Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D00644)
Name
Sulindac
Synonyms    Click to Show/Hide the Synonyms of This API
sulindac; Clinoril; 38194-50-2; Arthrocine; Sulindaco; Sulindacum; Aflodac; Sulindac sulfoxide; Sulreuma; Mobilin; cis-5-Fluoro-2-methyl-1-((p-methylsulfinyl)benzylidene)indene-3-acetic acid; CHEBI:9352; MK 231; Algocetil; Artribid; Citireuma; Clisundac; Imbaral; Reumofil; Sulinol; CHEMBL15770; 32004-68-5; NCGC00015970-02; CAS-38194-50-2; DSSTox_CID_3624; Sulindacum [INN-Latin]; DSSTox_RID_77117; DSSTox_GSID_23624; Sulindaco [INN-Spanish]; MK-231; C20H17FO3S; cis-Sulindac; Sulindac (Clinoril); Clinoril (TN); CCRIS 3305; SR-01000075237; EINECS 253-819-2; BRN 2951842; Moblilin; EINECS 250-893-8; EINECS 256-402-3; Sulindac [USAN:USP:INN:BAN:JAN]; Tocris-1707; Prestwick3_000073; Spectrum5_001024; Lopac-S-8139; S 8139; Sulindac, >=98.0%; SCHEMBL4202; SCHEMBL4203; Lopac0_001070; BSPBio_000285; BSPBio_002890; MLS001056554; SPECTRUM1500556; Sulindac (JP17/USP/INN); BPBio1_000315; GTPL5425; DTXSID4023624; CHEBI:93811; HMS501O03; cMAP_000021; HMS1921C11; HMS2092K15; HMS2095O07; HMS2231N24; HMS3259K06; HMS3263E22; HMS3414N11; HMS3649P19; HMS3678N09; HMS3712O07; HMS3884K18; Pharmakon1600-01500556; HY-B0008; Tox21_110270; Tox21_301418; Tox21_501070; BDBM50012899; BDBM50103504; CCG-39264; NSC757344; SBB058181; AKOS015895412; cis-5-Fluoro-2-methyl-1-((p-methylsulfinyl)benzylidenyl)indene-3-acetic acid; Tox21_110270_1; CS-0569; DB00605; KS-5153; LP01070; NC00540; NSC-757344; SDCCGSBI-0051040.P005; IDI1_000601; Sulindac 100 microg/mL in Acetonitrile; NCGC00015970-01; NCGC00015970-03; NCGC00015970-04; NCGC00015970-05; NCGC00015970-06; NCGC00015970-07; NCGC00015970-08; NCGC00015970-11; NCGC00025268-01; NCGC00025268-02; NCGC00025268-03; NCGC00094349-01; NCGC00094349-02; NCGC00255143-01; NCGC00261755-01; NCGC00381714-10; BP-30208; SMR000326718; SBI-0051040.P004; Sulindac, meets USP testing specifications; AB00513800; EU-0101070; ST51015123; SW219748-1; 9222-EP2275420A1; 9222-EP2277565A2; 9222-EP2277566A2; 9222-EP2277567A1; 9222-EP2277568A2; 9222-EP2277569A2; 9222-EP2277570A2; 9222-EP2280008A2; 9222-EP2281815A1; 9222-EP2284166A1; 9222-EP2292280A1; 9222-EP2295055A2; 9222-EP2295409A1; 9222-EP2298764A1; 9222-EP2298765A1; 9222-EP2301933A1; 9222-EP2305640A2; 9222-EP2305652A2; 9222-EP2308872A1; 9222-EP2311453A1; 9222-EP2311827A1; 9222-EP2314585A1; 9222-EP2314590A1; 9222-EP2316829A1; C01531; D00120; W-5115; AB00052105-07; AB00052105_08; AB00052105_09; Q963093; J-008554; J-012337; SR-01000075237-2; SR-01000075237-3; SR-01000075237-5; SR-01000075237-7; BRD-A13946108-001-04-9; BRD-A13946108-001-08-0; SR-01000075237-13; Sulindac, European Pharmacopoeia (EP) Reference Standard; Sulindac, United States Pharmacopeia (USP) Reference Standard; (Z)-5-Fluoro-2-methyl-1-[(p-methylsulfinyl)benzylidene]-1H-indene-3-acetic Acid; Sulindac
Clinical Status
Approved
Disease Indication Rheumatoid arthritis ICD-11: FA20 [1]
PubChem CID
1548887
Formula
C20H17FO3S
Canonical SMILES
CC\\1=C(C2=C(/C1=C\\C3=CC=C(C=C3)S(=O)C)C=CC(=C2)F)CC(=O)O
InChI
1S/C20H17FO3S/c1-12-17(9-13-3-6-15(7-4-13)25(2)24)16-8-5-14(21)10-19(16)18(12)11-20(22)23/h3-10H,11H2,1-2H3,(H,22,23)/b17-9-
InChIKey
MLKXDPUZXIRXEP-MFOYZWKCSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=1548887"></iframe>
3D MOL 2D MOL
Physicochemical Properties Molecular Weight 356.4 Topological Polar Surface Area 73.6
XlogP 3.4 Complexity 616
Heavy Atom Count 25 Rotatable Bond Count 4
Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 5
Full List of Drug Formulations (DFMs) Containing This API
          Sulindac 150 mg tablet Click to Show/Hide the Full List of Formulation(s):          7 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Sodium lauryl sulfate; Magnesium stearate; Croscarmellose sodium; Silicon dioxide; Cellulose, microcrystalline; Starch, corn
                   Dosage Form Oral Tablet
                   Company Avera McKennan Hospital; Mylan Pharamceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [3]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Sodium lauryl sulfate; Magnesium stearate; Povidone; Cellulose, microcrystalline; Starch, corn
                   Dosage Form Oral Tablet
                   Company State of Florida DOH Central Pharmacy
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [2]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [4]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Sodium lauryl sulfate; Magnesium stearate; Povidone k30; Cellulose, microcrystalline; Starch, corn
                   Dosage Form Oral Tablet
                   Company Heritage Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
             Drug Formulation 4 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Magnesium stearate; Cellulose, microcrystalline; Starch, corn
                   Dosage Form Oral Tablet
                   Company Actavis Pharma; Bryant Ranch Prepack; Physicians Total Care
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [5]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
             Drug Formulation 5 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Cellulose, microcrystalline; Povidone k29/32; Sodium starch glycolate type a potato
                   Dosage Form Oral Tablet
                   Company Major Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
             Drug Formulation 6 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Cellulose, microcrystalline; Povidone k29/32; Sodium starch glycolate type a potato
                   Dosage Form Oral Tablet
                   Company AvKARE; Epic Pharma; Golden State Medical Supply; PuraCap Laboratories
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
             Drug Formulation 7 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Cellulose, microcrystalline
                   Dosage Form Oral Tablet
                   Company Golden State Medical Supply; Sun Pharmaceutical Industries
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
          Sulindac 200 mg tablet Click to Show/Hide the Full List of Formulation(s):        10 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Sodium lauryl sulfate; Magnesium stearate; Croscarmellose sodium; Silicon dioxide; Cellulose, microcrystalline; Starch, corn
                   Dosage Form Oral Tablet
                   Company Mylan Pharamceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [3]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Sodium lauryl sulfate; Magnesium stearate; Povidone; Cellulose, microcrystalline; Starch, corn
                   Dosage Form Oral Tablet
                   Company State of Florida DOH Central Pharmacy
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [2]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [4]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Sodium lauryl sulfate; Magnesium stearate; Povidone k30; Cellulose, microcrystalline; Starch, corn
                   Dosage Form Oral Tablet
                   Company Heritage Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
             Drug Formulation 4 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Magnesium stearate; Cellulose, microcrystalline; Starch, corn
                   Dosage Form Oral Tablet
                   Company Actavis Pharma; Bryant Ranch Prepack; Carilion Materials Management; H. J. Harkins Company; PD-Rx Pharmaceuticals; Physicians Total Care
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [5]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
             Drug Formulation 5 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Magnesium stearate; Cellulose, microcrystalline; Starch, corn
                   Dosage Form Oral Tablet
                   Company Lake Eire Medical & Surgical Supply DBA Quality Care Products
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [5]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
             Drug Formulation 6 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Povidone k30; Cellulose, microcrystalline; Sodium starch glycolate type a potato
                   Dosage Form Oral Tablet
                   Company Aidarex Pharmaceuticals; AvKARE; Epic Pharma; Golden State Medical Supply; PuraCap Laboratories; Stat Rx USA; State of Florida DOH Central Pharmacy
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
             Drug Formulation 7 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Povidone k30; Microcrystalline cellulose; Sodium starch glycolate type a potato
                   Dosage Form Oral Tablet
                   Company A-S Medication Solutions
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
             Drug Formulation 8 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Cellulose, microcrystalline; Povidone k29/32; Sodium starch glycolate type a potato
                   Dosage Form Oral Tablet
                   Company Major Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
             Drug Formulation 9 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Cellulose, microcrystalline; Starch, corn
                   Dosage Form Oral Tablet
                   Company DirectRX
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
             Drug Formulation 10 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Cellulose, microcrystalline; Starch, corn
                   Dosage Form Oral Tablet
                   Company State of Florida DOH Central Pharmacy
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
References
1 FDA label for approved sulindac from the official website of the U.S. Food and Drug Administration.
2 Bacterial metabolism rescues the inhibition of intestinal drug absorption by food and drug additives. Proc Natl Acad Sci U S A. 2020 Jul 7;117(27):16009-16018.
3 Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12.
4 Mediation of in vitro cytochrome p450 activity by common pharmaceutical excipients. Mol Pharm. 2013 Jul 1;10(7):2739-48.
5 The activities of drug inactive ingredients on biological targets. Science. 2020 Jul 24;369(6502):403-413.

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