Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D00483)
Name
Ofloxacin
Synonyms    Click to Show/Hide the Synonyms of This API
ofloxacin; 82419-36-1; Floxin; Ofloxacine; Tarivid; Ocuflox; Ofloxacino; Ofloxacinum; Exocin; Hoe-280; DL-8280; Floxin otic; HOE 280; Oxaldin; Dextrofloxacin; DL-ofloxacin; CHEBI:7731; Oflocet; Visiren; CHEMBL4; MFCD00226105; MLS000028749; Ofloxacina; Ofloxacin Otic; MFCD00865049; Ofloxacin, 98%; Ofloxacina [DCIT]; Ofloxacine [French]; Ofloxacinum [Latin]; Exocine; Flobacin; SMR000058192; Zanocin; Floxil; Ofloxacino [Spanish]; DSSTox_CID_21085; DSSTox_RID_79623; DSSTox_GSID_41085; C18H20FN3O4; FLOXIN IN DEXTROSE 5%; DL 8280; ORF 18489; Floxin (TN); CCRIS 5233; (+/-)-Floxin; SR-01000076050; FLOXIN IN DEXTROSE 5% IN PLASTIC CONTAINER; BRN 3657947; Monoflocet; ofloxacin;; HSDB 8030; J01MA01; Ofloxacin,(S); NCGC00016948-01; Ofloxacin (Floxin); CAS-82419-36-1; Exocin (eye drops); Ofloxacin [USAN:USP:INN:BAN:JAN]; WP-0405; Spectrum_001186; Opera_ID_1114; Prestwick0_000237; Prestwick1_000237; Prestwick2_000237; Prestwick3_000237; Spectrum2_001464; Spectrum3_001499; Spectrum4_000324; Spectrum5_001063; ACMC-20m40v; Epitope ID:116889; O 8757; Lopac0_000904; Oprea1_242882; SCHEMBL24373; BSPBio_000313; BSPBio_003117; KBioGR_000667; KBioSS_001666; fluoro-methyl-(4-methylpiperazin-1-yl)-oxo-[?]carboxylic acid; MLS001074203; MLS006011774; DivK1c_000721; SPECTRUM1502044; SPBio_001387; SPBio_002234; (S)-Ofloxacin;Levaquin;Quixin; Ofloxacin (JP17/USP/INN); BPBio1_000345; DTXSID3041085; SCHEMBL14163982; GTPL10918; HMS502E03; KBio1_000721; KBio2_001666; KBio2_004234; KBio2_006802; KBio3_002617; NINDS_000721; HMS1568P15; HMS1921H12; HMS2090F07; HMS2092B10; HMS2095P15; HMS2235C05; HMS3259G07; HMS3262F10; HMS3369B01; HMS3393K06; HMS3604B17; HMS3712P15; Pharmakon1600-01502044; BCP14346; BCP22048; EBD13209; HY-B0125; RKL10083; Ofloxacin, fluoroquinolone antibiotic; Tox21_110703; Tox21_500904; BBL005605; BDBM50045004; CCG-39210; NSC727071; NSC758178; STK256723; AKOS001033517; AKOS016042783; Ofloxacine; DL-8280; HOE-280; Tox21_110703_1; AC-7616; BCP9000851; CS-1891; DB01165; KS-5011; LP00904; NC00466; NSC-727071; NSC-758178; SDCCGSBI-0050879.P004; VA11432; IDI1_000721; NCGC00015772-02; NCGC00015772-03; NCGC00015772-04; NCGC00015772-05; NCGC00015772-06; NCGC00015772-07; NCGC00015772-08; NCGC00015772-09; NCGC00015772-10; NCGC00015772-12; NCGC00015772-13; NCGC00015772-22; NCGC00094219-01; NCGC00094219-02; NCGC00094219-03; NCGC00094219-04; NCGC00094219-05; NCGC00094219-06; NCGC00178284-01; NCGC00178284-02; NCGC00261589-01; Ofloxacin 100 microg/mL in Acetonitrile; 83380-47-6; AK163167; AK163316; ST073364; SY007392; SBI-0050879.P003; AB0013254; DB-056608; AB00513820; EU-0100904; FT-0627808; FT-0630905; FT-0670773; FT-0673216; Ofloxacin, VETRANAL(TM), analytical standard; VU0243192-7; 86O854; A10666; C07321; D00453; J10376; O-2800; W-3058; AB00052263-12; AB00052263-13; AB00052263_14; AB00052263_15; Ofloxacin, Antibiotic for Culture Media Use Only; Q411447; SR-01000076050-1; SR-01000076050-4; SR-01000076050-7; BRD-A24228527-001-05-9; BRD-A24228527-001-19-0; Z56761309; F0020-0095; F0472-0226; 138199-71-0 (0.5H2O); 7-Chloro-4-hydroxy-8-methylquinoline-3-carboxylicethylester; Ofloxacin, European Pharmacopoeia (EP) Reference Standard; Ofloxacin, United States Pharmacopeia (USP) Reference Standard; (+/-)-9-Fluoro-2,2,3-de)-1,4-benzoxazine-6-carboxylic acid; 8-Methyl-2,3-dihydrofuro[3,2-e]imidazo-[1,2-c]pyrimidine-9-carboxylicacid; Ofloxacin, Pharmaceutical Secondary Standard; Certified Reference Material
Clinical Status
Approved
Disease Indication Pneumocystis pneumonia ICD-11: CA40 [1]
PubChem CID
4583
Formula
C18H20FN3O4
Canonical SMILES
CC1COC2=C3N1C=C(C(=O)C3=CC(=C2N4CCN(CC4)C)F)C(=O)O
InChI
1S/C18H20FN3O4/c1-10-9-26-17-14-11(16(23)12(18(24)25)8-22(10)14)7-13(19)15(17)21-5-3-20(2)4-6-21/h7-8,10H,3-6,9H2,1-2H3,(H,24,25)
InChIKey
GSDSWSVVBLHKDQ-UHFFFAOYSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=4583"></iframe>
3D MOL 2D MOL
Physicochemical Properties Molecular Weight 361.4 Topological Polar Surface Area 73.3
XlogP -0.4 Complexity 634
Heavy Atom Count 26 Rotatable Bond Count 2
Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 8
Full List of Drug Formulations (DFMs) Containing This API
          Ofloxacin 400 mg tablet Click to Show/Hide the Full List of Formulation(s):          5 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Magnesium stearate; Ferric oxide red; Ferric oxide yellow; Titanium dioxide; Polyethylene glycol 400; Polysorbate 80; Hydroxypropyl cellulose (type h); Hypromellose 2910 (3 mpa.s); Hypromellose 2910 (5 mpa.s); Sodium starch glycolate type a potato; Starch, corn
                   Dosage Form Oral Tablet
                   Company PD-Rx Pharmaceuticals; Teva Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
Polyethylene glycol 400 DIG Info Albendazole monooxygenase (IC50 = 10.77 mg.mL-1) [4]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Magnesium stearate; Titanium dioxide; Polyethylene glycol 400; Polysorbate 80; Hydroxypropyl cellulose; Hypromellose 2208 (3 mpa.s); Hypromellose 2910 (6 mpa.s); Sodium starch glycolate type a potato; Starch, corn
                   Dosage Form Oral Tablet
                   Company Larken Laboratories
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
Polyethylene glycol 400 DIG Info Albendazole monooxygenase (IC50 = 10.77 mg.mL-1) [4]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Ferric oxide yellow; Talc; Titanium dioxide; Polyethylene glycol 400; Hydroxypropyl cellulose (1200000 mw); Sodium starch glycolate type a potato
                   Dosage Form Oral Tablet
                   Company Nivagen Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
Polyethylene glycol 400 DIG Info Albendazole monooxygenase (IC50 = 10.77 mg.mL-1) [4]
             Drug Formulation 4 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Ferric oxide yellow; Talc; Titanium dioxide; Polyethylene glycol 400; Hypromellose 2910 (5 mpa.s); Hypromelloses; Sodium starch glycolate type a potato; Starch, corn
                   Dosage Form Oral Tablet
                   Company Cadila Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
Polyethylene glycol 400 DIG Info Albendazole monooxygenase (IC50 = 10.77 mg.mL-1) [4]
             Drug Formulation 5 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Ferric oxide yellow; Titanium dioxide; Polysorbate 80; Colloidal silicon dioxide; Hypromellose 2910 (5 cps); Polyethylene glycol; Sodium starch glycolate type a potato; Starch, corn
                   Dosage Form Oral Tablet
                   Company Dr Reddy's Laboratories
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
          Ofloxacin 200 mg tablet Click to Show/Hide the Full List of Formulation(s):          4 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Magnesium stearate; Ferric oxide yellow; Titanium dioxide; Polyethylene glycol 400; Polysorbate 80; Hydroxypropyl cellulose (type h); Hypromellose 2910 (3 mpa.s); Hypromellose 2910 (5 mpa.s); Sodium starch glycolate type a potato; Starch, corn
                   Dosage Form Oral Tablet
                   Company RemedyRepack; Teva Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
Polyethylene glycol 400 DIG Info Albendazole monooxygenase (IC50 = 10.77 mg.mL-1) [4]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Ferric oxide yellow; Talc; Titanium dioxide; Polyethylene glycol 400; Hydroxypropyl cellulose (1200000 mw); Sodium starch glycolate type a potato
                   Dosage Form Oral Tablet
                   Company Nivagen Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
Polyethylene glycol 400 DIG Info Albendazole monooxygenase (IC50 = 10.77 mg.mL-1) [4]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Ferric oxide yellow; Talc; Titanium dioxide; Polyethylene glycol 400; Hypromellose 2910 (5 mpa.s); Hypromelloses; Sodium starch glycolate type a potato; Starch, corn
                   Dosage Form Oral Tablet
                   Company Cadila Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
Polyethylene glycol 400 DIG Info Albendazole monooxygenase (IC50 = 10.77 mg.mL-1) [4]
             Drug Formulation 4 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Ferric oxide yellow; Titanium dioxide; Polysorbate 80; Colloidal silicon dioxide; Hypromellose 2910 (5 cps); Polyethylene glycol; Sodium starch glycolate type a potato; Starch, corn
                   Dosage Form Oral Tablet
                   Company Dr Reddy's Laboratories
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
          Ofloxacin 300 mg tablet Click to Show/Hide the Full List of Formulation(s):          4 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Magnesium stearate; Titanium dioxide; Polyethylene glycol 400; Polysorbate 80; Hydroxypropyl cellulose (type h); Hypromellose 2910 (3 mpa.s); Hypromellose 2910 (5 mpa.s); Sodium starch glycolate type a potato; Starch, corn
                   Dosage Form Oral Tablet
                   Company Teva Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
Polyethylene glycol 400 DIG Info Albendazole monooxygenase (IC50 = 10.77 mg.mL-1) [4]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Talc; Titanium dioxide; Polyethylene glycol 400; Hydroxypropyl cellulose (1200000 mw); Sodium starch glycolate type a potato
                   Dosage Form Oral Tablet
                   Company Nivagen Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
Polyethylene glycol 400 DIG Info Albendazole monooxygenase (IC50 = 10.77 mg.mL-1) [4]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Talc; Titanium dioxide; Polyethylene glycol 400; Hypromellose 2910 (5 mpa.s); Sodium starch glycolate type a potato; Starch, corn
                   Dosage Form Oral Tablet
                   Company Cadila Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
Polyethylene glycol 400 DIG Info Albendazole monooxygenase (IC50 = 10.77 mg.mL-1) [4]
             Drug Formulation 4 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Titanium dioxide; Polysorbate 80; Colloidal silicon dioxide; Hypromellose 2910 (5 cps); Polyethylene glycol; Sodium starch glycolate type a potato; Starch, corn
                   Dosage Form Oral Tablet
                   Company Dr Reddy's Laboratories
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
References
1 FDA label for approved ofloxacin from the official website of the U.S. Food and Drug Administration.
2 The activities of drug inactive ingredients on biological targets. Science. 2020 Jul 24;369(6502):403-413.
3 Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12.
4 Pharmaceutical excipients inhibit cytochrome P450 activity in cell free systems and after systemic administration. Eur J Pharm Biopharm. 2008 Sep;70(1):279-88.

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