118]
Selexipag
 API Info
Pulmonary hypertension [ICD-11: BB01]
 [119]
Nimodipine
 API Info
Cerebral vasospasm [ICD-11: BA85]
 [120]
Candesartan cilexetil
 API Info
Essential hypertension [ICD-11: BA00]
 [121]
Azilsartan medoxomil
 API Info
Essential hypertension [ICD-11: BA00]
 [122]
       ICD Disease Classification 12 Respiratory system disease Click to Show/Hide
Montelukast
 API Info
Asthma [ICD-11: CA23]
 [123]
Fexofenadine
 API Info
Allergic rhinitis [ICD-11: CA08]
 [124]
Loratadine
 API Info
Allergic rhinitis [ICD-11: CA08]
 [125]
Desloratadine
 API Info
Allergic rhinitis [ICD-11: CA08]
 [126]
Sirolimus
 API Info
Lymphangioleiomyomatosis [ICD-11: CB07]
 [127]
Cefditoren pivoxil
 API Info
Pneumocystis pneumonia [ICD-11: CA40]
 [128]
Zileuton
 API Info
Asthma [ICD-11: CA23]
 [129]
Dexbrompheniramine
 API Info
Allergic rhinitis [ICD-11: CA08]
 [130]
       ICD Disease Classification 13 Digestive system disease Click to Show/Hide
Doxycycline
 API Info
Periodontal disease [ICD-11: DA0C]
 [131]
Omeprazole
 API Info
Gastro-oesophageal reflux disease [ICD-11: DA22]
 [132]
Pantoprazole
 API Info
Gastro-oesophageal reflux disease [ICD-11: DA22]
 [133]
Meclizine
 API Info
Functional nausea/vomiting [ICD-11: DD90]
 [134]
Lansoprazole
 API Info
Duodenal ulcer [ICD-11: DA63]
 [135]
Simethicone
 API Info
Irritable bowel syndrome [ICD-11: DD91]
 [136]
Esomeprazole
 API Info
Duodenal ulcer [ICD-11: DA63]
 [137]
Bismuth subsalicylate
 API Info
Irritable bowel syndrome [ICD-11: DD91]
 [138]
Ondansetron
 API Info
Gastritis [ICD-11: DA42]
 [139]
Metoclopramide
 API Info
Gastro-oesophageal reflux disease [ICD-11: DA22]
 [140]
Rabeprazole
 API Info
Gastro-oesophageal reflux disease [ICD-11: DA22]
 [141]
Dimenhydrinate
 API Info
Functional nausea/vomiting [ICD-11: DD90]
 [142]
Aprepitant
 API Info
Functional nausea/vomiting [ICD-11: DD90]
 [143]
Sodium fluoride
 API Info
Periodontal disease [ICD-11: DA0C]
 [144]
Dexlansoprazole
 API Info
Gastro-oesophageal reflux disease [ICD-11: DA22]
 [145]
Eluxadoline
 API Info
Irritable bowel syndrome [ICD-11: DD91]
 [146]
Naloxegol
 API Info
Irritable bowel syndrome [ICD-11: DD91]
 [147]
Naldemedine
 API Info
Irritable bowel syndrome [ICD-11: DD91]
 [147]
       ICD Disease Classification 15 Musculoskeletal/connective-tissue disease Click to Show/Hide
Naproxen
 API Info
Rheumatoid arthritis [ICD-11: FA20]
 [148]
Indomethacin
 API Info
Rheumatoid arthritis [ICD-11: FA20]
 [149]
Celecoxib
 API Info
Rheumatoid arthritis [ICD-11: FA20]
 [150]
Alendronic acid
 API Info
Osteoporosis [ICD-11: FB83]
 [151]
Risedronic acid
 API Info
Paget's disease [ICD-11: FB85]
 [152]
Raloxifene
 API Info
Osteoporosis [ICD-11: FB83]
 [153]
       ICD Disease Classification 16 Genitourinary system disease Click to Show/Hide
Ibuprofen
 API Info
Dysmenorrhea [ICD-11: GA34]
 [154]
Oxybutynin
 API Info
Overactive bladder [ICD-11: GC50]
 [155]
Sevelamer
 API Info
Chronic kidney disease [ICD-11: GB61]
 [156]
Alfuzosin
 API Info
Prostatic hyperplasia [ICD-11: GA90]
 [157]
Ospemifene
 API Info
Dyspareunia [ICD-11: GA12]
 [158]
       ICD Disease Classification 17 Sexual health-related condition Click to Show/Hide
Avanafil
 API Info
Erectile dysfunction [ICD-11: HA01]
 [159]
Vardenafil
 API Info
Erectile dysfunction [ICD-11: HA01]
 [160]
       ICD Disease Classification 20 Developmental anomaly Click to Show/Hide
Calcitriol
 API Info
Congenital alopecia [ICD-11: LC30]
 [161]
Full List of Biological Targets of DIG (DBTs) Regulated by This DIG
      Transmembrane channel/porin (TC/P)
            DBT Name: Glycine receptor alpha-1 (GLRA1) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Biological Activity EC50 = 12589.25 nM (estimated based on the structural similarity with CHEMBL604608 ) [162]
                    Structural Similarity Tanimoto coefficient = 0.804878049
                    Tested Species Homo sapiens (Human)
                    UniProt ID GLRA1_HUMAN
References
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2 FDA label for approved ribavirin from the official website of the U.S. Food and Drug Administration.
3 FDA label for approved cefaclor from the official website of the U.S. Food and Drug Administration.
4 FDA label for approved ciprofloxacin from the official website of the U.S. Food and Drug Administration.
5 FDA label for approved linezolid from the official website of the U.S. Food and Drug Administration.
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7 FDA label for approved cefixime from the official website of the U.S. Food and Drug Administration.
8 FDA label for approved entecavir from the official website of the U.S. Food and Drug Administration.
9 FDA label for approved albendazole from the official website of the U.S. Food and Drug Administration.
10 FDA label for approved dolutegravir from the official website of the U.S. Food and Drug Administration.
11 FDA label for approved tenofovir disoproxil from the official website of the U.S. Food and Drug Administration.
12 FDA label for approved sofosbuvir from the official website of the U.S. Food and Drug Administration.
13 FDA label for approved tedizolid phosphate from the official website of the U.S. Food and Drug Administration.
14 FDA label for approved temozolomide from the official website of the U.S. Food and Drug Administration.
15 FDA label for approved prednisolone from the official website of the U.S. Food and Drug Administration.
16 FDA label for approved everolimus from the official website of the U.S. Food and Drug Administration.
17 FDA label for approved imatinib from the official website of the U.S. Food and Drug Administration.
18 FDA label for approved letrozole from the official website of the U.S. Food and Drug Administration.
19 FDA label for approved exemestane from the official website of the U.S. Food and Drug Administration.
20 FDA label for approved trametinib from the official website of the U.S. Food and Drug Administration.
21 FDA label for approved lomustine from the official website of the U.S. Food and Drug Administration.
22 FDA label for approved pomalidomide from the official website of the U.S. Food and Drug Administration.
23 FDA label for approved sunitinib from the official website of the U.S. Food and Drug Administration.
24 FDA label for approved topotecan from the official website of the U.S. Food and Drug Administration.
25 FDA label for approved olaparib from the official website of the U.S. Food and Drug Administration.
26 FDA label for approved panobinostat from the official website of the U.S. Food and Drug Administration.
27 FDA label for approved bexarotene from the official website of the U.S. Food and Drug Administration.
28 FDA label for approved osimertinib from the official website of the U.S. Food and Drug Administration.
29 FDA label for approved tamoxifen from the official website of the U.S. Food and Drug Administration.
30 FDA label for approved neratinib from the official website of the U.S. Food and Drug Administration.
31 FDA label for approved procarbazine from the official website of the U.S. Food and Drug Administration.
32 FDA label for approved eltrombopag from the official website of the U.S. Food and Drug Administration.
33 FDA label for approved cetirizine from the official website of the U.S. Food and Drug Administration.
34 FDA label for approved levothroid from the official website of the U.S. Food and Drug Administration.
35 FDA label for approved fenofibrate from the official website of the U.S. Food and Drug Administration.
36 FDA label for approved atorvastatin from the official website of the U.S. Food and Drug Administration.
37 FDA label for approved phentermine from the official website of the U.S. Food and Drug Administration.
38 FDA label for approved pravastatin from the official website of the U.S. Food and Drug Administration.
39 FDA label for approved rosuvastatin from the official website of the U.S. Food and Drug Administration.
40 FDA label for approved nateglinide from the official website of the U.S. Food and Drug Administration.
41 FDA label for approved liothyronine from the official website of the U.S. Food and Drug Administration.
42 FDA label for approved diethylpropion from the official website of the U.S. Food and Drug Administration.
43 FDA label for approved alogliptin from the official website of the U.S. Food and Drug Administration.
44 FDA label for approved pioglitazone from the official website of the U.S. Food and Drug Administration.
45 FDA label for approved lorcaserin from the official website of the U.S. Food and Drug Administration.
46 FDA label for approved risperidone from the official website of the U.S. Food and Drug Administration.
47 FDA label for approved bupropion from the official website of the U.S. Food and Drug Administration.
48 FDA label for approved alprazolam from the official website of the U.S. Food and Drug Administration.
49 FDA label for approved lamotrigine from the official website of the U.S. Food and Drug Administration.
50 FDA label for approved fluoxetine from the official website of the U.S. Food and Drug Administration.
51 FDA label for approved duloxetine from the official website of the U.S. Food and Drug Administration.
52 FDA label for approved venlafaxine from the official website of the U.S. Food and Drug Administration.
53 FDA label for approved olanzapine from the official website of the U.S. Food and Drug Administration.
54 FDA label for approved aripiprazole from the official website of the U.S. Food and Drug Administration.
55 FDA label for approved methylphenidate from the official website of the U.S. Food and Drug Administration.
56 FDA label for approved mirtazapine from the official website of the U.S. Food and Drug Administration.
57 FDA label for approved desipramine from the official website of the U.S. Food and Drug Administration.
58 FDA label for approved fluvoxamine from the official website of the U.S. Food and Drug Administration.
59 FDA label for approved clozapine from the official website of the U.S. Food and Drug Administration.
60 FDA label for approved buprenorphine from the official website of the U.S. Food and Drug Administration.
61 FDA label for approved escitalopram from the official website of the U.S. Food and Drug Administration.
62 FDA label for approved lisdexamfetamine from the official website of the U.S. Food and Drug Administration.
63 FDA label for approved citalopram from the official website of the U.S. Food and Drug Administration.
64 FDA label for approved amphetamine from the official website of the U.S. Food and Drug Administration.
65 FDA label for approved vortioxetine from the official website of the U.S. Food and Drug Administration.
66 FDA label for approved phenelzine from the official website of the U.S. Food and Drug Administration.
67 FDA label for approved asenapine from the official website of the U.S. Food and Drug Administration.
68 FDA label for approved lurasidone from the official website of the U.S. Food and Drug Administration.
69 FDA label for approved zolpidem from the official website of the U.S. Food and Drug Administration.
70 FDA label for approved modafinil from the official website of the U.S. Food and Drug Administration.
71 FDA label for approved acetaminophen from the official website of the U.S. Food and Drug Administration.
72 FDA label for approved morphine from the official website of the U.S. Food and Drug Administration.
73 FDA label for approved gabapentin from the official website of the U.S. Food and Drug Administration.
74 Efficacy of oxycodone in neuropathic pain: a randomized trial in postherpetic neuralgia. Neurology. 1998 Jun;50(6):1837-41.
75 FDA label for approved valproic acid from the official website of the U.S. Food and Drug Administration.
76 FDA label for approved pramipexole from the official website of the U.S. Food and Drug Administration.
77 FDA label for approved ropinirole from the official website of the U.S. Food and Drug Administration.
78 FDA label for approved levetiracetam from the official website of the U.S. Food and Drug Administration.
79 FDA label for approved tramadol from the official website of the U.S. Food and Drug Administration.
80 FDA label for approved carbamazepine from the official website of the U.S. Food and Drug Administration.
81 FDA label for approved clonazepam from the official website of the U.S. Food and Drug Administration.
82 FDA label for approved topiramate from the official website of the U.S. Food and Drug Administration.
83 FDA label for approved phenytoin from the official website of the U.S. Food and Drug Administration.
84 FDA label for approved galantamine from the official website of the U.S. Food and Drug Administration.
85 FDA label for approved hydromorphone from the official website of the U.S. Food and Drug Administration.
86 FDA label for approved rizatriptan from the official website of the U.S. Food and Drug Administration.
87 FDA label for approved donepezil from the official website of the U.S. Food and Drug Administration.
88 FDA label for approved zolmitriptan from the official website of the U.S. Food and Drug Administration.
89 FDA label for approved fentanyl from the official website of the U.S. Food and Drug Administration.
90 FDA label for approved almotriptan from the official website of the U.S. Food and Drug Administration.
91 FDA label for approved entacapone from the official website of the U.S. Food and Drug Administration.
92 FDA label for approved sumatriptan from the official website of the U.S. Food and Drug Administration.
93 FDA label for approved rasagiline from the official website of the U.S. Food and Drug Administration.
94 FDA label for approved selegiline from the official website of the U.S. Food and Drug Administration.
95 FDA label for approved ticagrelor from the official website of the U.S. Food and Drug Administration.
96 FDA label for approved deutetrabenazine from the official website of the U.S. Food and Drug Administration.
97 FDA label for approved droxidopa from the official website of the U.S. Food and Drug Administration.
98 FDA label for approved valbenazine from the official website of the U.S. Food and Drug Administration.
99 Benzocaine.
100 FDA label for approved dihydroergotamine from the official website of the U.S. Food and Drug Administration.
101 FDA label for approved fingolimod from the official website of the U.S. Food and Drug Administration.
102 FDA label for approved guanidine from the official website of the U.S. Food and Drug Administration.
103 FDA label for approved dextromethorphan from the official website of the U.S. Food and Drug Administration.
104 FDA label for approved diphenhydramine from the official website of the U.S. Food and Drug Administration.
105 FDA label for approved amoxicillin from the official website of the U.S. Food and Drug Administration.
106 FDA label for approved diltiazem from the official website of the U.S. Food and Drug Administration.
107 FDA label for approved lisinopril from the official website of the U.S. Food and Drug Administration.
108 FDA label for approved aspirin from the official website of the U.S. Food and Drug Administration.
109 FDA label for approved hydralazine from the official website of the U.S. Food and Drug Administration.
110 FDA label for approved losartan from the official website of the U.S. Food and Drug Administration.
111 FDA label for approved amlodipine from the official website of the U.S. Food and Drug Administration.
112 FDA label for approved clopidogrel from the official website of the U.S. Food and Drug Administration.
113 FDA label for approved valsartan from the official website of the U.S. Food and Drug Administration.
114 FDA label for approved telmisartan from the official website of the U.S. Food and Drug Administration.
115 FDA label for approved carvedilol from the official website of the U.S. Food and Drug Administration.
116 FDA label for approved irbesartan from the official website of the U.S. Food and Drug Administration.
117 FDA label for approved prasugrel from the official website of the U.S. Food and Drug Administration.
118 FDA label for approved betaxolol from the official website of the U.S. Food and Drug Administration.
119 FDA label for approved selexipag from the official website of the U.S. Food and Drug Administration.
120 FDA label for approved nimodipine from the official website of the U.S. Food and Drug Administration.
121 FDA label for approved candesartan cilexetil from the official website of the U.S. Food and Drug Administration.
122 FDA label for approved azilsartan medoxomil from the official website of the U.S. Food and Drug Administration.
123 FDA label for approved montelukast from the official website of the U.S. Food and Drug Administration.
124 FDA label for approved fexofenadine from the official website of the U.S. Food and Drug Administration.
125 FDA label for approved loratadine from the official website of the U.S. Food and Drug Administration.
126 FDA label for approved desloratadine from the official website of the U.S. Food and Drug Administration.
127 FDA label for approved sirolimus from the official website of the U.S. Food and Drug Administration.
128 FDA label for approved cefditoren pivoxil from the official website of the U.S. Food and Drug Administration.
129 FDA label for approved zileuton from the official website of the U.S. Food and Drug Administration.
130 FDA label for approved dexbrompheniramine from the official website of the U.S. Food and Drug Administration.
131 FDA label for approved doxycycline from the official website of the U.S. Food and Drug Administration.
132 FDA label for approved omeprazole from the official website of the U.S. Food and Drug Administration.
133 FDA label for approved pantoprazole from the official website of the U.S. Food and Drug Administration.
134 FDA label for approved meclizine from the official website of the U.S. Food and Drug Administration.
135 FDA label for approved lansoprazole from the official website of the U.S. Food and Drug Administration.
136 FDA label for approved simethicone from the official website of the U.S. Food and Drug Administration.
137 FDA label for approved esomeprazole from the official website of the U.S. Food and Drug Administration.
138 Bismuth Subsalicylate.
139 FDA label for approved ondansetron from the official website of the U.S. Food and Drug Administration.
140 FDA label for approved metoclopramide from the official website of the U.S. Food and Drug Administration.
141 FDA label for approved rabeprazole from the official website of the U.S. Food and Drug Administration.
142 FDA label for approved dimenhydrinate from the official website of the U.S. Food and Drug Administration.
143 FDA label for approved aprepitant from the official website of the U.S. Food and Drug Administration.
144 FDA label for approved sodium fluoride from the official website of the U.S. Food and Drug Administration.
145 FDA label for approved dexlansoprazole from the official website of the U.S. Food and Drug Administration.
146 FDA label for approved eluxadoline from the official website of the U.S. Food and Drug Administration.
147 FDA label for approved naldemedine from the official website of the U.S. Food and Drug Administration.
148 FDA label for approved naproxen from the official website of the U.S. Food and Drug Administration.
149 FDA label for approved indomethacin from the official website of the U.S. Food and Drug Administration.
150 FDA label for approved celecoxib from the official website of the U.S. Food and Drug Administration.
151 FDA label for approved alendronic acid from the official website of the U.S. Food and Drug Administration.
152 FDA label for approved risedronic acid from the official website of the U.S. Food and Drug Administration.
153 FDA label for approved raloxifene from the official website of the U.S. Food and Drug Administration.
154 FDA label for approved ibuprofen from the official website of the U.S. Food and Drug Administration.
155 FDA label for approved oxybutynin from the official website of the U.S. Food and Drug Administration.
156 FDA label for approved sevelamer from the official website of the U.S. Food and Drug Administration.
157 FDA label for approved alfuzosin from the official website of the U.S. Food and Drug Administration.
158 FDA label for approved ospemifene from the official website of the U.S. Food and Drug Administration.
159 FDA label for approved avanafil from the official website of the U.S. Food and Drug Administration.
160 FDA label for approved vardenafil from the official website of the U.S. Food and Drug Administration.
161 FDA label for approved calcitriol from the official website of the U.S. Food and Drug Administration.
162 Pharmacological property optimization for allosteric ligands: A medicinal chemistry perspective. Bioorg Med Chem Lett. 2017 Jun 1; 27(11):2239-2258.

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