Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D00498)
Name
Oxaprozin
Synonyms    Click to Show/Hide the Synonyms of This API
oxaprozin; 21256-18-8; Daypro; 3-(4,5-Diphenyl-1,3-oxazol-2-yl)propanoic acid; 3-(4,5-Diphenyloxazol-2-yl)propanoic acid; Oxaprozine; Oxaprozinum; Deflam; Oxaprozine [INN-French]; Oxaprozinum [INN-Latin]; WY-21743; Oxaprozina [INN-Spanish]; Oxaprozina; WY-21,743; 4,5-Diphenyl-2-oxazolepropionic acid; 4,5-Diphenyl-2-oxazolepropanoic acid; Duraprox; Oxaprozinum;Wy21743; 2-Oxazolepropanoic acid, 4,5-diphenyl-; WY 21743; NSC310839; 3-(4,5-Diphenyl-2-oxazolyl)propenoic acid; beta-(4,5-Diphenyloxazol-2-yl)propionic acid; UNII-MHJ80W9LRB; MFCD00215977; MHJ80W9LRB; NSC 310839; NSC-310839; CHEMBL1071; CHEBI:7822; 2-OXAZOLEPROPIONIC ACID, 4,5-DIPHENYL-; .beta.-(4,5-Diphenyloxazol-2-yl)propionic acid; Danoprox; Dayrun; 3-(4,5-Diphenyl-2-oxazolyl)propanoic acid; CAS-21256-18-8; 3-(diphenyl-1,3-oxazol-2-yl)propanoic acid; DSSTox_CID_25118; DSSTox_RID_80684; DSSTox_GSID_45118; Actirin; Xopane; SMR000058286; Daypro (TN); SR-01000076053; oxaprosin; Durapro; Duraprost; Oxaprozi; Oxapro; Oxaprozin, solid; Oxaprozin,(S); EINECS 244-296-1; NCI310839; 4, 5-Diphenyl-2-oxazolepropionic acid; BRN 1083168; Maybridge1_008800; Prestwick0_001060; Prestwick1_001060; Prestwick2_001060; Prestwick3_001060; Spectrum2_001696; Spectrum3_001078; Spectrum4_001231; Lopac-O-9637; O 9637; SCHEMBL3286; NCIStruc1_000799; NCIStruc2_000787; BIDD:PXR0149; Lopac0_000944; Oprea1_509470; BSPBio_001020; BSPBio_002696; KBioGR_001722; MLS000759535; MLS001424072; BIDD:GT0438; SPECTRUM1505267; SPBio_001652; SPBio_002940; Oxaprozin (JP17/USP/INN); BPBio1_001122; GTPL7252; DTXSID1045118; HMS566H22; HSDB 7586; KBio3_001916; HMS1571C22; HMS1922P17; HMS2051L15; HMS2093O08; HMS2098C22; HMS3262N10; HMS3393L15; HMS3652H17; HMS3715C22; HMS3885L11; Pharmakon1600-01505267; BCP28431; HY-B0808; Tox21_110059; Tox21_500944; 2-Oxazolepropanoic acid,5-diphenyl-; 2-Oxazolepropionic acid,5-diphenyl-; ANW-63377; BDBM50002861; CCG-36508; NCGC00014711; NSC758949; SBB053166; ZINC49643479; 4,5-diphenyloxazole-2-propanoic acid; 4,5-Diphenyloxazole-2-propionic acid; AKOS000206807; Oxaprozin [USAN:USP:INN:BAN:JAN]; Tox21_110059_1; CS-7975; DB00991; KS-5196; LP00944; MCULE-7099031811; NC00214; NSC-758949; SDCCGSBI-0050918.P004; NCGC00014711-01; NCGC00014711-02; NCGC00014711-03; NCGC00014711-04; NCGC00014711-05; NCGC00014711-06; NCGC00014711-07; NCGC00014711-08; NCGC00014711-09; NCGC00014711-10; NCGC00014711-11; NCGC00014711-14; NCGC00014711-15; NCGC00094249-01; NCGC00094249-02; NCGC00094249-03; NCGC00094249-04; NCGC00094249-05; NCGC00094249-06; NCGC00094249-07; NCGC00261629-01; AC-26512; AK-84489; NCI60_002681; SBI-0050918.P002; AB0011812; 3-(4,5-Diphenyl-2-oxazolyl)propionic acid; AB00514024; EU-0100944; FT-0638104; ST50949623; SW197319-4; 3-(4, 5-Diphenyl-2-oxazolyl)propenoic acid; EN300-25629; 3-(4,5-Diphenyl-oxazol-2-yl)-propionic acid; 4.5-Diphenyl-2-oxazolepropanoic acid; Daypro; C07356; D00463; J10396; K-6109; AB00514024_08; AB00514024_09; 256O188; A815225; 1-AMINOCYCLOBUTANE-CIS-1,3-DICARBOXYLICACID; J-013955; Q1749609; SR-01000076053-1; SR-01000076053-3; SR-01000076053-7; SR-01000076053-9; 3-(4,5-Diphenyl-1,3-oxazol-2-yl)propanoic acid #; BRD-K25394294-001-05-7; BRD-K25394294-001-08-1; Z217102860; Oxaprozin, United States Pharmacopeia (USP) Reference Standard
Clinical Status
Approved
Disease Indication Rheumatoid arthritis ICD-11: FA20 [1]
PubChem CID
4614
Formula
C18H15NO3
Canonical SMILES
C1=CC=C(C=C1)C2=C(OC(=N2)CCC(=O)O)C3=CC=CC=C3
InChI
1S/C18H15NO3/c20-16(21)12-11-15-19-17(13-7-3-1-4-8-13)18(22-15)14-9-5-2-6-10-14/h1-10H,11-12H2,(H,20,21)
InChIKey
OFPXSFXSNFPTHF-UHFFFAOYSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=4614"></iframe>
3D MOL 2D MOL
Physicochemical Properties Molecular Weight 293.3 Topological Polar Surface Area 63.3
XlogP 4.2 Complexity 361
Heavy Atom Count 22 Rotatable Bond Count 5
Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 4
Full List of Drug Formulations (DFMs) Containing This API
          Oxaprozin 600 mg tablet Click to Show/Hide the Full List of Formulation(s):        14 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; D&c yellow no. 10; Fd&c yellow no. 6; Magnesium stearate; Titanium dioxide; Triacetin; Cellulose, microcrystalline; Hypromelloses; Polydextrose; Polyethylene glycol; Sodium starch glycolate type a potato; Starch, corn
                   Dosage Form Oral Tablet
                   Company H. J. Harkins Company; Lake Eire Medical & Surgical Supply DBA Quality Care Products; Stat Rx USA
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [2]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; D&c yellow no. 10; Fd&c yellow no. 6; Magnesium stearate; Titanium dioxide; Triacetin; Cellulose, microcrystalline; Hypromelloses; Polydextrose; Polyethylene glycols; Sodium starch glycolate type a potato; Starch, corn
                   Dosage Form Oral Tablet
                   Company A-S Medication Solutions; California Pharmaceuticals; Clinical Solutions Wholesale; Dr Reddy's Laboratories
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [2]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; D&c yellow no. 10; Fd&c yellow no. 6; Magnesium stearate; Titanium dioxide; Triacetin; Hypromellose, unspecified; Microcrystalline cellulose; Polydextrose; Polyethylene glycol, unspecified; Sodium starch glycolate type a potato; Starch, corn
                   Dosage Form Oral Tablet
                   Company Preferred Pharamaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [2]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 4 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Titanium dioxide; Croscarmellose sodium; Silicon dioxide; Hydroxypropyl cellulose (type h); Hypromellose 2910 (15 mpa.s); Methylcellulose (1500 mpa.s); Polyethylene glycol 8000
                   Dosage Form Oral Tablet
                   Company Apotex
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [3]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [4]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 5 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Titanium dioxide; Polyethylene glycol 400; Polysorbate 80; Carnauba wax; Cellulose, microcrystalline; Hypromellose 2910 (3 mpa.s); Hypromellose 2910 (5 mpa.s); Methylcellulose (15 mpa.s); Polacrilin potassium; Starch, corn
                   Dosage Form Oral Tablet
                   Company PD-Rx Pharmaceuticals; Teva Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Polyethylene glycol 400 DIG Info Albendazole monooxygenase (IC50 = 10.77 mg.mL-1) [5]
             Drug Formulation 6 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Titanium dioxide; Polyethylene glycol 400; Polysorbate 80; Carnauba wax; Hypromellose 2910 (3 mpa.s); Hypromellose 2910 (5 mpa.s); Methylcellulose (15 mpa.s); Microcrystalline cellulose; Polacrilin potassium; Starch, corn
                   Dosage Form Oral Tablet
                   Company Bryant Ranch Prepack; Unit Dose Services
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Polyethylene glycol 400 DIG Info Albendazole monooxygenase (IC50 = 10.77 mg.mL-1) [5]
             Drug Formulation 7 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Titanium dioxide; Polysorbate 80; Silicon dioxide; Hypromellose, unspecified; Methylcellulose (100 mpa.s); Microcrystalline cellulose; Polacrilin potassium; Polyethylene glycol, unspecified; Starch, corn
                   Dosage Form Oral Tablet
                   Company Carilion Materials Management
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 8 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Titanium dioxide; Polysorbate 80; Silicon dioxide; Cellulose, microcrystalline; Hypromelloses; Methylcellulose (100 cps); Polacrilin potassium; Polyethylene glycols; Starch, corn
                   Dosage Form Oral Tablet
                   Company Dispensing Solution
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 9 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Titanium dioxide; Polysorbate 80; Silicon dioxide; Cellulose, microcrystalline; Hypromelloses; Methylcellulose (100 mpa.s); Polacrilin potassium; Polyethylene glycols; Starch, corn
                   Dosage Form Oral Tablet
                   Company American Health Packaging; Eon Labs
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 10 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Titanium dioxide; Polysorbate 80; Carnauba wax; Cellulose, microcrystalline; Hypromelloses; Methylcellulose (15 cps); Polacrilin potassium; Polyethylene glycol; Starch, corn
                   Dosage Form Oral Tablet
                   Company Rebel Distributors
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 11 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Titanium dioxide; Polysorbate 80; Cellulose, microcrystalline; Methylcellulose (100 cps); Polyethylene glycol; Sodium starch glycolate type a potato; Starch, corn
                   Dosage Form Oral Tablet
                   Company Physicians Total Care
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 12 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Titanium dioxide; Polysorbate 80; Cellulose, microcrystalline; Methylcellulose (400 mpa.s); Polyethylene glycols; Sodium starch glycolate type a potato; Starch, corn
                   Dosage Form Oral Tablet
                   Company AvKARE; Caraco Pharmaceutical Laboratories; DirectRX
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 13 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Titanium dioxide; Cellulose, microcrystalline; Hypromelloses; Methylcellulose (100 cps); Polacrilin potassium; Polyethylene glycols; Starch, corn
                   Dosage Form Oral Tablet
                   Company Amneal Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 14 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Titanium dioxide; Hypromellose, unspecified; Methylcellulose (100 mpa.s); Microcrystalline cellulose; Polacrilin potassium; Polyethylene glycol, unspecified
                   Dosage Form Oral Tablet
                   Company G.D. Searle LLC Division of Pfizer Inc; Greenstone; PD-Rx Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
References
1 FDA label for approved oxaprozin from the official website of the U.S. Food and Drug Administration.
2 Bacterial metabolism rescues the inhibition of intestinal drug absorption by food and drug additives. Proc Natl Acad Sci U S A. 2020 Jul 7;117(27):16009-16018.
3 The activities of drug inactive ingredients on biological targets. Science. 2020 Jul 24;369(6502):403-413.
4 Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12.
5 Pharmaceutical excipients inhibit cytochrome P450 activity in cell free systems and after systemic administration. Eur J Pharm Biopharm. 2008 Sep;70(1):279-88.

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