General Information of DIG (ID: E0ST5E)
DIG Name	Pregelatinized starch
DIG Function	Binding agent; Diluent; Disintegrant

Full List of Active Pharmaceutical Ingredients (APIs) Co-administrated with This DIG
ICD Disease Classification 01			Infectious/parasitic disease		Click to Show/Hide
Ciprofloxacin		API Info	Endocarditis [ICD-11: 1B12]			[1]
Bedaquiline		API Info	Pulmonary tuberculosis [ICD-11: 1B10]			[2]
ICD Disease Classification 02			Benign/in-situ/malignant neoplasm		Click to Show/Hide
Panobinostat		API Info	Multiple myeloma [ICD-11: 2A83]			[3]
Tamoxifen		API Info	Breast cancer [ICD-11: 2C60]			[4]
Alectinib		API Info	Lung cancer [ICD-11: 2C25]			[5]
ICD Disease Classification 05			Endocrine/nutritional/metabolic disease		Click to Show/Hide
Atorvastatin		API Info	Hyperlipidaemia [ICD-11: 5C8Z]			[6]
Pravastatin		API Info	Dyslipidaemia [ICD-11: 5C81]			[7]
Cysteamine		API Info	Nephropathic cystinosis [ICD-11: 5C60]			[8]
ICD Disease Classification 06			Mental/behavioural/neurodevelopmental disorder		Click to Show/Hide
Fluoxetine		API Info	Major depressive disorder [ICD-11: 6A70]			[9]
Cyclobenzaprine		API Info	Major depressive disorder [ICD-11: 6A70]			[10]
Trazodone		API Info	Major depressive disorder [ICD-11: 6A70]			[11]
Buprenorphine		API Info	Opiate dependence [ICD-11: 6C43]			[12]
Cariprazine		API Info	Bipolar disorder [ICD-11: 6A60]			[13]
Lurasidone		API Info	Schizophrenia [ICD-11: 6A20]			[14]
ICD Disease Classification 08			Nervous system disease		Click to Show/Hide
Tiagabine		API Info	Epilepsy [ICD-11: 8A60]			[15]
Valbenazine		API Info	Dyskinesia [ICD-11: 8A02]			[16]
Pimavanserin		API Info	Parkinsonism [ICD-11: 8A00]			[17]
ICD Disease Classification 11			Circulatory system disease		Click to Show/Hide
Losartan		API Info	Essential hypertension [ICD-11: BA00]			[18]
Benazepril		API Info	Essential hypertension [ICD-11: BA00]			[19]
Midodrine		API Info	Orthostatic hypotension [ICD-11: BA21]			[20]
Labetalol		API Info	Essential hypertension [ICD-11: BA00]			[21]
Acebutolol		API Info	Essential hypertension [ICD-11: BA00]			[22]
Disopyramide		API Info	Ventricular tachyarrhythmia [ICD-11: BC71]			[23]
Bisoprolol		API Info	Essential hypertension [ICD-11: BA00]			[24]
Penbutolol		API Info	Essential hypertension [ICD-11: BA00]			[25]
Dronedarone		API Info	Atrial fibrillation [ICD-11: BC81]			[26]
Eprosartan		API Info	Essential hypertension [ICD-11: BA00]			[27]
Ivabradine		API Info	Angina pectoris [ICD-11: BA40]			[28]
Moexipril		API Info	Essential hypertension [ICD-11: BA00]			[29]
ICD Disease Classification 12			Respiratory system disease		Click to Show/Hide
Fexofenadine		API Info	Allergic rhinitis [ICD-11: CA08]			[30]
Cefpodoxime		API Info	Bronchitis [ICD-11: CA20]			[31]
Terbutaline		API Info	Asthma [ICD-11: CA23]			[32]
ICD Disease Classification 13			Digestive system disease		Click to Show/Hide
Ondansetron		API Info	Gastritis [ICD-11: DA42]			[33]
Famotidine		API Info	Peptic ulcer [ICD-11: DA61]			[34]
Chenodeoxycholic acid		API Info	Cholelithiasis [ICD-11: DC11]			[35]
Rolapitant		API Info	Functional nausea/vomiting [ICD-11: DD90]			[36]
ICD Disease Classification 15			Musculoskeletal/connective-tissue disease		Click to Show/Hide
Tolmetin		API Info	Rheumatoid arthritis [ICD-11: FA20]			[37]
Raloxifene		API Info	Osteoporosis [ICD-11: FB83]			[38]
ICD Disease Classification 16			Genitourinary system disease		Click to Show/Hide
Terazosin		API Info	Prostatic hyperplasia [ICD-11: GA90]			[39]
Prazosin		API Info	Prostatic hyperplasia [ICD-11: GA90]			[40]

Full List of Biological Targets of DIG (DBTs) Regulated by This DIG
Oxidoreductase (ORase)
DBT Name: Albendazole monooxygenase (CYP3A4)			Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment (1) for Assessing the Biological Activity of the Studied DIG on This DBT
Biological Activity	Protein expression downregulation (tested by experiment)				[41]
Tested Species	Homo sapiens (Human)
UniProt ID	CP3A4_HUMAN
Experiment (2) for Assessing the Biological Activity of the Studied DIG on This DBT
Biological Activity	Protein expression downregulation (tested by experiment)				[41]
Tested Species	Homo sapiens (Human)
UniProt ID	CP3A4_HUMAN
Primary active transporter (PAT)
DBT Name: Multidrug resistance protein 1 (ABCB1)			Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Biological Activity	Protein expression downregulation (tested by experiment)				[41]
Tested Species	Homo sapiens (Human)
UniProt ID	MDR1_HUMAN

References
1	FDA label for approved ciprofloxacin from the official website of the U.S. Food and Drug Administration.
2	FDA label for approved bedaquiline from the official website of the U.S. Food and Drug Administration.
3	FDA label for approved panobinostat from the official website of the U.S. Food and Drug Administration.
4	FDA label for approved tamoxifen from the official website of the U.S. Food and Drug Administration.
5	FDA label for approved alectinib from the official website of the U.S. Food and Drug Administration.
6	FDA label for approved atorvastatin from the official website of the U.S. Food and Drug Administration.
7	FDA label for approved pravastatin from the official website of the U.S. Food and Drug Administration.
8	FDA label for approved cysteamine from the official website of the U.S. Food and Drug Administration.
9	FDA label for approved fluoxetine from the official website of the U.S. Food and Drug Administration.
10	FDA label for approved cyclobenzaprine from the official website of the U.S. Food and Drug Administration.
11	FDA label for approved trazodone from the official website of the U.S. Food and Drug Administration.
12	FDA label for approved buprenorphine from the official website of the U.S. Food and Drug Administration.
13	FDA label for approved cariprazine from the official website of the U.S. Food and Drug Administration.
14	FDA label for approved lurasidone from the official website of the U.S. Food and Drug Administration.
15	FDA label for approved tiagabine from the official website of the U.S. Food and Drug Administration.
16	FDA label for approved valbenazine from the official website of the U.S. Food and Drug Administration.
17	FDA label for approved pimavanserin from the official website of the U.S. Food and Drug Administration.
18	FDA label for approved losartan from the official website of the U.S. Food and Drug Administration.
19	FDA label for approved benazepril from the official website of the U.S. Food and Drug Administration.
20	FDA label for approved midodrine from the official website of the U.S. Food and Drug Administration.
21	FDA label for approved labetalol from the official website of the U.S. Food and Drug Administration.
22	FDA label for approved acebutolol from the official website of the U.S. Food and Drug Administration.
23	FDA label for approved disopyramide from the official website of the U.S. Food and Drug Administration.
24	FDA label for approved bisoprolol from the official website of the U.S. Food and Drug Administration.
25	FDA label for approved penbutolol from the official website of the U.S. Food and Drug Administration.
26	FDA label for approved dronedarone from the official website of the U.S. Food and Drug Administration.
27	FDA label for approved eprosartan from the official website of the U.S. Food and Drug Administration.
28	FDA label for approved ivabradine from the official website of the U.S. Food and Drug Administration.
29	FDA label for approved moexipril from the official website of the U.S. Food and Drug Administration.
30	FDA label for approved fexofenadine from the official website of the U.S. Food and Drug Administration.
31	FDA label for approved cefpodoxime from the official website of the U.S. Food and Drug Administration.
32	FDA label for approved terbutaline from the official website of the U.S. Food and Drug Administration.
33	FDA label for approved ondansetron from the official website of the U.S. Food and Drug Administration.
34	FDA label for approved famotidine from the official website of the U.S. Food and Drug Administration.
35	FDA label for approved chenodeoxycholic acid from the official website of the U.S. Food and Drug Administration.
36	FDA label for approved rolapitant from the official website of the U.S. Food and Drug Administration.
37	FDA label for approved tolmetin from the official website of the U.S. Food and Drug Administration.
38	FDA label for approved raloxifene from the official website of the U.S. Food and Drug Administration.
39	FDA label for approved terazosin from the official website of the U.S. Food and Drug Administration.
40	FDA label for approved prazosin from the official website of the U.S. Food and Drug Administration.
41	Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12.

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