Details of the Active Pharmaceutical Ingredient (API)
General Information of API (ID: D00074) | |||||
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Name |
Bosentan
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Synonyms |
Click to Show/Hide the Synonyms of This API
Bosentan; 147536-97-8; Tracleer; Ro 47-0203; Ro-47-0203; C27H29N5O6S; Bosentan [USAN:INN:BAN]; 4-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-pyrimidin-2-ylpyrimidin-4-yl]benzenesulfonamide; UNII-XUL93R30K2; p-tert-Butyl-N-(6-(2-hydroxyethoxy)-5-(o-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl)benzenesulfonamide; CHEMBL957; XUL93R30K2; Actelion; CHEBI:51450; 147536-97-8 (free); NCGC00167440-01; bosentan anhydrous; DSSTox_CID_26627; DSSTox_RID_81776; DSSTox_GSID_46627; 4-(1,1-Dimethylethyl)-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-(2,2'-bipyrimidin)-4-yl) benzenesulfornamide; 4-(tert-butyl)-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-[2,2'-bipyrimidin]-4-yl)benzenesulfonamide; 4-tert-butyl-N-[6-(2-hydroxyethyloxy)-5-(2-methoxyphenoxy)-2-pyrimidin-2-yl-pyrimidin-4-yl]benzenesulfonamide; Benzenesulfonamide, 4-(1,1-dimethylethyl)-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)(2,2'-bipyrimidin)-4-yl)-; bosentanum; Bosentan (INN); 4-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl]benzenesulfonamide; Benzenesulfonamide, 4-(1,1-dimethylethyl)-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)[2,2'-bipyrimidin]-4-yl]-; CAS-147536-97-8; Ro 47-0203/039; SR-05000001532; Ro 47-0203/029; 4-tert-butyl-n-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl)benzenesulfonamide; 4-(1,1-Dimethylethyl)-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-(2,2'-bipyrimidin)-4-yl)benzenesulfornamide; KS-5062; PubChem19119; Ro-47-0203/029; Ro-47-0203/039; SCHEMBL4218; N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-pyrimidin-2-yl-pyrimidin-4-yl]-4-tert-butyl-benzenesulfonamide; GTPL3494; DTXSID7046627; HMS2090N14; HMS3652F15; HMS3715N05; HMS3750A13; BCP05202; HY-A0013; ZINC1538857; Tox21_112444; ABP001094; AC-148; BDBM50061101; PDSP1_001731; PDSP2_001714; AKOS015852063; Tox21_112444_1; ACN-048487; AM84442; BCP9000445; CCG-221182; CS-0381; DB00559; MCULE-3074160312; SB17356; VA10428; NCGC00167440-02; 174227-18-0; AB0018010; Ro-470203029; FT-0658809; SW199648-3; Ro-47-0203-029; D07538; W-5165; AB01275536-01; 144096-EP2287165A2; 144096-EP2287166A2; 144096-EP2292620A2; 212B550; A808658; L001086; Q419769; J-008366; SR-05000001532-1; SR-05000001532-2; SR-05000001532-4; Z1541632805; 1174918-31-0; 4-(1,1-Dimethylethyl)-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-(2,2''-bipyrimidin)-4-yl) benzenesulfornamide; 4-(1,1-dimethylethyl)-n-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)[2,2'-bipyrimidin]-4-yl]benzenesulfonamide; 4-(tert-Butyl)-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)[2,2'-bipyrimidin]-4-yl]benzenesulfonamide; 4-tert butyl-N-[4-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-(2-pyrimidinyl)pyrimidin-6-yl]benzenesulphonamide; 4-tert-Butyl-N-[6-(2-hydroxy-ethoxy)-5-(2-methoxy-phenoxy)-[2,2']bipyrimidinyl-4-yl]-benzenesulfonamide; 4-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-[2,2'-bipyrimidine]-4-yl]benzene-1-sulfonamide; 4-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2,2''-bipyrimidin-4-yl]benzenesulfonamide; 4-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl]benzenesulfonamide; 4-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-(pyrimidin-2-yl)pyrimidin-4-yl]benzene-1-sulfonamide; 4-tert-Butyl-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-(pyrimidin-2-yl)pyrimidin-4-yl]benzenesulfonamide
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Clinical Status |
Approved
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Disease Indication | Pulmonary hypertension | ICD-11: BB01 | [1] | ||
PubChem CID | |||||
Formula |
C27H29N5O6S
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Canonical SMILES |
CC(C)(C)C1=CC=C(C=C1)S(=O)(=O)NC2=C(C(=NC(=N2)C3=NC=CC=N3)OCCO)OC4=CC=CC=C4OC
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InChI |
1S/C27H29N5O6S/c1-27(2,3)18-10-12-19(13-11-18)39(34,35)32-23-22(38-21-9-6-5-8-20(21)36-4)26(37-17-16-33)31-25(30-23)24-28-14-7-15-29-24/h5-15,33H,16-17H2,1-4H3,(H,30,31,32)
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InChIKey |
GJPICJJJRGTNOD-UHFFFAOYSA-N
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Click to Show/Hide the Molecular Data (Structure/Property) of This API | |||||
Structure |
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=104865"></iframe>
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3D MOL | 2D MOL | ||||
Physicochemical Properties | Molecular Weight | 551.6 | Topological Polar Surface Area | 154 | |
XlogP | 3.8 | Complexity | 839 | ||
Heavy Atom Count | 39 | Rotatable Bond Count | 11 | ||
Hydrogen Bond Donor Count | 2 | Hydrogen Bond Acceptor Count | 11 | ||
Full List of Drug Formulations (DFMs) Containing This API | ||||||
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Bosentan 32 mg tablet | Click to Show/Hide the Full List of Formulation(s): 1 Formulation(s) | |||||
Drug Formulation 1 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM
Phenylalanine; Acesulfame potassium; Aspartame; Magnesium stearate; Tartaric acid; Anhydrous dibasic calcium phosphate; Croscarmellose sodium; Silicon dioxide; Microcrystalline cellulose
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Dosage Form | Tablet for Oral Suspension | |||||
Company | Actelion Pharmaceuticals US | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
Phenylalanine | DIG Info | Calcium channel alpha-2/delta-1 (Ki = 977.24 nM) | [2] | |||
Acesulfame | DIG Info | Carbonic anhydrase IX (Ki = 2400 nM) | [3] | |||
Aspartame | DIG Info | Pregnane X receptor (Ki = 13 uM) | [4] | |||
Magnesium stearate | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [5] | |||
Calcium hydrogenphosphate | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [5] | |||
Carmellose sodium | DIG Info | Albendazole monooxygenase (Protein expression upregulation) | [5] | |||
Silicon dioxide | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [5] | |||
Bosentan 125 mg tablet | Click to Show/Hide the Full List of Formulation(s): 1 Formulation(s) | |||||
Drug Formulation 1 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM
Glyceryl dibehenate; Magnesium stearate; Ferric oxide red; Ferric oxide yellow; Talc; Titanium dioxide; Triacetin; Ethylcellulose, unspecified; Hypromellose, unspecified; Povidone k90; Sodium starch glycolate type a potato; Starch, corn
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Dosage Form | Oral Tablet | |||||
Company | Actelion Pharmaceuticals US | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
Magnesium stearate | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [5] | |||
Bosentan 62.5 mg tablet | Click to Show/Hide the Full List of Formulation(s): 1 Formulation(s) | |||||
Drug Formulation 1 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM
Glyceryl dibehenate; Magnesium stearate; Ferric oxide red; Ferric oxide yellow; Talc; Titanium dioxide; Triacetin; Ethylcellulose, unspecified; Hypromellose, unspecified; Povidone k90; Sodium starch glycolate type a potato; Starch, corn
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Dosage Form | Oral Tablet | |||||
Company | Actelion Pharmaceuticals US | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
Magnesium stearate | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [5] | |||
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