Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D01127)
Name
Glatiramer acetate
Synonyms    Click to Show/Hide the Synonyms of This API
Glatiramer acetate; 147245-92-9; Copaxone; Copolymer 1; Copolymer-1; Protiramer; Glatopa; COP-1; TV 5010; UNII-5M691HL4BO; Glatirameracetat; Glatiramer acetate [USAN:BAN]; 5M691HL4BO; DTXSID30163637; C9H11NO3.C6H14N2O2.; AM84438; L-Glutamic acid peptide with L-alanine, L-lysine and L-tyrosine, acetate (salt); L-Glutamic acid polymer with L-alanine, L-lysine and L-tyrosine, acetate (salt); AC-28732; L-alanine compound with L-glutamic acid and L-lysine and L-tyrosine and acetic acid (1:1:1:1:1); AB0110033; Y0429; Q418274; acetic acid;(2S)-2-amino-3-(4-hydroxyphenyl)propanoic acid;(2S)-2-aminopentanedioic acid;(2S)-2-aminopropanoic acid;(2S)-2,6-diaminohexanoic acid
Clinical Status
Approved
PubChem CID
3081884
Formula
C25H45N5O13
Canonical SMILES
C[C@@H](C(=O)O)N.CC(=O)O.C1=CC(=CC=C1C[C@@H](C(=O)O)N)O.C(CCN)C[C@@H](C(=O)O)N.C(CC(=O)O)[C@@H](C(=O)O)N
InChI
1S/C9H11NO3.C6H14N2O2.C5H9NO4.C3H7NO2.C2H4O2/c10-8(9(12)13)5-6-1-3-7(11)4-2-6;7-4-2-1-3-5(8)6(9)10;6-3(5(9)10)1-2-4(7)8;1-2(4)3(5)6;1-2(3)4/h1-4,8,11H,5,10H2,(H,12,13);5H,1-4,7-8H2,(H,9,10);3H,1-2,6H2,(H,7,8)(H,9,10);2H,4H2,1H3,(H,5,6);1H3,(H,3,4)/t8-;5-;3-;2-;/m0000./s1
InChIKey
FHEAIOHRHQGZPC-KIWGSFCNSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=3081884"></iframe>
3D MOL is unavailable 2D MOL
Physicochemical Properties Molecular Weight 623.7 Topological Polar Surface Area 374
XlogP N.A. Complexity 519
Heavy Atom Count 43 Rotatable Bond Count 13
Hydrogen Bond Donor Count 12 Hydrogen Bond Acceptor Count 18
Full List of Drug Formulations (DFMs) Containing This API
          Glatiramer Acetate 40mg/ml injectable Click to Show/Hide the Full List of Formulation(s):          2 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Mannitol; Water
                   Dosage Form Injectable
                   Company Mylan
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [1]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Mannitol
                   Dosage Form Injectable
                   Company Sandoz ; Teva Neuroscience
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [1]
References
1 Pharmacological property optimization for allosteric ligands: A medicinal chemistry perspective. Bioorg Med Chem Lett. 2017 Jun 1; 27(11):2239-2258.

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