Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D00173)
Name
Deferiprone
Synonyms    Click to Show/Hide the Synonyms of This API
deferiprone; 30652-11-0; 3-Hydroxy-1,2-dimethyl-4(1H)-pyridone; Ferriprox; 3-hydroxy-1,2-dimethylpyridin-4(1H)-one; 1,2-dimethyl-3-hydroxy-4-pyridone; 1,2-Dimethyl-3-hydroxypyrid-4-one; 1,2-Dimethyl-3-hydroxypyridine-4-one; 4(1H)-Pyridinone, 3-hydroxy-1,2-dimethyl-; APO-66; APO-066; UNII-2BTY8KH53L; DN-180-01-AF; MFCD00134497; Deferiprone (INN); CHEBI:68554; 1,2-Dimethyl-3-hydroxy-4(1H)-pyridinone; 3-hydroxy-1,2-dimethylpyridin-4-one; 2BTY8KH53L; MLS000069481; 4(1H)-Pyridinone, 1,2-dimethyl-3-hydroxy-; DN-18001AF; SMR000059136; 1,2-Dimethyl-3-hydroxy-4-pyridone, 99+%; CP20 (Chelating agent); Ferriprox (TN); 3-hydroxy-1,2-dimethylhydropyridin-4-one; BRN 1447108; Deferum; Deferiprone [USAN:INN:BAN]; CCRIS 8318; 1,2-dimethyl-3-hydroxy-4-pyridinone; 3-Hydroxy-1,2-dimethyl-4-pyridinone; L-1[chelating agent]; ACMC-209hhl; Opera_ID_366; 3-hydroxy-1,2-dimethyl-4(1H)-pyridinone; Deferiprone (USAN/INN); DSSTox_CID_20666; DSSTox_RID_79529; DSSTox_GSID_40666; SCHEMBL94474; MLS000758227; MLS001424029; MLS006011689; CHEMBL70927; CRMD-001; GTPL7456; ZINC6226; DTXSID6040666; HSDB 8335; TZXKOCQBRNJULO-UHFFFAOYSA-; EX-A972; HMS2051C05; HMS2232E24; HMS3264P17; HMS3393C05; HMS3873L13; Pharmakon1600-01504512; BCP09606; HY-B0568; 3-hydroxy-1,2-dimethylpyrid-4-one; Tox21_112429; 3231AB; ANW-26935; BBL036482; BDBM50525976; CGP-37391; NSC758880; SBB006753; STL559018; 1,2-dimetyl-3-hydroxy-4-pyridinone; AKOS015902286; CCG-100760; CS-5240; DB08826; DS-5493; MCULE-6406005067; NC00010; NSC-758880; VP13942; 3-hydroxy-1,2-dimethyl-4- pyridinone; 3-hydroxy-1,2-dimethyl-pyridin-4-one; NCGC00090548-01; NCGC00090548-02; NCGC00090548-04; AC-33026; AK112338; BP-12415; ST093416; SY052576; SBI-0207041.P001; CAS-30652-11-0; DB-047826; FT-0606424; D07416; 3-Hydroxy-1,2-dimethyl-4(1H)-pyridone, 98%; AB00572605_11; AB00572605_12; Q749664; SR-01000721891; 4(1H)-Pyridone, 3-hydroxy-1,2-dimethyl- (8CI); Deferiprone 1,2-DIMETHYL-3-HYDROXY-4-PYRIDONE; SR-01000721891-4; tert-Butyl2-chloro-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate
Clinical Status
Approved
Disease Indication Thalassaemia ICD-11: 3A50 [1]
PubChem CID
2972
Formula
C7H9NO2
Canonical SMILES
CC1=C(C(=O)C=CN1C)O
InChI
1S/C7H9NO2/c1-5-7(10)6(9)3-4-8(5)2/h3-4,10H,1-2H3
InChIKey
TZXKOCQBRNJULO-UHFFFAOYSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=2972"></iframe>
3D MOL 2D MOL
Physicochemical Properties Molecular Weight 139.15 Topological Polar Surface Area 40.5
XlogP 0.5 Complexity 228
Heavy Atom Count 10 Rotatable Bond Count 0
Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 3
Full List of Drug Formulations (DFMs) Containing This API
          Deferiprone 500 mg tablet Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Titanium dioxide; Polyethylene glycol 3350; Silicon dioxide; Cellulose, microcrystalline; Hypromellose 2910 (15000 mpa.s)
                   Dosage Form Oral Tablet
                   Company ApoPharma USA
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
Polyethylene glycol 3350 DIG Info Albendazole monooxygenase (Protein expression upregulation) [2]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
References
1 FDA label for approved deferiprone from the official website of the U.S. Food and Drug Administration.
2 Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12.

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