Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D01382)
Name
Remimazolam
Synonyms    Click to Show/Hide the Synonyms of This API
Remimazolam; 308242-62-8; CNS 7056; UNII-7V4A8U16MB; CNS-7056; 7V4A8U16MB; ONO-2745; 308242-62-8 (freee base); 4H-Imidazo[1,2-a][1,4]benzodiazepine-4-propanoic acid, 8-bromo-1-methyl-6-(2-pyridinyl)-, methyl ester, (4S)-; methyl (S)-3-(8-bromo-1-methyl-6-(pyridin-2-yl)-4H-benzo[f]imidazo[1,2-a][1,4]diazepin-4-yl)propanoate; methyl 3-[(4S)-8-bromo-1-methyl-6-pyridin-2-yl-4H-imidazo[1,2-a][1,4]benzodiazepin-4-yl]propanoate; 4H-Imidazo(1,2-a)(1,4)benzodiazepine-4-propanoic acid, 8-bromo-1-methyl-6-(2-pyridinyl)-, methyl ester, (4S)-; Remimazolam (USAN/INN); Remimazolam [USAN:INN]; SCHEMBL846435; IMI030; CHEMBL4297526; DTXSID20953024; ONO2745; AMY15524; ONO 2745; WHO 9232; ZINC3927450; AKOS025213215; DB12404; SB17134; HY-14867; 4523B; CS-0003605; D11788; 97896-EP2305647A1; (S)-methyl 3-(8-bromo-1-methyl-6-(pyridin-2-yl)-4H-benzo[f]imidazo[1,2-a][1,4]diazepin-4-yl)propanoate; 3-[(4S)-8-bromo-1-methyl-6-(2-pyridinyl)-4H-imidazo[1,2-a][1,4]benzodiazepine-4-yl]-propionic acid methyl ester; Methyl 3-[(4S)-8-bromo-1-methyl-6-(2-pyridyl)-4H-imidazo[1,2-a][1,4]benzodiazepin-4-yl]propanoate; Methyl 3-[8-bromo-1-methyl-6-(pyridin-2-yl)-4H-imidazo[1,2-a][1,4]benzodiazepin-4-yl]propanoate
Clinical Status
Approved
PubChem CID
9867812
Formula
C21H19BrN4O2
Canonical SMILES
CC1=CN=C2N1C3=C(C=C(C=C3)Br)C(=N[C@H]2CCC(=O)OC)C4=CC=CC=N4
InChI
1S/C21H19BrN4O2/c1-13-12-24-21-17(7-9-19(27)28-2)25-20(16-5-3-4-10-23-16)15-11-14(22)6-8-18(15)26(13)21/h3-6,8,10-12,17H,7,9H2,1-2H3/t17-/m0/s1
InChIKey
CYHWMBVXXDIZNZ-KRWDZBQOSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=9867812"></iframe>
3D MOL is unavailable 2D MOL
Physicochemical Properties Molecular Weight 439.3 Topological Polar Surface Area 69.4
XlogP 3.4 Complexity 601
Heavy Atom Count 28 Rotatable Bond Count 5
Hydrogen Bond Donor Count 0 Hydrogen Bond Acceptor Count 5
Full List of Drug Formulations (DFMs) Containing This API
          Remimazolam 20 mg For Injection Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Dextran 40; Lactose Monohydrate; Hydrochloric Acid; Sodium Hydroxide
                   Dosage Form For Injection
                   Company Acacia Pharma
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Hydrochloric acid DIG Info Carbonic anhydrase V (Ki = 156 nM) [1]
References
1 Carbonic anhydrase inhibitors. Inhibition of the newly isolated murine isozyme XIII with anions. Bioorg Med Chem Lett. 2004 Nov 1; 14(21):5435-9.

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