Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D00851)
Name
Atropine
Synonyms    Click to Show/Hide the Synonyms of This API
ATROPINE; dl-Hyoscyamine; Tropine tropate; Atropin; Atropen; dl-Tropyltropate; Atropinol; Eyesules; Isopto-atropine; Troyl tropate; 51-55-8; Atropina; Atropin [German]; Atropina [Italian]; Atropin-flexiolen; hyoscyamine; (+,-)-Tropyl tropate; DL-Tropyl tropate; (+-)-hyoscyamine; Tropine, tropate (ester); (+-)-atropine; Tropic acid, ester with tropine; (+/-)-Atropine; CCRIS 3080; Atropine (USP); (+/-)-Hyoscyamine; Tropic acid, 3-alpha-tropanyl ester; HSDB 2199; DL-Tropanyl 2-hydroxy-1-phenylpropionate; 2-Phenylhydracrylic acid 3-alpha-tropanyl ester; (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl tropate; L-Hyoscyamine; AI3-60219; beta-Phenyl-gamma-oxypropionsaure-tropyl-ester [German]; (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl 3-hydroxy-2-phenylpropanoate; 1alphaH,5alphaH-Tropan-3alpha-ol (+-)-tropate (ester); beta-Phenyl-gamma-oxypropionsaeure-tropyl-ester [German]; tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate; 8-Methyl-8-azabicyclo[3.2.1]oct-3-yl tropate; MLS000069795; CHEBI:16684; 8-Methyl-8-azabicyclo[3.2.1]oct-3-yl 3-hydroxy-2-phenylpropanoate; [(1R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] 3-hydroxy-2-phenylpropanoate; [(1S,5R)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl] 3-hydroxy-2-phenyl-propanoate; endo-(+/-)-alpha-(Hydroxymethyl)benzeneacetic acid 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester; Benzeneacetic acid, alpha-(hydroxymethyl)-8-methyl-8-azabicyclo(3,2,1)oct-3-yl ester, endo-(+-)-; NCGC00017333-03; SMR000058248; DSSTox_CID_113; 1-alpha-H,5-alpha-H-Tropan-3-alpha-ol (+-)-tropate (ester) (8CI); alpha-(Hydroxymethyl)benzeneacetic acid 8-methyl-8-azabicyclo(3.2.1)oct-3-yl ester; AB00694549-11; DSSTox_RID_75375; DSSTox_GSID_20113; Benzeneacetic acid, alpha-(hydroxymethyl)-, 8-methyl-8-azabicyclo(3.2.1)oct-3-yl ester, endo-(+-)-; 101-31-5; [(1S,5R)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] 3-hydroxy-2-phenylpropanoate; CAS-51-55-8; Atropen (TN); Protamine & Atropine; Atropine [USP:BAN]; EINECS 200-104-8; Tropine (+/-)-tropate; ropine tropate; MFCD00022622; Atropine solution; (1S,5R)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl 3-hydroxy-2-phenylpropanoate; (1R,3r,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl 3-hydroxy-2-phenylpropanoate; NCGC00159345-02; 3-tropoyloxytropane; Opera_ID_1088; beta-Phenyl-gamma-oxypropionsaure-tropyl-ester; bmse000649; beta-Phenyl-gamma-oxypropionsaeure-tropyl-ester; SCHEMBL2812; Atropine, analytical standard; GTPL320; Benzeneacetic acid, alpha-(hydroxymethyl)-, (3-endo)-8-methyl-8-azabicyclo(3.2.1)oct-3-yl ester; MLS001148094; MLS002695888; CHEMBL254656; CHEMBL475124; CHEMBL517712; cid_174174; MEGxp0_001878; DTXSID4020113; ACon1_000046; CHEBI:78734; Atropine, >=95.0% (NT); BDBM200229; HMS2089A16; HMS2231G17; HMS3259M13; BCP15060; HY-B1205; Atropine, >=99% (TLC), powder; Tox21_110816; Tox21_111590; Tox21_200487; BDBM50403547; SBB005985; AKOS015955538; CS-4834; DB00572; NC00493; NCGC00017333-02; NCGC00017333-04; NCGC00017333-05; NCGC00017333-06; NCGC00142514-01; NCGC00142514-03; NCGC00258041-01; NCGC00385525-01; AS-56020; Benzeneacetic acid, alpha-(hydroxymethyl)-8-methyl-8-azabicyclo(3.2.1)oct-3-yl ester, endo-(+-)-; ST057178; Atropine, meets USP testing specifications; C1504; FT-0627165; C01479; D00113; Q26272; AB00694549-12; AB00694549_14; rac-tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate; BRD-A27290375-001-01-8; BRD-A27290375-330-01-1; Atropine, European Pharmacopoeia (EP) Reference Standard; [(1R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] 3-hydroxy-2-phenyl-propanoate; [(1S,5R)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] 3-hydroxy-2-phenyl-propanoate; alpha-Hydroxymethylphenylacetic acid (1R,5S)-8-methyl-8-azabicyclo[3.2.1]octane-3-yl ester; Atropine for peak identification, European Pharmacopoeia (EP) Reference Standard; rac-(3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl 3-hydroxy-2-phenylpropanoate; (1beta,3alpha,5beta)-3-[(3-Hydroxy-1-oxo-2-phenylpropyl)oxy]-8-methyl-8-azabicyclo[3.2.1]octane; Benzeneacetic acid, alpha-(hydroxymethyl)- (3-endo)-8-methyl-8-azabicyclo(3.2.1)oct-3-yl ester; Benzeneacetic acid, alpha-(hydroxymethyl)-, 8-methyl-8-azabicyclo(3.2.1)oct-3-yl ester, endo-(+/-)-; Benzeneacetic acid, alpha-(hydroxymethyl)-8-methyl-8-azabicyclo [3.2.1]oct-3-yl ester, endo-(+/-)-
Clinical Status
Approved
PubChem CID
174174
Formula
C17H23NO3
Canonical SMILES
CN1[C@@H]2CC[C@H]1CC(C2)OC(=O)C(CO)C3=CC=CC=C3
InChI
1S/C17H23NO3/c1-18-13-7-8-14(18)10-15(9-13)21-17(20)16(11-19)12-5-3-2-4-6-12/h2-6,13-16,19H,7-11H2,1H3/t13-,14+,15?,16?
InChIKey
RKUNBYITZUJHSG-PJPHBNEVSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=174174"></iframe>
3D MOL 2D MOL
Physicochemical Properties Molecular Weight 289.4 Topological Polar Surface Area 49.8
XlogP 1.8 Complexity 353
Heavy Atom Count 21 Rotatable Bond Count 5
Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 4
Full List of Drug Formulations (DFMs) Containing This API
          Atropine 0.25mg/0.3ml solution Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Citric Acid Monohydrate; Water; Sodium Citrate, Unspecified Form; Nitrogen; Sodium Chloride
                   Dosage Form Solution
                   Company Meridian Medical Technologies
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sodium citrate anhydrous DIG Info Carbonic anhydrase IV (Ki = 99 nM) [1]
          Atropine 0.5mg/0.7ml solution Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Citric Acid Monohydrate; Water; Sodium Citrate, Unspecified Form; Nitrogen; Sodium Chloride
                   Dosage Form Solution
                   Company Meridian Medical Technologies
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sodium citrate anhydrous DIG Info Carbonic anhydrase IV (Ki = 99 nM) [1]
          Atropine 1mg/0.7ml solution Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Citric Acid Monohydrate; Water; Sodium Citrate, Unspecified Form; Nitrogen; Sodium Chloride
                   Dosage Form Solution
                   Company Meridian Medical Technologies
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sodium citrate anhydrous DIG Info Carbonic anhydrase IV (Ki = 99 nM) [1]
          Atropine 2mg/0.7ml solution Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Citric Acid Monohydrate; Water; Sodium Citrate, Unspecified Form; Nitrogen; Sodium Chloride
                   Dosage Form Solution
                   Company Meridian Medical Technologies
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sodium citrate anhydrous DIG Info Carbonic anhydrase IV (Ki = 99 nM) [1]
          Atropine 1mg/10ml solution Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Sodium Chloride; Sodium Hydroxide; Sulfuric Acid; Water
                   Dosage Form Solution
                   Company Hospira
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sulfuric acid DIG Info Carbonic anhydrase V (Ki = 680 nM) [2]
          Atropine 1% ointment Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lanolin Oil; Mineral Oil; Water; Petrolatum
                   Dosage Form Ointment
                   Company Avpak
References
1 Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with carboxylates. Bioorg Med Chem Lett. 2005 Feb 1; 15(3):573-8.
2 Carbonic anhydrase inhibitors. Inhibition of the newly isolated murine isozyme XIII with anions. Bioorg Med Chem Lett. 2004 Nov 1; 14(21):5435-9.

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