Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D01298)
Name	Omacetaxine mepesuccinate
Synonyms	Click to Show/Hide the Synonyms of This API homoharringtonine; Omacetaxine mepesuccinate; Synribo; 26833-87-4; Ceflatonin; Myelostat; CGX-635; (-)-homoharringtonine; Omapro; NSC-141633; UNII-6FG8041S5B; CHEBI:71019; C29H39NO9; (2'R,3S,4S,5R)-(-)-homoharringtonine; 6FG8041S5B; NSC 141633; Tekinex; Cephalotaxine 4-methyl (2R)-2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate; Synribo (TN); Homoharringtonin; NSC141633; NCGC00025155-01; Omacetaxine mepesuccinate [USAN:INN]; BRN 5687925; omacetaxini mepesuccinas; Homoharringtonine (8CI); ZJ-C; mepesuccinate d'omacetaxine; mepesuccinato de omacetaxina; MLS001424293; CHEMBL46286; Omacetaxine (homoharringtonine); CGX-635-14 (formulation); GTPL7454; SCHEMBL12745687; Omacetaxine mepesuccinate (USAN); HMS3267H22; HMS3414N05; HMS3678N03; AMY33459; Homoharringtonine, >=98% (HPLC); BDBM50480293; MFCD05618221; NSC758253; s9015; ZINC26011099; AKOS024456585; ACN-035229; CCG-269981; DB04865; NC00395; NSC-758253; NCGC00025155-02; NCGC00025155-03; NCGC00025155-04; NCGC00025155-07; HY-14944; NCI60_000917; SMR000469230; ST056357; AB0019750; Homoharringtonine; ; ; Omacetaxine mepesuccinate; N1504; V0232; D08956; AB00642561-02; SR-01000597562; Q7089373; SR-01000597562-1; BRD-K76674262-001-01-7; BRD-K76674262-001-02-5; Cephalotaxine, 3-[4-methyl (2R)-2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate]; Cephalotaxine, 4-methyl-, 2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate (ester); (2S,3S,6S)-4-methoxy-16,18-dioxa-10-azapentacyclo[11.7.0.0<2,6>.0<6,10>.0<15,1 9>]icosa-1(20),4,13,15(19)-tetraen-3-yl methyl (2R)-2-hydroxy-2-(4-hydroxy-4-m ethylpentyl)butane-1,4-dioate; 1-((1S,3aR,14bS)-2-Methoxy-1,5,6,8,9,14b-hexahydro-4H- cyclopenta(a)(1,3)dioxolo(4,5-h)pyrrolo(2,1-b)(3)benzazepin-1-yl) 4-methyl (2R)-2- hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate; Cephalotaxine, 4-methyl (2R)-2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate (ester) (9CI); Cephalotaxine, 4-methyl 2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate (ester), (3(R))- (9CI); Homoharringtonine; Cephalotaxine; [3(R)]-4-methyl 2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate
Clinical Status	Approved
PubChem CID	285033
Formula	C29H39NO9
Canonical SMILES	CC(C)(CCC[C@@](CC(=O)OC)(C(=O)O[C@H]1[C@H]2C3=CC4=C(C=C3CCN5[C@@]2(CCC5)C=C1OC)OCO4)O)O
InChI	1S/C29H39NO9/c1-27(2,33)8-5-10-29(34,16-23(31)36-4)26(32)39-25-22(35-3)15-28-9-6-11-30(28)12-7-18-13-20-21(38-17-37-20)14-19(18)24(25)28/h13-15,24-25,33-34H,5-12,16-17H2,1-4H3/t24-,25-,28+,29-/m1/s1
InChIKey	HYFHYPWGAURHIV-JFIAXGOJSA-N
	Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure	<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=285033"></iframe>
Structure	3D MOL is unavailable		2D MOL
Physicochemical Properties	Molecular Weight	545.6	Topological Polar Surface Area	124
	XlogP	0.8	Complexity	968
	Heavy Atom Count	39	Rotatable Bond Count	11
	Hydrogen Bond Donor Count	2	Hydrogen Bond Acceptor Count	10

Full List of Drug Formulations (DFMs) Containing This API
Omacetaxine Mepesuccinate 3.5mg/vial powder			Click to Show/Hide the Full List of Formulation(s): 1 Formulation(s)
Drug Formulation 1	DFM Info click to show the detail info of this DFM
All DIGs	Click to Show/Hide the Full List of DIGs in This DFM Mannitol
Dosage Form	Powder
Company	Teva Pharms Intl
DIG(s) with Biological Activity
	DIG Name	DIG Info	Representative Biological Activity of This DIG	REF
	Mannitol	DIG Info	Glycine receptor alpha-1 (EC50 = 12589.25 nM)	[1]

References
1	Pharmacological property optimization for allosteric ligands: A medicinal chemistry perspective. Bioorg Med Chem Lett. 2017 Jun 1; 27(11):2239-2258.

If you find any error in data or bug in web service, please kindly report it to Dr. Zhang and Dr. Mou.