Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D00954)
Name
Clobetasol propionate
Synonyms    Click to Show/Hide the Synonyms of This API
CLOBETASOL PROPIONATE; 25122-46-7; Clobetasol 17-propionate; Clobex; Dermovate; Temovate; Clobestasol propionate; clobetasol 17-propanoate; GR 2/925; CCI 4725; MLS000028708; [(8S,9R,10S,11S,13S,14S,16S,17R)-17-(2-chloroacetyl)-9-fluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] propanoate; 21-Chloro-9-fluoro-11beta,17-dihydroxy-16beta-methylpregna-1,4-diene-3,20-dione 17-propionate; Embeline; UNII-779619577M; Embeline E; SMR000058745; Clobesol; CHEBI:31414; Cormax; Olux; Temovate E; CCI-4725; MFCD00058499; Pregna-1,4-diene-3,20-dione, 21-chloro-9-fluoro-11-hydroxy-16-methyl-17-(1-oxopropoxy)-, (11beta,16beta)-; DSSTox_CID_25907; DSSTox_RID_81219; DSSTox_GSID_45907; Olux-E; 779619577M; C25H32ClFO5; Dermoxinale; Butavate; Dermoval; Yugofin; 21-chloro-9-fluoro-11beta-hydroxy-16beta-methyl-3,20-dioxopregna-1,4-dien-17-yl propanoate; Olux E; 21-Chloro-9alpha-fluoro-11beta,17alpha-dihydroxy-16beta-methyl-1,4-pregnadiene-3,20-dione 17-Propionate; clobetasol-propionate; CGP 9555; Clobetasol propionate gel; EINECS 246-634-3; CLOBETASOL PROPIONATE (EMOLLIENT); Clarelux; Impoyz; NCGC00095078-01; CAS-25122-46-7; Clobex (TN); Cormax (TN); Clobetasol propionate [USAN:USP:JAN]; Olux (TN); Clobetasol propionate E; Propionic acid clobetasol; Opera_ID_1470; SCHEMBL3997; 21-Chloro-9-fluoro-11-hydroxy-16-methyl-17-(1-oxopropoxy)pregna-1,4-diene-3,20-dione (11beta,16beta)-; cid_32798; MLS001076345; AMOT0927; GTPL7062; CHEMBL1159650; DTXSID6045907; BDBM39347; EBD6220; HMS2090A04; HMS2230H08; HMS3259A10; HMS3714M04; Clobetasol propionate (JP17/USP); BCP04125; ZINC3977767; Tox21_111414; AM9637; s2584; AKOS015951278; Tox21_111414_1; BCP9000539; CCG-220781; DB01013; NC00551; 21-Chloro-9-fluoro-11beta-hydroxy-16beta-methylpregna-1,4-diene-3,20-dione 17-propionate; NCGC00023373-03; NCGC00023373-04; AC-17990; AS-12555; Clobetasol propionate, analytical standard; CPD000058745; HY-13600; Pregna-1,4-diene-3,20-dione, 21-chloro-9-fluoro-11-beta,17-dihydroxy-16-beta-methyl-, 17-propionate; BCP0726000094; D01272; AB00383081-10; AB00383081_11; 122C467; Q421637; SR-01000000280; SR-01000000280-4; BRD-K10799896-001-10-6; BRD-K10799896-001-26-2; Clobetasol propionate, European Pharmacopoeia (EP) Reference Standard; Clobetasol propionate, United States Pharmacopeia (USP) Reference Standard; 21-Chloro-9-fluoro-11b,17-dihydroxy-16b-methylpregna-1,4-diene-3,20-dione 17-propionate; Clobetasol for peak identification, European Pharmacopoeia (EP) Reference Standard; Clobetasol Propionate, Pharmaceutical Secondary Standard; Certified Reference Material; (11b,16b)-21-Chloro-9-fluoro-11-hydroxy-16-methyl-17-(1-oxopropoxy)pregna-1,4-diene-3,20-dione; CGP9555 pound>> CCl 4725 pound>>CGP 9555 pound>> CCl4725 pound>>CGP-9555 pound>> CCl-4725
Clinical Status
Approved
PubChem CID
32798
Formula
C25H32ClFO5
Canonical SMILES
CCC(=O)O[C@@]1([C@H](C[C@@H]2[C@@]1(C[C@@H]([C@]3([C@H]2CCC4=CC(=O)C=C[C@@]43C)F)O)C)C)C(=O)CCl
InChI
1S/C25H32ClFO5/c1-5-21(31)32-25(20(30)13-26)14(2)10-18-17-7-6-15-11-16(28)8-9-22(15,3)24(17,27)19(29)12-23(18,25)4/h8-9,11,14,17-19,29H,5-7,10,12-13H2,1-4H3/t14-,17-,18-,19-,22-,23-,24-,25-/m0/s1
InChIKey
CBGUOGMQLZIXBE-XGQKBEPLSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=32798"></iframe>
3D MOL 2D MOL
Physicochemical Properties Molecular Weight 467 Topological Polar Surface Area 80.7
XlogP 3.8 Complexity 929
Heavy Atom Count 32 Rotatable Bond Count 5
Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 6
Full List of Drug Formulations (DFMs) Containing This API
          Clobetasol Propionate 0.05% aerosol Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Cetyl Alcohol; Citric Acid Anhydrous; Dehydrated Alcohol; Polysorbate 60; Potassium Citrate; Propylene Glycol; Purified Water; Stearyl Alcohol; Hydrocarbon; Propane; Butane
                   Dosage Form Aerosol
                   Company Taro Pharmaceuticals U.S.A.
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Kyselina citronova DIG Info Perilipin-1 (IC50 = 3708 nM) [1]
Cetyl alcohol DIG Info Breast cancer FM3A cells (EC50 = 1600 nM) [2]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [3]
References
1 PubChem BioAssay data set.
2 Synthesis and notable antimalarial activity of acyclic peroxides, L-(alkyldioxy)-L-(methyldioxy)cyclododecanes. J Med Chem. 2002 Mar 14; 45(6):1374-8.
3 Pharmaceutical excipients inhibit cytochrome P450 activity in cell free systems and after systemic administration. Eur J Pharm Biopharm. 2008 Sep;70(1):279-88.

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