Details of the Drug Inactive Ingredient (DIG)

General Information of DIG (ID: E00FTX)
DIG Name	Gelatin
DIG Function	Other agent

Full List of Active Pharmaceutical Ingredients (APIs) Co-administrated with This DIG
ICD Disease Classification 01		Infectious/parasitic disease	Click to Show/Hide
Saquinavir	API Info	Human immunodeficiency virus infection [ICD-11: 1C60]		[1]
Indinavir	API Info	Human immunodeficiency virus infection [ICD-11: 1C60]		[2]
Simeprevir	API Info	Viral hepatitis [ICD-11: 1E51]		[3]
ICD Disease Classification 02		Benign/in-situ/malignant neoplasm	Click to Show/Hide
Topotecan	API Info	Ovarian cancer [ICD-11: 2C73]		[4]
Panobinostat	API Info	Multiple myeloma [ICD-11: 2A83]		[5]
Niraparib	API Info	Ovarian cancer [ICD-11: 2C73]		[6]
Procarbazine	API Info	Hodgkin lymphoma [ICD-11: 2B30]		[7]
Nilotinib	API Info	Chronic myelogenous leukaemia [ICD-11: 2A20]		[8]
ICD Disease Classification 05		Endocrine/nutritional/metabolic disease	Click to Show/Hide
Liothyronine	API Info	Hypothyroidism [ICD-11: 5A00]		[9]
Cysteamine	API Info	Nephropathic cystinosis [ICD-11: 5C60]		[10]
Trientine	API Info	Hyperphosphatemia [ICD-11: 5C64]		[11]
Eliglustat	API Info	Gaucher disease [ICD-11: 5C56]		[12]
Ixazomib	API Info	Amyloidosis [ICD-11: 5D00]		[13]
ICD Disease Classification 06		Mental/behavioural/neurodevelopmental disorder	Click to Show/Hide
Fluoxetine	API Info	Major depressive disorder [ICD-11: 6A70]		[14]
Venlafaxine	API Info	Major depressive disorder [ICD-11: 6A70]		[15]
Ziprasidone	API Info	Schizophrenia [ICD-11: 6A20]		[16]
Lithium carbonate	API Info	Bipolar disorder [ICD-11: 6A60]		[17]
Nortriptyline	API Info	Major depressive disorder [ICD-11: 6A70]		[18]
Loxapine	API Info	Schizophrenia [ICD-11: 6A20]		[19]
Chlordiazepoxide	API Info	Anxiety disorder [ICD-11: 6B00]		[20]
Trimipramine	API Info	Major depressive disorder [ICD-11: 6A70]		[21]
Tranylcypromine	API Info	Major depressive disorder [ICD-11: 6A70]		[22]
Asenapine	API Info	Schizophrenia [ICD-11: 6A20]		[23]
Cariprazine	API Info	Bipolar disorder [ICD-11: 6A60]		[24]
Naltrexone	API Info	Alcohol dependence [ICD-11: 6C40]		[25]
ICD Disease Classification 08		Nervous system disease	Click to Show/Hide
Gabapentin	API Info	Focal seizure [ICD-11: 8A68]		[26]
Tizanidine	API Info	Tic disorder [ICD-11: 8A05]		[27]
Methylergonovine	API Info	Migraine [ICD-11: 8A80]		[28]
Pentosan polysulfate	API Info	Anaesthesia [ICD-11: 8E22]		[29]
ICD Disease Classification 09		Visual system disease	Click to Show/Hide
Acetazolamide	API Info	Glaucoma [ICD-11: 9C61]		[30]
ICD Disease Classification 11		Circulatory system disease	Click to Show/Hide
Amlodipine	API Info	Angina pectoris [ICD-11: BA40]		[31]
Acebutolol	API Info	Essential hypertension [ICD-11: BA00]		[32]
Disopyramide	API Info	Ventricular tachyarrhythmia [ICD-11: BC71]		[33]
Phenoxybenzamine	API Info	Essential hypertension [ICD-11: BA00]		[34]
Quinapril	API Info	Essential hypertension [ICD-11: BA00]		[35]
ICD Disease Classification 13		Digestive system disease	Click to Show/Hide
Omeprazole	API Info	Gastro-oesophageal reflux disease [ICD-11: DA22]		[36]
Esomeprazole	API Info	Duodenal ulcer [ICD-11: DA63]		[37]
Loperamide	API Info	Irritable bowel syndrome [ICD-11: DD91]		[38]
ICD Disease Classification 15		Musculoskeletal/connective-tissue disease	Click to Show/Hide
Celecoxib	API Info	Rheumatoid arthritis [ICD-11: FA20]		[39]
Cyclosporin A	API Info	Rheumatoid arthritis [ICD-11: FA20]		[40]
Rifampicin	API Info	Osteoporosis [ICD-11: FB83]		[41]
Fenoprofen	API Info	Rheumatoid arthritis [ICD-11: FA20]		[42]
Tolmetin	API Info	Rheumatoid arthritis [ICD-11: FA20]		[43]
ICD Disease Classification 16		Genitourinary system disease	Click to Show/Hide
Terazosin	API Info	Prostatic hyperplasia [ICD-11: GA90]		[44]
Tamsulosin	API Info	Prostatic hyperplasia [ICD-11: GA90]		[45]
Prazosin	API Info	Prostatic hyperplasia [ICD-11: GA90]		[46]

Full List of Biological Targets of DIG (DBTs) Regulated by This DIG
Oxidoreductase (ORase)
DBT Name: Cytochrome P450 2E1 (CYP2E1)		Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Biological Activity	IC50 = 141.2 uM (tested by experiment)		[47]
Tested Species	Homo sapiens (Human)
UniProt ID	CP2E1_HUMAN
DBT Name: Cytochrome P450 2C9 (CYP2C9)		Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Biological Activity	EC50 = 249.5 uM (tested by experiment)		[47]
Tested Species	Homo sapiens (Human)
UniProt ID	CP2C9_HUMAN
DBT Name: Mephenytoin 4-hydroxylase (CYP2C19)		Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Biological Activity	EC50 = 20.5 uM (tested by experiment)		[47]
Tested Species	Homo sapiens (Human)
UniProt ID	CP2CJ_HUMAN
DBT Name: Debrisoquine 4-hydroxylase (CYP2D6)		Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Biological Activity	EC50 = 379.9 uM (tested by experiment)		[47]
Tested Species	Homo sapiens (Human)
UniProt ID	CP2D6_HUMAN
Lyase/isomerase/ligase (L/I/G)
DBT Name: Cholesterol 25-hydroxylase (CYP1A2)		Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Biological Activity	IC50 = 40.9 uM (tested by experiment)		[47]
Tested Species	Homo sapiens (Human)
UniProt ID	CP1A2_HUMAN

References
1	FDA label for approved saquinavir from the official website of the U.S. Food and Drug Administration.
2	FDA label for approved indinavir from the official website of the U.S. Food and Drug Administration.
3	FDA label for approved simeprevir from the official website of the U.S. Food and Drug Administration.
4	FDA label for approved topotecan from the official website of the U.S. Food and Drug Administration.
5	FDA label for approved panobinostat from the official website of the U.S. Food and Drug Administration.
6	FDA label for approved niraparib from the official website of the U.S. Food and Drug Administration.
7	FDA label for approved procarbazine from the official website of the U.S. Food and Drug Administration.
8	FDA label for approved nilotinib from the official website of the U.S. Food and Drug Administration.
9	FDA label for approved liothyronine from the official website of the U.S. Food and Drug Administration.
10	FDA label for approved cysteamine from the official website of the U.S. Food and Drug Administration.
11	FDA label for approved trientine from the official website of the U.S. Food and Drug Administration.
12	FDA label for approved eliglustat from the official website of the U.S. Food and Drug Administration.
13	FDA label for approved ixazomib from the official website of the U.S. Food and Drug Administration.
14	FDA label for approved fluoxetine from the official website of the U.S. Food and Drug Administration.
15	FDA label for approved venlafaxine from the official website of the U.S. Food and Drug Administration.
16	FDA label for approved ziprasidone from the official website of the U.S. Food and Drug Administration.
17	FDA label for approved lithium carbonate from the official website of the U.S. Food and Drug Administration.
18	FDA label for approved nortriptyline from the official website of the U.S. Food and Drug Administration.
19	FDA label for approved loxapine from the official website of the U.S. Food and Drug Administration.
20	FDA label for approved chlordiazepoxide from the official website of the U.S. Food and Drug Administration.
21	FDA label for approved trimipramine from the official website of the U.S. Food and Drug Administration.
22	FDA label for approved tranylcypromine from the official website of the U.S. Food and Drug Administration.
23	FDA label for approved asenapine from the official website of the U.S. Food and Drug Administration.
24	FDA label for approved cariprazine from the official website of the U.S. Food and Drug Administration.
25	FDA label for approved naltrexone from the official website of the U.S. Food and Drug Administration.
26	FDA label for approved gabapentin from the official website of the U.S. Food and Drug Administration.
27	FDA label for approved tizanidine from the official website of the U.S. Food and Drug Administration.
28	FDA label for approved methylergonovine from the official website of the U.S. Food and Drug Administration.
29	FDA label for approved pentosan polysulfate from the official website of the U.S. Food and Drug Administration.
30	FDA label for approved acetazolamide from the official website of the U.S. Food and Drug Administration.
31	FDA label for approved amlodipine from the official website of the U.S. Food and Drug Administration.
32	FDA label for approved acebutolol from the official website of the U.S. Food and Drug Administration.
33	FDA label for approved disopyramide from the official website of the U.S. Food and Drug Administration.
34	FDA label for approved phenoxybenzamine from the official website of the U.S. Food and Drug Administration.
35	FDA label for approved quinapril from the official website of the U.S. Food and Drug Administration.
36	FDA label for approved omeprazole from the official website of the U.S. Food and Drug Administration.
37	FDA label for approved esomeprazole from the official website of the U.S. Food and Drug Administration.
38	FDA label for approved loperamide from the official website of the U.S. Food and Drug Administration.
39	FDA label for approved celecoxib from the official website of the U.S. Food and Drug Administration.
40	FDA label for approved cyclosporin A from the official website of the U.S. Food and Drug Administration.
41	FDA label for approved rifampicin from the official website of the U.S. Food and Drug Administration.
42	FDA label for approved fenoprofen from the official website of the U.S. Food and Drug Administration.
43	FDA label for approved tolmetin from the official website of the U.S. Food and Drug Administration.
44	FDA label for approved terazosin from the official website of the U.S. Food and Drug Administration.
45	FDA label for approved tamsulosin from the official website of the U.S. Food and Drug Administration.
46	FDA label for approved prazosin from the official website of the U.S. Food and Drug Administration.
47	Mediation of in vitro cytochrome p450 activity by common pharmaceutical excipients. Mol Pharm. 2013 Jul 1;10(7):2739-48.

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