Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D00943)
Name
Cholic acid
Synonyms    Click to Show/Hide the Synonyms of This API
cholic acid; 81-25-4; Colalin; Cholalic acid; cholate; Cholalin; Cholsaeure; Cholbam; NSC-6135; 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholanic acid; Cholic acid, 5beta-; 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholan-24-oic acid; (R)-4-((3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-Trihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid; SODIUM CHOLATE; UNII-G1JO7801AE; MFCD00003672; HSDB 982; Cholic acid [USAN]; 3,7,12-Trihydroxycholanic acid; Cholan-24-oic acid, 3,7,12-trihydroxy-, (3a,5b,7a,12a)-; CHEMBL205596; G1JO7801AE; CHEBI:16359; NSC6135; 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholanate; (4R)-4-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-trihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid; CHD; Cholic acid (USAN); 3-alpha,7-alpha,12-alpha-Trihydroxy-5-beta-cholan-24-oic acid; 5beta-Cholan-24-oic acid, 3alpha,7alpha,12alpha-trihydroxy-; C24H40O5; 3,7,12-Trihydroxycholan-24-oic acid, (3alpha,5beta,7alpha,12alpha)-; 17-beta-(1-Methyl-3-carboxypropyl)etiocholane-3alpha,7alpha,12alpha-triol; 3,7,12-Trihydroxy-cholan-24-oic acid (3-alpha,5-beta,7-alpha,12-alpha); Cholan-24-oic acid, 3,7,12-trihydroxy-, (3alpha,5beta,7alpha,12alpha)-; kolbam; cholic-acid; (3alpha,5beta,7alpha,12alpha)-3,7,12-trihydroxycholan-24-oic acid; (3alpha,5beta,7alpha,8x,12alpha)-3,7,12-trihydroxycholan-24-oic acid; 4-((1S,2S,7S,11S,16S,5R,9R,10R,14R,15R)-5,9,16-trihydroxy-2,15-dimethyltetracy clo[8.7.0.0<2,7>.0<11,15>]heptadec-14-yl)pentanoic acid; SMR000112165; Colalin (VAN); Cholsaeure [German]; 5beta-Cholanic acid-3alpha,7alpha,12alpha-triol; Cholalate; OrphacolReg; CCRIS 1626; 5a-Allocholate; (3alpha,5beta,7alpha,8xi,12alpha)-3,7,12-trihydroxycholan-24-oic acid; 5a-cholic acid; 5a-Cholate; 5b-Cholate; 5b-Cholic acid; CholsA currencyure; 5a-Allocholic acid; Cholbam (TN); EINECS 201-337-8; Cholic acid (8CI); 5.beta.-Cholic acid; BRN 2822009; PubChem16772; Spectrum5_002005; 3alpha,7alpha,12alpha-Trihydroxycholanic acid; bmse000650; EC 201-337-8; 3-alpha,7-alpha,12-alpha-Trihydroxycholansaeure; BIDD:PXR0196; SCHEMBL27461; GTPL609; 3.alpha.,7.alpha.,12.alpha.-Trihydroxy-5.beta.-cholanic acid; 4-10-00-02072 (Beilstein Handbook Reference); MLS001066422; MLS002207051; 3a,7a,12a-Trihydroxycholanate; 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholanoic acid; DTXSID6040660; BDBM21680; 3-alpha,7-alpha,12-alpha-Trihydroxycholansaeure [German]; HMS2268L18; 3a,7a,12a-Trihydroxy-b-cholanate; 3a,7a,12a-Trihydroxycholanic acid; HY-N0324; ZINC6858022; 3a,7a,12a-Trihydroxy-5b-cholanate; 5b-Cholanic acid-3a,7a,12a-triol; BBL029799; LMST04010001; s3742; STK801993; 3a,7a,12a-Trihydroxy-5b-cholanoate; 3a,7a,12a-Trihydroxy-beta-cholanate; AKOS005622502; 3a,7a,12a-Trihydroxy-b-cholanic acid; CCG-268746; CS-6608; DB02659; MCULE-7032345049; 3a,7a,12a-Trihydroxy-5A-cholanic acid; 3a,7a,12a-Trihydroxy-5b-cholanic acid; NCGC00142384-03; 3a,7a,12a-Trihydroxy-5b-cholanoic acid; 3a,7a,12a-Trihydroxy-beta-cholanic acid; AS-69849; BP-30084; K446; ST024722; 3a,7a,12a-trihydroxy-5a-cholan-24-oate; 3a,7a,12a-Trihydroxy-5b-cholan-24-oate; Cholic acid, Vetec(TM) reagent grade, 98%; N1680; 3a,7a,12a-trihydroxy-(5a)-cholan-24-oate; Cholic acid, from ox or sheep bile, >=98%; 3a,7a,12a-trihydroxy-5a-cholan-24-oic acid; 3a,7a,12a-Trihydroxy-5b-cholan-24-oic acid; 7060-EP2289879A1; 7060-EP2289883A1; 7060-EP2315303A1; C00695; D10699; 3??,7??,12??-Trihydroxy-5??-cholanic acid; 3a,7a,12a-trihydroxy-(5a)-cholan-24-oic acid; 198976-EP2280282A1; Q287415; SR-01000765698; 3alpha,7alpha,12alpha-Trihydroxy-beta-cholanic acid; SR-01000765698-4; 3.alpha.,12.alpha.-Trihydroxy-5.beta.-cholanic acid; 3-.alpha.,7-.alpha.,12-.alpha.-Trihydroxycholansaeure; 3alpha, 7alpha, 12alpha-trihydroxy-5beta-cholanic acid; 3alpha, 7alpha, 12alpha-trihydroxy-5beta-cholanoic acid; 3-&alpha,7-&alpha,12-&alpha-trihydroxy-5-&beta-cholanate; Cholic acid, British Pharmacopoeia (BP) Reference Standard; Cholic acid, European Pharmacopoeia (EP) Reference Standard; UNII-JIY1ILR284 component BHQCQFFYRZLCQQ-OELDTZBJSA-N; 17b-[1-Methyl-3-carboxypropyl]etiocholane-3a,7a,12a-triol; 5.beta.-Cholan-24-oic acid,7.alpha.,12.alpha.-trihydroxy-; 5beta-Cholanic acid, 3alpha,7alpha,12alpha-trihydroxy- (7CI); 3,7,12-trihydroxy-(3alpha,5alpha,7alpha,12alpha)-cholan-24-oate; 5beta-Cholanic acid-3alpha,7alpha,12alpha-triol 5beta-Cholic acid; Cholic acid, 500 mug/mL in methanol, certified reference material; Cholic acid, United States Pharmacopeia (USP) Reference Standard; 17beta-[1-Methyl-3-carboxypropyl]etiocholane-3alpha,7alpha,12alpha-triol; 3,7,12-trihydroxy-(3alpha,5alpha,7alpha,12alpha)-cholan-24-oic acid; 3-.alpha.,7-.alpha.,12-.alpha.-Trihydroxy-5-.beta.-cholan-24-oic acid; 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholan-24-oic Acid (Cholic Acid); 5.beta.-Cholan-24-oic acid, 3.alpha.,7.alpha.,12.alpha.-trihydroxy-; (3.alpha.,5.beta.,7.alpha.,12.alpha.)-3,7,12-Trihydroxycholan-24-oic acid sodium salt; (3alpha,5beta,7alpha,8alpha,12alpha,14beta,17alpha)-3,7,12-trihydroxycholan-24-oic acid; 17.beta.-(1-Methyl-3-carboxypropyl)etiocholane-3.alpha.,7.alpha.,12.alpha.-triol; 3,7,12-Trihydroxy-cholan-24-oic acid, (3.alpha.,5.beta.,7.alpha.,12.alpha.)-; Cholan-24-oic acid, 3,7,12-trihydroxy-, (3-alpha,5-beta,7-alpha,12-alpha)-; Cholan-24-oic acid, 3,7,12-trihydroxy-, (3-alpha,5-beta,7-alpha,12-alpha)- (9CI); Cholan-24-oic acid, 3,7,12-trihydroxy-, (3alpha,5beta,7alpha,12alpha)- (9CI); Cholan-24-oic acid,7,12-trihydroxy-, (3.alpha.,5.beta.,7.alpha.,12.alpha.)-; (4R)-4-((3R,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-trihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid; (4R)-4-[(1R,3aS,3bR,4R,5aS,7R,9aS,9bS,11S,11aR)-4,7,11-trihydroxy-9a,11a-dimethyl-hexadecahydro-1H-cyclopenta[a]phenanthren-1-yl]pentanoic acid; (4R)-4-[(1S,2S,5R,7S,9R,10R,11S,14R,15R,16S)-5,9,16-trihydroxy-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadecan-14-yl]pentanoic acid; (R)-4-((3R,5S,7R,8R,10S,12S,13R,14S,17R)-3,7,12-trihydroxy-10,13-dimethyl-hexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid; 10321-98-9
Clinical Status
Approved
PubChem CID
221493
Formula
C24H40O5
Canonical SMILES
C[C@H](CCC(=O)O)[C@H]1CC[C@@H]2[C@@]1([C@H](C[C@H]3[C@H]2[C@@H](C[C@H]4[C@@]3(CC[C@H](C4)O)C)O)O)C
InChI
1S/C24H40O5/c1-13(4-7-21(28)29)16-5-6-17-22-18(12-20(27)24(16,17)3)23(2)9-8-15(25)10-14(23)11-19(22)26/h13-20,22,25-27H,4-12H2,1-3H3,(H,28,29)/t13-,14+,15-,16-,17+,18+,19-,20+,22+,23+,24-/m1/s1
InChIKey
BHQCQFFYRZLCQQ-OELDTZBJSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=221493"></iframe>
3D MOL 2D MOL
Physicochemical Properties Molecular Weight 408.6 Topological Polar Surface Area 98
XlogP 3.6 Complexity 637
Heavy Atom Count 29 Rotatable Bond Count 4
Hydrogen Bond Donor Count 4 Hydrogen Bond Acceptor Count 5
Full List of Drug Formulations (DFMs) Containing This API
          Cholic Acid 50mg capsule Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Silicified Microcrystalline Cellulose; Magnesium Stearate; Gelatin; Red Iron Oxide; Titanium Dioxide
                   Dosage Form Capsule
                   Company Travere
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Gelatin DIG Info Mephenytoin 4-hydroxylase (EC50 = 20.5 uM) [1]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
          Cholic Acid 250mg capsule Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Silicified Microcrystalline Cellulose; Magnesium Stearate; Gelatin; Titanium Dioxide
                   Dosage Form Capsule
                   Company Travere
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Gelatin DIG Info Mephenytoin 4-hydroxylase (EC50 = 20.5 uM) [1]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
References
1 Mediation of in vitro cytochrome p450 activity by common pharmaceutical excipients. Mol Pharm. 2013 Jul 1;10(7):2739-48.
2 Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12.

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