Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D01394)
Name
Rimexolone
Synonyms    Click to Show/Hide the Synonyms of This API
RIMEXOLONE; Vexol; 49697-38-3; Org-6216; Org 6216; UNII-O7M2E4264D; MLS002154105; Rimexel; O7M2E4264D; Trimexolone; Rimexolona; Rimexolonum; Rimexolon; (8S,9S,10R,11S,13S,14S,16R,17S)-11-hydroxy-10,13,16,17-tetramethyl-17-propionyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one; Rimexolonum [INN-Latin]; Rimexolona [INN-Spanish]; Rimexolone [USAN:USP:INN:BAN]; Vexol (TN); AL 02178; Rimexolone (USP/INN); Prestwick0_001020; Prestwick1_001020; Prestwick2_001020; Prestwick3_001020; BSPBio_001179; SCHEMBL445300; SPBio_003050; BPBio1_001297; GTPL7099; CHEMBL1200617; CHEBI:135566; HMS1571K21; HMS2098K21; HMS2235B18; HMS3715K21; ZINC3945984; 11beta-Hydroxy-16alpha,17,21-trimethyl-1,4-pregnadien-3,20-dion; BDBM50103606; 11beta-Hydroxy-16alpha,17alpha-dimethyl-17-propionylandrosta-1,4-dien-3-one; AL-2178; CCG-221020; DB00896; NCGC00179273-01; (8S,9S,10R,11S,13S,14S,16R,17S)-11-hydroxy-10,13,16,17-tetramethyl-17-propanoyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one; SMR001233413; AB00514006; D05729; 697R383; SR-01000841221; Q7334443; SR-01000841221-2; BRD-K31627533-001-03-8; (11beta,16alpha,17beta)-11-Hydroxy-16,17-dimethyl-17-(1-oxopropyl)androsta-1,4-dien-3-one; Androsta-1,4-dien-3-one, 11-hydroxy-16,17-dimethyl-17-(1-oxopropyl)-, (11beta,16alpha,17beta)-
Clinical Status
Approved
PubChem CID
5311412
Formula
C24H34O3
Canonical SMILES
CCC(=O)[C@]1([C@@H](C[C@@H]2[C@@]1(C[C@@H]([C@H]3[C@H]2CCC4=CC(=O)C=C[C@]34C)O)C)C)C
InChI
1S/C24H34O3/c1-6-20(27)24(5)14(2)11-18-17-8-7-15-12-16(25)9-10-22(15,3)21(17)19(26)13-23(18,24)4/h9-10,12,14,17-19,21,26H,6-8,11,13H2,1-5H3/t14-,17+,18+,19+,21-,22+,23+,24-/m1/s1
InChIKey
QTTRZHGPGKRAFB-OOKHYKNYSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=5311412"></iframe>
3D MOL is unavailable 2D MOL
Physicochemical Properties Molecular Weight 370.5 Topological Polar Surface Area 54.4
XlogP 3.5 Complexity 749
Heavy Atom Count 27 Rotatable Bond Count 2
Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 3
Full List of Drug Formulations (DFMs) Containing This API
          Rimexolone 1% suspension Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Carbomer 974P; Polysorbate 80; Sodium Chloride; Edetate Disodium; Sodium Hydroxide; Hydrochloric Acid; Purified Water
                   Dosage Form Suspension
                   Company Eyevance
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Hydrochloric acid DIG Info Carbonic anhydrase V (Ki = 156 nM) [1]
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [2]
References
1 Carbonic anhydrase inhibitors. Inhibition of the newly isolated murine isozyme XIII with anions. Bioorg Med Chem Lett. 2004 Nov 1; 14(21):5435-9.
2 The activities of drug inactive ingredients on biological targets. Science. 2020 Jul 24;369(6502):403-413.

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