Details of the Drug Inactive Ingredient (DIG)

General Information of DIG (ID: E0F6AN)
DIG Name
Kyselina citronova
Synonyms    Click to Show/Hide the Synonyms of This DIG
citric acid; 77-92-9; 2-hydroxypropane-1,2,3-tricarboxylic acid; Citric acid, anhydrous; Anhydrous citric acid; Citro; Citretten; Aciletten; Chemfill; Hydrocerol A; 1,2,3-Propanetricarboxylic acid, 2-hydroxy-; Kyselina citronova; 2-hydroxy-1,2,3-propanetricarboxylic acid; 2-Hydroxytricarballylic acid; Citric acid anhydrous; Caswell No. 221C; F 0001 (polycarboxylic acid); 3-Carboxy-3-hydroxypentane-1,5-dioic acid; 2-Hydroxypropanetricarboxylic acid; FEMA No. 2306; FEMA Number 2306; K-Lyte; Kyselina citronova [Czech]; K-Lyte DS; CCRIS 3292; HSDB 911; EPA Pesticide Chemical Code 021801; Uro-trainer; AI3-06286; UNII-XF417D3PSL; Suby G; MFCD00011669; NSC 30279; NSC 626579; BRN 0782061; CHEMBL1261; XF417D3PSL; Kyselina 2-hydroxy-1,2,3-propantrikarbonova [Czech]; Kyselina 2-hydroxy-1,2,3-propantrikarbonova; CHEBI:30769; .beta.-Hydroxytricarballylic acid; citr; NSC30279; NSC-30279; NSC626579; NSC-626579; Citric acid, 99%; NCGC00090954-03; E330; DSSTox_CID_332; E 330; beta-Hydroxytricarballylic acid; CITRATE ANION; DSSTox_RID_75520; DSSTox_GSID_20332; citric-acid; Citric acid, 99%, pure, anhydrous; 2-hydroxy-1,2,3-propanetricarboxylic; Citric acid [USAN:JAN]; CAS-77-92-9; 1,3-Propanetricarboxylic acid, 2-hydroxy-; Citric acid, 99.5%, for analysis, anhydrous; NSC-112226; EINECS 201-069-1; Citraclean; Citronensaeure; Anhydrous citrate; citric acid group; 2fwp; 4aci; 4nrm; H3cit; Citric acid, anhydrous [USP:JAN]; Citric Acid,(S); Citric acid,anhydrous; Citric acid (8CI); K-Lyte (Salt/Mix); PubChem20283; 1i2s; 1o4l; 1rq2; 1y4a; 2bo4; 2c4v; 2fw6; 4to8; Citraclean (Salt/Mix); ACMC-209pcr; Citric acid-[13C6]; Citric Acid (Anhydrous); 10402-15-0; Spectrum3_001850; WLN: QV1XQVQ1VQ; beta-Hydroxytricarballylate; cid_311; K-Lyte/Cl (Salt/Mix); K-Lyte DS (Salt/Mix); bmse000076; HOC(CH2COOH)2COOH; EC 201-069-1; NCIStruc1_000057; NCIStruc2_000099; NCIOpen2_004062; NCIOpen2_004502; Oprea1_502996; BSPBio_003240; Citric acid anhydrous (JAN); 4-03-00-01272 (Beilstein Handbook Reference); Citric Acid, anhydrous, USP; MLS001066346; citric acid (Fragrance Grade); Citric acid, anhydrous (USP); Anhydrous citric acid (JP17); GTPL2478; INS NO.330; Citric Acid (Industrial Grade); Citric acid, analytical standard; DTXSID3020332; BDBM14672; Citric acid, p.a., 99.5%; KBio3_002740; INS-330; 4o61; Citric acid 5% solution in water; Citric acid, Electrophoresis Grade; HMS1787N01; HMS2268B04; Pharmakon1600-01300013; ZINC895081; Citric acid 10% solution in water; Citric acid 50% solution in water; HY-N1428; STR12052; 1,2,3-Tricarboxy-2-hydroxypropane; Tox21_113436; Tox21_202405; Tox21_300124; ANW-37129; ANW-44011; BBL002530; NSC759606; s5761; SBB008922; STK286098; AKOS000119911; Citric acid, LR, anhydrous, >=99%; 2-hydroxy-1,2,3-propanetricarboxylate; CS-6965; DB04272; MCULE-7981253226; NE10694; NSC-759606; 3-Carboxy-3-hydroxypentane-1,5-dioate; Citric acid, >=99.5%, FCC, FG; Citric acid, ACS reagent, >=99.5%; Citric Acid, anhydrous powder, A.C.S.; 2-Hydroxy-1,3-propanetricarboxylic acid; NCGC00090954-01; NCGC00090954-02; NCGC00090954-04; NCGC00090954-05; NCGC00254055-01; NCGC00259954-01; AK116143; BP-31028; Citric Acid, anhydrous granular, A.C.S.; NCI60_022579; SMR000471840; 2-hydroxy-1,2,3-propanetricarboxyic acid; SBI-0206765.P001; Citric acid, SAJ first grade, >=99.5%; 2-Hydroxy-1,2,3-propane tricarboxylic acid; 2-Hydroxy-1,2,3-propanenetricarboxylic acid; B7297; C1949; Citric Acid, Aqueous Solution (Food Grade); Citric acid, Vetec(TM) reagent grade, 99%; E-330; FT-0623957; FT-0665073; FT-0728530; ST50308093; T8019; Citric acid, 99.6%, ACS reagent, anhydrous; 1466-EP2269610A2; 1466-EP2269986A1; 1466-EP2269988A2; 1466-EP2269989A1; 1466-EP2269990A1; 1466-EP2270002A1; 1466-EP2270003A1; 1466-EP2270006A1; 1466-EP2270008A1; 1466-EP2270011A1; 1466-EP2270017A1; 1466-EP2270505A1; 1466-EP2272516A2; 1466-EP2272537A2; 1466-EP2272817A1; 1466-EP2272822A1; 1466-EP2272825A2; 1466-EP2272827A1; 1466-EP2272832A1; 1466-EP2272834A1; 1466-EP2272841A1; 1466-EP2272843A1; 1466-EP2275102A1; 1466-EP2275105A1; 1466-EP2275401A1; 1466-EP2275403A1; 1466-EP2275404A1; 1466-EP2275410A1; 1466-EP2275411A2; 1466-EP2275412A1; 1466-EP2275413A1; 1466-EP2275414A1; 1466-EP2277507A1; 1466-EP2277848A1; 1466-EP2277858A1; 1466-EP2277866A1; 1466-EP2277867A2; 1466-EP2280000A1; 1466-EP2280001A1; 1466-EP2280003A2; 1466-EP2280004A1; 1466-EP2280009A1; 1466-EP2280010A2; 1466-EP2280012A2; 1466-EP2280020A1; 1466-EP2280021A1; 1466-EP2281559A1; 1466-EP2281563A1; 1466-EP2281813A1; 1466-EP2281816A1; 1466-EP2281817A1; 1466-EP2281818A1; 1466-EP2281819A1; 1466-EP2281820A2; 1466-EP2281823A2; 1466-EP2284149A1; 1466-EP2284160A1; 1466-EP2284169A1; 1466-EP2284178A2; 1466-EP2284179A2; 1466-EP2286795A1; 1466-EP2286811A1; 1466-EP2287153A1; 1466-EP2287155A1; 1466-EP2287156A1; 1466-EP2287160A1; 1466-EP2287161A1; 1466-EP2287162A1; 1466-EP2287165A2; 1466-EP2287166A2; 1466-EP2287167A1; 1466-EP2289509A2; 1466-EP2289510A1; 1466-EP2289518A1; 1466-EP2289876A1; 1466-EP2289879A1; 1466-EP2289883A1; 1466-EP2289887A2; 1466-EP2289888A2; 1466-EP2289890A1; 1466-EP2289893A1; 1466-EP2292227A2; 1466-EP2292228A1; 1466-EP2292231A1; 1466-EP2292233A2; 1466-EP2292234A1; 1466-EP2292592A1; 1466-EP2292593A2; 1466-EP2292611A1; 1466-EP2292612A2; 1466-EP2292615A1; 1466-EP2292617A1; 1466-EP2292619A1; 1466-EP2292620A2; 1466-EP2292621A1; 1466-EP2292622A1; 1466-EP2292628A2; 1466-EP2295053A1; 1466-EP2295401A2; 1466-EP2295402A2; 1466-EP2295406A1; 1466-EP2295407A1; 1466-EP2295408A1; 1466-EP2295410A1; 1466-EP2295412A1; 1466-EP2295413A1; 1466-EP2295414A1; 1466-EP2295415A1; 1466-EP2295416A2; 1466-EP2295418A1; 1466-EP2295424A1; 1466-EP2295426A1; 1466-EP2295427A1; 1466-EP2295432A1; 1466-EP2295433A2; 1466-EP2295437A1; 1466-EP2298731A1; 1466-EP2298734A2; 1466-EP2298735A1; 1466-EP2298736A1; 1466-EP2298742A1; 1466-EP2298744A2; 1466-EP2298746A1; 1466-EP2298747A1; 1466-EP2298748A2; 1466-EP2298750A1; 1466-EP2298751A2; 1466-EP2298754A1; 1466-EP2298755A1; 1466-EP2298757A2; 1466-EP2298758A1; 1466-EP2298759A1; 1466-EP2298767A1; 1466-EP2298768A1; 1466-EP2298772A1; 1466-EP2298775A1; 1466-EP2298776A1; 1466-EP2298778A1; 1466-EP2298779A1; 1466-EP2301536A1; 1466-EP2301538A1; 1466-EP2301544A1; 1466-EP2301922A1; 1466-EP2301923A1; 1466-EP2301925A1; 1466-EP2301928A1; 1466-EP2301929A1; 1466-EP2301930A1; 1466-EP2301931A1; 1466-EP2301933A1; 1466-EP2301934A1; 1466-EP2301935A1; 1466-EP2301936A1; 1466-EP2301937A1; 1466-EP2301939A1; 1466-EP2301940A1; 1466-EP2301941A1; 1466-EP2305219A1; 1466-EP2305248A1; 1466-EP2305250A1; 1466-EP2305257A1; 1466-EP2305633A1; 1466-EP2305636A1; 1466-EP2305641A1; 1466-EP2305646A1; 1466-EP2305651A1; 1466-EP2305652A2; 1466-EP2305653A1; 1466-EP2305655A2; 1466-EP2305657A2; 1466-EP2305659A1; 1466-EP2305663A1; 1466-EP2305664A1; 1466-EP2305666A1; 1466-EP2305668A1; 1466-EP2305672A1; 1466-EP2305673A1; 1466-EP2305674A1; 1466-EP2305675A1; 1466-EP2305682A1; 1466-EP2305683A1; 1466-EP2305684A1; 1466-EP2305687A1; 1466-EP2305808A1; 1466-EP2308479A2; 1466-EP2308492A1; 1466-EP2308510A1; 1466-EP2308562A2; 1466-EP2308812A2; 1466-EP2308828A2; 1466-EP2308838A1; 1466-EP2308839A1; 1466-EP2308849A1; 1466-EP2308850A1; 1466-EP2308851A1; 1466-EP2308854A1; 1466-EP2308857A1; 1466-EP2308861A1; 1466-EP2308869A1; 1466-EP2308871A1; 1466-EP2308872A1; 1466-EP2308873A1; 1466-EP2308875A1; 1466-EP2308877A1; 1466-EP2308879A1; 1466-EP2311455A1; 1466-EP2311494A1; 1466-EP2311807A1; 1466-EP2311808A1; 1466-EP2311809A1; 1466-EP2311810A1; 1466-EP2311811A1; 1466-EP2311814A1; 1466-EP2311818A1; 1466-EP2311820A1; 1466-EP2311821A1; 1466-EP2311822A1; 1466-EP2311823A1; 1466-EP2311824A1; 1466-EP2311827A1; 1466-EP2311829A1; 1466-EP2311830A1; 1466-EP2311831A1; 1466-EP2311834A1; 1466-EP2311837A1; 1466-EP2311839A1; 1466-EP2311840A1; 1466-EP2311842A2; 1466-EP2311850A1; 1466-EP2314574A1; 1466-EP2314575A1; 1466-EP2314576A1; 1466-EP2314577A1; 1466-EP2314584A1; 1466-EP2314585A1; 1466-EP2314586A1; 1466-EP2314587A1; 1466-EP2314589A1; 1466-EP2314593A1; 1466-EP2316457A1; 1466-EP2316458A1; 1466-EP2316459A1; 1466-EP2316470A2; 1466-EP2316824A1; 1466-EP2316825A1; 1466-EP2316826A1; 1466-EP2316827A1; 1466-EP2316828A1; 1466-EP2316829A1; 1466-EP2316831A1; 1466-EP2316832A1; 1466-EP2316833A1; 1466-EP2316834A1; 1466-EP2316835A1; 1466-EP2316836A1; 1466-EP2316837A1; 1466-EP2316974A1; 1466-EP2371799A1; 1466-EP2371802A1; 1466-EP2371811A2; 1466-EP2371814A1; 1466-EP2372017A1; 1466-EP2374454A1; 1466-EP2374526A1; 1466-EP2374780A1; 1466-EP2374781A1; 1466-EP2374790A1; 1466-EP2374895A1; 1466-EP2377510A1; 1466-EP2377848A1; 1466-EP2380568A1; C00158; D00037; 111855-EP2295439A1; 111855-EP2298761A1; AE-562/40806920; Citric acid, BioUltra, anhydrous, >=99.5% (T); Q159683; J-520099; 1,2,3-Propanetricarboxylic acid, 2-hydroxy- (9CI); Z56754862; Citric acid, certified reference material, TraceCERT(R); Citric acid, meets USP testing specifications, anhydrous; F2191-0222; 8F5D336A-442D-434A-9FB0-E400FF74E343; Citrate standard for IC, 1000 mg/L, analytical standard; 1,2,3-PROPANETRICARBOXYLIC ACID,2-HYDROXY (CITRIC ACID); Citric acid, United States Pharmacopeia (USP) Reference Standard; Citric acid, anhydrous, cell culture tested, plant cell culture tested; Citric acid, anhydrous, European Pharmacopoeia (EP) Reference Standard; Citric acid, anhydrous, free-flowing, Redi-Dri(TM), ACS reagent, >=99.5%; Citric acid, for molecular biology, anhydrous, Rnase and Protease free; Citric acid, Anhydrous, Pharmaceutical Secondary Standard; Certified Reference Material; Citric acid, meets analytical specification of Ph. Eur., BP, USP, E330, anhydrous, 99.5-100.5% (based on anhydrous substance)
DIG Function
Acidulant; Antioxidant; Buffering agent; Complexing agent; Flavoring agent
PubChem CID
311
Formula
C6H8O7
Canonical SMILES
C(C(=O)O)C(CC(=O)O)(C(=O)O)O
InChI
1S/C6H8O7/c7-3(8)1-6(13,5(11)12)2-4(9)10/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)
InChIKey
KRKNYBCHXYNGOX-UHFFFAOYSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This DIG
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=311"></iframe>
3D MOL 2D MOL
Physicochemical Properties Molecular Weight 192.12 Topological Polar Surface Area 132
XlogP -1.7 Complexity 227
Heavy Atom Count 13 Rotatable Bond Count 5
Hydrogen Bond Donor Count 4 Hydrogen Bond Acceptor Count 7
Full List of Active Pharmaceutical Ingredients (APIs) Co-administrated with This DIG
       ICD Disease Classification 01 Infectious/parasitic disease Click to Show/Hide
Fluconazole
 API Info
Candidiasis [ICD-11: 1F23]
 [1]
Chloroquine
 API Info
Malaria [ICD-11: 1F40]
 [2]
Delafloxacin
 API Info
Methicillin-resistant staphylococcus infection [ICD-11: 1D01]
 [3]
Ivermectin
 API Info
Onchocerciasis [ICD-11: 1F6A]
 [4]
       ICD Disease Classification 02 Benign/in-situ/malignant neoplasm Click to Show/Hide
Temozolomide
 API Info
Brain cancer [ICD-11: 2A00]
 [5]
Prednisolone
 API Info
Multiple myeloma [ICD-11: 2A83]
 [6]
Hydroxyurea
 API Info
Chronic myelogenous leukaemia [ICD-11: 2A20]
 [7]
Etoposide
 API Info
Testicular carcinoma [ICD-11: 2C80]
 [8]
       ICD Disease Classification 04 Immune system disease Click to Show/Hide
Cetirizine
 API Info
Allergy [ICD-11: 4A80]
 [9]
       ICD Disease Classification 05 Endocrine/nutritional/metabolic disease Click to Show/Hide
Simvastatin
 API Info
Dyslipidaemia [ICD-11: 5C81]
 [10]
Nateglinide
 API Info
Diabetes mellitus [ICD-11: 5A10]
 [11]
       ICD Disease Classification 06 Mental/behavioural/neurodevelopmental disorder Click to Show/Hide
Methylphenidate
 API Info
Attention deficit hyperactivity disorder [ICD-11: 6A05]
 [12]
Dexmethylphenidate
 API Info
Attention deficit hyperactivity disorder [ICD-11: 6A05]
 [13]
Quetiapine
 API Info
Schizophrenia [ICD-11: 6A20]
 [14]
Mirtazapine
 API Info
Major depressive disorder [ICD-11: 6A70]
 [15]
Buprenorphine
 API Info
Opiate dependence [ICD-11: 6C43]
 [16]
Tranylcypromine
 API Info
Major depressive disorder [ICD-11: 6A70]
 [17]
       ICD Disease Classification 08 Nervous system disease Click to Show/Hide
Acetaminophen
 API Info
Anaesthesia [ICD-11: 8E22]
 [18]
Zolmitriptan
 API Info
Migraine [ICD-11: 8A80]
 [19]
Fentanyl
 API Info
Anaesthesia [ICD-11: 8E22]
 [20]
Selegiline
 API Info
Parkinsonism [ICD-11: 8A00]
 [21]
Benzocaine
 API Info
Anaesthesia [ICD-11: 8E22]
 [22]
Dopamine
 API Info
Parkinsonism [ICD-11: 8A00]
 [23]
       ICD Disease Classification 09 Visual system disease Click to Show/Hide
Dextromethorphan
 API Info
Allergic conjunctivitis [ICD-11: 9A60]
 [24]
       ICD Disease Classification 10 Ear/mastoid process disease Click to Show/Hide
Diphenhydramine
 API Info
Meniere disease [ICD-11: AB31]
 [25]
       ICD Disease Classification 11 Circulatory system disease Click to Show/Hide
Atenolol
 API Info
Essential hypertension [ICD-11: BA00]
 [26]
Nadolol
 API Info
Essential hypertension [ICD-11: BA00]
 [27]
Labetalol
 API Info
Essential hypertension [ICD-11: BA00]
 [28]
Methyldopa
 API Info
Essential hypertension [ICD-11: BA00]
 [29]
       ICD Disease Classification 12 Respiratory system disease Click to Show/Hide
Clarithromycin
 API Info
Pneumocystis pneumonia [ICD-11: CA40]
 [30]
Fexofenadine
 API Info
Allergic rhinitis [ICD-11: CA08]
 [31]
Loratadine
 API Info
Allergic rhinitis [ICD-11: CA08]
 [32]
Desloratadine
 API Info
Allergic rhinitis [ICD-11: CA08]
 [33]
       ICD Disease Classification 13 Digestive system disease Click to Show/Hide
Ranitidine
 API Info
Gastric ulcer [ICD-11: DA60]
 [34]
Esomeprazole
 API Info
Duodenal ulcer [ICD-11: DA63]
 [35]
Mesalamine
 API Info
Inflammatory bowel disease [ICD-11: DD72]
 [36]
Dimenhydrinate
 API Info
Functional nausea/vomiting [ICD-11: DD90]
 [37]
Famotidine
 API Info
Peptic ulcer [ICD-11: DA61]
 [38]
Sodium fluoride
 API Info
Periodontal disease [ICD-11: DA0C]
 [39]
Dexlansoprazole
 API Info
Gastro-oesophageal reflux disease [ICD-11: DA22]
 [40]
Granisetron
 API Info
Functional nausea/vomiting [ICD-11: DD90]
 [41]
       ICD Disease Classification 15 Musculoskeletal/connective-tissue disease Click to Show/Hide
Naproxen
 API Info
Rheumatoid arthritis [ICD-11: FA20]
 [42]
Alendronic acid
 API Info
Osteoporosis [ICD-11: FB83]
 [43]
Flurbiprofen
 API Info
Rheumatoid arthritis [ICD-11: FA20]
 [44]
       ICD Disease Classification 16 Genitourinary system disease Click to Show/Hide
Ibuprofen
 API Info
Dysmenorrhea [ICD-11: GA34]
 [45]
Oxybutynin
 API Info
Overactive bladder [ICD-11: GC50]
 [46]
Erythromycin
 API Info
Pelvic inflammatory disease [ICD-11: GA05]
 [47]
Dutasteride
 API Info
Prostatic hyperplasia [ICD-11: GA90]
 [48]
Mefenamic acid
 API Info
Dysmenorrhea [ICD-11: GA34]
 [49]
Full List of Biological Targets of DIG (DBTs) Regulated by This DIG
      Oxidoreductase (ORase)
            DBT Name: N1-methyl adenine demethylase (FTO) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Biological Activity IC50 = 300000 nM (tested by experiment) [50]
                    Tested Species Homo sapiens (Human)
                    UniProt ID FTO_HUMAN
            DBT Name: RNA demethylase ALKBH5 (ALKB5) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Biological Activity IC50 = 488000 nM (tested by experiment) [51]
                    Tested Species Homo sapiens (Human)
                    UniProt ID ALKB5_HUMAN
      Nuclear receptor (NR)
            DBT Name: Factor HNF-4-alpha (HNF4A) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Biological Activity IC50 = 39869 nM (tested by experiment) [52]
                    Tested Species Homo sapiens (Human)
                    UniProt ID HNF4A_HUMAN
      Other protein families (OPF)
            DBT Name: Perilipin-1 (PLIN1) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Biological Activity IC50 = 3708 nM (tested by experiment) [52]
                    Tested Species Homo sapiens (Human)
                    UniProt ID PLIN1_HUMAN
References
1 FDA label for approved fluconazole from the official website of the U.S. Food and Drug Administration.
2 FDA label for approved chloroquine from the official website of the U.S. Food and Drug Administration.
3 FDA label for approved delafloxacin from the official website of the U.S. Food and Drug Administration.
4 FDA label for approved ivermectin from the official website of the U.S. Food and Drug Administration.
5 FDA label for approved temozolomide from the official website of the U.S. Food and Drug Administration.
6 FDA label for approved prednisolone from the official website of the U.S. Food and Drug Administration.
7 FDA label for approved hydroxyurea from the official website of the U.S. Food and Drug Administration.
8 FDA label for approved etoposide from the official website of the U.S. Food and Drug Administration.
9 FDA label for approved cetirizine from the official website of the U.S. Food and Drug Administration.
10 FDA label for approved simvastatin from the official website of the U.S. Food and Drug Administration.
11 FDA label for approved nateglinide from the official website of the U.S. Food and Drug Administration.
12 FDA label for approved methylphenidate from the official website of the U.S. Food and Drug Administration.
13 FDA label for approved dexmethylphenidate from the official website of the U.S. Food and Drug Administration.
14 FDA label for approved quetiapine from the official website of the U.S. Food and Drug Administration.
15 FDA label for approved mirtazapine from the official website of the U.S. Food and Drug Administration.
16 FDA label for approved buprenorphine from the official website of the U.S. Food and Drug Administration.
17 FDA label for approved tranylcypromine from the official website of the U.S. Food and Drug Administration.
18 FDA label for approved acetaminophen from the official website of the U.S. Food and Drug Administration.
19 FDA label for approved zolmitriptan from the official website of the U.S. Food and Drug Administration.
20 FDA label for approved fentanyl from the official website of the U.S. Food and Drug Administration.
21 FDA label for approved selegiline from the official website of the U.S. Food and Drug Administration.
22 Benzocaine.
23 FDA label for approved dopamine from the official website of the U.S. Food and Drug Administration.
24 FDA label for approved dextromethorphan from the official website of the U.S. Food and Drug Administration.
25 FDA label for approved diphenhydramine from the official website of the U.S. Food and Drug Administration.
26 FDA label for approved atenolol from the official website of the U.S. Food and Drug Administration.
27 FDA label for approved nadolol from the official website of the U.S. Food and Drug Administration.
28 FDA label for approved labetalol from the official website of the U.S. Food and Drug Administration.
29 FDA label for approved methyldopa from the official website of the U.S. Food and Drug Administration.
30 FDA label for approved clarithromycin from the official website of the U.S. Food and Drug Administration.
31 FDA label for approved fexofenadine from the official website of the U.S. Food and Drug Administration.
32 FDA label for approved loratadine from the official website of the U.S. Food and Drug Administration.
33 FDA label for approved desloratadine from the official website of the U.S. Food and Drug Administration.
34 FDA label for approved ranitidine from the official website of the U.S. Food and Drug Administration.
35 FDA label for approved esomeprazole from the official website of the U.S. Food and Drug Administration.
36 FDA label for approved mesalamine from the official website of the U.S. Food and Drug Administration.
37 FDA label for approved dimenhydrinate from the official website of the U.S. Food and Drug Administration.
38 FDA label for approved famotidine from the official website of the U.S. Food and Drug Administration.
39 FDA label for approved sodium fluoride from the official website of the U.S. Food and Drug Administration.
40 FDA label for approved dexlansoprazole from the official website of the U.S. Food and Drug Administration.
41 FDA label for approved granisetron from the official website of the U.S. Food and Drug Administration.
42 FDA label for approved naproxen from the official website of the U.S. Food and Drug Administration.
43 FDA label for approved alendronic acid from the official website of the U.S. Food and Drug Administration.
44 FDA label for approved flurbiprofen from the official website of the U.S. Food and Drug Administration.
45 FDA label for approved ibuprofen from the official website of the U.S. Food and Drug Administration.
46 FDA label for approved oxybutynin from the official website of the U.S. Food and Drug Administration.
47 FDA label for approved erythromycin from the official website of the U.S. Food and Drug Administration.
48 FDA label for approved dutasteride from the official website of the U.S. Food and Drug Administration.
49 FDA label for approved mefenamic acid from the official website of the U.S. Food and Drug Administration.
50 Structural basis for inhibition of the fat mass and obesity associated protein (FTO). J Med Chem. 2013 May 9; 56(9):3680-8.
51 Repair of methyl lesions in RNA by oxidative demethylation. Med Chem Comm. (2014) 5:1797-1803.
52 PubChem BioAssay data set.

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