Details of the Drug Inactive Ingredient (DIG)

General Information of DIG (ID: E04KTP)
DIG Name	Sucralose
Synonyms	Click to Show/Hide the Synonyms of This DIG Sucralose; 56038-13-2; Trichlorosucrose; Splenda; Aspasvit; Acucar Light; Trichlorogalacto-sucrose; 1',4,6'-Trichlorogalactosucrose; UNII-96K6UQ3ZD4; EINECS 259-952-2; BRN 3654410; 96K6UQ3ZD4; 1,6-Dichloro-1,6-dideoxy-beta-D-fructofuranosyl 4-chloro-4-deoxy-alpha-D-galactopyranoside; CHEBI:32159; 1,6-Dichloro-1,6-dideoxy-beta-D-fructofuranosyl-4-chloro-4-deoxy-alpha-D-galactopyranoside; (2R,3R,4R,5R,6R)-2-[(2R,3S,4S,5S)-2,5-bis(chloromethyl)-3,4-dihydroxyoxolan-2-yl]oxy-5-chloro-6-(hydroxymethyl)oxane-3,4-diol; CHEMBL3185084; DSSTox_CID_20245; DSSTox_RID_79457; DSSTox_GSID_40245; MFCD03648615; 4,1',6'-Trichloro-4,1',6'-trideoxy-galacto-sucrose; a-D-Galactopyranoside, 1,6-dichloro-1,6-dideoxy-b-D-fructofuranosyl4-chloro-4-deoxy-; (2R,3R,4R,5R,6R)-2-(((2R,3S,4S,5S)-2,5-Bis(chloromethyl)-3,4-dihydroxytetrahydrofuran-2-yl)oxy)-5-chloro-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4-diol; CAS-56038-13-2; Sucralose [BAN:NF]; 1,6-Dichloro-1,6-dideoxy-beta-D-fructofuranosyl 4-chloro-4-deoxy-alpha-D-galactose; E955; CCRIS 8449; Sucralose FCC; HSDB 7964; SCHEMBL3686; alpha-D-Galactopyranoside, 1,6-dichloro-1,6-dideoxy-beta-D-fructofuranosyl 4-chloro-4-deoxy-; Sucralose, analytical standard; DTXSID1040245; Sucralose 25% Liquid Concentrate; HMS2093H16; Pharmakon1600-01505953; (2R,3R,4R,5R,6R)-2-{[(2S,3R,4R,5R)-2,5-BIS(CHLOROMETHYL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]OXY}-5-CHLORO-6-(HYDROXYMETHYL)TETRAHYDRO-2H-PYRAN-3,4-DIOL; 40J; HY-N0614; Sucralose, >=98.0% (HPLC); ZINC4654665; Tox21_113658; Tox21_201752; Tox21_303425; BDBM50367128; NSC759272; s4214; AKOS015962432; CCG-213995; CS-8130; NSC-759272; NCGC00249110-01; NCGC00249110-03; NCGC00249110-04; NCGC00257400-01; NCGC00259301-01; (2R,3R,4R,5R,6R)-2-[(2R,3S,4S,5S)-2,5-bis(chloromethyl)-3,4-dihydroxy-tetrahydrofuran-2-yl]oxy-5-chloro-6-(hydroxymethyl)tetrahydropyran-3,4-diol; 1-(1,6-Dichloro-1,6-dideoxy-beta-D-fructofuranosyl)-4-chloro-4-deoxy-alpha-D-galactopyranoside; SBI-0206860.P001; Sucralose 1000 microg/mL in Acetonitrile; S0839; A22902; C12285; K-9960; AB01563242_01; AB01563242_02; 038S132; Q410209; SR-05000001935; SR-05000001935-1; W-203112; BRD-K58968598-001-03-6; Sucralose, European Pharmacopoeia (EP) Reference Standard; Sucralose, United States Pharmacopeia (USP) Reference Standard; Sucralose, Pharmaceutical Secondary Standard; Certified Reference Material; 1,6-Dichloro-1,6-dideoxy-beta-D-fructofuranosyl 4-chloro-4-deoxy-alpha-D-galactopyranoside; 1,6-dichloro-1,6-dideoxy-beta-d-fructofuranosyl4-chloro-4-deoxy-alpha-d-gala;; (2R,3R,4R,5R,6R)-2-((2R,3S,4S,5S)-2,5-bis(chloromethyl)-3,4-dihydroxytetrahydrofuran-2-yloxy)-5-chloro-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4-diol
DIG Function	Flavoring agent
PubChem CID	71485
Formula	C12H19Cl3O8
Canonical SMILES	C([C@@H]1[C@@H]([C@@H]([C@H]([C@H](O1)O[C@]2([C@H]([C@@H]([C@H](O2)CCl)O)O)CCl)O)O)Cl)O
InChI	1S/C12H19Cl3O8/c13-1-4-7(17)10(20)12(3-14,22-4)23-11-9(19)8(18)6(15)5(2-16)21-11/h4-11,16-20H,1-3H2/t4-,5-,6+,7-,8+,9-,10+,11-,12+/m1/s1
InChIKey	BAQAVOSOZGMPRM-QBMZZYIRSA-N
	Click to Show/Hide the Molecular Data (Structure/Property) of This DIG
Structure	<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=71485"></iframe>
Structure	3D MOL		2D MOL
Physicochemical Properties	Molecular Weight	397.6	Topological Polar Surface Area	129
	XlogP	-1.5	Complexity	405
	Heavy Atom Count	23	Rotatable Bond Count	5
	Hydrogen Bond Donor Count	5	Hydrogen Bond Acceptor Count	8

Full List of Active Pharmaceutical Ingredients (APIs) Co-administrated with This DIG
ICD Disease Classification 01		Infectious/parasitic disease	Click to Show/Hide
Raltegravir	API Info	Human immunodeficiency virus infection [ICD-11: 1C60]		[1]
Mebendazole	API Info	Ascariasis [ICD-11: 1F62]		[2]
Albendazole	API Info	Cysticercosis [ICD-11: 1F70]		[3]
Dolutegravir	API Info	Human immunodeficiency virus infection [ICD-11: 1C60]		[4]
ICD Disease Classification 02		Benign/in-situ/malignant neoplasm	Click to Show/Hide
Prednisolone	API Info	Multiple myeloma [ICD-11: 2A83]		[5]
ICD Disease Classification 03		Blood/blood-forming organ disease	Click to Show/Hide
Eltrombopag	API Info	Thrombocytopenia [ICD-11: 3B64]		[6]
ICD Disease Classification 04		Immune system disease	Click to Show/Hide
Cetirizine	API Info	Allergy [ICD-11: 4A80]		[7]
ICD Disease Classification 05		Endocrine/nutritional/metabolic disease	Click to Show/Hide
Phentermine	API Info	Obesity [ICD-11: 5B81]		[8]
ICD Disease Classification 06		Mental/behavioural/neurodevelopmental disorder	Click to Show/Hide
Alprazolam	API Info	Anxiety disorder [ICD-11: 6B00]		[9]
Lamotrigine	API Info	Bipolar disorder [ICD-11: 6A60]		[10]
Olanzapine	API Info	Schizophrenia [ICD-11: 6A20]		[11]
Methylphenidate	API Info	Attention deficit hyperactivity disorder [ICD-11: 6A05]		[12]
Lisdexamfetamine	API Info	Attention deficit hyperactivity disorder [ICD-11: 6A05]		[13]
Amphetamine	API Info	Attention deficit hyperactivity disorder [ICD-11: 6A05]		[14]
Asenapine	API Info	Schizophrenia [ICD-11: 6A20]		[15]
ICD Disease Classification 07		Sleep-wake disorder	Click to Show/Hide
Zolpidem	API Info	Insomnia [ICD-11: 7A00]		[16]
ICD Disease Classification 08		Nervous system disease	Click to Show/Hide
Acetaminophen	API Info	Anaesthesia [ICD-11: 8E22]		[17]
Levetiracetam	API Info	Focal seizure [ICD-11: 8A68]		[18]
Rizatriptan	API Info	Migraine [ICD-11: 8A80]		[19]
Donepezil	API Info	Alzheimer disease [ICD-11: 8A20]		[20]
Tapentadol	API Info	Neuropathic pain [ICD-11: 8E43]		[21]
Entacapone	API Info	Parkinsonism [ICD-11: 8A00]		[22]
Benzocaine	API Info	Anaesthesia [ICD-11: 8E22]		[23]
ICD Disease Classification 09		Visual system disease	Click to Show/Hide
Dextromethorphan	API Info	Allergic conjunctivitis [ICD-11: 9A60]		[24]
Acetylcysteine	API Info	Pterygium [ICD-11: 9A61]		[25]
ICD Disease Classification 10		Ear/mastoid process disease	Click to Show/Hide
Diphenhydramine	API Info	Meniere disease [ICD-11: AB31]		[26]
ICD Disease Classification 11		Circulatory system disease	Click to Show/Hide
Aspirin	API Info	Myocardial infarction [ICD-11: BA41]		[27]
Verapamil	API Info	Essential hypertension [ICD-11: BA00]		[28]
ICD Disease Classification 12		Respiratory system disease	Click to Show/Hide
Montelukast	API Info	Asthma [ICD-11: CA23]		[29]
Guaifenesin	API Info	Asthma [ICD-11: CA23]		[30]
Dexbrompheniramine	API Info	Allergic rhinitis [ICD-11: CA08]		[31]
Triprolidine	API Info	Allergic rhinitis [ICD-11: CA08]		[32]
ICD Disease Classification 13		Digestive system disease	Click to Show/Hide
Omeprazole	API Info	Gastro-oesophageal reflux disease [ICD-11: DA22]		[33]
Bisacodyl	API Info	Irritable bowel syndrome [ICD-11: DD91]		[34]
Lansoprazole	API Info	Duodenal ulcer [ICD-11: DA63]		[35]
Simethicone	API Info	Irritable bowel syndrome [ICD-11: DD91]		[36]
Ranitidine	API Info	Gastric ulcer [ICD-11: DA60]		[37]
Loperamide	API Info	Irritable bowel syndrome [ICD-11: DD91]		[38]
Bismuth subsalicylate	API Info	Irritable bowel syndrome [ICD-11: DD91]		[39]
Famotidine	API Info	Peptic ulcer [ICD-11: DA61]		[40]
Sodium fluoride	API Info	Periodontal disease [ICD-11: DA0C]		[41]
Dexlansoprazole	API Info	Gastro-oesophageal reflux disease [ICD-11: DA22]		[42]
ICD Disease Classification 15		Musculoskeletal/connective-tissue disease	Click to Show/Hide
Alendronic acid	API Info	Osteoporosis [ICD-11: FB83]		[43]
Tofacitinib	API Info	Rheumatoid arthritis [ICD-11: FA20]		[44]
ICD Disease Classification 16		Genitourinary system disease	Click to Show/Hide
Ibuprofen	API Info	Dysmenorrhea [ICD-11: GA34]		[45]
Trospium	API Info	Overactive bladder [ICD-11: GC50]		[46]
ICD Disease Classification 18		Pregnancy/childbirth/puerperium condition	Click to Show/Hide
Doxylamine	API Info	Morning sickness [ICD-11: JA60]		[47]

Full List of Biological Targets of DIG (DBTs) Regulated by This DIG
Lyase/isomerase/ligase (L/I/G)
DBT Name: Carbonic anhydrase II (CA2)		Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Biological Activity	Ki = 300 nM (tested by experiment)		[48]
Tested Species	Homo sapiens (Human)
UniProt ID	CAH2_HUMAN
DBT Name: Carbonic anhydrase IX (CA9)		Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Biological Activity	Ki = 2200 nM (tested by experiment)		[48]
Tested Species	Homo sapiens (Human)
UniProt ID	CAH9_HUMAN

References
1	2007 FDA drug approvals: a year of flux. Nat Rev Drug Discov. 2008 Feb;7(2):107-9.
2	FDA label for approved mebendazole from the official website of the U.S. Food and Drug Administration.
3	FDA label for approved albendazole from the official website of the U.S. Food and Drug Administration.
4	FDA label for approved dolutegravir from the official website of the U.S. Food and Drug Administration.
5	FDA label for approved prednisolone from the official website of the U.S. Food and Drug Administration.
6	FDA label for approved eltrombopag from the official website of the U.S. Food and Drug Administration.
7	FDA label for approved cetirizine from the official website of the U.S. Food and Drug Administration.
8	FDA label for approved phentermine from the official website of the U.S. Food and Drug Administration.
9	FDA label for approved alprazolam from the official website of the U.S. Food and Drug Administration.
10	FDA label for approved lamotrigine from the official website of the U.S. Food and Drug Administration.
11	FDA label for approved olanzapine from the official website of the U.S. Food and Drug Administration.
12	FDA label for approved methylphenidate from the official website of the U.S. Food and Drug Administration.
13	FDA label for approved lisdexamfetamine from the official website of the U.S. Food and Drug Administration.
14	FDA label for approved amphetamine from the official website of the U.S. Food and Drug Administration.
15	FDA label for approved asenapine from the official website of the U.S. Food and Drug Administration.
16	FDA label for approved zolpidem from the official website of the U.S. Food and Drug Administration.
17	FDA label for approved acetaminophen from the official website of the U.S. Food and Drug Administration.
18	FDA label for approved levetiracetam from the official website of the U.S. Food and Drug Administration.
19	FDA label for approved rizatriptan from the official website of the U.S. Food and Drug Administration.
20	FDA label for approved donepezil from the official website of the U.S. Food and Drug Administration.
21	FDA label for approved tapentadol from the official website of the U.S. Food and Drug Administration.
22	FDA label for approved entacapone from the official website of the U.S. Food and Drug Administration.
23	Benzocaine.
24	FDA label for approved dextromethorphan from the official website of the U.S. Food and Drug Administration.
25	FDA label for approved acetylcysteine from the official website of the U.S. Food and Drug Administration.
26	FDA label for approved diphenhydramine from the official website of the U.S. Food and Drug Administration.
27	FDA label for approved aspirin from the official website of the U.S. Food and Drug Administration.
28	FDA label for approved verapamil from the official website of the U.S. Food and Drug Administration.
29	FDA label for approved montelukast from the official website of the U.S. Food and Drug Administration.
30	FDA label for approved guaifenesin from the official website of the U.S. Food and Drug Administration.
31	FDA label for approved dexbrompheniramine from the official website of the U.S. Food and Drug Administration.
32	FDA label for approved triprolidine from the official website of the U.S. Food and Drug Administration.
33	FDA label for approved omeprazole from the official website of the U.S. Food and Drug Administration.
34	FDA label for approved bisacodyl from the official website of the U.S. Food and Drug Administration.
35	FDA label for approved lansoprazole from the official website of the U.S. Food and Drug Administration.
36	FDA label for approved simethicone from the official website of the U.S. Food and Drug Administration.
37	FDA label for approved ranitidine from the official website of the U.S. Food and Drug Administration.
38	FDA label for approved loperamide from the official website of the U.S. Food and Drug Administration.
39	Bismuth Subsalicylate.
40	FDA label for approved famotidine from the official website of the U.S. Food and Drug Administration.
41	FDA label for approved sodium fluoride from the official website of the U.S. Food and Drug Administration.
42	FDA label for approved dexlansoprazole from the official website of the U.S. Food and Drug Administration.
43	FDA label for approved alendronic acid from the official website of the U.S. Food and Drug Administration.
44	FDA label for approved tofacitinib from the official website of the U.S. Food and Drug Administration.
45	FDA label for approved ibuprofen from the official website of the U.S. Food and Drug Administration.
46	FDA label for approved trospium from the official website of the U.S. Food and Drug Administration.
47	FDA label for approved doxylamine from the official website of the U.S. Food and Drug Administration.
48	Sweet Binders: Carbonic Anhydrase IX in Complex with Sucralose. ACS Med Chem Lett. 2018 May 10; 9(7):657-661.

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