Details of the Drug Inactive Ingredient (DIG)

General Information of DIG (ID: E0M5SQ)
DIG Name
Sodium citrate anhydrous
Synonyms    Click to Show/Hide the Synonyms of This DIG
Sodium citrate; TRISODIUM CITRATE; 68-04-2; Natrocitral; Sodium citrate anhydrous; sodium citrate, anhydrous; Citric acid, trisodium salt; Trisodium citrate, anhydrous; 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, trisodium salt; Sodium 2-hydroxypropane-1,2,3-tricarboxylate; Trisodium citrate anhydrous; FEMA No. 3026; Citric acid trisodium salt; UNII-RS7A450LGA; Sodium citrate,anhydrous; MFCD00012462; RS7A450LGA; Citrosodine; CHEBI:53258; Citric acid trisodium salt, anhydrous; CITRIC ACID, SODIUM SALT; Citrosodina; Citnatin; Citreme; Citrosodna; Sodium citrate hydrate; trisodium;2-hydroxypropane-1,2,3-tricarboxylate; 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, sodium salt (1:3); CCRIS 3293; Sodium citrate (Na3C6H5O7); HSDB 5201; anhydrous sodium citrate; 994-36-5; Citric acid, trisodium salt, 98%, pure, anhydrous; EINECS 200-675-3; trisodium-citrate; tri-sodium citrate; Trisodium 2-hydroxy-1,2,3-propanetricarboxylate; sodium citrate salt; sodium (iii) citrate; Sodium citrate (USP); Anhydrous trisodium citrate; EC 200-675-3; C6H5Na3O7; Anticoagulant Sodium Citrate; trisodium 2-hydroxypropane-1,2,3-tricarboxylate; CHEMBL1355; INS NO.331(III); INS-331(III); DTXSID2026363; 2-Hydroxy-1,2,3-propanetricarboxylic acid, trisodium salt; Citric acid sodium salt anhydrous; Citric acid trisodium salt, 99%; E-331(III); CS-B1704; AKOS015915009; FEMA NO. 3026, ANHYDROUS-; Citrate Solution, pH ~3.0, 30 mM; DB09154; AC-15008; E331; K121; Sodium citrate dihydrate USP Fine Granular; B7298; FT-0623960; 1835-EP2269978A2; 1835-EP2269985A2; 1835-EP2269991A2; 1835-EP2270017A1; 1835-EP2270505A1; 1835-EP2272817A1; 1835-EP2272822A1; 1835-EP2272843A1; 1835-EP2275413A1; 1835-EP2277565A2; 1835-EP2277566A2; 1835-EP2277567A1; 1835-EP2277568A2; 1835-EP2277569A2; 1835-EP2277570A2; 1835-EP2277867A2; 1835-EP2280003A2; 1835-EP2280010A2; 1835-EP2281559A1; 1835-EP2281817A1; 1835-EP2281818A1; 1835-EP2281823A2; 1835-EP2284150A2; 1835-EP2284151A2; 1835-EP2284152A2; 1835-EP2284153A2; 1835-EP2284155A2; 1835-EP2284156A2; 1835-EP2284160A1; 1835-EP2284164A2; 1835-EP2287140A2; 1835-EP2287148A2; 1835-EP2287150A2; 1835-EP2287155A1; 1835-EP2287156A1; 1835-EP2287160A1; 1835-EP2287163A1; 1835-EP2289871A1; 1835-EP2289893A1; 1835-EP2292227A2; 1835-EP2292280A1; 1835-EP2292590A2; 1835-EP2292611A1; 1835-EP2292612A2; 1835-EP2295402A2; 1835-EP2295406A1; 1835-EP2295414A1; 1835-EP2295416A2; 1835-EP2295419A2; 1835-EP2295426A1; 1835-EP2295427A1; 1835-EP2295437A1; 1835-EP2298731A1; 1835-EP2298732A1; 1835-EP2298734A2; 1835-EP2298735A1; 1835-EP2298748A2; 1835-EP2298772A1; 1835-EP2298775A1; 1835-EP2301534A1; 1835-EP2301912A2; 1835-EP2301913A1; 1835-EP2301914A1; 1835-EP2301916A2; 1835-EP2301941A1; 1835-EP2305243A1; 1835-EP2305637A2; 1835-EP2305657A2; 1835-EP2305678A1; 1835-EP2308510A1; 1835-EP2308562A2; 1835-EP2308832A1; 1835-EP2308839A1; 1835-EP2308861A1; 1835-EP2308863A1; 1835-EP2308872A1; 1835-EP2308873A1; 1835-EP2308875A1; 1835-EP2311451A1; 1835-EP2311796A1; 1835-EP2311797A1; 1835-EP2311798A1; 1835-EP2311799A1; 1835-EP2311807A1; 1835-EP2311821A1; 1835-EP2311823A1; 1835-EP2311831A1; 1835-EP2311837A1; 1835-EP2311842A2; 1835-EP2314575A1; 1835-EP2314584A1; 1835-EP2314586A1; 1835-EP2314593A1; 1835-EP2316450A1; 1835-EP2316459A1; 1835-EP2316470A2; 1835-EP2316829A1; 1835-EP2316831A1; 1835-EP2316834A1; 1835-EP2316836A1; 1835-EP2316937A1; 1835-EP2371811A2; 1835-EP2374454A1; 1835-EP2380568A1; D05855; N-1560; 88676-EP2272841A1; 88676-EP2280001A1; 88676-EP2301936A1; 88676-EP2305825A1; Sodium citrate, 0.5M buffer solution, pH 5.0; Sodium citrate, 0.5M buffer solution, pH 5.5; Sodium citrate, 0.5M buffer solution, pH 6.0; Sodium citrate, 0.5M buffer solution, pH 6.5; Q409728; J-520101; Citric acid trisodium salt, anhydrous, >=98% (GC); Citrate Solution, pH 3.6+/-0.1 (25 C), 27 mM; Citric acid trisodium salt, Vetec(TM) reagent grade, 98%; UNII-1Q73Q2JULR component HRXKRNGNAMMEHJ-UHFFFAOYSA-K; 2-Hydroxy-1,2,3-propanenetricarboxylic acid trisodium salt dihydrate; Citrate Concentrated Solution, BioUltra, for molecular biology, 1 M in H2O; Buffer solution pH 5.0 (20 C), citric acid ~0.096 M, sodium hydroxide ~0.20 M; Citrate Concentrated Solution, BioReagent, suitable for coagulation assays, 4 % (w/v)
DIG Function
Alkalizing agent; Buffering agent; Complexing agent; Emulsifying agent
PubChem CID
6224
Formula
C6H5Na3O7
Canonical SMILES
C(C(=O)[O-])C(CC(=O)[O-])(C(=O)[O-])O.[Na+].[Na+].[Na+]
InChI
1S/C6H8O7.3Na/c7-3(8)1-6(13,5(11)12)2-4(9)10;;;/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);;;/q;3*+1/p-3
InChIKey
HRXKRNGNAMMEHJ-UHFFFAOYSA-K
   Click to Show/Hide the Molecular Data (Structure/Property) of This DIG
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=6224"></iframe>
3D MOL is not available 2D MOL
Physicochemical Properties Molecular Weight 258.07 Topological Polar Surface Area 141
XlogP N.A. Complexity 211
Heavy Atom Count 16 Rotatable Bond Count 2
Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 7
Full List of Active Pharmaceutical Ingredients (APIs) Co-administrated with This DIG
       ICD Disease Classification 01 Infectious/parasitic disease Click to Show/Hide
Penicillin V
 API Info
Pulmonary tuberculosis [ICD-11: 1B10]
 [1]
       ICD Disease Classification 02 Benign/in-situ/malignant neoplasm Click to Show/Hide
Etoposide
 API Info
Testicular carcinoma [ICD-11: 2C80]
 [2]
       ICD Disease Classification 05 Endocrine/nutritional/metabolic disease Click to Show/Hide
Rosuvastatin
 API Info
Hypertriglyceridaemia [ICD-11: 5C80]
 [3]
       ICD Disease Classification 06 Mental/behavioural/neurodevelopmental disorder Click to Show/Hide
Quetiapine
 API Info
Schizophrenia [ICD-11: 6A20]
 [4]
Buprenorphine
 API Info
Opiate dependence [ICD-11: 6C43]
 [5]
       ICD Disease Classification 08 Nervous system disease Click to Show/Hide
Acetaminophen
 API Info
Anaesthesia [ICD-11: 8E22]
 [6]
Pramipexole
 API Info
Parkinsonism [ICD-11: 8A00]
 [7]
       ICD Disease Classification 09 Visual system disease Click to Show/Hide
Dextromethorphan
 API Info
Allergic conjunctivitis [ICD-11: 9A60]
 [8]
       ICD Disease Classification 10 Ear/mastoid process disease Click to Show/Hide
Amoxicillin
 API Info
Acute otitis media [ICD-11: AB00]
 [9]
       ICD Disease Classification 11 Circulatory system disease Click to Show/Hide
Carvedilol
 API Info
Congestive heart failure [ICD-11: BD10]
 [10]
       ICD Disease Classification 15 Musculoskeletal/connective-tissue disease Click to Show/Hide
Meloxicam
 API Info
Rheumatoid arthritis [ICD-11: FA20]
 [11]
Flurbiprofen
 API Info
Rheumatoid arthritis [ICD-11: FA20]
 [12]
       ICD Disease Classification 16 Genitourinary system disease Click to Show/Hide
Ibuprofen
 API Info
Dysmenorrhea [ICD-11: GA34]
 [13]
Oxybutynin
 API Info
Overactive bladder [ICD-11: GC50]
 [14]
Erythromycin
 API Info
Pelvic inflammatory disease [ICD-11: GA05]
 [15]
Full List of Biological Targets of DIG (DBTs) Regulated by This DIG
      Lyase/isomerase/ligase (L/I/G)
            DBT Name: Carbonic anhydrase IV (CA4) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Biological Activity Ki = 99 nM (tested by experiment) [16]
                    Tested Species Homo sapiens (Human)
                    UniProt ID CAH4_HUMAN
References
1 FDA label for approved penicillin V from the official website of the U.S. Food and Drug Administration.
2 FDA label for approved etoposide from the official website of the U.S. Food and Drug Administration.
3 FDA label for approved rosuvastatin from the official website of the U.S. Food and Drug Administration.
4 FDA label for approved quetiapine from the official website of the U.S. Food and Drug Administration.
5 FDA label for approved buprenorphine from the official website of the U.S. Food and Drug Administration.
6 FDA label for approved acetaminophen from the official website of the U.S. Food and Drug Administration.
7 FDA label for approved pramipexole from the official website of the U.S. Food and Drug Administration.
8 FDA label for approved dextromethorphan from the official website of the U.S. Food and Drug Administration.
9 FDA label for approved amoxicillin from the official website of the U.S. Food and Drug Administration.
10 FDA label for approved carvedilol from the official website of the U.S. Food and Drug Administration.
11 FDA label for approved meloxicam from the official website of the U.S. Food and Drug Administration.
12 FDA label for approved flurbiprofen from the official website of the U.S. Food and Drug Administration.
13 FDA label for approved ibuprofen from the official website of the U.S. Food and Drug Administration.
14 FDA label for approved oxybutynin from the official website of the U.S. Food and Drug Administration.
15 FDA label for approved erythromycin from the official website of the U.S. Food and Drug Administration.
16 Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with carboxylates. Bioorg Med Chem Lett. 2005 Feb 1; 15(3):573-8.

If you find any error in data or bug in web service, please kindly report it to Dr. Zhang and Dr. Mou.