Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D00533)
Name
Pindolol
Synonyms    Click to Show/Hide the Synonyms of This API
pindolol; 13523-86-9; Visken; Prinodolol; Betapindol; Carvisken; Durapindol; Pinbetol; Calvisken; Decreten; Pectobloc; Pynastin; Blocklin L; Pindololum; Glauco-visken; Blockin L; Blocklin-L; 4-(2-Hydroxy-3-isopropylaminopropoxy)-indole; 1-(1H-indol-4-yloxy)-3-(propan-2-ylamino)propan-2-ol; 1-(1H-Indol-4-yloxy)-3-[(1-methylethyl)amino]-2-propanol; l-Pindolol; 1-(Indol-4-yloxy)-3-(isopropylamino)-2-propanol; 1-(1H-indol-4-yloxy)-3-(isopropylamino)propan-2-ol; 4-(3-(Isopropylamino)-2-hydroxypropoxy)indole; 1-(1H-Indol-4-yloxy)-3-((1-methylethyl)amino)-2-propanol; 2-Propanol, 1-(1H-indol-4-yloxy)-3-[(1-methylethyl)amino]-; 2-Propanol, 1-(4-indolyloxy)-3-(isopropylamino)-; 1-(1H-Indol-4-yloxy)-3-(isopropylamino)-2-propanol; CHEBI:8214; 1-(1H-indol-4-yloxy)-3-[(1-methylethyl)amino]propan-2-ol; 2-Propanol, 1-(1H-indol-4-yloxy)-3-((1-methylethyl)amino)-; Glauco-Viskin; 1-(1H-indol-4-yloxy)-3-(propan-2-ylamino)-propan-2-ol; NCGC00015786-11; (+-)-Pindolol; DSSTox_CID_3476; DL-Pindolol; Pindololum [INN-Latin]; (-)-Pindolol; (S)-(-)-Pindolol; S-Pindolol; DSSTox_RID_77043; DSSTox_GSID_23476; 1-[1H-INDOL-4-YLOXY]-3-[ISOPROPYLAMINO]-2-PROPANOL; Blocklin; Carvisken (TN); SMR000059120; Blocklin-L (TN); Visken (TN); CCRIS 9215; HSDB 6539; 1-((1-Methylethyl)amino)-3-(4-indolyloxy)-2-propanol; SR-01000000027; EINECS 236-867-9; EINECS 244-623-8; BRN 1536506; DL-LB 46; Prestwick_397; CAS-13523-86-9; Pindolol [USAN:USP:INN:BAN:JAN]; Spectrum_001109; (1)-1-(1H-Indol-4-yloxy)-3-(isopropylamino)propan-2-ol; (.+/-.)-Pindolol; Prestwick0_000090; Prestwick1_000090; Prestwick2_000090; Prestwick3_000090; Spectrum2_001285; Spectrum3_000547; Spectrum4_000479; Spectrum5_001266; (R,S)-PINDOLOL; CHEMBL500; GTPL91; PINDOLOL,(-); P 0778; P-6820; SCHEMBL5219; Lopac0_000955; Oprea1_770884; BSPBio_000020; BSPBio_002193; KBioGR_000958; KBioSS_001589; 5-21-03-00017 (Beilstein Handbook Reference); DL-4-[2-Hydroxy-3-(isopropylamino)propoxy]indole; MLS000069496; MLS002548891; DivK1c_000837; SPECTRUM1500488; Pindolol (JP17/USP/INN); SPBio_001289; SPBio_001959; BPBio1_000022; 1-((1H-indol-4-yl)oxy)-3-(isopropylamino)propan-2-ol; DTXSID8023476; HMS502J19; KBio1_000837; KBio2_001589; KBio2_004157; KBio2_006725; KBio3_001693; NINDS_000837; 1-(1H-indol-4-yloxy)-3-[(propan-2-yl)amino]propan-2-ol; 2-Propanol, 1-(1H-indol-4-yloxy)-3-(1-methylethyl)amino-; 2-Propanol, 1-(indol-4-yloxy)-3-(isopropylamino)-, (+-)-; HMS1568A22; HMS1920H16; HMS2089I21; HMS2091P20; HMS2095A22; HMS3259I07; HMS3262P12; HMS3267K17; HMS3369E14; HMS3414J03; HMS3678H21; HMS3712A22; HMS3742C07; HMS3885N04; Pharmakon1600-01500488; HY-B0982; Pindolol, >=98% (TLC), powder; Tox21_110221; Tox21_500955; BDBM50019443; CCG-39223; MFCD00010530; NSC757276; PDSP1_000771; PDSP1_000772; PDSP2_000759; PDSP2_000760; (+/-)-Pindolol-d7(iso-propyl-d7); AKOS015969756; Tox21_110221_1; CS-4473; DB00960; LP00955; MCULE-7764948919; NC00467; NSC-757276; SDCCGSBI-0050929.P005; IDI1_000837; NCGC00015786-06; NCGC00015786-07; NCGC00015786-08; NCGC00015786-09; NCGC00015786-10; NCGC00015786-13; NCGC00015786-14; NCGC00015786-16; NCGC00015786-20; NCGC00015786-22; NCGC00024925-03; NCGC00024925-04; NCGC00024925-05; NCGC00024925-06; NCGC00024925-07; NCGC00261640-01; SBI-0050929.P004; AB00052072; EU-0100955; FT-0673907; ST50319990; SW196641-3; C07445; D00513; AB00052072-11; AB00052072_12; AB00052072_13; 1-(4-Indolyloxy)-3-(isopropylamino)-2-propanol; 523P869; L000006; Q418101; 3-indol-4-yloxy-1-[(methylethyl)amino]propan-2-ol; SR-01000000027-2; SR-01000000027-4; SR-01000000027-5; SR-01000000027-7; 1-(1H-Indol-4-yloxy)-3-isopropylamino-propan-2-ol; BRD-A97701745-001-05-3; BRD-A97701745-001-09-5; 1-(1H-Indol-4-yloxy)-3-(isopropylamino)-2-propanol #; Pindolol, European Pharmacopoeia (EP) Reference Standard; 1-(1H-Indol-4-yloxy)-3-isopropylamino-propan-2-ol(pindolol); Pindolol, United States Pharmacopeia (USP) Reference Standard; 1-(1H-Indol-4-yloxy)-3-isopropylamino-propan-2-ol((-)-Pindolol)
Clinical Status
Approved
Disease Indication Angina pectoris ICD-11: BA40 [1]
PubChem CID
4828
Formula
C14H20N2O2
Canonical SMILES
CC(C)NCC(COC1=CC=CC2=C1C=CN2)O
InChI
1S/C14H20N2O2/c1-10(2)16-8-11(17)9-18-14-5-3-4-13-12(14)6-7-15-13/h3-7,10-11,15-17H,8-9H2,1-2H3
InChIKey
JZQKKSLKJUAGIC-UHFFFAOYSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=4828"></iframe>
3D MOL 2D MOL
Physicochemical Properties Molecular Weight 248.32 Topological Polar Surface Area 57.3
XlogP 1.8 Complexity 248
Heavy Atom Count 18 Rotatable Bond Count 6
Hydrogen Bond Donor Count 3 Hydrogen Bond Acceptor Count 3
Full List of Drug Formulations (DFMs) Containing This API
          Pindolol 10 mg tablet Click to Show/Hide the Full List of Formulation(s):          5 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Sodium lauryl sulfate; Magnesium stearate; Croscarmellose sodium; Silicon dioxide; Cellulose, microcrystalline; Starch, corn
                   Dosage Form Oral Tablet
                   Company Carilion Materials Management; Mylan Pharamceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [3]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Sodium lauryl sulfate; Magnesium stearate; Croscarmellose sodium; Silicon dioxide; Cellulose, microcrystalline; Starch, pregelatinized corn
                   Dosage Form Oral Tablet
                   Company Cadila Healthcare; Zydus Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [3]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Silicon dioxide; Microcrystalline cellulose; Starch, corn
                   Dosage Form Oral Tablet
                   Company ANI Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
             Drug Formulation 4 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Magnesium stearate; Crospovidone (15 mpa.s at 5%); Microcrystalline cellulose; Starch, corn
                   Dosage Form Oral Tablet
                   Company Sun Pharmaceutical Industries
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
             Drug Formulation 5 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Cellulose, microcrystalline; Colloidal silicon dioxide; Sodium starch glycolate type a corn; Starch, corn
                   Dosage Form Oral Tablet
                   Company Nostrum Laboratories
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
          Pindolol 5 mg tablet Click to Show/Hide the Full List of Formulation(s):          6 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Sodium lauryl sulfate; Magnesium stearate; Croscarmellose sodium; Silicon dioxide; Cellulose, microcrystalline; Starch, corn
                   Dosage Form Oral Tablet
                   Company Mylan Pharamceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [3]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Sodium lauryl sulfate; Magnesium stearate; Croscarmellose sodium; Silicon dioxide; Cellulose, microcrystalline; Starch, pregelatinized corn
                   Dosage Form Oral Tablet
                   Company Cadila Healthcare; Zydus Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [3]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Sodium lauryl sulfate; Magnesium stearate; Croscarmellose sodium; Silicon dioxide; Microcrystalline cellulose; Starch, corn
                   Dosage Form Oral Tablet
                   Company Carilion Materials Management
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [3]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
             Drug Formulation 4 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Silicon dioxide; Cellulose, microcrystalline; Sodium starch glycolate type a corn; Starch, corn
                   Dosage Form Oral Tablet
                   Company Nostrum Laboratories
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
             Drug Formulation 5 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Silicon dioxide; Microcrystalline cellulose; Starch, corn
                   Dosage Form Oral Tablet
                   Company ANI Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
             Drug Formulation 6 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Magnesium stearate; Crospovidone (15 mpa.s at 5%); Microcrystalline cellulose; Starch, corn
                   Dosage Form Oral Tablet
                   Company Sun Pharmaceutical Industries
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
References
1 FDA label for approved pindolol from the official website of the U.S. Food and Drug Administration.
2 Bacterial metabolism rescues the inhibition of intestinal drug absorption by food and drug additives. Proc Natl Acad Sci U S A. 2020 Jul 7;117(27):16009-16018.
3 Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12.

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