Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D00709)
Name
Triprolidine
Synonyms    Click to Show/Hide the Synonyms of This API
triprolidine; Actidil; 486-12-4; Triprolidin; Myidyl; Triprolidinum; Tripolidina; Histafed; Actifed; UNII-2L8T9S52QM; trans-1-(2-Pyridyl)-3-pyrrolidino-1-p-tolylprop-1-ene; ACTAHIST; ALLERFED; CORPHED; TRILITRON; TRIPHED; trans-1-(4-Methylphenyl)-1-(2-pyridyl)-3-pyrrolidinoprop-1-ene; CHEMBL855; 2-[(E)-1-(4-methylphenyl)-3-pyrrolidin-1-ylprop-1-enyl]pyridine; 2L8T9S52QM; CHEBI:84116; NCGC00024714-03; NCI-C61450; trans-2-(3-(1-Pyrrolidinyl)-1-p-tolylpropenyl)pyridine; DSSTox_CID_3718; 2-[(1E)-1-(4-methylphenyl)-3-(pyrrolidin-1-yl)prop-1-en-1-yl]pyridine; DSSTox_RID_77161; DSSTox_GSID_23718; Triprolidine [INN:BAN]; Tripolidina [INN-Spanish]; Triprolidinum [INN-Latin]; (E)-2-[3-(1-Pyrrolidinyl)-1-p-toluenepropenyl]pyridine; HSDB 6316; (E)-2-1-(4-METHYLPHENYL)-3-(1-PYRROLIDINYL)-1-PROPENYL-PYRIDINE; CAS-486-12-4; Pyridine, 2-(3-(1-pyrrolidinyl)-1-p-tolylpropenyl)-, (E)-; Triprolidine (INN); CCRIS 7212; EINECS 207-627-0; (E)-2-(1-(4-Methylphenyl)-3-(1-pyrrolidinyl)-1-propenyl)pyridine; Prestwick2_000262; Prestwick3_000262; Spectrum5_001467; SCHEMBL4905; Lopac0_001130; BSPBio_000104; BSPBio_002255; (E)-2-(3-(pyrrolidin-1-yl)-1-p-tolylprop-1-enyl)pyridine; BIDD:GT0569; BPBio1_000116; GTPL1228; DTXSID3023718; HMS2089M21; 10191-42-1; Tox21_110919; BDBM50292411; CCG-12422; ZINC12503099; Tox21_110919_1; DB00427; SDCCGSBI-0025383.P005; IDI1_000297; NCGC00024714-02; NCGC00024714-04; NCGC00024714-05; NCGC00024714-06; NCGC00024714-07; NCGC00024714-08; NCGC00024714-11; NCGC00024714-15; BIM-0025383.P001; SBI-0025383.P004; D08648; AB00053563-02; AB00053563-13; AB00053563_14; 486T124; L000901; Q417654; 2-(3-Pyrrolidin-1-yl-1-p-tolyl-propenyl)-pyridine; BRD-K11742128-003-05-1; BRD-K11742128-003-15-0; 1-((E)-3-Pyridin-2-yl-3-p-tolyl-allyl)-pyrrolidinium; 2-((E)-3-Pyrrolidin-1-yl-1-p-tolyl-propenyl)-pyridine; 2-(3-(pyrrolidin-1-yl)-1-p-tolylprop-1-enyl)pyridine; (E)-2-(3-(Pyrrolidin-1-yl)-1-(p-tolyl)prop-1-en-1-yl)pyridine
Clinical Status
Approved
Disease Indication Allergic rhinitis ICD-11: CA08 [1]
PubChem CID
5282443
Formula
C19H22N2
Canonical SMILES
CC1=CC=C(C=C1)/C(=C\\CN2CCCC2)/C3=CC=CC=N3
InChI
1S/C19H22N2/c1-16-7-9-17(10-8-16)18(19-6-2-3-12-20-19)11-15-21-13-4-5-14-21/h2-3,6-12H,4-5,13-15H2,1H3/b18-11+
InChIKey
CBEQULMOCCWAQT-WOJGMQOQSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=5282443"></iframe>
3D MOL 2D MOL
Physicochemical Properties Molecular Weight 278.4 Topological Polar Surface Area 16.1
XlogP 3.9 Complexity 336
Heavy Atom Count 21 Rotatable Bond Count 4
Hydrogen Bond Donor Count 0 Hydrogen Bond Acceptor Count 2
Full List of Drug Formulations (DFMs) Containing This API
          Triprolidine 1.25 mg tablet Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Sucralose; Magnesium stearate; Xylitol; Microcrystalline cellulose; Sodium starch glycolate type a potato
                   Dosage Form Chewable Tablet
                   Company Allegis Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sucralose DIG Info Carbonic anhydrase II (Ki = 300 nM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
References
1 FDA label for approved triprolidine from the official website of the U.S. Food and Drug Administration.
2 Sweet Binders: Carbonic Anhydrase IX in Complex with Sucralose. ACS Med Chem Lett. 2018 May 10; 9(7):657-661.
3 Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12.

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