Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D01367)
Name	Propofol
Synonyms	Click to Show/Hide the Synonyms of This API propofol; 2,6-DIISOPROPYLPHENOL; 2078-54-8; Diprivan; Disoprofol; Disoprivan; Diisopropylphenol; 2,6-Bis(1-methylethyl)phenol; Fresofol; Ampofol; Phenol, 2,6-bis(1-methylethyl)-; Rapinovet; Propofolum; Recofol; Ivofol; Propofol-Lipuro; 2,6-di(propan-2-yl)phenol; Pofol; ICI 35868; 2,6-Diisopropyl phenol; Diprifusor; Diprofol; Propovan; Phenol, 2,6-diisopropyl-; Diprivan 10; UNII-YI7VU623SF; NSC 5105; ICI-35868; 2,6-bis(propan-2-yl)phenol; 2,6-diisopropyl-phenol; MFCD00008885; 2,6-bis(Isopropyl)phenol; CHEMBL526; ICI 35,868; YI7VU623SF; CHEBI:44915; NSC5105; NSC-5105; Propofolum [Latin]; NCGC00015389-08; Aquafol; CAS-2078-54-8; DSSTox_CID_3523; DSSTox_RID_77063; DSSTox_GSID_23523; Diprivan Injectable emulsion; 2,6 Diisopropylphenol; Dipravan; Propoven; Aquafo; Propofol IDD-D; Diprivan (TN); SMR000059151; CCRIS 9000; Propofol(2,6-Diisopropylphenol); HSDB 7123; 2, 6-Diisopropylphenol; SR-01000075468; EINECS 218-206-6; BRN 1866484; DDS-04F; ghl.PD_Mitscher_leg0.558; AI3-26295; Propofol solution; Propofol [USAN:USP:INN:BAN]; ICI35,868; Propofol (Diprivan); 1189467-93-3; ZD-0859; Phenol,6-diisopropyl-; ACMC-1CPLW; Prestwick0_000931; Prestwick1_000931; Prestwick2_000931; Prestwick3_000931; 2,6-di isopropyl phenol; Biomol-NT_000248; Lopac-D126608; Diisopropylphenol (Related); 2,6-bis(methylethyl)phenol; Propofol (JAN/USP/INN); Lopac0_000437; SCHEMBL36245; BSPBio_000862; 4-06-00-03435 (Beilstein Handbook Reference); MLS001066348; MLS001335999; MLS002454360; BIDD:GT0436; SPECTRUM1505022; SPBio_003031; 2,6-Diisopropylphenol, 97%; 2,6-Di-iso-propylphenol-d18; BPBio1_000950; BPBio1_000969; GTPL5464; Phenol,6-bis(1-methylethyl)-; DTXSID6023523; CC(C)c1cccc(C(C)C)c1[O]; Propofol 1.0 mg/ml in Methanol; 2,6-Diisopropylphenol, >=97%; 3f33; 3p50; HMS1570L04; HMS2089O21; HMS2094E17; HMS2097L04; HMS2231E16; HMS3259E03; HMS3261G16; HMS3369I16; HMS3714L04; Pharmakon1600-01505022; ZINC968303; BCP02920; HY-B0649; Tox21_110134; Tox21_201371; Tox21_303225; Tox21_500437; ANW-24224; BDBM50058046; CP0141; NSC758909; Phenol, 2, 6-bis(1-methylethyl)-; AKOS009159417; Tox21_110134_1; AC-2038; AM90311; CCG-204529; CS-W020057; DB00818; ICI 35-868; LP00437; MCULE-1903292305; NC00449; NSC-758909; SDCCGSBI-0050422.P002; VZ22957; 2,6-DIISOPROPYLPHENOL; PROPOFOL; MLS-0318084; NCGC00015389-01; NCGC00015389-02; NCGC00015389-03; NCGC00015389-04; NCGC00015389-05; NCGC00015389-06; NCGC00015389-07; NCGC00015389-09; NCGC00015389-10; NCGC00015389-11; NCGC00015389-14; NCGC00015389-17; NCGC00091538-01; NCGC00091538-02; NCGC00091538-03; NCGC00091538-04; NCGC00091538-05; NCGC00091538-06; NCGC00257228-01; NCGC00260670-01; NCGC00261122-01; AS-13299; H835; SY013479; 2,6-Diisopropylphenol, analytical standard; BCP0726000298; MLS-0318084.P017; AB00513968; D0617; EU-0100437; ST50405911; C07523; D00549; AB00513968-07; AB00513968_08; A814898; D126608; Q422740; Q-201631; SR-01000075468-1; SR-01000075468-4; SR-01000075468-6; BRD-K82255054-001-03-5; BRD-K82255054-001-08-4; Propofol, British Pharmacopoeia (BP) Reference Standard; Propofol, European Pharmacopoeia (EP) Reference Standard; Z1245735300; Propofol, United States Pharmacopeia (USP) Reference Standard; Propofol, Pharmaceutical Secondary Standard; Certified Reference Material; Propofol for peak identification, European Pharmacopoeia (EP) Reference Standard; Propofol solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material; 113981-41-2
Clinical Status	Approved
PubChem CID	4943
Formula	C12H18O
Canonical SMILES	CC(C)C1=C(C(=CC=C1)C(C)C)O
InChI	1S/C12H18O/c1-8(2)10-6-5-7-11(9(3)4)12(10)13/h5-9,13H,1-4H3
InChIKey	OLBCVFGFOZPWHH-UHFFFAOYSA-N
	Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure	<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=4943"></iframe>
Structure	3D MOL is unavailable		2D MOL
Physicochemical Properties	Molecular Weight	178.27	Topological Polar Surface Area	20.2
	XlogP	3.8	Complexity	135
	Heavy Atom Count	13	Rotatable Bond Count	2
	Hydrogen Bond Donor Count	1	Hydrogen Bond Acceptor Count	1

Full List of Drug Formulations (DFMs) Containing This API
Propofol 200mg/20ml injectable			Click to Show/Hide the Full List of Formulation(s): 2 Formulation(s)
Drug Formulation 1	DFM Info click to show the detail info of this DFM
All DIGs	Click to Show/Hide the Full List of DIGs in This DFM Benzyl Alcohol; Egg Phospholipids; Glycerin; Soybean Oil
Dosage Form	Injectable
Company	Hikma Pharmaceuticals Usa
DIG(s) with Biological Activity
	DIG Name	DIG Info	Representative Biological Activity of This DIG	REF
	Benzyl alcohol	DIG Info	Indoleamine 2,3-dioxygenase 1 (IC50 = 1400 nM)	[1]
Drug Formulation 2	DFM Info click to show the detail info of this DFM
All DIGs	Click to Show/Hide the Full List of DIGs in This DFM Benzyl Alcohol
Dosage Form	Injectable
Company	Civica
DIG(s) with Biological Activity
	DIG Name	DIG Info	Representative Biological Activity of This DIG	REF
	Benzyl alcohol	DIG Info	Indoleamine 2,3-dioxygenase 1 (IC50 = 1400 nM)	[1]

References
1	O-alkylhydroxylamines as rationally-designed mechanism-based inhibitors of indoleamine 2,3-dioxygenase-1. Eur J Med Chem. 2016 Jan 27; 108:564-576.

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