Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D00341)
Name
Ixazomib
Synonyms    Click to Show/Hide the Synonyms of This API
Ixazomib; 1072833-77-2; MLN2238; MLN-2238; MLN 2238; (R)-1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutylboronic acid; (R)-(1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutyl)boronic acid; UNII-71050168A2; CHEMBL2141296; [(1R)-1-[[2-[(2,5-dichlorobenzoyl)amino]acetyl]amino]-3-methylbutyl]boronic acid; 71050168A2; Ixazomib [INN]; Ixazomib [USAN:INN]; Ixazomib (MLN2238); Ixozamib; Ixazomib Impurity; Ixazomib (USAN); Ixazomib(MLN2238); MLN2238(Ixazomib); Ixazomib (MLN-2238); cc-437; C14H19BCl2N2O4; GTPL8450; MLN-9708 FREE BASE; SCHEMBL3742758; CHEBI:90942; EX-A547; BCP02410; BCP24078; ABP000732; BDBM50398609; MFCD18251438; NSC766907; AKOS015995120; ZINC169946773; BCP9000953; CCG-264938; CS-1657; DB09570; NSC-766907; SB19501; Boronic acid, b-((1R)-1-((2-((2,5-dichlorobenzoyl)amino)acetyl)amino)-3-methylbutyl)-; 1072833-77-2 (free); NCGC00249611-01; NCGC00249611-03; NCGC00249611-04; AC-28456; AS-55976; AT-42310; HY-10453; AB0033791; SW219743-1; J3.602.191H; D10130; MLN2238,MLN 2238,MLN-2238/; S-7673; J-001749; BRD-K78659596-001-01-3; Q20948663; 1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutylboronic acid; N-[(1R)-1-borono-3-methylbutyl]-N(2)-(2,5-dichlorobenzoyl)glycinamide; [(1R)-1-[[2-[(2,5-dichlorobenzoyl)amino]acetyl]amino]-3-methyl-butyl]boronic acid; [(1R)-1-{2-[(2,5-dichlorophenyl)formamido]acetamido}-3-methylbutyl]boronic acid; MLN-2238; [(1R)-1-[[2-[(2,5-Dichlorobenzoyl)amino]acetyl]amino]-3-methylbutyl]boronic acid
Clinical Status
Approved
Disease Indication Amyloidosis ICD-11: 5D00 [1]
PubChem CID
25183872
Formula
C14H19BCl2N2O4
Canonical SMILES
B([C@H](CC(C)C)NC(=O)CNC(=O)C1=C(C=CC(=C1)Cl)Cl)(O)O
InChI
1S/C14H19BCl2N2O4/c1-8(2)5-12(15(22)23)19-13(20)7-18-14(21)10-6-9(16)3-4-11(10)17/h3-4,6,8,12,22-23H,5,7H2,1-2H3,(H,18,21)(H,19,20)/t12-/m0/s1
InChIKey
MXAYKZJJDUDWDS-LBPRGKRZSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=25183872"></iframe>
3D MOL is unavailable 2D MOL
Physicochemical Properties Molecular Weight 361 Topological Polar Surface Area 98.7
XlogP N.A. Complexity 412
Heavy Atom Count 23 Rotatable Bond Count 7
Hydrogen Bond Donor Count 4 Hydrogen Bond Acceptor Count 4
Full List of Drug Formulations (DFMs) Containing This API
          Ixazomib Citrate eq 4mg base capsule Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Microcrystalline Cellulose; Magnesium Stearate; Talc; Gelatin; Titanium Dioxide; Red And Yellow Iron Oxide; Shellac; Propylene Glycol; Potassium Hydroxide; Black Iron Oxide
                   Dosage Form Capsule
                   Company Millennium Pharms
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [2]
Gelatin DIG Info Mephenytoin 4-hydroxylase (EC50 = 20.5 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
          Ixazomib Citrate eq 2.3mg base capsule Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Microcrystalline Cellulose; Magnesium Stearate; Talc; Gelatin; Titanium Dioxide; Red Iron Oxide; Shellac; Propylene Glycol; Potassium Hydroxide; Black Iron Oxide
                   Dosage Form Capsule
                   Company Millennium Pharms
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [2]
Gelatin DIG Info Mephenytoin 4-hydroxylase (EC50 = 20.5 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
          Ixazomib Citrate eq 3mg base capsule Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Microcrystalline Cellulose; Magnesium Stearate; Talc; Gelatin; Titanium Dioxide; Black Iron Oxide; Shellac; Propylene Glycol; Potassium Hydroxide
                   Dosage Form Capsule
                   Company Millennium Pharms
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [2]
Gelatin DIG Info Mephenytoin 4-hydroxylase (EC50 = 20.5 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
          Ixazomib 2.3 mg capsule Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Talc; Cellulose, microcrystalline
                   Dosage Form Oral Capsule
                   Company Millennium Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
          Ixazomib 3 mg capsule Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Talc; Cellulose, microcrystalline
                   Dosage Form Oral Capsule
                   Company Millennium Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
          Ixazomib 4 mg capsule Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Talc; Cellulose, microcrystalline
                   Dosage Form Oral Capsule
                   Company Millennium Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
References
1 FDA label for approved ixazomib from the official website of the U.S. Food and Drug Administration.
2 Pharmaceutical excipients inhibit cytochrome P450 activity in cell free systems and after systemic administration. Eur J Pharm Biopharm. 2008 Sep;70(1):279-88.
3 Mediation of in vitro cytochrome p450 activity by common pharmaceutical excipients. Mol Pharm. 2013 Jul 1;10(7):2739-48.
4 Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12.

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