Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D00078)
Name
Brivaracetam
Synonyms    Click to Show/Hide the Synonyms of This API
Brivaracetam; 357336-20-0; Briviact; UCB-34714; UCB34714; UCB 34714; UNII-U863JGG2IA; 2-(2-oxo-4-propylpyrrolidin-1-yl)butanamide; U863JGG2IA; (2S)-2-((4R)-2-Oxo-4-propylpyrrolidin-1-yl)butanamide; (2s)-2-[(4r)-2-oxo-4-propylpyrrolidin-1-yl]butanamide; 1-Pyrrolidineacetamide, alpha-ethyl-2-oxo-4-propyl-, (alphaS,4R)-; Rikelta; Brivaracetam [USAN:INN]; compound 83alpha; Briviact (TN); Brivaracetam. 97%; SCHEMBL122081; Brivaracetam (JAN/USAN/INN); CHEMBL607400; GTPL9041; DTXSID00905081; CHEBI:133013; EX-A2748; ZINC3979899; BDBM50422531; MFCD25976668; AKOS027324306; ACN-055569; CCG-266666; CS-3418; DB05541; SB17229; NCGC00390779-02; AC-29289; AS-35277; HY-14449; D08879; Q408099; (?S,4R)-?-Ethyl-2-oxo-4-propyl-1-pyrrolidineacetamide; (S)-2-((R)-2-Oxo-4-propylpyrrolidin-1-yl)butanamide; (2S)-2-((4R)-2-oxo-4-n-propyl-1-pyrrolidinyl)butanamide
Clinical Status
Approved
Disease Indication Focal seizure ICD-11: 8A68 [1]
PubChem CID
9837243
Formula
C11H20N2O2
Canonical SMILES
CCC[C@@H]1CC(=O)N(C1)[C@@H](CC)C(=O)N
InChI
1S/C11H20N2O2/c1-3-5-8-6-10(14)13(7-8)9(4-2)11(12)15/h8-9H,3-7H2,1-2H3,(H2,12,15)/t8-,9+/m1/s1
InChIKey
MSYKRHVOOPPJKU-BDAKNGLRSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=9837243"></iframe>
3D MOL 2D MOL
Physicochemical Properties Molecular Weight 212.29 Topological Polar Surface Area 63.4
XlogP 1 Complexity 253
Heavy Atom Count 15 Rotatable Bond Count 5
Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 2
Full List of Drug Formulations (DFMs) Containing This API
          Brivaracetam 75 mg tablet Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Lactose monohydrate; Magnesium stearate; Ferric oxide red; Ferric oxide yellow; Ferrosoferric oxide; Talc; Titanium dioxide; Croscarmellose sodium; Polyethylene glycol 3350; Betadex; Polyvinyl alcohol, unspecified
                   Dosage Form Oral Tablet
                   Company UCB
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [2]
Polyethylene glycol 3350 DIG Info Albendazole monooxygenase (Protein expression upregulation) [2]
          Brivaracetam 100 mg tablet Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Lactose monohydrate; Magnesium stearate; Ferric oxide yellow; Ferrosoferric oxide; Talc; Titanium dioxide; Croscarmellose sodium; Polyethylene glycol 3350; Betadex; Polyvinyl alcohol, unspecified
                   Dosage Form Oral Tablet
                   Company UCB
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [2]
Polyethylene glycol 3350 DIG Info Albendazole monooxygenase (Protein expression upregulation) [2]
          Brivaracetam 25 mg tablet Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Lactose monohydrate; Magnesium stearate; Ferric oxide yellow; Ferrosoferric oxide; Talc; Titanium dioxide; Croscarmellose sodium; Polyethylene glycol 3350; Betadex; Polyvinyl alcohol, unspecified
                   Dosage Form Oral Tablet
                   Company UCB
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [2]
Polyethylene glycol 3350 DIG Info Albendazole monooxygenase (Protein expression upregulation) [2]
          Brivaracetam 50 mg tablet Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Lactose monohydrate; Magnesium stearate; Ferric oxide red; Ferric oxide yellow; Talc; Titanium dioxide; Croscarmellose sodium; Polyethylene glycol 3350; Betadex; Polyvinyl alcohol, unspecified
                   Dosage Form Oral Tablet
                   Company UCB
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [2]
Polyethylene glycol 3350 DIG Info Albendazole monooxygenase (Protein expression upregulation) [2]
          Brivaracetam 10 mg tablet Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Lactose monohydrate; Magnesium stearate; Talc; Titanium dioxide; Croscarmellose sodium; Polyethylene glycol 3350; Betadex; Polyvinyl alcohol, unspecified
                   Dosage Form Oral Tablet
                   Company UCB
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [2]
Polyethylene glycol 3350 DIG Info Albendazole monooxygenase (Protein expression upregulation) [2]
References
1 FDA label for approved brivaracetam from the official website of the U.S. Food and Drug Administration.
2 Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12.

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