Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D01439)
Name
Sparfloxacin
Synonyms    Click to Show/Hide the Synonyms of This API
sparfloxacin; 110871-86-8; Zagam; AT-4140; CI-978; Spara; CI 978; SPFX; PD-131501; AT 4140; PD 131501; UNII-Q90AGA787L; CHEBI:9212; MFCD00869619; 5-amino-1-cyclopropyl-7-((3S,5R)-3,5-dimethylpiperazin-1-yl)-6,8-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; 5-amino-1-cyclopropyl-7-[(3R,5S)-3,5-dimethylpiperazin-1-yl]-6,8-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; Q90AGA787L; 5-Amino-1-cyclopropyl-7-(cis-3,5-dimethyl-1-piperazinyl)-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid; 5-amino-1-cyclopropyl-7-[(3R,5S)-3,5-dimethylpiperazin-1-yl]-6,8-difluoro-4-oxoquinoline-3-carboxylic acid; cis-5-Amino-1-cyclopropyl-7-(3,5-dimethyl-1-piperazinyl)-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid; Esparfloxacino; Sparfloxacine; Sparfloxacinum; 111542-93-9; DSSTox_CID_3590; DSSTox_RID_77097; DSSTox_GSID_23590; 5-amino-1-cyclopropyl-7-((3R,5S)-3,5-dimethylpiperazin-1-yl)-6,8-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; Sparfloxacine [INN-French]; Sparfloxacinum [INN-Latin]; DRG-0143; Esparfloxacino [INN-Spanish]; Parox; 5-amino-1-cyclopropyl-7-[(3S,5R)-3,5-dimethylpiperazin-1-yl]-6,8-difluoro-4-oxo-quinoline-3-carboxylic acid; CAS-110871-86-8; Zagam (TN); CP 103826; SR-05000001521; BRN 3658018; Sparfloxacin & RU 40555; PD 1315-1; Sparfloxacin (JAN/USAN/INN); Liposome-encapsulated sparfloxacin; Sparfloxacin,(S); NCGC00159333-02; Sparfloxacin [USAN:INN:BAN:JAN]; Sparfloxacinhydrochloride; PD131501; RP-64206; CP-103826; CHEMBL850; Epitope ID:119065; SCHEMBL41311; MLS000759417; DTXSID9023590; GTPL10860; CI978; HMS2090N19; HMS3715J13; ZINC538362; BCP23886; HY-B0308; RKL10082; Sparfloxacin, >=98.0% (HPLC); Tox21_111580; AT4140; BBL010957; BDBM50366822; s1884; STK802067; AKOS005622503; Tox21_111580_1; CCG-221166; DB01208; KS-5009; MCULE-1827276157; NCGC00166294-01; NCGC00166294-02; NCGC00166294-03; 3-Quinolinecarboxylic acid, 1,4-dihydro-5-amino-1-cyclopropyl-6,8-difluoro-7-(3,5-dimethyl-1-piperazinyl)-4-oxo-, cis-; 3-Quinolinecarboxylic acid, 5-amino-1-cyclopropyl-7-(3,5-dimethyl-1-piperazinyl)-6,8-difluoro-1,4-dihydro-4-oxo-, cis-; 5-Amino-1-cyclohexyl-7-(cis-3,5-dimethylpiperazino)-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid; AC-11574; SMR000466312; S0896; SW199632-2; C07662; D00590; AB00639950-02; AB00639950_03; Sparfloxacin, VETRANAL(TM), analytical standard; 871S868; A802376; Q976559; SR-01000759357; Sparfloxacin, Antibiotic for Culture Media Use Only; SR-01000759357-2; SR-05000001521-1; SR-05000001521-2; BRD-K07612980-001-07-9; 4-BROMO-1-(TERT-BUTYL)-3-METHYL-1H-PYRAZOLE-5-CARBOXYLICACID; 5-amino-1-cyclopropyl-6,8-difluoro-7-(cis-3,5-dimethyl-1-piperazinyl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid; 5-Amino-1-cyclopropyl-7-(cis-3,5-dimethyl)-6,8- difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid & RU 40555; 5-Amino-1-cyclopropyl-7-(cis-3,5-dimethyl-1-piperazinyl)-6,8-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic Acid; 5-amino-1-cyclopropyl-7-[(3R,5S)-3,5-dimethylpiperazin-1-yl]-6,8-difluoro-4-oxo-quinoline-3-carboxylic acid; 5-amino-1-cyclopropyl-7-[(3S,5R)-3,5-dimethyl-1-piperazinyl]-6,8-difluoro-4-oxo-3-quinolinecarboxylic acid; 5-amino-1-cyclopropyl-7-[(3S,5R)-3,5-dimethylpiperazin-1-yl]-6,8-difluoro-4-oxoquinoline-3-carboxylic acid; 5-azanyl-1-cyclopropyl-7-[(3S,5R)-3,5-dimethylpiperazin-1-yl]-6,8-bis(fluoranyl)-4-oxidanylidene-quinoline-3-carboxylic acid; AT-4140 pound>>CI-978 pound>>CI 978 pound>>CI978 pound>>AT 4140 pound>>AT4140 pound>>PD 131501 pound>>PD131501 pound>>PD-131501
Clinical Status
Approved
PubChem CID
60464
Formula
C19H22F2N4O3
Canonical SMILES
C[C@@H]1CN(C[C@@H](N1)C)C2=C(C(=C3C(=C2F)N(C=C(C3=O)C(=O)O)C4CC4)N)F
InChI
1S/C19H22F2N4O3/c1-8-5-24(6-9(2)23-8)17-13(20)15(22)12-16(14(17)21)25(10-3-4-10)7-11(18(12)26)19(27)28/h7-10,23H,3-6,22H2,1-2H3,(H,27,28)/t8-,9+
InChIKey
DZZWHBIBMUVIIW-DTORHVGOSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=60464"></iframe>
3D MOL is unavailable 2D MOL
Physicochemical Properties Molecular Weight 392.4 Topological Polar Surface Area 98.9
XlogP 0.1 Complexity 691
Heavy Atom Count 28 Rotatable Bond Count 3
Hydrogen Bond Donor Count 3 Hydrogen Bond Acceptor Count 9
Full List of Drug Formulations (DFMs) Containing This API
          Sparfloxacin 200mg tablet Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Cornstarch; L-Hydroxypropylcellulose; Magnesium Stearate; Colloidal Silicone Dioxide
                   Dosage Form Tablet
                   Company Mylan
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [1]
Pregelatinized starch DIG Info Multidrug resistance protein 1 (Protein expression downregulation) [1]
References
1 Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12.

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