Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D00612)
Name
Safinamide
Synonyms    Click to Show/Hide the Synonyms of This API
Safinamide; 133865-89-1; Xadago; (S)-2-((4-((3-Fluorobenzyl)oxy)benzyl)amino)propanamide; Fce-26743; UNII-90ENL74SIG; EMD 1195686; EMD-1195686; 90ENL74SIG; CHEMBL396778; 133865-89-1 (free base); (2S)-2-[[4-[(3-Fluorophenyl)methoxy]phenyl]methylamino]propanamide; (2S)-2-[({4-[(3-fluorophenyl)methoxy]phenyl}methyl)amino]propanamide; (S)-2-[[4-[(3-Fluorobenzyl)oxy]benzyl]amino]propanamide; CHEMBL48582; Safinamide [USAN:INN]; 2(s)-(4-(3-fluorobenzyloxy)benzylamino)propionamide; 2-(4-(3-Fluorobenzyloxy)benzylamino)propionamide; Safinamide (USAN/INN); (S)-2-(((4-((3-Fluorophenyl)methoxy)phenyl)methyl)amino)propanamide; EC 603-772-2; N2-(4-((3-Fluorbenzyl)oxy)benzyl)-L-alaninamid; SCHEMBL69350; GTPL8291; BDBM19187; CHEBI:134718; DTXSID601010282; HMS3886M21; Safinamide mesylate Intermediate 2; BCP12082; EX-A2759; 6135AA; ANW-58666; BDBM50078694; MFCD00897036; ZINC53084692; AKOS016002015; CCG-267489; CS-0556; DB06654; ER-0076; SB16691; (S)-(+)-2-[4-(3-FLUOROBENZYLOXY)BENZYLAMINO]PROPANAMIDE METHANSULFONATE; NCGC00346529-01; NCGC00346529-03; AC-26829; HY-70057; D10158; W-5197; (S)-2[4-(3-fluorobenzyloxy)benzylamino]propanamide; J-506604; Q2211523; (5)-2-[4-(3-fluorobenzyloxy)benzylamino]propanamide; (S)-2-[4-(3-fluorobenzyloxy)benzylamino]propanamide; (S)-2[4-(3-fluorobenzyloxy)benzylamino] propanamide; (2S)-2-[4-(3-fluorobenzyloxy)benzylamino]propionamide; 2(S)-[4-(3-Fluorobenzyloxy) benzylamino] propionamide; (S)-2-[[4-[(3-Fluorobenzyl)oxy]benzyl]amino]propionamide; (+-)-(S)-2-((p-((m-Fluorobenzyl)oxy)benzyl)amino)propionamide; Propanamide, 2-(((4-((3-fluorophenyl)methoxy)phenyl)methyl)amino)-, (S)-; (S)-2-[4-(3-Fluoro-benzyloxy)-benzylamino]-propionamide; compound with methanesulfonic acid; EMD 1195686;FCE 26743;EMD-1195686;EMD1195686;FCE-26743; SAFINAMIDE:(S)-(+)-2-[4-(3-FLUOROBENZYLOXY)BENZYLAMINO]PROPANAMIDEMETHANSULFONATE
Clinical Status
Approved
Disease Indication Parkinsonism ICD-11: 8A00 [1]
PubChem CID
131682
Formula
C17H19FN2O2
Canonical SMILES
C[C@@H](C(=O)N)NCC1=CC=C(C=C1)OCC2=CC(=CC=C2)F
InChI
1S/C17H19FN2O2/c1-12(17(19)21)20-10-13-5-7-16(8-6-13)22-11-14-3-2-4-15(18)9-14/h2-9,12,20H,10-11H2,1H3,(H2,19,21)/t12-/m0/s1
InChIKey
NEMGRZFTLSKBAP-LBPRGKRZSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=131682"></iframe>
3D MOL 2D MOL
Physicochemical Properties Molecular Weight 302.34 Topological Polar Surface Area 64.4
XlogP 2.2 Complexity 346
Heavy Atom Count 22 Rotatable Bond Count 7
Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 4
Full List of Drug Formulations (DFMs) Containing This API
          Safinamide Mesylate 100 mg tablet Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Colloidal Silicon Dioxide; Crospovidone; Hypromellose; Iron Oxide (Red); Magnesium Stearate; Microcrystalline Cellulose; Polyethylene Glycol 6000; Potassium Aluminum Silicate; Titanium Dioxide
                   Dosage Form Tablet
                   Company Mdd Us Operations
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Hypromellose DIG Info Cytochrome P450 3A5 (IC50 = 19.4 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
Crospovidone DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
Polyethylene glycol 6000 DIG Info Albendazole monooxygenase (Inhibition ratio < 70 %) [4]
          Safinamide Mesylate 50 mgl tablet Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Colloidal Silicon Dioxide; Crospovidone; Hypromellose; Iron Oxide (Red); Magnesium Stearate; Microcrystalline Cellulose; Polyethylene Glycol 6000; Potassium Aluminum Silicate; Titanium Dioxide
                   Dosage Form Tablet
                   Company Mdd Us Operations
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Hypromellose DIG Info Cytochrome P450 3A5 (IC50 = 19.4 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
Crospovidone DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
Polyethylene glycol 6000 DIG Info Albendazole monooxygenase (Inhibition ratio < 70 %) [4]
          Safinamide 100 mg tablet Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Ferric oxide red; Titanium dioxide; Polyethylene glycol 6000; Silicon dioxide; Crospovidone (15 mpa.s at 5%); Hypromellose, unspecified; Mica; Microcrystalline cellulose
                   Dosage Form Oral Tablet
                   Company US WorldMeds
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
Polyethylene glycol 6000 DIG Info Albendazole monooxygenase (Inhibition ratio < 70 %) [4]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
          Safinamide 50 mg tablet Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Ferric oxide red; Titanium dioxide; Polyethylene glycol 6000; Silicon dioxide; Crospovidone (15 mpa.s at 5%); Hypromellose, unspecified; Mica; Microcrystalline cellulose
                   Dosage Form Oral Tablet
                   Company US WorldMeds
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
Polyethylene glycol 6000 DIG Info Albendazole monooxygenase (Inhibition ratio < 70 %) [4]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
References
1 FDA label for approved safinamide from the official website of the U.S. Food and Drug Administration.
2 Mediation of in vitro cytochrome p450 activity by common pharmaceutical excipients. Mol Pharm. 2013 Jul 1;10(7):2739-48.
3 Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12.
4 Pharmaceutical excipients inhibit cytochrome P450 activity in cell free systems and after systemic administration. Eur J Pharm Biopharm. 2008 Sep;70(1):279-88.

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