Details of the Drug Inactive Ingredient (DIG)
General Information of DIG (ID: E0PC2L) | |||||
---|---|---|---|---|---|
DIG Name |
Polyethylene glycol 400
|
||||
DIG Function |
Coating agent; Diluent; Ointment base; Plasticizing agent; Solvent; Suppository base; lubricant
|
||||
Full List of Active Pharmaceutical Ingredients (APIs) Co-administrated with This DIG | ||||||
---|---|---|---|---|---|---|
ICD Disease Classification 01 | Infectious/parasitic disease | Click to Show/Hide | ||||
Minocycline
|
API Info |
Streptococcus bacterial infection [ICD-11: 1C41]
|
[1] | |||
Valacyclovir
|
API Info |
Herpes zoster [ICD-11: 1E91]
|
[2] | |||
Metronidazole
|
API Info |
Amebiasis [ICD-11: 1A36]
|
[3] | |||
Famciclovir
|
API Info |
Genital herpes [ICD-11: 1A94]
|
[4] | |||
Penicillin V
|
API Info |
Pulmonary tuberculosis [ICD-11: 1B10]
|
[5] | |||
Cefaclor
|
API Info |
Clostridium difficile infection [ICD-11: 1A04]
|
[6] | |||
Ciprofloxacin
|
API Info |
Endocarditis [ICD-11: 1B12]
|
[7] | |||
Griseofulvin
|
API Info |
Dermatophytosis [ICD-11: 1F28]
|
[8] | |||
Cefprozil
|
API Info |
Streptococcus bacterial infection [ICD-11: 1C41]
|
[9] | |||
Linezolid
|
API Info |
Streptococcus bacterial infection [ICD-11: 1C41]
|
[10] | |||
Raltegravir
|
API Info |
Human immunodeficiency virus infection [ICD-11: 1C60]
|
[11] | |||
Chloroquine
|
API Info |
Malaria [ICD-11: 1F40]
|
[12] | |||
Entecavir
|
API Info |
Viral hepatitis [ICD-11: 1E51]
|
[13] | |||
Ritonavir
|
API Info |
Human immunodeficiency virus infection [ICD-11: 1C60]
|
[14] | |||
Lamivudine
|
API Info |
Human immunodeficiency virus infection [ICD-11: 1C60]
|
[15] | |||
Primaquine
|
API Info |
Malaria [ICD-11: 1F40]
|
[16] | |||
Valganciclovir
|
API Info |
Cytomegalovirus infection [ICD-11: 1D82]
|
[17] | |||
Zidovudine
|
API Info |
Human immunodeficiency virus infection [ICD-11: 1C60]
|
[18] | |||
Daclatasvir
|
API Info |
Viral hepatitis [ICD-11: 1E51]
|
[19] | |||
Hydroxychloroquine
|
API Info |
Malaria [ICD-11: 1F40]
|
[20] | |||
Moxifloxacin
|
API Info |
Streptococcus bacterial infection [ICD-11: 1C41]
|
[21] | |||
Abacavir
|
API Info |
Human immunodeficiency virus infection [ICD-11: 1C60]
|
[22] | |||
ICD Disease Classification 02 | Benign/in-situ/malignant neoplasm | Click to Show/Hide | ||||
Nicotinic acid
|
API Info |
Lung cancer [ICD-11: 2C25]
|
[23] | |||
Bicalutamide
|
API Info |
Prostate cancer [ICD-11: 2C82]
|
[24] | |||
Letrozole
|
API Info |
Breast cancer [ICD-11: 2C60]
|
[25] | |||
Methotrexate
|
API Info |
Breast cancer [ICD-11: 2C60]
|
[26] | |||
Nystatin
|
API Info |
Acute lymphoblastic leukemia [ICD-11: 2B33]
|
[27] | |||
Olaparib
|
API Info |
Ovarian cancer [ICD-11: 2C73]
|
[28] | |||
Bexarotene
|
API Info |
Anaplastic large cell lymphoma [ICD-11: 2A90]
|
[29] | |||
Tamoxifen
|
API Info |
Breast cancer [ICD-11: 2C60]
|
[30] | |||
Lapatinib
|
API Info |
Breast cancer [ICD-11: 2C60]
|
[31] | |||
Midostaurin
|
API Info |
Mastocytosis [ICD-11: 2A21]
|
[32] | |||
Anastrozole
|
API Info |
Breast cancer [ICD-11: 2C60]
|
[33] | |||
Melphalan
|
API Info |
Multiple myeloma [ICD-11: 2A83]
|
[34] | |||
Pazopanib
|
API Info |
Renal cell carcinoma [ICD-11: 2C90]
|
[35] | |||
ICD Disease Classification 03 | Blood/blood-forming organ disease | Click to Show/Hide | ||||
Eltrombopag
|
API Info |
Thrombocytopenia [ICD-11: 3B64]
|
[36] | |||
ICD Disease Classification 04 | Immune system disease | Click to Show/Hide | ||||
Cetirizine
|
API Info |
Allergy [ICD-11: 4A80]
|
[37] | |||
ICD Disease Classification 05 | Endocrine/nutritional/metabolic disease | Click to Show/Hide | ||||
Fenofibrate
|
API Info |
Hypertriglyceridaemia [ICD-11: 5C80]
|
[38] | |||
Glipizide
|
API Info |
Diabetes mellitus [ICD-11: 5A10]
|
[39] | |||
Lovastatin
|
API Info |
Hypertriglyceridaemia [ICD-11: 5C80]
|
[40] | |||
Metformin
|
API Info |
Diabetes mellitus [ICD-11: 5A10]
|
[41] | |||
Gemfibrozil
|
API Info |
Hypertriglyceridaemia [ICD-11: 5C80]
|
[42] | |||
Miglitol
|
API Info |
Diabetic complication [ICD-11: 5A2Y]
|
[43] | |||
ICD Disease Classification 06 | Mental/behavioural/neurodevelopmental disorder | Click to Show/Hide | ||||
Risperidone
|
API Info |
Schizophrenia [ICD-11: 6A20]
|
[44] | |||
Bupropion
|
API Info |
Nicotine dependence [ICD-11: 6C4A]
|
[45] | |||
Lamotrigine
|
API Info |
Bipolar disorder [ICD-11: 6A60]
|
[46] | |||
Fluoxetine
|
API Info |
Major depressive disorder [ICD-11: 6A70]
|
[47] | |||
Duloxetine
|
API Info |
Major depressive disorder [ICD-11: 6A70]
|
[48] | |||
Venlafaxine
|
API Info |
Major depressive disorder [ICD-11: 6A70]
|
[49] | |||
Sertraline
|
API Info |
Major depressive disorder [ICD-11: 6A70]
|
[50] | |||
Amitriptyline
|
API Info |
Major depressive disorder [ICD-11: 6A70]
|
[51] | |||
Olanzapine
|
API Info |
Schizophrenia [ICD-11: 6A20]
|
[52] | |||
Hydroxyzine
|
API Info |
Anxiety disorder [ICD-11: 6B00]
|
[53] | |||
Dexmethylphenidate
|
API Info |
Attention deficit hyperactivity disorder [ICD-11: 6A05]
|
[54] | |||
Paroxetine
|
API Info |
Major depressive disorder [ICD-11: 6A70]
|
[55] | |||
Quetiapine
|
API Info |
Schizophrenia [ICD-11: 6A20]
|
[56] | |||
Lithium carbonate
|
API Info |
Bipolar disorder [ICD-11: 6A60]
|
[57] | |||
Cyclobenzaprine
|
API Info |
Major depressive disorder [ICD-11: 6A70]
|
[58] | |||
Mirtazapine
|
API Info |
Major depressive disorder [ICD-11: 6A70]
|
[59] | |||
Fluvoxamine
|
API Info |
Obsessive-compulsive disorder [ICD-11: 6B20]
|
[60] | |||
Escitalopram
|
API Info |
Major depressive disorder [ICD-11: 6A70]
|
[61] | |||
Citalopram
|
API Info |
Major depressive disorder [ICD-11: 6A70]
|
[62] | |||
Tranylcypromine
|
API Info |
Major depressive disorder [ICD-11: 6A70]
|
[63] | |||
Milnacipran
|
API Info |
Asperger syndrome [ICD-11: 6A02]
|
[64] | |||
Vortioxetine
|
API Info |
Major depressive disorder [ICD-11: 6A70]
|
[65] | |||
Protriptyline
|
API Info |
Major depressive disorder [ICD-11: 6A70]
|
[66] | |||
Acamprosate
|
API Info |
Alcohol dependence [ICD-11: 6C40]
|
[67] | |||
Naltrexone
|
API Info |
Alcohol dependence [ICD-11: 6C40]
|
[68] | |||
ICD Disease Classification 07 | Sleep-wake disorder | Click to Show/Hide | ||||
Dextroamphetamine
|
API Info |
Narcolepsy [ICD-11: 7A20]
|
[69] | |||
Zolpidem
|
API Info |
Insomnia [ICD-11: 7A00]
|
[70] | |||
Eszopiclone
|
API Info |
Insomnia [ICD-11: 7A00]
|
[71] | |||
ICD Disease Classification 08 | Nervous system disease | Click to Show/Hide | ||||
Acetaminophen
|
API Info |
Anaesthesia [ICD-11: 8E22]
|
[72] | |||
Morphine
|
API Info |
Anaesthesia [ICD-11: 8E22]
|
[73] | |||
Gabapentin
|
API Info |
Focal seizure [ICD-11: 8A68]
|
[74] | |||
Oxycodone
|
API Info |
Anaesthesia [ICD-11: 8E22]
|
[75] | |||
Valproic acid
|
API Info |
Epilepsy [ICD-11: 8A60]
|
[76] | |||
Propranolol
|
API Info |
Migraine [ICD-11: 8A80]
|
[77] | |||
Ropinirole
|
API Info |
Parkinsonism [ICD-11: 8A00]
|
[78] | |||
Levetiracetam
|
API Info |
Focal seizure [ICD-11: 8A68]
|
[79] | |||
Tramadol
|
API Info |
Anaesthesia [ICD-11: 8E22]
|
[80] | |||
Topiramate
|
API Info |
Focal seizure [ICD-11: 8A68]
|
[81] | |||
Galantamine
|
API Info |
Alzheimer disease [ICD-11: 8A20]
|
[82] | |||
Hydromorphone
|
API Info |
Anaesthesia [ICD-11: 8E22]
|
[83] | |||
Memantine
|
API Info |
Alzheimer disease [ICD-11: 8A20]
|
[84] | |||
Donepezil
|
API Info |
Alzheimer disease [ICD-11: 8A20]
|
[85] | |||
Zolmitriptan
|
API Info |
Migraine [ICD-11: 8A80]
|
[86] | |||
Sumatriptan
|
API Info |
Migraine [ICD-11: 8A80]
|
[87] | |||
Naratriptan
|
API Info |
Migraine [ICD-11: 8A80]
|
[88] | |||
Ethosuximide
|
API Info |
Epilepsy [ICD-11: 8A60]
|
[89] | |||
Ticagrelor
|
API Info |
Cerebral stroke [ICD-11: 8B11]
|
[90] | |||
Ticlopidine
|
API Info |
Cerebral stroke [ICD-11: 8B11]
|
[91] | |||
Riluzole
|
API Info |
Amyotrophic lateral sclerosis [ICD-11: 8B60]
|
[92] | |||
ICD Disease Classification 09 | Visual system disease | Click to Show/Hide | ||||
Dextromethorphan
|
API Info |
Allergic conjunctivitis [ICD-11: 9A60]
|
[93] | |||
ICD Disease Classification 10 | Ear/mastoid process disease | Click to Show/Hide | ||||
Diphenhydramine
|
API Info |
Meniere disease [ICD-11: AB31]
|
[94] | |||
Amoxicillin
|
API Info |
Acute otitis media [ICD-11: AB00]
|
[95] | |||
Cephalexin
|
API Info |
Acute otitis media [ICD-11: AB00]
|
[96] | |||
ICD Disease Classification 11 | Circulatory system disease | Click to Show/Hide | ||||
Aspirin
|
API Info |
Myocardial infarction [ICD-11: BA41]
|
[97] | |||
Metoprolol
|
API Info |
Essential hypertension [ICD-11: BA00]
|
[98] | |||
Verapamil
|
API Info |
Essential hypertension [ICD-11: BA00]
|
[99] | |||
Losartan
|
API Info |
Essential hypertension [ICD-11: BA00]
|
[100] | |||
Caffeine
|
API Info |
Orthostatic hypotension [ICD-11: BA21]
|
[101] | |||
Felodipine
|
API Info |
Essential hypertension [ICD-11: BA00]
|
[102] | |||
Nifedipine
|
API Info |
Angina pectoris [ICD-11: BA40]
|
[103] | |||
Clopidogrel
|
API Info |
Deep vein thrombosis [ICD-11: BD71]
|
[104] | |||
Valsartan
|
API Info |
Essential hypertension [ICD-11: BA00]
|
[105] | |||
Benazepril
|
API Info |
Essential hypertension [ICD-11: BA00]
|
[106] | |||
Carvedilol
|
API Info |
Congestive heart failure [ICD-11: BD10]
|
[107] | |||
Spironolactone
|
API Info |
Congestive heart failure [ICD-11: BD10]
|
[108] | |||
Labetalol
|
API Info |
Essential hypertension [ICD-11: BA00]
|
[109] | |||
Betaxolol
|
API Info |
Essential hypertension [ICD-11: BA00]
|
[110] | |||
Bisoprolol
|
API Info |
Essential hypertension [ICD-11: BA00]
|
[111] | |||
Nimodipine
|
API Info |
Cerebral vasospasm [ICD-11: BA85]
|
[112] | |||
Quinapril
|
API Info |
Essential hypertension [ICD-11: BA00]
|
[113] | |||
Ranolazine
|
API Info |
Angina pectoris [ICD-11: BA40]
|
[114] | |||
ICD Disease Classification 12 | Respiratory system disease | Click to Show/Hide | ||||
Montelukast
|
API Info |
Asthma [ICD-11: CA23]
|
[115] | |||
Clarithromycin
|
API Info |
Pneumocystis pneumonia [ICD-11: CA40]
|
[116] | |||
Fexofenadine
|
API Info |
Allergic rhinitis [ICD-11: CA08]
|
[117] | |||
Levofloxacin
|
API Info |
Bronchitis [ICD-11: CA20]
|
[118] | |||
Zileuton
|
API Info |
Asthma [ICD-11: CA23]
|
[119] | |||
Levocetirizine
|
API Info |
Allergic rhinitis [ICD-11: CA08]
|
[120] | |||
Ofloxacin
|
API Info |
Pneumocystis pneumonia [ICD-11: CA40]
|
[121] | |||
Zafirlukast
|
API Info |
Asthma [ICD-11: CA23]
|
[122] | |||
ICD Disease Classification 13 | Digestive system disease | Click to Show/Hide | ||||
Doxycycline
|
API Info |
Periodontal disease [ICD-11: DA0C]
|
[123] | |||
Bisacodyl
|
API Info |
Irritable bowel syndrome [ICD-11: DD91]
|
[124] | |||
Pantoprazole
|
API Info |
Gastro-oesophageal reflux disease [ICD-11: DA22]
|
[125] | |||
Lansoprazole
|
API Info |
Duodenal ulcer [ICD-11: DA63]
|
[126] | |||
Ranitidine
|
API Info |
Gastric ulcer [ICD-11: DA60]
|
[127] | |||
Ondansetron
|
API Info |
Gastritis [ICD-11: DA42]
|
[128] | |||
Mycophenolate mofetil
|
API Info |
Crohn disease [ICD-11: DD70]
|
[129] | |||
Ursodeoxycholic acid
|
API Info |
Hepatic fibrosis/cirrhosis [ICD-11: DB93]
|
[130] | |||
Famotidine
|
API Info |
Peptic ulcer [ICD-11: DA61]
|
[131] | |||
Naloxegol
|
API Info |
Irritable bowel syndrome [ICD-11: DD91]
|
[132] | |||
Granisetron
|
API Info |
Functional nausea/vomiting [ICD-11: DD90]
|
[133] | |||
ICD Disease Classification 14 | Skin disease | Click to Show/Hide | ||||
Pseudoephedrine
|
API Info |
Erythema multiforme [ICD-11: EB12]
|
[134] | |||
Demeclocycline
|
API Info |
Acne vulgaris [ICD-11: ED80]
|
[135] | |||
ICD Disease Classification 15 | Musculoskeletal/connective-tissue disease | Click to Show/Hide | ||||
Naproxen
|
API Info |
Rheumatoid arthritis [ICD-11: FA20]
|
[136] | |||
Diclofenac
|
API Info |
Knee osteoarthritis [ICD-11: FA01]
|
[137] | |||
Etodolac
|
API Info |
Rheumatoid arthritis [ICD-11: FA20]
|
[138] | |||
Nabumetone
|
API Info |
Rheumatoid arthritis [ICD-11: FA20]
|
[139] | |||
Phenylephrine
|
API Info |
Juvenile rheumatoid arthritis [ICD-11: FA24]
|
[140] | |||
Cyclosporin A
|
API Info |
Rheumatoid arthritis [ICD-11: FA20]
|
[141] | |||
Conjugated estrogen
|
API Info |
Osteoporosis [ICD-11: FB83]
|
[142] | |||
Risedronic acid
|
API Info |
Paget's disease [ICD-11: FB85]
|
[143] | |||
Diflunisal
|
API Info |
Osteoporosis [ICD-11: FB83]
|
[144] | |||
Ibandronic acid
|
API Info |
Osteoporosis [ICD-11: FB83]
|
[145] | |||
Flurbiprofen
|
API Info |
Rheumatoid arthritis [ICD-11: FA20]
|
[146] | |||
Oxaprozin
|
API Info |
Rheumatoid arthritis [ICD-11: FA20]
|
[147] | |||
Raloxifene
|
API Info |
Osteoporosis [ICD-11: FB83]
|
[148] | |||
Ketorolac
|
API Info |
Rheumatoid arthritis [ICD-11: FA20]
|
[149] | |||
Flavoxate
|
API Info |
Knee osteoarthritis [ICD-11: FA01]
|
[150] | |||
ICD Disease Classification 16 | Genitourinary system disease | Click to Show/Hide | ||||
Ibuprofen
|
API Info |
Dysmenorrhea [ICD-11: GA34]
|
[151] | |||
Finasteride
|
API Info |
Prostatic hyperplasia [ICD-11: GA90]
|
[152] | |||
Oxybutynin
|
API Info |
Overactive bladder [ICD-11: GC50]
|
[153] | |||
Progesterone
|
API Info |
Endometrial hyperplasia [ICD-11: GA16]
|
[154] | |||
Phenazopyridine
|
API Info |
Infectious cystitis [ICD-11: GC00]
|
[155] | |||
Trospium
|
API Info |
Overactive bladder [ICD-11: GC50]
|
[156] | |||
Darifenacin
|
API Info |
Overactive bladder [ICD-11: GC50]
|
[157] | |||
Full List of Biological Targets of DIG (DBTs) Regulated by This DIG | ||||||
---|---|---|---|---|---|---|
Oxidoreductase (ORase) | ||||||
DBT Name: Albendazole monooxygenase (CYP3A4) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Biological Activity | IC50 = 10.77 mg.mL-1 (tested by experiment) | [158] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | CP3A4_HUMAN | |||||
Primary active transporter (PAT) | ||||||
DBT Name: Multidrug resistance protein 2 (ABCC2) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment (1) for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Biological Activity | Inhibition ratio = 67 % (tested by experiment) | [159] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | MRP2_HUMAN | |||||
Experiment (2) for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Biological Activity | Inhibition ratio > 73 % (tested by experiment) | [160] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | MRP2_HUMAN | |||||
DBT Name: Multidrug resistance protein 1 (ABCB1) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment (1) for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Biological Activity | Inhibition ratio = 28 % (tested by experiment) | [161] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | MDR1_HUMAN ; MDR3_HUMAN ; ABCB5_HUMAN | |||||
Experiment (2) for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Biological Activity | Inhibition ratio = 64 % (tested by experiment) | [162] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | MDR1_HUMAN ; MDR3_HUMAN ; ABCB5_HUMAN | |||||
Potential-driven transporter (PDT) | ||||||
DBT Name: Solute carrier SLCO1A2 (OATP-A) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment (1) for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Biological Activity | IC50 = 0.14 %(w/v) (tested by experiment) | [163] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | SO1A2_HUMAN | |||||
Experiment (2) for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Biological Activity | IC50 = 0.05 %(w/v) (tested by experiment) | [163] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | SO1A2_HUMAN | |||||
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