Details of the Drug Inactive Ingredient (DIG)

General Information of DIG (ID: E09BYS)
DIG Name	Polyethylene glycol 6000
DIG Function	Coating agent; Diluent; Ointment base; Plasticizing agent; Solvent; Suppository base; lubricant

Full List of Active Pharmaceutical Ingredients (APIs) Co-administrated with This DIG
ICD Disease Classification 01		Infectious/parasitic disease	Click to Show/Hide
Minocycline	API Info	Streptococcus bacterial infection [ICD-11: 1C41]		[1]
Valacyclovir	API Info	Herpes zoster [ICD-11: 1E91]		[2]
Famciclovir	API Info	Genital herpes [ICD-11: 1A94]		[3]
Vancomycin	API Info	Methicillin-resistant staphylococcus infection [ICD-11: 1D01]		[4]
Griseofulvin	API Info	Dermatophytosis [ICD-11: 1F28]		[5]
Entecavir	API Info	Viral hepatitis [ICD-11: 1E51]		[6]
Gemifloxacin	API Info	Streptococcus bacterial infection [ICD-11: 1C41]		[7]
Voriconazole	API Info	Candidiasis [ICD-11: 1F23]		[8]
ICD Disease Classification 02		Benign/in-situ/malignant neoplasm	Click to Show/Hide
Exemestane	API Info	Breast cancer [ICD-11: 2C60]		[9]
Anastrozole	API Info	Breast cancer [ICD-11: 2C60]		[10]
ICD Disease Classification 05		Endocrine/nutritional/metabolic disease	Click to Show/Hide
Fenofibrate	API Info	Hypertriglyceridaemia [ICD-11: 5C80]		[11]
Atorvastatin	API Info	Hyperlipidaemia [ICD-11: 5C8Z]		[12]
Pravastatin	API Info	Dyslipidaemia [ICD-11: 5C81]		[13]
Rosuvastatin	API Info	Hypertriglyceridaemia [ICD-11: 5C80]		[14]
Metformin	API Info	Diabetes mellitus [ICD-11: 5A10]		[15]
Colestid	API Info	Hypertriglyceridaemia [ICD-11: 5C80]		[16]
ICD Disease Classification 06		Mental/behavioural/neurodevelopmental disorder	Click to Show/Hide
Risperidone	API Info	Schizophrenia [ICD-11: 6A20]		[17]
Bupropion	API Info	Nicotine dependence [ICD-11: 6C4A]		[18]
Fluoxetine	API Info	Major depressive disorder [ICD-11: 6A70]		[19]
Sertraline	API Info	Major depressive disorder [ICD-11: 6A70]		[20]
Dexmethylphenidate	API Info	Attention deficit hyperactivity disorder [ICD-11: 6A05]		[21]
Paroxetine	API Info	Major depressive disorder [ICD-11: 6A70]		[22]
Lithium carbonate	API Info	Bipolar disorder [ICD-11: 6A60]		[23]
Mirtazapine	API Info	Major depressive disorder [ICD-11: 6A70]		[24]
Escitalopram	API Info	Major depressive disorder [ICD-11: 6A70]		[25]
Desvenlafaxine	API Info	Major depressive disorder [ICD-11: 6A70]		[26]
Perphenazine	API Info	Schizophrenia [ICD-11: 6A20]		[27]
ICD Disease Classification 07		Sleep-wake disorder	Click to Show/Hide
Eszopiclone	API Info	Insomnia [ICD-11: 7A00]		[28]
ICD Disease Classification 08		Nervous system disease	Click to Show/Hide
Acetaminophen	API Info	Anaesthesia [ICD-11: 8E22]		[29]
Morphine	API Info	Anaesthesia [ICD-11: 8E22]		[30]
Ropinirole	API Info	Parkinsonism [ICD-11: 8A00]		[31]
Levetiracetam	API Info	Focal seizure [ICD-11: 8A68]		[32]
Tramadol	API Info	Anaesthesia [ICD-11: 8E22]		[33]
Topiramate	API Info	Focal seizure [ICD-11: 8A68]		[34]
Memantine	API Info	Alzheimer disease [ICD-11: 8A20]		[35]
Donepezil	API Info	Alzheimer disease [ICD-11: 8A20]		[36]
Zolmitriptan	API Info	Migraine [ICD-11: 8A80]		[37]
Sumatriptan	API Info	Migraine [ICD-11: 8A80]		[38]
Riluzole	API Info	Amyotrophic lateral sclerosis [ICD-11: 8B60]		[39]
Safinamide	API Info	Parkinsonism [ICD-11: 8A00]		[40]
ICD Disease Classification 10		Ear/mastoid process disease	Click to Show/Hide
Diphenhydramine	API Info	Meniere disease [ICD-11: AB31]		[41]
ICD Disease Classification 11		Circulatory system disease	Click to Show/Hide
Aspirin	API Info	Myocardial infarction [ICD-11: BA41]		[42]
Metoprolol	API Info	Essential hypertension [ICD-11: BA00]		[43]
Losartan	API Info	Essential hypertension [ICD-11: BA00]		[44]
Caffeine	API Info	Orthostatic hypotension [ICD-11: BA21]		[45]
Felodipine	API Info	Essential hypertension [ICD-11: BA00]		[46]
Clopidogrel	API Info	Deep vein thrombosis [ICD-11: BD71]		[47]
Benazepril	API Info	Essential hypertension [ICD-11: BA00]		[48]
Carvedilol	API Info	Congestive heart failure [ICD-11: BD10]		[49]
Bisoprolol	API Info	Essential hypertension [ICD-11: BA00]		[50]
Dronedarone	API Info	Atrial fibrillation [ICD-11: BC81]		[51]
Ivabradine	API Info	Angina pectoris [ICD-11: BA40]		[52]
Moexipril	API Info	Essential hypertension [ICD-11: BA00]		[53]
ICD Disease Classification 12		Respiratory system disease	Click to Show/Hide
Montelukast	API Info	Asthma [ICD-11: CA23]		[54]
Fexofenadine	API Info	Allergic rhinitis [ICD-11: CA08]		[55]
Desloratadine	API Info	Allergic rhinitis [ICD-11: CA08]		[56]
Levofloxacin	API Info	Bronchitis [ICD-11: CA20]		[57]
ICD Disease Classification 13		Digestive system disease	Click to Show/Hide
Doxycycline	API Info	Periodontal disease [ICD-11: DA0C]		[58]
Omeprazole	API Info	Gastro-oesophageal reflux disease [ICD-11: DA22]		[59]
Bisacodyl	API Info	Irritable bowel syndrome [ICD-11: DD91]		[60]
Pantoprazole	API Info	Gastro-oesophageal reflux disease [ICD-11: DA22]		[61]
Lansoprazole	API Info	Duodenal ulcer [ICD-11: DA63]		[62]
Ondansetron	API Info	Gastritis [ICD-11: DA42]		[63]
Tacrolimus	API Info	Ulcerative colitis [ICD-11: DD71]		[64]
Mesalamine	API Info	Inflammatory bowel disease [ICD-11: DD72]		[65]
Ursodeoxycholic acid	API Info	Hepatic fibrosis/cirrhosis [ICD-11: DB93]		[66]
ICD Disease Classification 15		Musculoskeletal/connective-tissue disease	Click to Show/Hide
Naproxen	API Info	Rheumatoid arthritis [ICD-11: FA20]		[67]
Etodolac	API Info	Rheumatoid arthritis [ICD-11: FA20]		[68]
Nabumetone	API Info	Rheumatoid arthritis [ICD-11: FA20]		[69]
Ibandronic acid	API Info	Osteoporosis [ICD-11: FB83]		[70]
ICD Disease Classification 16		Genitourinary system disease	Click to Show/Hide
Finasteride	API Info	Prostatic hyperplasia [ICD-11: GA90]		[71]
Tamsulosin	API Info	Prostatic hyperplasia [ICD-11: GA90]		[72]
Tolterodine	API Info	Overactive bladder [ICD-11: GC50]		[73]
Trospium	API Info	Overactive bladder [ICD-11: GC50]		[74]
Darifenacin	API Info	Overactive bladder [ICD-11: GC50]		[75]

Full List of Biological Targets of DIG (DBTs) Regulated by This DIG
Oxidoreductase (ORase)
DBT Name: Albendazole monooxygenase (CYP3A4)		Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Biological Activity	Inhibition ratio < 70 % (tested by experiment)		[76]
Tested Species	Homo sapiens (Human)
UniProt ID	CP3A4_HUMAN

References
1	FDA label for approved minocycline from the official website of the U.S. Food and Drug Administration.
2	FDA label for approved valacyclovir from the official website of the U.S. Food and Drug Administration.
3	FDA label for approved famciclovir from the official website of the U.S. Food and Drug Administration.
4	FDA label for approved vancomycin from the official website of the U.S. Food and Drug Administration.
5	FDA label for approved griseofulvin from the official website of the U.S. Food and Drug Administration.
6	FDA label for approved entecavir from the official website of the U.S. Food and Drug Administration.
7	FDA label for approved gemifloxacin from the official website of the U.S. Food and Drug Administration.
8	FDA label for approved voriconazole from the official website of the U.S. Food and Drug Administration.
9	FDA label for approved exemestane from the official website of the U.S. Food and Drug Administration.
10	FDA label for approved anastrozole from the official website of the U.S. Food and Drug Administration.
11	FDA label for approved fenofibrate from the official website of the U.S. Food and Drug Administration.
12	FDA label for approved atorvastatin from the official website of the U.S. Food and Drug Administration.
13	FDA label for approved pravastatin from the official website of the U.S. Food and Drug Administration.
14	FDA label for approved rosuvastatin from the official website of the U.S. Food and Drug Administration.
15	FDA label for approved metformin from the official website of the U.S. Food and Drug Administration.
16	FDA label for approved colestid from the official website of the U.S. Food and Drug Administration.
17	FDA label for approved risperidone from the official website of the U.S. Food and Drug Administration.
18	FDA label for approved bupropion from the official website of the U.S. Food and Drug Administration.
19	FDA label for approved fluoxetine from the official website of the U.S. Food and Drug Administration.
20	FDA label for approved sertraline from the official website of the U.S. Food and Drug Administration.
21	FDA label for approved dexmethylphenidate from the official website of the U.S. Food and Drug Administration.
22	FDA label for approved paroxetine from the official website of the U.S. Food and Drug Administration.
23	FDA label for approved lithium carbonate from the official website of the U.S. Food and Drug Administration.
24	FDA label for approved mirtazapine from the official website of the U.S. Food and Drug Administration.
25	FDA label for approved escitalopram from the official website of the U.S. Food and Drug Administration.
26	FDA label for approved desvenlafaxine from the official website of the U.S. Food and Drug Administration.
27	FDA label for approved perphenazine from the official website of the U.S. Food and Drug Administration.
28	FDA label for approved eszopiclone from the official website of the U.S. Food and Drug Administration.
29	FDA label for approved acetaminophen from the official website of the U.S. Food and Drug Administration.
30	FDA label for approved morphine from the official website of the U.S. Food and Drug Administration.
31	FDA label for approved ropinirole from the official website of the U.S. Food and Drug Administration.
32	FDA label for approved levetiracetam from the official website of the U.S. Food and Drug Administration.
33	FDA label for approved tramadol from the official website of the U.S. Food and Drug Administration.
34	FDA label for approved topiramate from the official website of the U.S. Food and Drug Administration.
35	FDA label for approved memantine from the official website of the U.S. Food and Drug Administration.
36	FDA label for approved donepezil from the official website of the U.S. Food and Drug Administration.
37	FDA label for approved zolmitriptan from the official website of the U.S. Food and Drug Administration.
38	FDA label for approved sumatriptan from the official website of the U.S. Food and Drug Administration.
39	FDA label for approved riluzole from the official website of the U.S. Food and Drug Administration.
40	FDA label for approved safinamide from the official website of the U.S. Food and Drug Administration.
41	FDA label for approved diphenhydramine from the official website of the U.S. Food and Drug Administration.
42	FDA label for approved aspirin from the official website of the U.S. Food and Drug Administration.
43	FDA label for approved metoprolol from the official website of the U.S. Food and Drug Administration.
44	FDA label for approved losartan from the official website of the U.S. Food and Drug Administration.
45	FDA label for approved caffeine from the official website of the U.S. Food and Drug Administration.
46	FDA label for approved felodipine from the official website of the U.S. Food and Drug Administration.
47	FDA label for approved clopidogrel from the official website of the U.S. Food and Drug Administration.
48	FDA label for approved benazepril from the official website of the U.S. Food and Drug Administration.
49	FDA label for approved carvedilol from the official website of the U.S. Food and Drug Administration.
50	FDA label for approved bisoprolol from the official website of the U.S. Food and Drug Administration.
51	FDA label for approved dronedarone from the official website of the U.S. Food and Drug Administration.
52	FDA label for approved ivabradine from the official website of the U.S. Food and Drug Administration.
53	FDA label for approved moexipril from the official website of the U.S. Food and Drug Administration.
54	FDA label for approved montelukast from the official website of the U.S. Food and Drug Administration.
55	FDA label for approved fexofenadine from the official website of the U.S. Food and Drug Administration.
56	FDA label for approved desloratadine from the official website of the U.S. Food and Drug Administration.
57	FDA label for approved levofloxacin from the official website of the U.S. Food and Drug Administration.
58	FDA label for approved doxycycline from the official website of the U.S. Food and Drug Administration.
59	FDA label for approved omeprazole from the official website of the U.S. Food and Drug Administration.
60	FDA label for approved bisacodyl from the official website of the U.S. Food and Drug Administration.
61	FDA label for approved pantoprazole from the official website of the U.S. Food and Drug Administration.
62	FDA label for approved lansoprazole from the official website of the U.S. Food and Drug Administration.
63	FDA label for approved ondansetron from the official website of the U.S. Food and Drug Administration.
64	FDA label for approved tacrolimus from the official website of the U.S. Food and Drug Administration.
65	FDA label for approved mesalamine from the official website of the U.S. Food and Drug Administration.
66	FDA label for approved ursodeoxycholic acid from the official website of the U.S. Food and Drug Administration.
67	FDA label for approved naproxen from the official website of the U.S. Food and Drug Administration.
68	FDA label for approved etodolac from the official website of the U.S. Food and Drug Administration.
69	FDA label for approved nabumetone from the official website of the U.S. Food and Drug Administration.
70	FDA label for approved ibandronic acid from the official website of the U.S. Food and Drug Administration.
71	FDA label for approved finasteride from the official website of the U.S. Food and Drug Administration.
72	FDA label for approved tamsulosin from the official website of the U.S. Food and Drug Administration.
73	FDA label for approved tolterodine from the official website of the U.S. Food and Drug Administration.
74	FDA label for approved trospium from the official website of the U.S. Food and Drug Administration.
75	FDA label for approved darifenacin from the official website of the U.S. Food and Drug Administration.
76	Pharmaceutical excipients inhibit cytochrome P450 activity in cell free systems and after systemic administration. Eur J Pharm Biopharm. 2008 Sep;70(1):279-88.

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