Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D00675)
Name
Ticlopidine
Synonyms    Click to Show/Hide the Synonyms of This API
ticlopidine; 55142-85-3; 5-(2-Chlorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine; Ticlid; Ticlopidinum; Ticlopidina; PCR 5332; UNII-OM90ZUW7M1; 5-[(2-chlorophenyl)methyl]-6,7-dihydro-4H-thieno[3,2-c]pyridine; 5-[(2-chlorophenyl)methyl]-4,5,6,7-tetrahydrothieno[3,2-c]pyridine; 5-((2-Chlorophenyl)methyl)-4,5,6,7-tetrahydrothieno(3,2-c)pyridine; OM90ZUW7M1; CHEBI:9588; 5-[(2-chlorophenyl)methyl]-4H,5H,6H,7H-thieno[3,2-c]pyridine; Ticlopidine-d4; Thieno(3,2-c)pyridine, 4,5,6,7-tetrahydro-5-((2-chlorophenyl)methyl)-; PCR 5332; Ticlid; Ticlop;Tiklyd; NCGC00016872-06; DSSTox_CID_3669; Thieno[3,2-c]pyridine, 5-[(2-chlorophenyl)methyl]-4,5,6,7-tetrahydro-; Ticlopidine [INN:BAN]; DSSTox_RID_77136; DSSTox_GSID_23669; Ticlopidinum [INN-Latin]; Ticlopidina [INN-Spanish]; Thieno(3,2-c)pyridine, 5-((2-chlorophenyl)methyl)-4,5,6,7-tetrahydro-; SMR000641861; Ticlopidine (INN); CAS-55142-85-3; Ticlopidin-Puren (TN); EINECS 259-498-5; BRN 1216802; 1246817-49-1; Thieno[3,2-c]pyridine, 5-[(2-chlorophenyl)methyl]-4,5,6,7-tetrahydro-, hydrochloride; Prestwick0_000047; Prestwick1_000047; Prestwick2_000047; Prestwick3_000047; CHEMBL833; SCHEMBL4204; BIDD:PXR0169; BSPBio_000173; MLS001201825; MLS006011439; SPBio_002094; BPBio1_000191; GTPL7307; DTXSID5023669; BDBM85509; HMS2089I18; HMS2962E14; BCP25528; NSC_5472; Tox21_110658; BBL028843; MFCD00661081; STK589340; ZINC19594599; AKOS005511613; Tox21_110658_1; DB00208; DS-6623; MCULE-3971692083; NCGC00016872-01; NCGC00016872-02; NCGC00016872-03; NCGC00016872-04; NCGC00016872-05; NCGC00016872-07; NCGC00016872-09; NCGC00016872-10; NCGC00016872-12; NCGC00024361-04; AC-15204; AK122369; SBI-0206813.P001; CAS-53885-35-1; CAS_55142-85-3; UNM-0000345023; FT-0619727; FT-0675227; ST51015152; C07140; D08594; 142T853; L001108; Q420571; BRD-K00603606-003-03-4; BRD-K00603606-003-13-3; Z231745614; 5-(2-chlorobenzyl)-6,7-dihydro-4H-thieno[3,2-c]pyridine; 5-(2-chlorobenzyl)-4,5,6,7tetrahydrothieno[3,2-c]pyridine; 5-(O-Chlorobenzyl)-4,5,6,7-tetrahydrothieno-[3,2-c]pyridine; 5-(2-Chlorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine #; 5-[(2-chlorophenyl)methyl]-4,5,6,7-tetrahydrothiopheno[3,2-c]pyridine
Clinical Status
Approved
Disease Indication Cerebral stroke ICD-11: 8B11 [1]
PubChem CID
5472
Formula
C14H14ClNS
Canonical SMILES
C1CN(CC2=C1SC=C2)CC3=CC=CC=C3Cl
InChI
1S/C14H14ClNS/c15-13-4-2-1-3-11(13)9-16-7-5-14-12(10-16)6-8-17-14/h1-4,6,8H,5,7,9-10H2
InChIKey
PHWBOXQYWZNQIN-UHFFFAOYSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=5472"></iframe>
3D MOL 2D MOL
Physicochemical Properties Molecular Weight 263.8 Topological Polar Surface Area 31.5
XlogP 3.6 Complexity 261
Heavy Atom Count 17 Rotatable Bond Count 2
Hydrogen Bond Donor Count 0 Hydrogen Bond Acceptor Count 2
Full List of Drug Formulations (DFMs) Containing This API
          Ticlopidine 250 mg tablet Click to Show/Hide the Full List of Formulation(s):          5 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Magnesium stearate; Butylated hydroxyanisole; Titanium dioxide; Povidone; Cellulose, microcrystalline; Hypromelloses; Polyethylene glycols; Starch, corn
                   Dosage Form Oral Tablet
                   Company AvKARE; Teva Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [2]
Butylhydroxyanisole DIG Info Prostaglandin G/H synthase 2 (IC50 = 2.6 uM) [2]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Magnesium stearate; Butylated hydroxyanisole; Titanium dioxide; Cellulose, microcrystalline; Hypromelloses; Polyethylene glycols; Povidones; Starch, corn
                   Dosage Form Oral Tablet
                   Company Carilion Materials Management
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [2]
Butylhydroxyanisole DIG Info Prostaglandin G/H synthase 2 (IC50 = 2.6 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Titanium dioxide; Croscarmellose sodium; Cellulose, microcrystalline; Hypromellose 2910 (5 mpa.s); Polyethylene glycol
                   Dosage Form Oral Tablet
                   Company Apotex
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [2]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [4]
             Drug Formulation 4 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Titanium dioxide; Polysorbate 80; Povidone; Cellulose, microcrystalline; Colloidal silicon dioxide; Hypromelloses; Polyethylene glycol; Starch, corn
                   Dosage Form Oral Tablet
                   Company Eon Labs
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [2]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 5 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Talc; Titanium dioxide; Polyethylene glycol 400; Polysorbate 80; Cellulose, microcrystalline; Hypromelloses; Polyethylene glycols; Starch, pregelatinized corn
                   Dosage Form Oral Tablet
                   Company Caraco Pharmaceutical Laboratories
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [2]
Polyethylene glycol 400 DIG Info Albendazole monooxygenase (IC50 = 10.77 mg.mL-1) [5]
References
1 FDA label for approved ticlopidine from the official website of the U.S. Food and Drug Administration.
2 The activities of drug inactive ingredients on biological targets. Science. 2020 Jul 24;369(6502):403-413.
3 Mediation of in vitro cytochrome p450 activity by common pharmaceutical excipients. Mol Pharm. 2013 Jul 1;10(7):2739-48.
4 Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12.
5 Pharmaceutical excipients inhibit cytochrome P450 activity in cell free systems and after systemic administration. Eur J Pharm Biopharm. 2008 Sep;70(1):279-88.

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