Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D01508)
Name
Tropicamide
Synonyms    Click to Show/Hide the Synonyms of This API
tropicamide; 1508-75-4; Mydriacyl; Mydriaticum; N-ethyl-3-hydroxy-2-phenyl-N-(pyridin-4-ylmethyl)propanamide; Tropicamidum; Ro 1-7683; N-Ethyl-2-phenyl-N-(4-pyridylmethyl)hydracrylamide; Mydriafair; Tropicacyl; Minims tropicamide; Bistropamide; Epitromina; Tropikamid; Mydrum; Visumidriatic; Tropimil; Benzeneacetamide, N-ethyl-alpha-(hydroxymethyl)-N-(4-pyridinylmethyl)-; MFCD00058580; NCGC00016065-07; Tropicamida; Benzeneacetamide, N-ethyl-.alpha.-(hydroxymethyl)-N-(4-pyridinylmethyl)-; DSSTox_CID_25220; DSSTox_RID_80757; DSSTox_GSID_45220; Tropicamidum [INN-Latin]; Tropicamida [INN-Spanish]; Tropicamid; Mydriacyl (TN); N-Ethyl-N-(4-pyridylmethyl)tropamid; N-Ethyl-N-(4-pyridylmethyl)tropamide; SMR000058523; SR-01000075351; EINECS 216-140-2; N-Ethyl-alpha-(hydroxymethyl)-N-(4-pyridinylmethyl)benzeneacetamide; BRN 0285563; Tropicamide, solid; Prestwick_487; CAS-1508-75-4; component of Paremyd; Hydracrylamide, N-ethyl-2-phenyl-N-(4-pyridylmethyl)-; Tropicamide [USAN:USP:INN:BAN:JAN]; (+-)-N-Ethyl-2-phenyl-N-(4-pyridylmethyl)hydracrylamide; Spectrum_000584; Prestwick0_000228; Prestwick1_000228; Prestwick2_000228; Prestwick3_000228; Spectrum2_000936; Spectrum3_000655; Spectrum4_000377; Spectrum5_001585; T 9778; Lopac0_001223; SCHEMBL23975; BSPBio_000275; BSPBio_002289; KBioGR_000873; KBioSS_001064; 5-22-09-00359 (Beilstein Handbook Reference); MLS001306442; MLS002154240; DivK1c_000448; SPECTRUM1500599; SPBio_000872; SPBio_002196; BPBio1_000303; CHEBI:9757; GTPL7319; Tropicamide (JP17/USP/INN); CHEMBL1200604; DTXSID8045220; BDBM82371; HMS501G10; KBio1_000448; KBio2_001064; KBio2_003632; KBio2_006200; KBio3_001509; N-ethyl-3-hydroxy-2-phenyl-N-(4-pyridylmethyl)propanamide; NINDS_000448; HMS1568N17; HMS1921I09; HMS2089M05; HMS2092A18; HMS2095N17; HMS2235J15; HMS3259M18; HMS3263F08; HMS3267A13; HMS3373B07; HMS3411F14; HMS3651K04; HMS3675F14; HMS3712N17; HMS3742C05; HMS3884E16; Pharmakon1600-01500599; BCP13504; EBD22886; HY-B0321; NSC_5593; Tox21_110297; Tox21_501223; AC-816; BBL028074; CCG-40076; NSC757372; s1913; STK934612; AKOS005664076; Tox21_110297_1; ACN-036667; AM84467; DB00809; KS-5174; LP01223; MCULE-4102613027; NC00589; NSC-757372; SDCCGSBI-0051190.P004; Benzeneacetamide, N-ethyl-alpha-(hydroxymethyl)-N-(4-pyridinylmethyl)-, (+-)-; IDI1_000448; SMP1_000304; NCGC00016065-03; NCGC00016065-04; NCGC00016065-05; NCGC00016065-06; NCGC00016065-08; NCGC00016065-09; NCGC00016065-11; NCGC00016065-22; NCGC00024866-02; NCGC00024866-03; NCGC00024866-04; NCGC00024866-05; NCGC00024866-06; NCGC00261908-01; AK164485; CAS_1508-75-4; SBI-0051190.P003; AB0011259; RO-1-7683; AB00052120; EU-0101223; FT-0657590; ST51015162; SW196691-3; D00397; K-4793; Q29310; AB00052120-10; AB00052120_11; AB00052120_12; 508T754; L001262; Q-201902; SR-01000075351-1; SR-01000075351-3; SR-01000075351-5; SR-01000075351-7; BRD-A79672927-001-05-8; BRD-A79672927-001-10-8; Tropicamide, European Pharmacopoeia (EP) Reference Standard; N-Ethyl-3-hydroxy-2-phenyl-N-(4-pyridinylmethyl)propanamide #; Tropicamide, United States Pharmacopeia (USP) Reference Standard; Tropicamide for peak identification, European Pharmacopoeia (EP) Reference Standard
Clinical Status
Approved
PubChem CID
5593
Formula
C17H20N2O2
Canonical SMILES
CCN(CC1=CC=NC=C1)C(=O)C(CO)C2=CC=CC=C2
InChI
1S/C17H20N2O2/c1-2-19(12-14-8-10-18-11-9-14)17(21)16(13-20)15-6-4-3-5-7-15/h3-11,16,20H,2,12-13H2,1H3
InChIKey
BGDKAVGWHJFAGW-UHFFFAOYSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=5593"></iframe>
3D MOL is unavailable 2D MOL
Physicochemical Properties Molecular Weight 284.35 Topological Polar Surface Area 53.4
XlogP 1.5 Complexity 310
Heavy Atom Count 21 Rotatable Bond Count 6
Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 3
Full List of Drug Formulations (DFMs) Containing This API
          Tropicamide 1% solution Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Benzalkonium Chloride; Sodium Chloride; Edetate Disodium; Hydrochloric Acid; Sodium Hydroxide; Water
                   Dosage Form Solution
                   Company Alcon Laboratories
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Hydrochloric acid DIG Info Carbonic anhydrase V (Ki = 156 nM) [1]
Benzalkonium chloride DIG Info Solute carrier SLCO2B1 (Ki = 62.1 uM) [2]
          Tropicamide 0.5% solution Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Benzalkonium Chloride; Sodium Chloride; Edetate Disodium; Hydrochloric Acid; Sodium Hydroxide; Water
                   Dosage Form Solution
                   Company Sandoz
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Hydrochloric acid DIG Info Carbonic anhydrase V (Ki = 156 nM) [1]
Benzalkonium chloride DIG Info Solute carrier SLCO2B1 (Ki = 62.1 uM) [2]
References
1 Carbonic anhydrase inhibitors. Inhibition of the newly isolated murine isozyme XIII with anions. Bioorg Med Chem Lett. 2004 Nov 1; 14(21):5435-9.
2 Bacterial metabolism rescues the inhibition of intestinal drug absorption by food and drug additives. Proc Natl Acad Sci U S A. 2020 Jul 7;117(27):16009-16018.

If you find any error in data or bug in web service, please kindly report it to Dr. Zhang and Dr. Mou.