Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D01094)
Name
Fluorometholone
Synonyms    Click to Show/Hide the Synonyms of This API
fluorometholone; Oxylone; 426-13-1; Flumetholon; Fluormetholone; Cortilet; Delmeson; FML Liquifilm; Fluor-Op; Trilcin; Fluoromethalone; FML Forte; Fluorometolona; Fluorometholonum; Fluormetholon; NSC 33001; component of Neo-Oxylone; UNII-SV0CSG527L; FML; U 8614; (6S,8S,9R,10S,11S,13S,14S,17R)-17-acetyl-9-fluoro-11,17-dihydroxy-6,10,13-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one; CHEBI:31625; 9-Fluoro-11beta,17-dihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione; SV0CSG527L; MLS000069537; MLS001076157; Fluormetholonum; NSC33001; MFCD00056461; NSC-33001; Fluorometolone; SMR000058598; 9-Fluoro-11,17-dihydroxy-6-methylpregna-1,4-diene-3,20-dione; Fluorometolone [DCIT]; Neo-Oxylone; FML-S Liquifilm; DSSTox_CID_27435; DSSTox_RID_82345; FML S.O.P.; DSSTox_GSID_47435; Fluorometholonum [INN-Latin]; Fluorometolona [INN-Spanish]; Oxylone (TN); Fluor-op (TN); Fml (TN); EINECS 207-041-5; Fluorometholon; AI3-52813; NCGC00016442-01; CAS-426-13-1; Prestwick_227; 9-Fluoro-11-beta,17-dihydroxy-6-alpha-methylpregna-1,4-diene-3,20-dione; Fluorometholone [USP:INN:BAN:JAN]; Fluorometholone, 97%; Opera_ID_341; Prestwick0_000718; Prestwick1_000718; Prestwick2_000718; Prestwick3_000718; F0414; Fluorometholone, >=98%; Pregna-1,4-diene-3,20-dione, 9-fluoro-11-beta,17-dihydroxy-6-alpha-methyl-; SCHEMBL5051; Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17-dihydroxy-6-methyl-, (6alpha,11beta)-; BSPBio_000935; SPBio_002856; BPBio1_001029; GTPL7079; CHEMBL1200600; DTXSID7047435; Pregna-1,4-diene-3,20-dione, 9-fluoro-11.beta.,17-dihydroxy-6.alpha.-methyl-; Fluorometholone (JP17/USP/INN); HMS1570O17; HMS2097O17; HMS2234F16; HMS3714O17; HY-B1893; Tox21_110440; Tox21_302593; BDBM50103631; s5486; 11beta,17alpha-Dihydroxy-9-fluoro-6-methyl-1,4-pregnadiene-3,20-dione; AKOS015895108; Tox21_110440_1; ZINC118912517; AC-3520; CCG-220718; DB00324; (6alpha,11beta)-9-Fluoro-11,17-dihydroxy-6-methylpregna-1,4-diene-3,20-dione; NCGC00021575-03; NCGC00021575-05; NCGC00256631-01; AS-12363; NCI60_002886; CS-0013955; Progesterone, 17-dihydroxy-6.alpha.-methyl-; D01367; 426F131; Q607349; SR-01000003019; SR-01000003019-2; BRD-K64862097-001-03-9; BRD-K64862097-001-12-0; Fluorometholone, British Pharmacopoeia (BP) Reference Standard; Fluorometholone, United States Pharmacopeia (USP) Reference Standard; Pregna-1,20-dione, 9-fluoro-11.beta.,17-dihydroxy-6.alpha.-methyl-; Progesterone, 1-dehydro-9-fluoro-11.beta., 17-dihydroxy-6.alpha.-methyl-; Pregna-1,20-dione, 9-fluoro-11,17-dihydroxy-6-methyl-, (6.alpha.,11.beta.)-; Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17-dihydroxy-6-methyl-, (6I+/-,11I(2))-; Pregna-1,4-diene-3,20-dione, 9-fluoro-11beta,17-dihydroxy-6alpha-methyl- (8CI); (1R,2S,8S,10S,11S,14R,15S,17S)-14-acetyl-1-fluoro-14,17-dihydroxy-2,8,15-trimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-3,6-dien-5-one; (1R,2S,8S,10S,11S,14R,15S,17S)-14-acetyl-1-fluoro-14,17-dihydroxy-2,8,15-trimethyltetracyclo[8.7.0.02,7.011,15]heptadeca-3,6-dien-5-one; Pregna-1, 4-diene-3,20-dione, 9-fluoro-11,17-dihydroxy-6-methyl-, (6.alpha., 11.beta.)-
Clinical Status
Approved
PubChem CID
9878
Formula
C22H29FO4
Canonical SMILES
C[C@H]1C[C@H]2[C@@H]3CC[C@@]([C@]3(C[C@@H]([C@@]2([C@@]4(C1=CC(=O)C=C4)C)F)O)C)(C(=O)C)O
InChI
1S/C22H29FO4/c1-12-9-17-15-6-8-21(27,13(2)24)20(15,4)11-18(26)22(17,23)19(3)7-5-14(25)10-16(12)19/h5,7,10,12,15,17-18,26-27H,6,8-9,11H2,1-4H3/t12-,15-,17-,18-,19-,20-,21-,22-/m0/s1
InChIKey
FAOZLTXFLGPHNG-KNAQIMQKSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=9878"></iframe>
3D MOL 2D MOL
Physicochemical Properties Molecular Weight 376.5 Topological Polar Surface Area 74.6
XlogP 2 Complexity 787
Heavy Atom Count 27 Rotatable Bond Count 1
Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 5
Full List of Drug Formulations (DFMs) Containing This API
          Fluorometholone 0.1% suspension Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Benzalkonium Chloride; Edetate Disodium; Polysorbate 80; Polyvinyl Alcohol, Unspecified; Water; Sodium Chloride; Sodium Phosphate, Dibasic; Sodium Phosphate, Monobasic; Sodium Hydroxide
                   Dosage Form Suspension
                   Company Pacific Pharma
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Benzalkonium chloride DIG Info Solute carrier SLCO2B1 (Ki = 62.1 uM) [1]
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [2]
Polyvinyl alcohol DIG Info Debrisoquine 4-hydroxylase (EC50 = 354.8 uM) [3]
References
1 Bacterial metabolism rescues the inhibition of intestinal drug absorption by food and drug additives. Proc Natl Acad Sci U S A. 2020 Jul 7;117(27):16009-16018.
2 The activities of drug inactive ingredients on biological targets. Science. 2020 Jul 24;369(6502):403-413.
3 Mediation of in vitro cytochrome p450 activity by common pharmaceutical excipients. Mol Pharm. 2013 Jul 1;10(7):2739-48.

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