Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D00429)
Name
Miconazole
Synonyms    Click to Show/Hide the Synonyms of This API
miconazole; 22916-47-8; Monistat; Monistat IV; Daktarin IV; Miconazol; Miconazolo; Miconazolum; Minostate; Monistat-Derm; 1-[2-(2,4-Dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]-1H-imidazole; MJR 1762; Miconazolum [INN-Latin]; Vusion; Florid(nitrate); 1-(2-((2,4-Dichlorobenzyl)oxy)-2-(2,4-dichlorophenyl)ethyl)-1H-imidazole; Brentan; R 18134; 1-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]imidazole; Miconazole 3; NSC 170986; C18H14Cl4N2O; Daktarin; Miconazole (Monistat); Miconazole 7; R18134 nitrate; Monistat 3; Monistat 5; Monistat 7; 1H-Imidazole, 1-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]-; Monistat 1 Combination Pack; CHEMBL91; Monistat (TN); MFCD00216019; Miconazole 7 Combination Pack; 1-(2,4-Dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl)imidazole; 1H-Imidazole, 1-(2-(2,4-dichlorophenyl)-2-((2,4-dichlorophenyl)methoxy)ethyl)-; Dactarin; CHEBI:82892; M-zole 3 Combination Pack; Monistat 3 Combination Pack; 22916-47-8 (free); NSC-170986; Miconazolo [DCIT]; NCGC00016770-01; Micozole; Zimycan; 1-(2,4-dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl) imidazole; Imidazole, 1-(2,4-dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl)-; Femizol-M; Miconazole-7; Monazole 7; 1-[2-(2,4-dichlorophenyl)-2-{[(2,4-dichlorophenyl)methyl]oxy}ethyl]-1H-imidazole; Miconazol [INN-Spanish]; 75319-47-0; Oravig; Aflorix(nitrate); 1-(2,4-dichlorophenyl)-1-[(2,4-dichlorophenyl)methoxy]-2-imidazolylethane; 1-[2-(2,4-dichlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole; 1-{2-[(2,4-dichlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl}-1H-imidazole; imidazole, 1-(2,4-dichloro-beta-((2,4-dichlorobenzyl)oxy) phenethyl)-; Albistat(nitrate); Andergin(nitrate); Conofite(nitrate); 1H-imidazole, 1-(2-(2,4-dichlorophenyl)-2-((2,4-dichlorophenyl) methoxy)ethyl)-; Monista (nitrate); Micantin (nitrate); Novo-Miconazole Vaginal Ovules; CCRIS 7924; Gyno-Daktar(nitrate); Lotrimin AF(nitrate); NSC169434; Epi-Monistat(nitrate); Monistat 7 Vaginal Suppositories; EINECS 245-324-5; BRN 0965511; Zimybase; Miconazole Base; 1-(2,4-Dichloro-beta-[(2,4-dichlorobenzyl)oxy]phenethyl)imidazole; R-14889; SR-01000000271; 1-(2-(2,4-dichlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl)-1H-imidazole; 1-[2-[(2,4-Dichlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole; Miconazole [USP:INN:BAN:JAN]; Prestwick_335; Oravig (TN); Spectrum_000965; Prestwick0_000067; Prestwick1_000067; Prestwick2_000067; Prestwick3_000067; Spectrum2_001048; Spectrum3_000507; Spectrum4_000061; Spectrum5_001297; DSSTox_CID_3319; bmse000924; (+-)-1-(2,4-Dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl)imidazole; cid_4189; SCHEMBL2866; DSSTox_RID_76975; DSSTox_GSID_23319; Oprea1_091955; BSPBio_000253; BSPBio_002033; KBioGR_000581; KBioSS_001445; MLS002222203; DivK1c_000156; SPBio_000976; SPBio_002174; BPBio1_000279; GTPL2449; Miconazole (JP17/USP/INN); DTXSID6023319; SCHEMBL13934598; BDBM31772; KBio1_000156; KBio2_001445; KBio2_004013; KBio2_006581; KBio3_001533; NINDS_000156; HMS1568M15; HMS2090B21; HMS2095M15; HMS2232B14; HMS3374J10; HMS3656E14; HMS3712M15; HY-B0454; Tox21_110601; ANW-42336; DL-448; NSC170986; SBB057453; STK834405; AKOS001574474; AKOS016842489; CCG-220067; DB01110; DS-1881; MCULE-2106181573; IDI1_000156; Imidazole, 1-(2-(2,4-dichlorophenyl)-2-((2,4-dichlorophenyl)methoxy)ethyl)-; NCGC00018294-02; NCGC00018294-04; NCGC00018294-06; NCGC00018294-08; AK-34234; NCI60_001353; NCI60_001380; SMR001307249; ST024747; SBI-0051448.P003; AB0023582; CAS-22916-47-8; DB-046018; AB00053500; FT-0628942; SW196614-4; D00416; J10390; M-4631; AB00053500-23; AB00053500-24; AB00053500-25; AB00053500_26; AB00053500_27; AB00053500_28; 216M019; AE-641/01941016; Q410534; J-014898; SR-01000000271-5; BRD-A82396632-001-03-0; BRD-A82396632-008-02-7; 1-[2,4dichloro-beta-(2,4-dichlorobenzyloxy)phenethyl]imidazole; 1-[2,4-Dichloro-beta-([2,4-dichlorobenzyl]oxy)-phenethyl]imidazole; 1-[2,4-dichloro-beta-(2,4-dichlorobenzyloxy)-phenethyl]imidazole; 1-[2,4-dichloro-beta-(2,4-dichlorobenzyloxy)phenethyl]-imidazole; 1-[2,4-dichloro-beta-(2,4-dichlorobenzyloxy)phenethyl]imidazole; Imidazole,4-dichloro-.beta.-[(2,4-dichlorobenzyl)oxy]phenethyl]-; 1-(2-(2,4-dichlorophenyl)-2-((2,4-dichlorophenyl)methoxy)ethyl)-imidazol; 1-[2,4-Dichloro-.beta.-[(2,4-dichlorobenzyl)oxy]phenethyl]imidazole; 1-[2,4-Dichloro-beta-([2,4-dichlorobenzyl]oxy)-phenethyl] imidazole; 1-[2-(2,4-dichlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl]imidazole; 1H-Imidazole,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]-; Imidazole, 1-(2,4-dichloro-.beta.-((2,4-dichlorobenzyl)oxy)phenethyl)-; 1-[2-(2,4-Dichloro-benzyloxy)-2-(2,4-dichloro-phenyl)-ethyl]-1H-imidazole; 1-[2-(2,4-dichlorobenzyl)oxy-2-(2,4-dichlorophenyl)ethyl]imidazole;nitric acid; 1-[2-(2,4-Dichlorophenyl)-2-[(2,4-dichlorophenyl)-methoxy]ethyl]-1H-imidazole; 1-[2-[(2,4-Dichlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole #
Clinical Status
Approved
Disease Indication Dermatophytosis ICD-11: 1F28 [1]
PubChem CID
4189
Formula
C18H14Cl4N2O
Canonical SMILES
C1=CC(=C(C=C1Cl)Cl)COC(CN2C=CN=C2)C3=C(C=C(C=C3)Cl)Cl
InChI
1S/C18H14Cl4N2O/c19-13-2-1-12(16(21)7-13)10-25-18(9-24-6-5-23-11-24)15-4-3-14(20)8-17(15)22/h1-8,11,18H,9-10H2
InChIKey
BYBLEWFAAKGYCD-UHFFFAOYSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=4189"></iframe>
3D MOL 2D MOL
Physicochemical Properties Molecular Weight 416.1 Topological Polar Surface Area 27
XlogP 5.3 Complexity 417
Heavy Atom Count 25 Rotatable Bond Count 6
Hydrogen Bond Donor Count 0 Hydrogen Bond Acceptor Count 2
Full List of Drug Formulations (DFMs) Containing This API
          Miconazole 50 mg tablet Click to Show/Hide the Full List of Formulation(s):          2 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Sodium lauryl sulfate; Magnesium stearate; Talc; Casein; Hypromellose, unspecified; Starch, corn
                   Dosage Form Buccal Tablet
                   Company Midatech Pharma US
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Sodium lauryl sulfate; Magnesium stearate; Talc; Casein; Hypromelloses; Starch, corn
                   Dosage Form Buccal Tablet
                   Company Praelia Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
References
1 FDA label for approved miconazole from the official website of the U.S. Food and Drug Administration.
2 Bacterial metabolism rescues the inhibition of intestinal drug absorption by food and drug additives. Proc Natl Acad Sci U S A. 2020 Jul 7;117(27):16009-16018.
3 Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12.

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