Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D01273)
Name
Naphazoline
Synonyms    Click to Show/Hide the Synonyms of This API
naphazoline; 835-31-4; 2-(naphthalen-1-ylmethyl)-4,5-dihydro-1H-imidazole; Naphthizine; Antan; Ciba 2020/R; NAFAZAIR; 2-(1-Naphthylmethyl)-2-imidazoline; 1H-Imidazole, 4,5-dihydro-2-(1-naphthalenylmethyl)-; UNII-H231GF11BV; 2-(Naphthyl-(1')-methyl)imidazolin; Naphcon; 2-Imidazoline, 2-(1-naphthylmethyl)-; Naphcon forte; H231GF11BV; Clearine; 2-(1-Naphthylmethyl)-4,5-dihydro-1H-imidazole; 2-[(naphthalen-1-yl)methyl]-4,5-dihydro-1H-imidazole; Nafazolina [DCIT]; Naphazolinum; Nafazolina; Nafazoline; Nafazoline [Spanish]; Naphazolinum [Latin]; Naphazoline [INN:BAN]; Naphazolinum [INN-Latin]; 2-(1-naphthalenylmethyl)-4,5-dihydro-1H-imidazole; Nafazolin; Rhinazine; alpha-Naphthylmethyl imidazoline; CHEMBL1706; 2-(alpha-Naphthylmethyl)-imidazoline; Nafazolin (TN); Naphazoline (INN); 4,5-Dihydro-2-(1-naphthylmethyl)imidazole; Enamine_000333; 2-(Naphthyl-(1')-methyl)imidazolin [German]; EINECS 212-641-5; BRN 0151864; Nadaplatin; Imidin; Privine (Salt/Mix); Sanorin (Salt/Mix); Spectrum_000975; 10061-11-7; Prestwick0_000046; Prestwick1_000046; Prestwick2_000046; Prestwick3_000046; Spectrum2_001054; Spectrum3_000513; Spectrum4_000068; Spectrum5_001424; CHEMBL761; SCHEMBL34532; BSPBio_000171; BSPBio_002065; KBioGR_000595; KBioSS_001455; 5-23-08-00293 (Beilstein Handbook Reference); cid_11079; DivK1c_000456; SPBio_001008; SPBio_002092; BPBio1_000189; GTPL5509; IMI033; DTXSID3048449; CHEBI:93363; KBio1_000456; KBio2_001455; KBio2_004023; KBio2_006591; KBio3_001565; 2-(naphthylmethyl)-2-imidazoline; NINDS_000456; .alpha.-Naphthylmethyl imidazoline; HMS1394P03; HMS2090D15; ZINC119717; BBL012612; BDBM50001922; MFCD00066737; STK300042; AKOS000295230; CCG-250339; DB06711; MCULE-9097339235; 2-(.alpha.-Naphthylmethyl)-imidazoline; 2-(1-Naphthalenylmethyl)-2-imidazoline; IDI1_000456; NCGC00016506-01; NCGC00016506-02; NCGC00016506-03; NCGC00016506-04; NCGC00016506-05; K490; VS-03410; SBI-0051454.P003; DB-050155; FT-0725973; ST45061546; T8212; D08253; AB00053505-11; AB00053505-12; AB00053505_13; AB00053505_14; 550N992; A840596; L000878; Q415433; 2-(1-Naphthylmethyl)-4,5-dihydro-1H-imidazole #; BRD-K77641333-003-05-7; BRD-K77641333-003-15-6; BRD-K77641333-003-25-5; Z56762888; 2-Naphthalen-1-ylmethyl-4,5-dihydro-1H-imidazole; hydrochloride
Clinical Status
Approved
PubChem CID
4436
Formula
C14H14N2
Canonical SMILES
C1CN=C(N1)CC2=CC=CC3=CC=CC=C32
InChI
1S/C14H14N2/c1-2-7-13-11(4-1)5-3-6-12(13)10-14-15-8-9-16-14/h1-7H,8-10H2,(H,15,16)
InChIKey
CNIIGCLFLJGOGP-UHFFFAOYSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=4436"></iframe>
3D MOL is unavailable 2D MOL
Physicochemical Properties Molecular Weight 210.27 Topological Polar Surface Area 24.4
XlogP 2.1 Complexity 272
Heavy Atom Count 16 Rotatable Bond Count 2
Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 1
Full List of Drug Formulations (DFMs) Containing This API
          Naphazoline 0.05% solution Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Sodium Chloride; Benzalkonium Chloride; Sodium Bisulfite; Water; Sodium Citrate
                   Dosage Form Solution
                   Company Duy Drugs
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sodium citrate anhydrous DIG Info Carbonic anhydrase IV (Ki = 99 nM) [1]
Benzalkonium chloride DIG Info Solute carrier SLCO2B1 (Ki = 62.1 uM) [2]
Sodium sulhydrate DIG Info Albendazole monooxygenase (Inhibition ratio < 90 %) [3]
          Naphazoline 0.012% solution Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Camphor(Synthetic); Benzalkonium Chloride; Sodium Chloride; Boric Acid; Sodium Borate; Water
                   Dosage Form Solution
                   Company Sato Pharmaceutical Co. Ltd.
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Benzalkonium chloride DIG Info Solute carrier SLCO2B1 (Ki = 62.1 uM) [2]
          Naphazoline 0.01% solution Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Boric Acid; Sodium Borate; Edetate Disodium; Thimerosal; Water
                   Dosage Form Solution
                   Company International Nature Nutraceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Thimerosal DIG Info Dopamine D3 receptor (Ki = 0.32 uM) [4]
References
1 Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with carboxylates. Bioorg Med Chem Lett. 2005 Feb 1; 15(3):573-8.
2 Bacterial metabolism rescues the inhibition of intestinal drug absorption by food and drug additives. Proc Natl Acad Sci U S A. 2020 Jul 7;117(27):16009-16018.
3 Pharmaceutical excipients inhibit cytochrome P450 activity in cell free systems and after systemic administration. Eur J Pharm Biopharm. 2008 Sep;70(1):279-88.
4 The activities of drug inactive ingredients on biological targets. Science. 2020 Jul 24;369(6502):403-413.

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