Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D00950)
Name
Cisplatin
Synonyms    Click to Show/Hide the Synonyms of This API
cisplatin; 14913-33-8; trans-Dichlorodiamineplatinum(II); azane;dichloroplatinum; Platinum, diamminedichloro-, (SP-4-1)-; H6Cl2N2Pt; trans-Diamminedichloro platinum(II); MFCD00011623; trans-Platinum(II)diammine dichloride; CACP; trans-Dichlorodiamineplatinum(II);Transplatin; SR-05000001586; IA call; Cisplatin,(S); DDP-H; PLATINOL (TN); Cl.2H3N.Pt; SPECTRUM1502107; Cisplatin (JP17/USP/INN); cis-Dichlorodiamine platinum(II); HMS502M12; Trans-Platinum diammine dichloride; HMS1921J18; HMS2092D04; BCP01792; BCP18182; 7433AA; CCG-39901; AKOS005137969; NSC-119875; NCGC00094962-01; NCGC00094962-02; NCGC00094962-03; H878; AK00634598; FT-0777996; C06911; D00275; J90019; cis-Diammineplatinum(II) dichloride, crystalline; 913C338; Q412415; SR-01000076254; SR-01000076254-1; SR-05000001586-1; SR-05000001586-3; Cisplatin, European Pharmacopoeia (EP) Reference Standard; Cisplatin, United States Pharmacopeia (USP) Reference Standard; cis-Diamineplatinum(II) dichloride, >=99.9% trace metals basis; Cisplatin impurity A, European Pharmacopoeia (EP) Reference Standard; Transplatin, United States Pharmacopeia (USP) Reference Standard; Cisplatin, Pharmaceutical Secondary Standard; Certified Reference Material
Clinical Status
Approved
PubChem CID
5702198
Formula
Cl2H6N2Pt
Canonical SMILES
N.N.Cl[Pt]Cl
InChI
1S/2ClH.2H3N.Pt/h2*1H;2*1H3;/q;;;;+2/p-2
InChIKey
LXZZYRPGZAFOLE-UHFFFAOYSA-L
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
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3D MOL is unavailable 2D MOL
Physicochemical Properties Molecular Weight 300 Topological Polar Surface Area 2
XlogP N.A. Complexity 2.8
Heavy Atom Count 5 Rotatable Bond Count 0
Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 2
Full List of Drug Formulations (DFMs) Containing This API
          Cisplatin 10mg/vial injectable Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Sodium Chloride; Mannitol
                   Dosage Form Injectable
                   Company Hq Spclt Pharma
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [1]
References
1 Pharmacological property optimization for allosteric ligands: A medicinal chemistry perspective. Bioorg Med Chem Lett. 2017 Jun 1; 27(11):2239-2258.

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