Details of the Drug Inactive Ingredient (DIG)

General Information of DIG (ID: E0NY1O)
DIG Name	Benzyl alcohol
Synonyms	Click to Show/Hide the Synonyms of This DIG benzyl alcohol; phenylmethanol; benzenemethanol; 100-51-6; phenylcarbinol; Benzoyl alcohol; benzylalcohol; Benzenecarbinol; Hydroxytoluene; Phenylmethyl alcohol; alpha-Toluenol; (Hydroxymethyl)benzene; Phenolcarbinol; Benzal alcohol; alpha-hydroxytoluene; benzylic alcohol; Alcool benzylique; Benzylicum; Methanol, phenyl-; Phenylcarbinolum; BENZYL-ALCOHOL; hydroxymethylbenzene; Phenyl-Methanol; Euxyl K 100; Bentalol; Aromatic alcohol; Caswell No. 081F; .alpha.-Toluenol; Benzyl alcohol (natural); Alcool benzilico [DCIT]; Itch-X; alcoholum benzylicum; NCI-C06111; benzenmethanol; .alpha.-Hydroxytoluene; Benzylalkohol; FEMA No. 2137; Aromatic primary alcohol; Alcool benzylique [INN-French]; Benzyl alkohol; Alcohol bencilico [INN-Spanish]; Methanol benzene; Alcoholum benzylicum [INN-Latin]; UNII-LKG8494WBH; NSC 8044; HOCH-Ph-polymer; phenylmethan-1-ol; BnOH; Benzyl-d7 alcohol; Benzyl alcohol Natural; MFCD00004599; 66072-40-0; TOLUENE,ALPHA-HYDROXY; LKG8494WBH; CHEBI:17987; NSC-8044; Hydroxymethyl resin (100-200 mesh); NCGC00091865-01; Phenyl Methanol; DSSTox_CID_152; DSSTox_RID_75404; Benzyl alcohol, ACS reagent; Benzyl alcohol, for analysis; DSSTox_GSID_20152; MBN; Ulesfia; Alcool benzilico; Alcohol bencilico; CAS-100-51-6; HSDB 46; Ulesfia (TN); CCRIS 2081; Benzyl alcohol [USAN:INN:JAN]; Benzyl alcohol, 98+%, Extra Dry, AcroSeal(R); EINECS 202-859-9; EPA Pesticide Chemical Code 009502; BRN 0878307; enzylalcohol; Benzalalcohol; Benzalcohol; Bentanol; Benzyl alcohol, polymer-bound; Benzyl alcohol, specified according to requirements of Ph.Eur.; Alcoolbenzylique; benzene-methanol; Benzyl Alcohole; a-Hydroxytoluene; a-Toluenol; AI3-01680; Benzyl alcohol [INN:JAN:NF]; phenylmethan-d2-ol; OBZ; HOCH2-Ph-polymer; O[C]c1ccccc1; Sunmorl BK 20; Nat. Benzyl Alcohol; PhCH2OH; 201740-95-6; Bn-OH; Benzyl alcohol-13C6; ACMC-1BQPG; SCHEMBL147; bmse000407; C6H5CH2OH; CHEMBL720; EC 202-859-9; WLN: Q1R; PINAPUR?9 BA-R; Benzyl alcohol (JP15/NF); Benzyl alcohol, 99%, pure; $l^{1}-oxidanylmethylbenzene; 4-06-00-02222 (Beilstein Handbook Reference); BIDD:ER0248; TB 13G; Benzyl alcohol, LR, >=99%; Benzyl alcohol (Benzenemethanol); DTXSID5020152; BDBM16418; INS NO.1519; NSC8044; Benzyl alcohol (JP17/NF/INN); Benzyl Alcohol Reagent ACS Grade; HMS3264B16; HMS3885F10; Pharmakon1600-01502555; ZINC895302; Benzyl alcohol, analytical standard; Benzyl alcohol, AR, >=99.5%; HY-B0892; INS-1519; Benzyl alcohol, anhydrous, 99.8%; Tox21_111172; Tox21_202447; Tox21_300044; BBL011938; MFCD03792087; NSC760098; s4600; SBB058558; STL163453; Benzyl alcohol, >=99%, FCC, FG; AKOS000119907; AS04466; Benzyl alcohol, natural, >=98%, FG; CCG-213843; DB06770; Hydroxymethyl resin (200-400 mesh); LS41488; MCULE-6011707909; NSC-760098; NCGC00091865-02; NCGC00091865-03; NCGC00091865-04; NCGC00254154-01; NCGC00259996-01; AK146334; Benzyl alcohol, ACS reagent, >=99.0%; Benzyl alcohol, ReagentPlus(R), >=99%; Benzyl alcohol, USP, 98.0-100.5%; I765; Benzyl alcohol on polystyrene, 3.5 mmol/g; B2378; Benzyl alcohol, tested according to Ph.Eur.; Benzylalcohol 100 microg/mL in Acetonitrile; E1519; FT-0622812; ST51028320; Benzyl alcohol, p.a., ACS reagent, 99.0%; Benzyl alcohol, SAJ first grade, >=98.5%; 3983-EP2269992A1; 3983-EP2270004A1; 3983-EP2270005A1; 3983-EP2270011A1; 3983-EP2270505A1; 3983-EP2272516A2; 3983-EP2272813A2; 3983-EP2272817A1; 3983-EP2272822A1; 3983-EP2272825A2; 3983-EP2272841A1; 3983-EP2274983A1; 3983-EP2275102A1; 3983-EP2275401A1; 3983-EP2275411A2; 3983-EP2275414A1; 3983-EP2275425A1; 3983-EP2277565A2; 3983-EP2277566A2; 3983-EP2277567A1; 3983-EP2277568A2; 3983-EP2277569A2; 3983-EP2277570A2; 3983-EP2277848A1; 3983-EP2277867A2; 3983-EP2277876A1; 3983-EP2277879A1; 3983-EP2279750A1; 3983-EP2280001A1; 3983-EP2280003A2; 3983-EP2280005A1; 3983-EP2280008A2; 3983-EP2280010A2; 3983-EP2280012A2; 3983-EP2281823A2; 3983-EP2284149A1; 3983-EP2284160A1; 3983-EP2287155A1; 3983-EP2287160A1; 3983-EP2287165A2; 3983-EP2287166A2; 3983-EP2289884A1; 3983-EP2289887A2; 3983-EP2289888A2; 3983-EP2289892A1; 3983-EP2289894A2; 3983-EP2292227A2; 3983-EP2292280A1; 3983-EP2292596A2; 3983-EP2292611A1; 3983-EP2292612A2; 3983-EP2292614A1; 3983-EP2292615A1; 3983-EP2292620A2; 3983-EP2295402A2; 3983-EP2295406A1; 3983-EP2295411A1; 3983-EP2295412A1; 3983-EP2295413A1; 3983-EP2295426A1; 3983-EP2295427A1; 3983-EP2295437A1; 3983-EP2295550A2; 3983-EP2298731A1; 3983-EP2298734A2; 3983-EP2298735A1; 3983-EP2298743A1; 3983-EP2298744A2; 3983-EP2298750A1; 3983-EP2298755A1; 3983-EP2298768A1; 3983-EP2298772A1; 3983-EP2298775A1; 3983-EP2298783A1; 3983-EP2301918A1; 3983-EP2301931A1; 3983-EP2301936A1; 3983-EP2305243A1; 3983-EP2305636A1; 3983-EP2305640A2; 3983-EP2305651A1; 3983-EP2305673A1; 3983-EP2305676A1; 3983-EP2305695A2; 3983-EP2305696A2; 3983-EP2305697A2; 3983-EP2305698A2; 3983-EP2305808A1; 3983-EP2308812A2; 3983-EP2308828A2; 3983-EP2308833A2; 3983-EP2308839A1; 3983-EP2308844A2; 3983-EP2308845A2; 3983-EP2308846A2; 3983-EP2308854A1; 3983-EP2308857A1; 3983-EP2308858A1; 3983-EP2308861A1; 3983-EP2308867A2; 3983-EP2308870A2; 3983-EP2308872A1; 3983-EP2308873A1; 3983-EP2308875A1; 3983-EP2308877A1; 3983-EP2311806A2; 3983-EP2311815A1; 3983-EP2311816A1; 3983-EP2311817A1; 3983-EP2311823A1; 3983-EP2311824A1; 3983-EP2311829A1; 3983-EP2311831A1; 3983-EP2311834A1; 3983-EP2311837A1; 3983-EP2311842A2; 3983-EP2314575A1; 3983-EP2314584A1; 3983-EP2314585A1; 3983-EP2316470A2; 3983-EP2316829A1; 3983-EP2316831A1; 3983-EP2316834A1; 3983-EP2316835A1; 3983-EP2316836A1; 3983-EP2372017A1; 3983-EP2374454A1; 3983-EP2374783A1; 3983-EP2374790A1; 3983-EP2374792A1; 3983-EP2380568A1; A14564; Benzyl alcohol, SAJ special grade, >=99.0%; Benzyl alcohol, Vetec(TM) reagent grade, 98%; C00556; C03485; D00077; Q52353; AB01563201_01; A800221; SR-01000872610; J-000153; SR-01000872610-3; F0001-0019; Z955123784; 3762963D-6C2A-4BFF-AD94-3180E51BCA68; Benzyl alcohol, certified reference material, TraceCERT(R); Benzyl alcohol, European Pharmacopoeia (EP) Reference Standard; Benzyl alcohol, puriss. p.a., ACS reagent, >=99.0% (GC); Benzyl alcohol, United States Pharmacopeia (USP) Reference Standard; (Hydroxymethyl)polystyrene, 200-400 mesh, extent of labeling: ~1.7 mmol/g loading; (Hydroxymethyl)polystyrene, 200-500 mesh, extent of labeling: ~1.1 mmol/g loading; Benzyl alcohol, Pharmaceutical Secondary Standard; Certified Reference Material; Benzyl alcohol, PharmaGrade, USP/NF, Ph Eur, Manufactured under appropriate GMP controls for pharma or biopharmaceutical production.; Benzyl alcohol, polymer-bound, 100-200 mesh, extent of labeling: 0.5-1.0 mmol/g loading, 1 % cross-linked; Benzyl alcohol, polymer-bound, 100-200 mesh, extent of labeling: 1.0-2.0 mmol/g loading, 1 % cross-linked with divinylbenzene; Benzyl alcohol, polymer-bound, 70-90 mesh, extent of labeling: 0.5-1.0 mmol/g loading, 1 % cross-linked with divinylbenzene; Benzyl alcohol, polymer-bound, 70-90 mesh, extent of labeling: 1.0-1.5 mmol/g loading, 1 % cross-linked; Benzyl alcohol, polymer-bound, 70-90 mesh, extent of labeling: 2.0-3.0 mmol loading, 1 % cross-linked; Benzyl alcohol, puriss., meets analytical specification of Ph.??Eur., BP, NF, 99-100.5% (GC); StratoSpheres(TM) PL-HMS (Hydroxymethylstyrene) resin, 50-100 mesh, extent of labeling: 2.0 mmol loading, 1 % cross-linked
DIG Function	Antimicrobial preservative; Solvent
PubChem CID	244
Formula	C7H8O
Canonical SMILES	C1=CC=C(C=C1)CO
InChI	1S/C7H8O/c8-6-7-4-2-1-3-5-7/h1-5,8H,6H2
InChIKey	WVDDGKGOMKODPV-UHFFFAOYSA-N
	Click to Show/Hide the Molecular Data (Structure/Property) of This DIG
Structure	<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=244"></iframe>
Structure	3D MOL		2D MOL
Physicochemical Properties	Molecular Weight	108.14	Topological Polar Surface Area	20.2
	XlogP	1.1	Complexity	55.4
	Heavy Atom Count	8	Rotatable Bond Count	1
	Hydrogen Bond Donor Count	1	Hydrogen Bond Acceptor Count	1

Full List of Active Pharmaceutical Ingredients (APIs) Co-administrated with This DIG
ICD Disease Classification 01		Infectious/parasitic disease	Click to Show/Hide
Tetracycline	API Info	Spotted fever [ICD-11: 1C31]		[1]
ICD Disease Classification 02		Benign/in-situ/malignant neoplasm	Click to Show/Hide
Hydroxyurea	API Info	Chronic myelogenous leukaemia [ICD-11: 2A20]		[2]
ICD Disease Classification 04		Immune system disease	Click to Show/Hide
Cetirizine	API Info	Allergy [ICD-11: 4A80]		[3]
ICD Disease Classification 05		Endocrine/nutritional/metabolic disease	Click to Show/Hide
Ergocalciferol	API Info	Hypoparathyroidism [ICD-11: 5A50]		[4]
Fluvastatin	API Info	Hypertriglyceridaemia [ICD-11: 5C80]		[5]
ICD Disease Classification 06		Mental/behavioural/neurodevelopmental disorder	Click to Show/Hide
Olanzapine	API Info	Schizophrenia [ICD-11: 6A20]		[6]
Nortriptyline	API Info	Major depressive disorder [ICD-11: 6A70]		[7]
Loxapine	API Info	Schizophrenia [ICD-11: 6A20]		[8]
Trimipramine	API Info	Major depressive disorder [ICD-11: 6A70]		[9]
Oxazepam	API Info	Anxiety disorder [ICD-11: 6B00]		[10]
Cycloserine	API Info	Dementia [ICD-11: 6D8Z]		[11]
ICD Disease Classification 07		Sleep-wake disorder	Click to Show/Hide
Temazepam	API Info	Insomnia [ICD-11: 7A00]		[12]
ICD Disease Classification 08		Nervous system disease	Click to Show/Hide
Acetaminophen	API Info	Anaesthesia [ICD-11: 8E22]		[13]
Phenytoin	API Info	Epilepsy [ICD-11: 8A60]		[14]
ICD Disease Classification 10		Ear/mastoid process disease	Click to Show/Hide
Diphenhydramine	API Info	Meniere disease [ICD-11: AB31]		[15]
ICD Disease Classification 12		Respiratory system disease	Click to Show/Hide
Montelukast	API Info	Asthma [ICD-11: CA23]		[16]
Ceftibuten	API Info	Bronchitis [ICD-11: CA20]		[17]
ICD Disease Classification 13		Digestive system disease	Click to Show/Hide
Omeprazole	API Info	Gastro-oesophageal reflux disease [ICD-11: DA22]		[18]
ICD Disease Classification 15		Musculoskeletal/connective-tissue disease	Click to Show/Hide
Auranofin	API Info	Rheumatoid arthritis [ICD-11: FA20]		[19]

Full List of Biological Targets of DIG (DBTs) Regulated by This DIG
Oxidoreductase (ORase)
DBT Name: Indoleamine 2,3-dioxygenase 1 (IDO1)		Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Biological Activity	IC50 = 1400 nM (estimated based on the structural similarity with CHEMBL3763371 )		[20]
Structural Similarity	Tanimoto coefficient = 0.848101266
Tested Species	Homo sapiens (Human)
UniProt ID	I23O1_HUMAN

References
1	FDA label for approved tetracycline from the official website of the U.S. Food and Drug Administration.
2	FDA label for approved hydroxyurea from the official website of the U.S. Food and Drug Administration.
3	FDA label for approved cetirizine from the official website of the U.S. Food and Drug Administration.
4	FDA label for approved ergocalciferol from the official website of the U.S. Food and Drug Administration.
5	FDA label for approved fluvastatin from the official website of the U.S. Food and Drug Administration.
6	FDA label for approved olanzapine from the official website of the U.S. Food and Drug Administration.
7	FDA label for approved nortriptyline from the official website of the U.S. Food and Drug Administration.
8	FDA label for approved loxapine from the official website of the U.S. Food and Drug Administration.
9	FDA label for approved trimipramine from the official website of the U.S. Food and Drug Administration.
10	FDA label for approved oxazepam from the official website of the U.S. Food and Drug Administration.
11	FDA label for approved cycloserine from the official website of the U.S. Food and Drug Administration.
12	FDA label for approved temazepam from the official website of the U.S. Food and Drug Administration.
13	FDA label for approved acetaminophen from the official website of the U.S. Food and Drug Administration.
14	FDA label for approved phenytoin from the official website of the U.S. Food and Drug Administration.
15	FDA label for approved diphenhydramine from the official website of the U.S. Food and Drug Administration.
16	FDA label for approved montelukast from the official website of the U.S. Food and Drug Administration.
17	FDA label for approved ceftibuten from the official website of the U.S. Food and Drug Administration.
18	FDA label for approved omeprazole from the official website of the U.S. Food and Drug Administration.
19	FDA label for approved auranofin from the official website of the U.S. Food and Drug Administration.
20	O-alkylhydroxylamines as rationally-designed mechanism-based inhibitors of indoleamine 2,3-dioxygenase-1. Eur J Med Chem. 2016 Jan 27; 108:564-576.

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