Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D00309)
Name
Guanidine
Synonyms    Click to Show/Hide the Synonyms of This API
guanidine; Iminourea; Aminomethanamidine; Carbamidine; Carbamamidine; 113-00-8; Guanidin; Imidourea; Aminoformamidine; UNII-JU58VJ6Y3B; Guanidine, free base; CHEBI:42820; JU58VJ6Y3B; H2N-C(=NH)-NH2; Guanidine, Hydrochloride; EINECS 204-021-8; BRN 0506044; guanidine group; HSDB 7603; Guandine thiocyanate; CHEMBL821; Epitope ID:140101; NCIOpen2_007946; 4-03-00-00148 (Beilstein Handbook Reference); (NH2)2C=NH; GTPL4783; DTXSID0023117; [N]C(N)=N; BCP26146; ZINC8101126; BDBM50420178; STL223269; AKOS009031425; DB00536; MCULE-1152750770; SBI-0207070.P001; FT-0626820; C17349; AB00053583_04; 113G008; Q183309; A9B89FF5-2922-47CC-82CE-AC4157B624AE; Ribavirin Impurity T; Iminourea;Diaminomethanimine;Guanidinebase;Carbamidine; 90332-86-8
Clinical Status
Approved
Disease Indication Lambert-eaton syndrome ICD-11: 8C62 [1]
PubChem CID
3520
Formula
CH5N3
Canonical SMILES
C(=N)(N)N
InChI
1S/CH5N3/c2-1(3)4/h(H5,2,3,4)
InChIKey
ZRALSGWEFCBTJO-UHFFFAOYSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=3520"></iframe>
3D MOL 2D MOL
Physicochemical Properties Molecular Weight 59.07 Topological Polar Surface Area 75.9
XlogP -1.3 Complexity 26.3
Heavy Atom Count 4 Rotatable Bond Count 0
Hydrogen Bond Donor Count 3 Hydrogen Bond Acceptor Count 1
Full List of Drug Formulations (DFMs) Containing This API
          Guanidine 125 mg tablet Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Mannitol; Silicon dioxide; Cellulose, microcrystalline
                   Dosage Form Oral Tablet
                   Company Merck Sharp & Dohme
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
References
1 FDA label for approved guanidine from the official website of the U.S. Food and Drug Administration.
2 Pharmacological property optimization for allosteric ligands: A medicinal chemistry perspective. Bioorg Med Chem Lett. 2017 Jun 1; 27(11):2239-2258.
3 Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12.

If you find any error in data or bug in web service, please kindly report it to Dr. Zhang and Dr. Mou.