Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D00127)
Name
Chlorzoxazone
Synonyms    Click to Show/Hide the Synonyms of This API
chlorzoxazone; 95-25-0; Paraflex; Chloroxazone; Chlorzoxazon; 5-Chloro-2-benzoxazolone; 5-Chloro-2-benzoxazolinone; 2(3H)-Benzoxazolone, 5-chloro-; Biomioran; Escoflex; Myoflexin; Myoflexine; Pathorysin; 5-Chloro-2-hydroxybenzoxazole; Mioran; Miotran; Neoflex; Solaxin; Parafon Forte DSC; 5-Chlorobenzoxazolidone; 5-Chloro-2(3H)-benzoxazolone; Chlorzoxane; 5-Chloro-1,3-benzoxazol-2(3H)-one; 5-Chloro-2-benzoxazolol; Usaf ma-10; 5-Chlorobenzoxazol-2-one; Strifon Forte Dsc; 5-Chlorobenzoxazolone; 5-chloro-3H-1,3-benzoxazol-2-one; 2-Hydroxy-5-chlorobenzoxazole; 5-Chlorobenzo[d]oxazol-2(3H)-one; Chlorzoxazonum; 5-Chlorbenzoxazolin-2-on; 5-Chloro-3(H)-2-benzoxazolone; 5-Chlorobenzoksazolon-2; 5-Chlorobenzoksazolinon-2; 5-chlorobenzoxazolin-2-one; UNII-H0DE420U8G; MFCD00005717; NSC 26189; 2-BENZOXAZOLINONE, 5-CHLORO-; 5-chlorobenzo[d]oxazol-2-ol; 5-chloro-3H-benzooxazol-2-one; 5-chloro-1,3-benzoxazol-2-ol; CHEMBL1371; MLS000069380; CHEBI:3655; H0DE420U8G; Chlorsoxazone; Klorzoxazon; Nyoflex; Parafon; Remofleks; 5-chloro-2,3-dihydro-1,3-benzoxazol-2-one; Parafon Forte; NSC-26189; Chloroxazone, 98%; CAS-95-25-0; NCGC00015238-02; Clorzoxazona; Lorzone; SMR000058269; DSSTox_CID_2813; DSSTox_RID_76739; DSSTox_GSID_22813; Chlorzoxazonum [INN-Latin]; Clorzoxazona [INN-Spanish]; chlorzoxazona; 5-chloro-3-hydrobenzoxazol-2-one; 5-Chlorobenzoksazolon-2 [Polish]; 5-Chlorobenzoksazolinon-2 [Polish]; Paraflex (TN); SR-01000075207; EINECS 202-403-9; component of Parafon Forte; Strifon; AI3-63119; Chlorzoxazone (JAN/USP/INN); Prestwick_62; Chlorzoxazone,(S); Chlorzoxazone [USP:INN:BAN:JAN]; PubChem8642; 5-Chlorobenzoxazolinone; Spectrum_000148; Opera_ID_1659; Prestwick0_000163; Prestwick1_000163; Prestwick2_000163; Prestwick3_000163; Spectrum2_001149; Spectrum3_000350; Spectrum4_000287; Spectrum5_000745; Lopac-C-4397; C 4397; 5-Chloro-benzooxazol-2-ol; 5-chloro-benzoxazolin-2-one; Lopac0_000253; SCHEMBL35177; BSPBio_000025; BSPBio_002019; KBioGR_000814; KBioSS_000628; WLN: T56 BMVOJ HG; DivK1c_000895; SPECTRUM1500188; SPBio_001077; SPBio_001946; BPBio1_000029; GTPL2322; DTXSID9022813; HMS502M17; KBio1_000895; KBio2_000628; KBio2_003196; KBio2_005764; KBio3_001239; NINDS_000895; HMS1568B07; HMS1920O07; HMS2091E14; HMS2095B07; HMS2235I19; HMS3259I15; HMS3260D08; HMS3373P17; HMS3652K22; HMS3712B07; HMS3885N07; Pharmakon1600-01500188; 5-Chloro-2-hydroxybenzo[d]oxazole; ACT08248; ALBB-012641; BCP07916; HY-B1462; NSC26189; STR00805; Tox21_110105; Tox21_500253; BBL003952; BDBM50290811; CCG-40323; KM3336; NSC756693; SBB003864; STK071582; ZINC84843283; AKOS000404381; Tox21_110105_1; component of Parafon Forte (Salt/Mix); CS-5155; DB00356; HG-0202; LP00253; MCULE-3638156868; NC00499; NSC-756693; SDCCGSBI-0050241.P005; 5-chloranyl-3H-1,3-benzoxazol-2-one; 5-chloro-1,3-benzoxazole-2(3H)-one; IDI1_000895; Chlorzoxazone 1.0 mg/ml in Acetonitrile; NCGC00015238-01; NCGC00015238-03; NCGC00015238-04; NCGC00015238-05; NCGC00015238-06; NCGC00015238-07; NCGC00015238-08; NCGC00015238-09; NCGC00015238-10; NCGC00015238-13; NCGC00015238-24; NCGC00093714-01; NCGC00093714-02; NCGC00093714-03; NCGC00093714-04; NCGC00260938-01; 5-Chloro-1,3-benzoxazol-2(3H)-one #; AC-12192; BP-11613; meso-Butane-1,2,3,4-tetracarboxylicAcid; SBI-0050241.P004; AB0011060; DB-057571; AB00051947; EU-0100253; FT-0620220; ST45024437; SW196377-3; EN300-31026; A16449; C07931; D00771; AB00051947_05; AB00051947_06; A845253; Q3294630; SR-01000075207-1; SR-01000075207-3; SR-01000075207-5; W-100168; BRD-K98174813-001-05-7; BRD-K98174813-001-08-1; Z57183224; Chlorzoxazone, United States Pharmacopeia (USP) Reference Standard
Clinical Status
Approved
Disease Indication Anaesthesia ICD-11: 8E22 [1]
PubChem CID
2733
Formula
C7H4ClNO2
Canonical SMILES
C1=CC2=C(C=C1Cl)NC(=O)O2
InChI
1S/C7H4ClNO2/c8-4-1-2-6-5(3-4)9-7(10)11-6/h1-3H,(H,9,10)
InChIKey
TZFWDZFKRBELIQ-UHFFFAOYSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=2733"></iframe>
3D MOL 2D MOL
Physicochemical Properties Molecular Weight 169.56 Topological Polar Surface Area 38.3
XlogP 1.8 Complexity 185
Heavy Atom Count 11 Rotatable Bond Count 0
Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 2
Full List of Drug Formulations (DFMs) Containing This API
          Chlorzoxazone 500 mg tablet Click to Show/Hide the Full List of Formulation(s):          8 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Sodium benzoate; D&c yellow no. 10; Docusate sodium; Fd&c blue no. 1; Magnesium stearate; Croscarmellose sodium; Silicon dioxide; Aluminum oxide; Cellulose, microcrystalline
                   Dosage Form Oral Tablet
                   Company Dispensing Solution
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [2]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [3]
Sodium benzoate DIG Info Carbonic anhydrase II (Ki = 30000 nM) [4]
Docusate sodium DIG Info Solute carrier SLCO2B1 (Ki = 2.3 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Sodium benzoate; D&c yellow no. 10; Docusate sodium; Fd&c blue no. 1; Magnesium stearate; Croscarmellose sodium; Cellulose, microcrystalline; Colloidal silicon dioxide
                   Dosage Form Oral Tablet
                   Company Keltman Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [2]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [3]
Sodium benzoate DIG Info Carbonic anhydrase II (Ki = 30000 nM) [4]
Docusate sodium DIG Info Solute carrier SLCO2B1 (Ki = 2.3 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [5]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose; Sodium benzoate; D&c yellow no. 10; Docusate sodium; Fd&c blue no. 1; Magnesium stearate; Cellulose, microcrystalline; Sodium starch glycolate type a potato; Starch, corn
                   Dosage Form Oral Tablet
                   Company RemedyRepack
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [2]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [3]
Sodium benzoate DIG Info Carbonic anhydrase II (Ki = 30000 nM) [4]
Docusate sodium DIG Info Solute carrier SLCO2B1 (Ki = 2.3 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 4 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose; Sodium benzoate; D&c yellow no. 10; Docusate sodium; Fd&c blue no. 1; Magnesium stearate; Cellulose, microcrystalline; Sodium starch glycolate type a potato; Starch, corn
                   Dosage Form Oral Tablet
                   Company RemedyRepack
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [2]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [3]
Sodium benzoate DIG Info Carbonic anhydrase II (Ki = 30000 nM) [4]
Docusate sodium DIG Info Solute carrier SLCO2B1 (Ki = 2.3 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 5 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Sodium benzoate; Docusate sodium; Magnesium stearate; Cellulose, microcrystalline; Sodium starch glycolate type a potato; Starch, corn
                   Dosage Form Oral Tablet
                   Company RemedyRepack
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sodium benzoate DIG Info Carbonic anhydrase II (Ki = 30000 nM) [4]
Docusate sodium DIG Info Solute carrier SLCO2B1 (Ki = 2.3 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 6 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Sodium benzoate; Docusate sodium; Magnesium stearate; Cellulose, microcrystalline; Sodium starch glycolate type a potato; Starch, pregelatinized corn
                   Dosage Form Oral Tablet
                   Company Clinical Solutions Wholesale; DirectRX; Lake Eire Medical & Surgical Supply DBA Quality Care Products; Physicians Total Care; Stat Rx USA
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sodium benzoate DIG Info Carbonic anhydrase II (Ki = 30000 nM) [4]
Docusate sodium DIG Info Solute carrier SLCO2B1 (Ki = 2.3 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 7 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Sodium benzoate; Docusate sodium; Magnesium stearate; Microcrystalline cellulose; Sodium starch glycolate type a potato; Starch, corn
                   Dosage Form Oral Tablet
                   Company A-S Medication Solutions; Unit Dose Services
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sodium benzoate DIG Info Carbonic anhydrase II (Ki = 30000 nM) [4]
Docusate sodium DIG Info Solute carrier SLCO2B1 (Ki = 2.3 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 8 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Sodium benzoate; Docusate sodium; Magnesium stearate; Cellulose, microcrystalline; Sodium starch glycolate type a potato; Starch, corn
                   Dosage Form Oral Tablet
                   Company A-S Medication Solutions; Actavis Pharma; Aidarex Pharmaceuticals; Bryant Ranch Prepack; NuCare Pharmaceuticals; PD-Rx Pharmaceuticals; Proficient Rx; RemedyRepack
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sodium benzoate DIG Info Carbonic anhydrase II (Ki = 30000 nM) [4]
Docusate sodium DIG Info Solute carrier SLCO2B1 (Ki = 2.3 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
          Chlorzoxazone 250 mg tablet Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Sodium benzoate; Docusate sodium; Magnesium stearate; Croscarmellose sodium; Cellulose, microcrystalline; Starch, corn
                   Dosage Form Oral Tablet
                   Company Mikart; Solubiomix
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sodium benzoate DIG Info Carbonic anhydrase II (Ki = 30000 nM) [4]
Docusate sodium DIG Info Solute carrier SLCO2B1 (Ki = 2.3 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [5]
          Chlorzoxazone 375 mg tablet Click to Show/Hide the Full List of Formulation(s):          2 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Sodium benzoate; Docusate sodium; Magnesium stearate; Croscarmellose sodium; Cellulose, microcrystalline; Starch, corn
                   Dosage Form Oral Tablet
                   Company Lake Eire Medical & Surgical Supply DBA Quality Care Products; Vertical Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sodium benzoate DIG Info Carbonic anhydrase II (Ki = 30000 nM) [4]
Docusate sodium DIG Info Solute carrier SLCO2B1 (Ki = 2.3 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [5]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Sodium benzoate; Docusate sodium; Magnesium stearate; Croscarmellose sodium; Cellulose, microcrystalline; Starch, corn
                   Dosage Form Oral Tablet
                   Company Mikart
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sodium benzoate DIG Info Carbonic anhydrase II (Ki = 30000 nM) [4]
Docusate sodium DIG Info Solute carrier SLCO2B1 (Ki = 2.3 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [5]
          Chlorzoxazone 750 mg tablet Click to Show/Hide the Full List of Formulation(s):          2 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Sodium benzoate; Docusate sodium; Magnesium stearate; Croscarmellose sodium; Cellulose, microcrystalline; Starch, corn
                   Dosage Form Oral Tablet
                   Company Vertical Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sodium benzoate DIG Info Carbonic anhydrase II (Ki = 30000 nM) [4]
Docusate sodium DIG Info Solute carrier SLCO2B1 (Ki = 2.3 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [5]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Sodium benzoate; Docusate sodium; Magnesium stearate; Croscarmellose sodium; Cellulose, microcrystalline; Starch, corn
                   Dosage Form Oral Tablet
                   Company Mikart
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sodium benzoate DIG Info Carbonic anhydrase II (Ki = 30000 nM) [4]
Docusate sodium DIG Info Solute carrier SLCO2B1 (Ki = 2.3 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [5]
References
1 FDA label for approved chlorzoxazone from the official website of the U.S. Food and Drug Administration.
2 Bacterial metabolism rescues the inhibition of intestinal drug absorption by food and drug additives. Proc Natl Acad Sci U S A. 2020 Jul 7;117(27):16009-16018.
3 The activities of drug inactive ingredients on biological targets. Science. 2020 Jul 24;369(6502):403-413.
4 Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with carboxylates. Bioorg Med Chem Lett. 2005 Feb 1; 15(3):573-8.
5 Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12.

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