Details of the Drug Inactive Ingredient (DIG) | ACDINA

General Information of DIG (ID: E05GVA)
DIG Name	Polyethylene glycol 300
DIG Function	Coating agent; Diluent; Ointment base; Plasticizing agent; Solvent; Suppository base; lubricant

Full List of Active Pharmaceutical Ingredients (APIs) Co-administrated with This DIG
ICD Disease Classification 02			Benign/in-situ/malignant neoplasm		Click to Show/Hide
Bicalutamide		API Info	Prostate cancer [ICD-11: 2C82]			[1]
Gefitinib		API Info	Lung cancer [ICD-11: 2C25]			[2]
Anastrozole		API Info	Breast cancer [ICD-11: 2C60]			[3]
Vandetanib		API Info	Thyroid cancer [ICD-11: 2D10]			[4]
ICD Disease Classification 06			Mental/behavioural/neurodevelopmental disorder		Click to Show/Hide
Escitalopram		API Info	Major depressive disorder [ICD-11: 6A70]			[5]
ICD Disease Classification 08			Nervous system disease		Click to Show/Hide
Acetaminophen		API Info	Anaesthesia [ICD-11: 8E22]			[6]
ICD Disease Classification 10			Ear/mastoid process disease		Click to Show/Hide
Diphenhydramine		API Info	Meniere disease [ICD-11: AB31]			[7]
ICD Disease Classification 11			Circulatory system disease		Click to Show/Hide
Aspirin		API Info	Myocardial infarction [ICD-11: BA41]			[8]
Caffeine		API Info	Orthostatic hypotension [ICD-11: BA21]			[9]
Irbesartan		API Info	Essential hypertension [ICD-11: BA00]			[10]
ICD Disease Classification 16			Genitourinary system disease		Click to Show/Hide
Ibuprofen		API Info	Dysmenorrhea [ICD-11: GA34]			[11]

Full List of Biological Targets of DIG (DBTs) Regulated by This DIG
Primary active transporter (PAT)
DBT Name: Multidrug resistance protein 1 (ABCB1)			Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment (1) for Assessing the Biological Activity of the Studied DIG on This DBT
Biological Activity	Inhibition ratio = 54 % (tested by experiment)				[12]
Tested Species	Homo sapiens (Human)
UniProt ID	MDR1_HUMAN ; MDR3_HUMAN ; ABCB5_HUMAN
Experiment (2) for Assessing the Biological Activity of the Studied DIG on This DBT
Biological Activity	Inhibition ratio = 90 % (tested by experiment)				[13]
Tested Species	Homo sapiens (Human)
UniProt ID	MDR1_HUMAN ; MDR3_HUMAN ; ABCB5_HUMAN
Experiment (3) for Assessing the Biological Activity of the Studied DIG on This DBT
Biological Activity	Inhibition ratio = 94 % (tested by experiment)				[13]
Tested Species	Homo sapiens (Human)
UniProt ID	MDR1_HUMAN ; MDR3_HUMAN ; ABCB5_HUMAN

References
1	FDA label for approved bicalutamide from the official website of the U.S. Food and Drug Administration.
2	FDA label for approved gefitinib from the official website of the U.S. Food and Drug Administration.
3	FDA label for approved anastrozole from the official website of the U.S. Food and Drug Administration.
4	FDA label for approved vandetanib from the official website of the U.S. Food and Drug Administration.
5	FDA label for approved escitalopram from the official website of the U.S. Food and Drug Administration.
6	FDA label for approved acetaminophen from the official website of the U.S. Food and Drug Administration.
7	FDA label for approved diphenhydramine from the official website of the U.S. Food and Drug Administration.
8	FDA label for approved aspirin from the official website of the U.S. Food and Drug Administration.
9	FDA label for approved caffeine from the official website of the U.S. Food and Drug Administration.
10	FDA label for approved irbesartan from the official website of the U.S. Food and Drug Administration.
11	FDA label for approved ibuprofen from the official website of the U.S. Food and Drug Administration.
12	The effect of polyoxyethylene polymers on the transport of ranitidine in Caco-2 cell monolayers. Int J Pharm. 2011 May 16;409(1-2):164-8.
13	A comparison of commonly used polyethoxylated pharmaceutical excipients on their ability to inhibit P-glycoprotein activity in vitro. J Pharm Sci. 2002 Sep;91(9):1991-2002.

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