Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D00720)
Name
Vandetanib
Synonyms    Click to Show/Hide the Synonyms of This API
Vandetanib; 443913-73-3; Zactima; ZD6474; Caprelsa; vandetanib (zd6474); ZD 6474; ZD-6474; UNII-YO460OQ37K; C22H24BrFN4O2; CHEMBL24828; YO460OQ37K; CHEBI:49960; GNF-PF-2188; MFCD07772346; NCGC00167513-01; DSSTox_CID_26681; DSSTox_RID_81816; DSSTox_GSID_46681; CAS-443913-73-3; Vandetanib (Zactima); Vandetinib; HSDB 8198; Vandetanib [USAN:INN:BAN:JAN]; Caprelsa (TN); AZD-6474; CH 331; CH-331; DMPC Cyclic Urea 1; Kinome_3316; PubChem22460; BDBM21; SCHEMBL9044; MLS006011672; Vandetanib (JAN/USAN/INN); F9995-0087; GTPL5717; QCR-37; Vandetanib(Zactima),ZD6474/; DTXSID1046681; SCHEMBL21067679; cid_3081361; EX-A422; SYN1090; BCPP000023; HMS3244K03; HMS3244K04; HMS3244L03; HMS3654E11; HMS3672C07; AOB87780; BCP01925; Tox21_112511; 443913-73-3 (free base); ABP000873; ANW-61824; NSC744325; NSC760766; NSC800961; ZINC53683345; AKOS015902350; Tox21_112511_1; AC-5251; CCG-269495; CS-0130; DB05294; MCULE-4705827953; NSC-744325; NSC-760766; NSC-800961; SB16919; NCGC00167513-02; NCGC00167513-03; NCGC00167513-04; NCGC00167513-09; 338992-00-0; AK106976; AS-11067; HY-10260; SMR002530472; SY027438; AB0008635; FT-0656736; SW218092-2; EC-000.2359; A25648; D06407; V-9402; W-5356; 68541-EP2298768A1; 68541-EP2308855A1; AB01273969-01; AB01273969-02; AB01273969_04; 913V733; SR-00000000462; Q7914515; SR-00000000462-2; BRD-K77625799-001-01-0
Clinical Status
Approved
Disease Indication Thyroid cancer ICD-11: 2D10 [1]
PubChem CID
3081361
Formula
C22H24BrFN4O2
Canonical SMILES
CN1CCC(CC1)COC2=C(C=C3C(=C2)N=CN=C3NC4=C(C=C(C=C4)Br)F)OC
InChI
1S/C22H24BrFN4O2/c1-28-7-5-14(6-8-28)12-30-21-11-19-16(10-20(21)29-2)22(26-13-25-19)27-18-4-3-15(23)9-17(18)24/h3-4,9-11,13-14H,5-8,12H2,1-2H3,(H,25,26,27)
InChIKey
UHTHHESEBZOYNR-UHFFFAOYSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=3081361"></iframe>
3D MOL 2D MOL
Physicochemical Properties Molecular Weight 475.4 Topological Polar Surface Area 59.5
XlogP 4.9 Complexity 539
Heavy Atom Count 30 Rotatable Bond Count 6
Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 7
Full List of Drug Formulations (DFMs) Containing This API
          Vandetanib 100 mg tablet Click to Show/Hide the Full List of Formulation(s):          3 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Dibasic calcium phosphate dihydrate; Titanium dioxide; Water; Crospovidone; Polyethylene glycol 300; Povidone; Cellulose, microcrystalline; Hypromelloses
                   Dosage Form Oral Tablet
                   Company AstraZeneca
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
Crospovidone DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
Polyethylene glycol 300 DIG Info Multidrug resistance protein 1 (Inhibition ratio = 54 %) [4]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Dibasic calcium phosphate dihydrate; Titanium dioxide; Water; Polyethylene glycol 300; Cellulose, microcrystalline; Crospovidone (15 mpa.s at 5%); Hypromelloses; Povidones
                   Dosage Form Oral Tablet
                   Company AstraZeneca
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
Polyethylene glycol 300 DIG Info Multidrug resistance protein 1 (Inhibition ratio = 54 %) [4]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Dibasic calcium phosphate dihydrate; Titanium dioxide; Water; Polyethylene glycol 300; Crospovidone (15 mpa.s at 5%); Hypromellose, unspecified; Microcrystalline cellulose; Povidone, unspecified
                   Dosage Form Oral Tablet
                   Company Genzyme Corporation
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
Polyethylene glycol 300 DIG Info Multidrug resistance protein 1 (Inhibition ratio = 54 %) [4]
          Vandetanib 300 mg tablet Click to Show/Hide the Full List of Formulation(s):          3 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Dibasic calcium phosphate dihydrate; Titanium dioxide; Water; Crospovidone; Polyethylene glycol 300; Povidone; Cellulose, microcrystalline; Hypromelloses
                   Dosage Form Oral Tablet
                   Company AstraZeneca
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
Crospovidone DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
Polyethylene glycol 300 DIG Info Multidrug resistance protein 1 (Inhibition ratio = 54 %) [4]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Dibasic calcium phosphate dihydrate; Titanium dioxide; Water; Polyethylene glycol 300; Cellulose, microcrystalline; Crospovidone (15 mpa.s at 5%); Hypromelloses; Povidones
                   Dosage Form Oral Tablet
                   Company AstraZeneca
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
Polyethylene glycol 300 DIG Info Multidrug resistance protein 1 (Inhibition ratio = 54 %) [4]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Dibasic calcium phosphate dihydrate; Titanium dioxide; Water; Polyethylene glycol 300; Crospovidone (15 mpa.s at 5%); Hypromellose, unspecified; Microcrystalline cellulose; Povidone, unspecified
                   Dosage Form Oral Tablet
                   Company Genzyme Corporation
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
Polyethylene glycol 300 DIG Info Multidrug resistance protein 1 (Inhibition ratio = 54 %) [4]
References
1 FDA label for approved vandetanib from the official website of the U.S. Food and Drug Administration.
2 Mediation of in vitro cytochrome p450 activity by common pharmaceutical excipients. Mol Pharm. 2013 Jul 1;10(7):2739-48.
3 Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12.
4 The effect of polyoxyethylene polymers on the transport of ranitidine in Caco-2 cell monolayers. Int J Pharm. 2011 May 16;409(1-2):164-8.

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